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Genome-wide methylation profiling reveals differentially methylated genes in blood DNA of small-cell lung cancer patients

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Precision Clinical Medicine 2022年第3期5卷 192-194页

作者： Yanqi He calvin wei Zhifu Sun Julie M.Cunningham Liang Wang Zong wei Ping Yang Division of Epidemiology Department of Quantitative Health SciencesMayo ClinicScottsdaleAZ 85259USA Department of Respiratory and Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Physiology and Biomedical Engineering Mayo ClinicScottsdaleAZ 85259USA School of Molecular Science Arizona State UniversityTempeAZ 85281USA Division of Computational Biology Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905USA Genomic Shared Resource Mayo Clinic Cancer CenterRochesterMN 55905USA Program of Tumor Biology Moffitt Cancer CenterTampaFL 33612USA

Dear Editor,Small-cell lung cancer(SCLC),one of the most-deadly malignant tumors,accounts for∼15%of all lung cancers.1,2 Although highly responsive to the standard chemoradiotherapy,the recurrence rate of SCLC is nearly unity,with median survival time ranging from 2–6 *** all SCLC patients are inoperable,leading to the difficulty in obtaining adequate biopsy tissue for research.3 Consequently,there is an urgent need to find noninvasive biomarkers to predict the risk and provide early diagnosis of *** aimed to identify potential epigenomic markers for SCLC development in blood DNA and reveal differentially methylated genes through a multi-omics approach,from genome-wide DNA methylation profiling,followed by pathway enrichment analyses and target gene validation utilizing Gene Expression Omnibus(GEO)and Oncomine microarray databases,to TCGA PanCancer *** is known that virtually all patients with SCLC are victims of tobacco smoking,4 but it is unknown whether stopping smoking before SCLC diagnosis would influence the epigenetic biomarkers under *** here report a study that identified aberrantly methylated genes between current and former smokers among SCLC patients,revealing a set of candidate biomarkers in peripheral blood DNA for better stratifying patients with high risk.

关键词： patients diagnosis cancer

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Warming and increased precipitation alter soil carbon cycling in a temperate desert steppe of Inner Mongolia

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Journal of Plant Ecology 2024年第2期17卷 161-172页

作者： Mu Lan Xiao Qiu wei La Huimin Wang Yahong Liu Liqing Zhao Hailian Sun Inner Mongolia Key Laboratory of Grassland Ecology and School of Ecology and Environment Inner Mongolia UniversityHohhot 010021China Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences Hohhot 010031China State Key Laboratory of Vegetation and Environmental Change Institute of Botanythe Chinese Academy of SciencesBeijing 100093China College of Resources and Environment Baotou Teachers’CollegeBaotou 014030China

Warming and precipitation are key global change factors driving soil carbon(C)dynamics in terrestrial ***,the effects of warming and altered precipitation on soil microbial diversity and functional genes involved in soil C cycling remain largely *** investigated the effects of warming and increased precipitation on soil C cycling in a temperate desert steppe of Inner Mongolia using metagenomic *** found that warming reduced plant richness,Shannon-Wiener and Simpson *** contrast,increased precipitation signifcantly infuenced Shannon-Wiener and Simpson *** reduced soil microbial species by 5.4%while increased precipitation and warming combined with increased precipitation led to increases in soil microbial species by 23.3%and 2.7%,*** relative abundance of Proteobacteria,which involve C cycling genes,was signifcantly increased by warming and increased *** signifcantly reduced the abundance of GAPDH(calvin cycle)and celF(cellulose degradation)while it enhanced the abundance of glxR(lignin degradation).Increased precipitation signifcantly enhanced the abundance of pgk(calvin cycle),coxL(carbon monoxide oxidation),malZ(starch degradation),and mttB(methane production).Moreover,a wide range of correlations among soil properties and C cycling functional genes was detected,suggesting the synergistic and/or antagonistic relationships under scenario of global *** results may suggest that warming is benefcial to soil C storage while increased precipitation negatively affects soil C *** fndings provide a new perspective for understanding the response of microbial communities to warming and increased precipitation in the temperate desert steppe.

关键词： carbon cycling desert steppe functional genes global change soil microbes precipitation warming

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Images and Car Information Event Recorder

Images and Car Information Event Recorder

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第二十四届中国控制会议

作者： Chin Chongho~1, wei Jichen~2, calvin Lo, loKuan Wong (Faculty of Science & Technology University of Macau, Macao SAR, China )

＜正＞ Abstract: This paper describes the design of the Images and Car Information Event Recorder （ICIER） - a colorful images and driving information event recorder for car’s cause of accidents analyzing. It is an embedded system and work as a vehicle black box. Its design is referred to the functions of the similar embedded system in the market and adds some new functions to do improvement. The basic structure of the system is first introduced and some procedures for its design are explained deeply through some flow charts. It is a developing system that is tested and successfully use in a model car. In addition, ICIER has obtained some awards at Macao in different matches.

关键词： embedded system black box ICIER

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Suboptimal Temperature Acclimation Enhances Chilling Tolerance by Improving Photosynthetic Adaptability and Osmoregulation Ability in Watermelon

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Horticultural Plant Journal 2020年第1期6卷 49-60页

作者： Junyang Lu Muhammad Azher Nawaz Nannan wei Fei Cheng Zhilong Bie Key Laboratory of Horticultural Plant Biology Ministry of Education/College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China Department of Horticulture University College of AgricultureUniversity of SargodhaSargodha 40100Pakistan

The temperature drop of plants from the optimal requirements can increase tolerance to severe chilling stress. Photosynthesis and osmoregulators were analyzed during chilling stress to explore the adaptation mechanisms that underlie the induction of chilling tolerance in response to suboptimal temperature. The relationships of these processes to suboptimal temperature acclimation in watermelon were then *** temperature-acclimated watermelon plants demonstrated tolerance during chilling stress, as indicated by the decreased electrolyte leakage and malondialdehyde accumulation compared with those non-acclimated watermelon plants. Chilling-induced photoinhibition and reduction in CO2 assimilation rate were alleviated after suboptimal temperature acclimation. The xanthophyll cycle level was enhanced by improving thermal dissipation ability and avoiding light damage. Consequently, the chilling tolerance of suboptimal temperature-acclimated watermelon plants was enhanced. The osmoregulation ability induced by suboptimal temperature acclimation protected watermelon plants against chilling injury because of the accumulation of small molecular substances, such as soluble sugar and proline. The protein levels of Rubisco activase(ClRCA) and the gene expression of the Benson–calvin cycle simultaneously increased in suboptimal temperature-acclimated watermelon plants during chilling stress. Chilling tolerance in watermelon plants induced by suboptimal temperature acclimation is associated with enhanced photosynthetic adaptability and osmoregulation ability.

关键词： Citrullus lanatus Chilling stress Acclimation Photosynthesis Osmoregulation ClRCA

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Dental trauma in endoscopy:A systematic review and experience of a tertiary endoscopy centre

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World Journal of Gastrointestinal Endoscopy 2023年第8期15卷 518-527页

作者： Chelsea Qiu Lin Tan Gabrielle Yi Wen Loh Tay wei Rong Benjamin calvin Jianyi Koh John Shao Rong Mok Juanda Leo Hartono Kai Ting Cheryl Chua Hee Hon Tan Kewin Tien Ho Siah Yong Loo Lin School of Medicine National University of SingaporeSingapore 117594Singapore Division of Gastroenterology and Hepatology National University Health SystemSingapore 119074Singapore Department of Medicine Ng Teng Fong General HospitalSingapore Division of Prosthodontics National University Centre for Oral HealthSingapore 119074Singapore

BACKGROUND Dental injury is the leading cause of litigation in anaesthesia but an underrecognized preventable complication of *** To determine frequency and effects of dental injury in endoscopy,we present findings from an audit of outpatient endoscopy procedures conducted at a tertiary university hospital and a systematic review of *** Retrospective review of 11265 outpatient upper endoscopy procedures over the period of 1 June 2019 to 31 May 2021 identified dental related complications in 0.284%of *** of literature identified a similar rate of 0.33%.RESULTS Pre-existing dental pathology or the presence of prostheses makes damage more likely but sound teeth may be ***-endoscopic history and tooth examination are key for risk stratification and may be conducted succinctly with limited time *** retrieval should be prioritized in the event of dental injury to minimize aspiration and be followed by prompt dental consultation for specific *** Dental complications occur in approximately 1 in 300 of upper endoscopy *** are easily preventable by pre-endoscopy *** to mitigate dental injury are also suggested.

关键词： Teeth Dental trauma Endoscopy Digestive system

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Pharmacological efficacy of the traditional Chinese medicinal formula Kun-Tai-1A in the treatment of letrozole-induced polycystic ovary syndrome

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Traditional Medicine Research 2022年第3期7卷 44-54页

作者： Leanne Lee Leung Jing Xie Ya-Cun Chen Kar-Ho Lam Hei Wan Su-Lan Yu Tzi-Bun Ng George Pak-Heng Leung Jin Yu Ren-Min Yao Shu-Jia Sun Sydney Chi-Wai Tang Hai-Yong Chen Jia Zhao Zhang-Jin Zhang calvin Kai-Fai Lee Kalin Yan-Bo Zhang Li-Xing Lao Yun Feng Xiang Lin wei Meng School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Workstation for Training and Research(Hong Kong Branch) Distinguished Professor Yu Jin Gynaecology of Chinese Medicine&Integrative MedicineHong Kong 999077China Shanghai Taikuntang Chinese Medicine Hospital Shanghai 200023China Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Virginia University of Integrative Medicine Virginia 22031USA Department of Ophthalmology Peking University Third HospitalBeijing 100191China Workstation of Zhu Nansun National Master of Chinese MedicineHong Kong Branch of Zhu’s School of Gynaecology of Chinese Medicine from ShanghaiHong Kong 999077China

Background:Polycystic ovary syndrome(PCOS)is an endocrine disorder that occurs in women of child-bearing ***,PCOS patients have decreased pregnancy rates and clomiphene citrate *** traditional Chinese medicine formula Kun-Tai-1S(KT1S),consisting of the seahorse species hippocampus,has been reported to elicit therapeutic effects in patients with ***,given the limited resources and global demand for wild hippocampus,whether KT1S with or without hippocampus can elicit similar therapeutic effects has not been ***:KT1S and Kun-Tai-1A(KT1A,KT1S without dry hippocampus)were used to treat a letrozole-induced rat model of PCOS with an established *** serum levels of testosterone,luteinizing hormone,anti-Müllerian hormone,and estradiol were determined,the luteinizing hormone/follicle-stimulating hormone ratio was determined,and the ovarian pathology was ***:Similar to the therapeutic effects of cyproterone acetate,both the KT1S and KT1A treatments reduced the body weight and ovarian and uterine indices in the rats with *** serum levels of testosterone,anti-Müllerian hormone,and luteinizing hormone and the luteinizing hormone/follicle-stimulating hormone ratio were significantly lower in the KT1S and KT1A treatment groups compared to the model group(P<0.01 and P<0.05,respectively).Moreover,the histopathological assessment results suggested that both the KT1S and KT1A treatments significantly ameliorated the PCOS pathology in the rats with an established disease,with a reduced number of cystic and atretic follicles and an increased number of corpora lutea being observed in the ***,there was no obvious difference in the disease outcomes between the KT1S and KT1A-treated *** pharmacology analysis revealed that 4’,7-dihydroxyflavanone,sinpemine A,quercetin,8-isopentenyl-kaempferol,and luteolin in KT1A may promote estrogen signaling;furthermore,the nitric oxide regulation pathway is also cl

关键词： polycystic ovary syndrome traditional Chinese medicine ovulation Kun-Tai-1A seahorse endocrine disease

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CD4(＋)CD25(＋) treg induction by an HSP60-derived peptide SJMHE1 from schistosoma japonicum is TLR2 dependent

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南京医科大学学报（自然科学版） 2010年第1期30卷 138-138页

作者： Wang, Xuefeng Zhou, Sha Chi, Ying Wen, Xiaoyun Hoellwarth, Jason He, Lei Liu, Feng Wu, calvin Dhesi, Shawn Zhao, Jiaqing Hu, wei Su, Chuan Nanjing Med Univ Jiangsu Key Lab Pathogen Biol Dept Pharmacol Dept Pathogen Biol & Immunol Nanjing 210029 Jiangsu Peoples R China. Univ So Calif Keck Sch Med Dept Educ Affairs Los Angeles CA 90033 USA. Chinese Ctr Dis Control & Prevent Natl Inst Parasit Dis Shanghai Peoples R China.

Chronic schistosome infection results in the suppression of host immune responses, allowing long-term schistosome survival and restricting *** theories suggest that Treg play an important role in this ***, the mechanism of Treg induction during schistosome infection is still *** aim of this study was to determine the mechanism behind the induction of CD4(+)CD25(+) T cells by Schistosoma japonicum HSP60(SjHSP60)-derived peptide SJMHE1 as well as to elucidate the cellular and molecular basis for the induction of CD4(+)CD25(+) T cells during *** *** immunized with SJMHE1 or spleen and LN cells from naive mice *** SJMHE1 in vitro all displayed an increase in CD4(+)CD25(+) T-cell *** of IL-10 and TGF-beta by SJMHE1 stimulation may contribute to *** transferred SJMHE1induced CD4(+)CD25(+) T cells inhibited delayed-type hypersensitivity in BALB / c ***, SJMHE1-treated APC were tolerogenic and induced CD4(+) cells to differentiate into suppressive CD4(+)CD25(+) ***, our data support a role for TLR2 in SJMHE1-mediated CD4(+)CD25(+) Treg *** findings provide the basis for a more complete understanding of the ***-host interactions that contribute to host homeostatic mechanisms, preventing an excessive immune response.

关键词：血吸虫病治疗方法临床分析细胞

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采用共晶方法提高白黎芦醇溶解度与可压性

采用共晶方法提高白黎芦醇溶解度与可压性

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中国晶体学会第六届学术年会暨会员代表大会——第六届全国晶型药物研发技术学术研讨会

作者：周政政李婉莹 wei-Jhe Sun 鲁统部 Henry H.Y.Tong Changquan calvin Sun 郑颖南方医科大学公共卫生学院卫生检验检疫系广东省热带病研究重点实验室 State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macau Department of Pharmaceutics University of Minnesota 中山大学化学化工学院中山大学药学院 School of Health Sciences Macao Polytechnic Institute

固体药物的理化性质特别是水溶性、机械性质等是影响成药性的关键因素,因此改善药物的理化性质对于进一步的新药开发具有十分重要的意义。药物共晶通过选择合适的共晶试剂与药物分子作用形成超分子体系可有效改善其理化性质。前期研究发... 详细信息

固体药物的理化性质特别是水溶性、机械性质等是影响成药性的关键因素,因此改善药物的理化性质对于进一步的新药开发具有十分重要的意义。药物共晶通过选择合适的共晶试剂与药物分子作用形成超分子体系可有效改善其理化性质。前期研究发现BCSⅡ类天然产物白黎芦醇水溶性低(0.03g.L)且可压性差,不易成型,因此采用共晶手段来改善其溶解度与机械性质等。通过综合PXRD、DSC、TG、ssNMR、FTIR等方法进行分析发现白黎芦醇可与4-aminobenzamide、isoniazid形成化学计量比例为1:1的新药物共晶体系,其中RES-ISN(1:1)共晶可形成稳定的基于热力学数据的二元相图。与白黎芦醇原料药相比,新形成的共晶体系在溶解度、可压性等理化性质方面具有显著提高,且溶解度具有pH依赖性,共晶在高湿环境中依然表现出良好的稳定性。研究结果可为白黎芦醇天然产物的进一步开发提供合适的候选固体形态,具有重要的科学意义与应用价值。

关键词：白黎芦醇共晶溶解度可压性机械性质

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Hydrogen peroxide functions as a secondary messenger for brassinosteroids-induced CO_2 assimilation and carbohydrate metabolism in Cucumis sativus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第10期13卷 811-823页

作者： Yu-ping JIANG Fei CHENG Yan-hong ZHOU Xiao-jian XIA wei-hua MAO Kai SHI Zhi-xiang CHEN Jing-quan YU Department of Horticulture College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China Key Laboratory of Horticultural Plants Growth Development and Quality ImprovementMinistry of AgricultureHangzhou 310058China Department of Botany and Plant Pathology Purdue UniversityWest Lafayette 47907-2054USA

Brassinosteroids(BRs) are potent regulators of photosynthesis and crop yield in agricultural crops;however,the mechanism by which BRs increase photosynthesis is not fully ***,we show that foliar application of 24-epibrassinolide(EBR) resulted in increases in CO 2 assimilation,hydrogen peroxide(H 2 O 2) accumulation,and leaf area in cucumber.H 2 O 2 treatment induced increases in CO 2 assimilation whilst inhibition of the H 2 O 2 accumulation by its generation inhibitor or scavenger completely abolished EBR-induced CO 2 *** of light harvesting due to larger leaf areas in EBR-and H 2 O 2-treated plants were accompanied by increases in the photochemical efficiency of photosystem II(Φ PSII) and photochemical quenching coefficient(q P).EBR and H 2 O 2 both activated carboxylation efficiency of ribulose-1,5-bisphosphate oxygenase/carboxylase(Rubisco) from analysis of CO 2 response curve and in vitro measurement of Rubisco ***,EBR and H 2 O 2 increased contents of total soluble sugar,sucrose,hexose,and starch,followed by enhanced activities of sugar metabolism such as sucrose phosphate synthase,sucrose synthase,and ***,expression of transcripts of enzymes involved in starch and sugar utilization were inhibited by EBR and H 2 O ***,the effects of EBR on carbohydrate metabolisms were reversed by the H 2 O 2 generation inhibitor diphenyleneodonium(DPI) or scavenger dimethylthiourea(DMTU) *** of these results indicate that H 2 O 2 functions as a secondary messenger for EBR-induced CO 2 assimilation and carbohydrate metabolism in cucumber *** study confirms that H 2 O 2 mediates the regulation of photosynthesis by BRs and suggests that EBR and H 2 O 2 regulate calvin cycle and sugar metabolism via redox signaling and thus increase the photosynthetic potential and yield of crops.

关键词： Metabolism Photosynthesis Reactive oxygen species Rubisco Sucrose

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叶绿体中calvin循环多酶复合体

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植物生理学通讯 2008年第3期44卷 392-398页

作者：李瑞陆巍周玮南京农业大学生命科学学院南京210095

从calvin循环、多酶复合体分离及其特性、可溶性酶组合成多酶复合体的优势及其与类囊体膜的结合对calvin循环多酶复合体的研究进展作了介绍。

关键词： calvin循环多酶复合体类襄体膜

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