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Contribution of Ambulatory Blood Pressure Monitoring to the Management of Arterial Hypertension at Blaise CompaoréUniversity Hospital

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World Journal of Cardiovascular Diseases 2017年第12期7卷 442-450页

作者： Yibar Kambiré Georges Kinda Georges R.C. Milllogo Lassina Konaté Issa Diallo K. Jonas Kologo Jean-Baptiste Tougouma Germain D. Mandi R. Aristide Yaméogo Salifou Yaogo caleb tindano André K. Samadoulougou Patrice Zabsonré Department of Medicine and Medical Specialties Blaise COMPAORE University Hospital Ouagadougou Burkina Faso Department of Health Sciences University of Ouagadougou Ouagadougou Burkina Faso Cardiology Department Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Cardiology Department Souro Sanou University Hospital Bobo-Dioulasso Burkina Faso

Background: Hypertension is a major public health concern in Burkina Faso. Its management relies on in-office medical setting blood pressure monitoring which is known to be an imperfect diagnosis tool. Objective: This study aims to assess the contribution of ambulatory blood pressure monitoring in the management of hypertension at Blaise Compaoré University Hospital. Methods: A monocentric descriptive retrospective study was conducted in the cardiology outpatient unit of Blaise Compaoré University Hospital. Patients aged at least 18 years who underwent ambulatory blood pressure monitoring between March 2013 and June 2015 were enrolled. Hypertension was defined as follows: average blood pressure over 24 hours > 130/80 mmHg, or diurnal blood pressure > 135/85 mmHg, or nocturnal blood pressure >120/70 mmHg. Data were analyzed using the SPSS 20.0 software. The threshold for significance was set at 5% for a validity interval at 95%. Chi square test was used for?the statistical analysis. Results: A total of 122 patients were enrolled. The main reasons for ambulatory monitoring were the evaluation of hypertensive therapy (51.6%) and the diagnosis confirmation (39.3%). The results of the ambulatory monitoring found 61.4% of the patients with hypertension and 37.7% with normal blood pressure. A treatment adjustment was made for 36.1% of the patients;an initiation of antihypertensive therapy was undertaken for 24.6%, an abstention from drug therapy was recommended?for 23.8%,?and the pursuit of previous treatment for 13.1% of the patients. Conclusion: Ambulatory blood pressure monitoring should be used more often in order to optimize the management of hypertension in our current practice.

关键词： Hypertension Diagnosis Treatment Ambulatory Monitoring Africa

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Identification of pests and assessment of their damage on Carapa procera and Lophira lanceolata in Burkina Faso,West Africa

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Journal of Forestry Research 2017年第3期28卷 585-591页

作者： Baslayi tindano Olivier Gnankine Amade Ouedraogo Mamadou Traore Jφrgen Axelsen Anne Mette Lykke Unite de Formation et de Recherche en Sciences de la vie et de la Terre Laboratoire d'Entomologie Fondamentale et AppliqueeUniversite de Ouagadougou03 BP 7021 OuagadougouBurkina Faso Unite de Formation et de Recherche en Sciences de la vie etde la Terre Laboratoire de Biologie et Ecologie VegetalesUniversite de Ouagadougou03 BP 7021 OuagadougouBurkina Faso INERA Institut de l'Environnement et de Recherches Agricoles01 BP 476 Ouagadougou 01Burkina Faso Department of Bioscience Aarhus UniversityAarhusDenmark

Nontimber forest products are a source of income for women in rural African communities. However, these products are frequently damaged by insect pests. The present study investigates the diversity and damage rates of insect pests that attack Carapa procera seeds and Lophira lanceolata fruits. The experiment was set up in western Burkina Faso and, for C. carapa, consisted of pests collected from seeds that had fallen to the ground and from stockpiled seeds. For L. lanceolata, pests were collected from fruits on the trees, and on the ground. The collected samples were sent to the laboratory to estimate the proportion of damaged seeds/fruits and rear the insects. The results showed that Ephestia spp., Tribolium castaneum, Oryzeaphilus spp., and Tenebroides mauritanicus were the pests of Carapa procera seeds and Lophira lanceolata fruits. Ephestia spp. was recorded as the main pest of both C. proeera and L. lanceolata, whereas T. castaneum was only detected from seeds of L. lanceolata. For C. procera, the stocks were the most infested （29 %） by Ephestia spp. The infestation rate of fruits of L. lanceolata by Ephestia spp, on trees （31.42 ± 3.75 %） was less than the rate of fruits by T. castaneum on the ground （44.00 ± 3.5 %）. The different body sizes of Ephestia spp. may indicate the occurrence of two putative species, one from C. procera and another one from L. lanceolata. This work provides important information that could contribute to the setting up of a local-scale sustainable management framework for oil tree pests in Burkina Faso and surrounding countries.

关键词： Insect diversity Carapa procera Lophiralanceolata Ephestia spp. Pest management

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Effects of Sarcocephalus latifolius Fruits Extract on Paracetamol-Induced Liver Damage in Wistar Rats

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Pharmacology & Pharmacy 2023年第4期14卷 112-122页

作者： Filkpièrè Léonard Da Basile tindano Géneviève Zabre Karim Sakira Balé Bayala Raymond G. Belemtougri Philippe Horlait Université Norbert ZONGO Laboratoire Sciences de la Vie et de la Terre Koudougou Burkina Faso Université Joseph KI-ZERBO Laboratoire de Physiologie Animale Ouagadougou Burkina Faso Ecole Normale Supérieure Koudougou Burkina Faso Université Joseph KI-ZERBO Laboratoire de Toxicologie Environnement et Santé Ouagadougou Burkina Faso Health Officer and Animal Welfare Animaleries Université Libre de Bruxelles Brussels Belgium

Background and Aim: Sarcocephalus latifolius is a medicinal plant commonly used in traditional medicine to treat various diseases. The aim of the present study is to evaluate the hepatoprotective activity of Sarcocephalus latifolius fruits aqueous extract against paracetamol-induced liver damage in rats. Material and Methods: Aqueous extract of Sarcocephalus latifolius fruits at doses of 100, 250 and 500 mg/kg were administered orally to rats with paracetamol-induced hepatotoxicity (1 g/kg). The treatment with the extract and paracetamol lasted 7 days. Silymarin (50 mg/kg) was given as reference control. All tested drugs were administered orally. Results: Our results show that the Sarcocephalus latifolius fruits extract induced a significant reduction (p < 0.05) of serum enzymes alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), alkaline phosphatase (PAL) and total bilirubin (TB). Then, the extract at the dose of 500 mg/kg showed a better protection (p < 0.001) of hepatocytes with a percentage of protection of 43.59% ± 2.03%;59.43% ± 4.12%;73.29% ± 5.72% and 62.55% ± 7.48% for ALAT, ASAT, PAL and TB, respectively. The histology of livers exposed to paracetamol shows an inflammation of the hepatocytes. In addition, there was a significant alteration of the liver parenchyma. The 500 mg/kg extract showed a resorption of the inflammation. Histopathological examination showed that the extract regenerated paracetamol-induced liver damage. Conclusion: Aqueous extract of Sarcocephalus latifolius fruits has hepatoprotective activity against paracetamol-induced hepatotoxicity in rats. But it would be important to evaluate the activity of aqueous extract of Sarcocephalus latifolius fruits on oxidative stress parameters in vivo in rats. .

关键词： Rats Paracetamol Hepatotoxicity Sarcocephalus latifolius Silymarin

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Antioxidant Activity and Phenolic Compounds Content of Extracts from Ceratotheca sesamoides Endl and Striga hermonthica (Delille) Benth Used as Antheminthic in Burkina Faso

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Journal of Biosciences and Medicines 2022年第11期10卷 203-213页

作者： Dicko Amadou Kam Eric Sami Hadidjatou Belem Konaté Almamy tindano Basile Meda Roland Nâg-Tiéro Ahoua Angora Rémi Constant Koné Mamidou Witabouna Kaboré Adama Traoré Amadou Bayala Balé Tamboura Hamidou Hamadou Laboratoire de Biologie et Santé Animale (LaBioSA) Centre National de recherche Scientifique et Technologique (CNRST)/Institut de l’Environnement et de Recherches Agricoles (INERA) Ouagadougou Burkina Faso Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales Unité de Formation et de Recherches en Sciences et Technique Université Nazi BONI Bobo Dioulasso Burkina Faso Laboratoire de Physiologie Animale (LaPA) Unité de Formation et de Recherches en Sciences de la vie et de la Terre Université Joseph KI-ZERBO Ouagadougou Burkina Faso Laboratoire de Botanique et Valorisation de la Diversité Végétale (LaBVDIV) Université Nangui Abrogoua Abidjan C&ocirc te d’Ivoire Centre Suisse de Recherche en Cô te d’Ivoire Abidjan C&ocirc te d’Ivoire

The revaluation of medicinal plants in the veterinary pharmacopoeia is essential for the development of livestock in Burkina Faso. In order to justify the use of C. sesamoides and S. hermonthica in the treatment of gastrointestinal parasitosis of small ruminants, a quantification of phenolic compounds as well as antioxidant activity and acute toxicité evaluation of both plants were performed. Acute toxicity was evaluated by administering a single dose of 2000 mg/kg body weight of aqueous extract of both plants to mice. The highest total polyphenol content for C. sesamo?des was obtained in the ethyl acetate fraction with 47.236 ± 2.57 mgEAG/100mg while that of S. hermonthica was 74.871 ± 2.57 mgEAG/100mg obtained with the n-butanol Fraction. The dichloromethane extract of S. hermonthica obtained the highest total flavonoid content with 7.31 ± 0.48 mgEQ/100 while the highest total flavonoid content of C. sesamo?des was obtained with ethyl acetate fraction with 5.4273 ± 0.35 mgEQ/100mg. The aqueous extract of C. sesamo?des obtained the highest content of condensed tannins with 3.028 ± 0.13 mgEAT/100mg. Both plant’s extracts did not show any signs of toxicity in NMRI mice after administration of the dose of 2000 mg/kg. The antioxidant activity by DPPH, FRAP and ABTS methods was good compared to those of Quercetin and Trolox taken as standard.

关键词： C. sesamoides S. hermonthica Polyphénols Content Flavonoids Content Condensed Tannins Antioxidant Activity

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