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Frontiers of Business Research in China 2020年第3期14卷 257-277页

作者： Ding Ding Chong Guan calvin mlchan Wenting Liu School of Business Singapore University of Social Sciences463 Clementi RdSingapore 599494Singapore

As the 2019 novel coronavirus disease(COVID-19)pandemic rages globally,its impact has been felt in the stock markets around the *** the gloomy economic outlook,certain sectors seem to have survived better than *** paper aims to investigate the sectors that have performed better even as market sentiment is affected by the *** daily closing stock prices of a total usable sample of 1,567 firms from 37 sectors are first an a lyzed using a combination of hierarchical clustering and shape-based distance(SBD)*** sentiment is modeled from Google trends on the COVID-19 *** is then analyzed against the time series of daily closing stock prices using augmented vector autoregression(VAR).The empirical results indicate that market sentiment towards the pandemic has significant effects on the stock prices of the ***,the stock price performance across sectors is differentiated by the level of the digital transformation of sectors,with those that are most digitally transformed,showing resili ence towards negative market sentime nt on the *** study contributes to the existing literature by incorporating search trends to an a lyze market sentiment,and by showing that digital transformation moderated the stock market resilience of firms against concern over the COVID-19 outbreak.

关键词： Digital transformation Stock market Search trends Market sentiment 2019 novel coronavirus disease(COVID-19)

基于TRIZ思想的社会韧性强化研究——以引入智慧社区为例

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海峡科学 2020年第4期 58-60,66页

作者：邱栋 calvin mlchan 福建工程学院管理学院福建福州350118 新跃社科大学商学院新加坡591301

社会韧性是社会系统在面对冲击时抵抗、恢复和适应成长的能力,以维持社会结构和功能,社会韧性来自于社会要素的共生相依性。该文借鉴TRIZ思想和方法,构建了社会韧性功能模型,更为深入地认识社会韧性系统的要素及其相互作用。通过引入基... 详细信息

社会韧性是社会系统在面对冲击时抵抗、恢复和适应成长的能力,以维持社会结构和功能,社会韧性来自于社会要素的共生相依性。该文借鉴TRIZ思想和方法,构建了社会韧性功能模型,更为深入地认识社会韧性系统的要素及其相互作用。通过引入基于数字平台的智慧社区,强化社区与其他社会韧性主体的交互,加强对制度和文化的参与,使智慧社区成为社会韧性系统的重要驱动力,形成更稳定长效的社会韧性生态系统,进而减少政府投入。研究将数字平台和智慧社区引入社会韧性的研究和应用,为强化社会韧性提供新思路。

关键词：社会韧性智慧社区数字平台 TRIZ 创新方法

Ebola virus disease model with a nonlinear incidence rate and density-dependent treatment

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Infectious Disease Modelling 2024年第3期9卷 775-804页

作者： Jacques NdéKengne calvin Tadmon Committed Mathematics Team Research Unit in Mathematics and ApplicationsDepartment of Mathematics and Computer ScienceUniversity of DschangP.O.Box 67 DschangCameroon Institute of Mathematics University of MainzStaudingerweg 955128MainzGermany

This paper studies an Ebola epidemic model with an exponential nonlinear incidence function that considers the efficacy and the behaviour *** current model also incorporates a new density-dependent treatment that catches the impact of the disease transmission on the ***,we provide a theoretical study of the nonlinear differential equations model *** precisely,we derive the effective reproduction number and,under suitable conditions,prove the stability of ***,we show that the model exhibits the phenomenon of backward-bifurcation whenever the bifurcation parameter and the reproduction number are less than *** find that the bi-stability and backward-bifurcation are not automatically connected in epidemic *** fact,when a backward-bifurcation occurs,the disease-free equilibrium may be globally ***,we use well-known standard tools to fit the model to the data reported for the 2018–2020 Kivu Ebola outbreak,and perform the sensitivity *** control Ebola epidemics,our findings recommend a combination of a rapid behaviour change and the implementation of a proper treatment strategy with a high level of ***,we propose and analyze a fractional-order Ebola epidemic model,which is an extension of the first model *** use the Caputo operator and construct the Grünwald-Letnikov nonstandard finite difference scheme,and show its advantages.

关键词： Ebola epidemic models Stability Bifurcation Density-dependent treatment Sensitivity analysis Fractional differential equations Caputo fractional derivative Grünwald-letnikov nonstandard finite difference scheme

Integrating sequence and graph information for enhanced drug-target affinity prediction

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Science China(Information Sciences) 2024年第2期67卷 325-326页

作者： Haohuai HE Guanxing CHEN calvin Yu-Chian CHEN Artificial Intelligence Medical Research Center School of Intelligent Systems EngineeringShenzhen Campus of Sun Yat-sen University

Drug discovery is a pivotal discipline involving the identification and development of innovative pharmaceuticals designed to combat a wide array of illnesses. It plays a crucial role in advancing global health outcomes and improving the standard of living for individuals worldwide. However,drug discovery often relies on laborious in vitro experiments,

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Quantifying droplet–solid friction using an atomic force microscope

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Droplet 2024年第2期3卷 105-112页

作者： Xue Qi Koh calvin Thenarianto Ville Jokinen Dan Daniel Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Department of Chemistry and Materials Science School of Chemical EngineeringAalto UniversityEspooFinland Division of Physical Sciences and Engineering King Abdullah University of Science and Technology(KAUST)ThuwalSaudi Arabia

Controlling the wetting and spreading of microdroplets is key to technologies such as microfluidics,ink-jet printing,and surface *** angle goniometry is commonly used to characterize surface wetting by droplets,but the technique is ill-suited for high contact angles close to 180°.Here,we attach a micrometric-sized droplet to an atomic force microscope cantilever to directly quantify droplet–solid friction on different surfaces(superhydrophobic and underwater superoleophobic)with sub-nanonewton force *** demonstrate the versatility of our approach by performing friction measurements using different liquids(water and oil droplets)and under different ambient environments(in air and underwater).Finally,we show that underwater superoleophobic surfaces can be qualitatively different from superhydrophobic surfaces:droplet–solid friction is highly sensitive to droplet speeds for the former but not for the latter surface.

关键词： surface. underwater latter

Screening for metabolic dysfunction-associated fatty liver disease:Time to discard the emperor’s clothes of normal liver enzymes?

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World Journal of Gastroenterology 2024年第22期30卷 2839-2842页

作者： Chen-Xiao Huang Xiao-Dong Zhou calvin Q Pan Ming-Hua Zheng Metabolic Dysfunction-Associated Fatty Liver Disease Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Cardiovascular Medicine The Key Laboratory of Cardiovascular Diseases of WenzhouThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Division of Gastroenterology and Hepatology Department of MedicineNew York University Langone HealthNew York University Grossman School of MedicineNew YorkNY 11355United States Institute of Hepatology Wenzhou Medical UniversityKey Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang ProvinceWenzhou 325000Zhejiang ProvinceChina

Metabolic dysfunction-associated fatty liver disease(MAFLD)is the most prevalent chronic liver condition *** liver enzyme-based screening methods have limitations that may missed diagnoses and treatment *** Chen et al,the risk of developing MAFLD remains elevated even when alanine aminotransferase levels fall within the normal ***,there is an urgent need for advanced diagnostic techniques and updated algorithms to enhance the accuracy of MAFLD diagnosis and enable early *** paper proposes two potential screening methods for identifying individuals who may be at risk of developing MAFLD:Lowering these thresholds and promoting the use of noninvasive liver fibrosis scores.

关键词： Metabolic dysfunction-associated fatty liver disease Non-alcoholic fatty liver disease Alanine aminotransferase Liver enzymes Screening Noninvasive liver fibrosis scores

The Impact of Privatization on Terminal Efficiency: A Case Study of Tema Port

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Journal of Transportation Technologies 2024年第3期14卷 358-371页

作者： Bernard Kwei Tetteh calvin Elorm Atsunyo Alex Boateng College of Transport and Communications Shanghai Maritime University Shanghai China Department of Transport Regional Maritime University Accra Ghana

Port and terminal efficiency are of utmost importance to the container shipping industry due to their significance in enhancing the competitive advantage of ports within a region. Consequently, there have always been notable variations of studies around it. This paper analyzes the impact of privatization on terminal efficiency using the Port of Tema as a Case Study. The main objective of this paper is to analyze the efficiency trends of the public and private terminals in the port over the years. To achieve this objective, DEA-CCR methodology was employed to calculate the annual technical efficiency trends of the private and public terminals using four input variables and three output variables. The main results of the paper indicated that the public and private terminals were efficient for multiple years. However, the efficiency scores over the years demonstrated inconsistency, exhibiting notable fluctuations. The findings of this study will aid policymakers across the region on policies relating to the efficiency and ownership structure of ports and terminals.

关键词： Privatization Terminal Efficiency DEA Tema Port

Construction of a broad-host-range Anderson promoter series and particulate methane monooxygenase promoter variants expand the methanotroph genetic toolbox

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Synthetic and Systems Biotechnology 2024年第2期9卷 250-258页

作者： Etash H.Bhat Jessica M.Henard Spencer A.Lee Dustin McHalffey Mahith S.Ravulapati Elle V.Rogers Logan Yu David Skiles calvin A.Henard Department of Biological Sciences and BioDiscovery Institute University of North TexasDentonTXUSA

Methanotrophic bacteria are currently used industrially for the bioconversion of methane-rich natural gas and anaerobic digestion-derived biogas to valuable *** bacteria may also serve to mitigate the negative effects of climate change by capturing atmospheric greenhouse *** genetic tools have previously been developed for genetic and metabolic engineering of ***,the available tools for use in methanotrophs are significantly underdeveloped compared to many other industrially relevant bacteria,which hinders genetic and metabolic engineering of these *** such,expansion of the methanotroph genetic toolbox is needed to further our understanding of methanotrophy and develop biotechnologies that leverage these unique microbes for mitigation and conversion of methane to valuable ***,we determined the copy number of three broad-host-range plasmids in Methylococcus capsulatus Bath and Methylosinus trichosporium OB3b,representing phylogenetically diverse Gammaproteobacterial and Alphaproteobacterial methanotrophs,***,we show that the commonly used synthetic Anderson series promoters are functional and exhibit similar relative activity in *** and *** OB3b,but the synthetic series had limited ***,we mutagenized the native *** particulate methane monooxygenase promoter and identified variants with activity that expand the activity range of synthetic,constitutive promoters functional not only in ***,but also in Escherichia ***,the tools developed here advance the methanotroph genetic engineering toolbox and represent additional synthetic genetic parts that may have broad applicability in Pseudomonadota bacteria.

关键词： Methanotroph Methane monooxygenase Promoter Metabolic engineering Synthetic biology

以专业使命为本的行业——专访中国香港会计师公会会长梁思杰

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新理财（公司理财） 2024年第4期 73-75页

作者： Jemelyn Yadao calvin Sit(图) 不详

中国香港会计师公会新任会长梁思杰听取过许多会员的不同观点,在担任会长后的首次访谈中,他讲述着如何让会计师创造价值以及他们所担任的各种不同的角色如何成为大众焦点。会计师在各行各业发挥着正面的影响力,但人们往往未必能即时察... 详细信息

中国香港会计师公会新任会长梁思杰听取过许多会员的不同观点,在担任会长后的首次访谈中,他讲述着如何让会计师创造价值以及他们所担任的各种不同的角色如何成为大众焦点。会计师在各行各业发挥着正面的影响力,但人们往往未必能即时察觉到会计师为社会作出的贡献。

关键词：香港会计师公会会计师会长影响力

Insight of Natural Compounds Halimane Diterpenoids against Mycobacterium tuberculosis: Virtual Screening, DFT, Drug-Likeness, and Molecular Dynamics Approach

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Computational Molecular Bioscience 2024年第2期14卷 35-58页

作者： Laurent Gael Eyia Andiga Boris Davy Bekono Désiré Mama Bikele Pie Pascal Onguéné Amoa Luc calvin Owono Owono Luc Léonard Mbaze Meva’a Department of Chemistry Faculty of Science University of Douala Douala Cameroon Department of Physics Ecole Normale Suprieure University of Yaound 1 Yaound Cameroon Center for Drug Discovery Faculty of Science University of Buea Buea Cameroon Department of Chemistry University of Yaound I Institute of Wood Technology Mbalmayo Cameroon CEPAMOQ Faculty of Science University of Douala Douala Cameroon

In the purpose to design novel antituberculosis (anti-TB) drugs agents against Mycobacterium tuberculosis (Mtb), we have built a molecular library around 42 Halimane Diterpenoids isolated from natural sources. Two Mtb enzymes drug targets (Mtb Mycothiol S-transferase and Mtb Homoserine transacetylase) have been adopted. The pharmacological potential was investigated through molecular docking, molecular dynamics simulation, density functional theory (gas phase and water) and ADMET analysis. Our results indicate that (2R,5R,6S)-1,2,3,4,5,6,7,8-octahydro-5-((E)-5-hydroxy-3-methylpent-3-enyl)-1,1,5,6-tetramethylnaphtha-lene-2-ol (compound 20) has displays higher docking score with each of the selected drug targets. In addition, this molecule exhibits a satisfactory drug potential activity and a good chemical reactivity. Its improved kinetic stability in the Mtb Mycothiol S-transferase enzyme reflects its suitability as a novel inhibitor of Mtb growth. This molecule has displayed a good absorption potential. Our results also show that its passive passage of the intestinal permeability barrier is more effective than that of first-line treatments (ethambutol, isoniazid). In the same way, this anti-TB druglikeness has shown to be able to cross the blood brain barrier.

关键词： Antituberculosis Druglikeness Density Functional Theory Halimane Diterpenoids Molecular Docking Molecular Dynamics Simulation