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Alder Hey伤员拣别分类中疼痛评分的有效性

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 18-19页

作者： Stewart B. Lancaster G. lawson J. 高蕊 Roy. Liverpool Child. Hosp. NHS T. Alder Hey Eaton Road LiverpoolLA1 2AP UnitedKingdom Dr.

目的:对将一种新的疼痛评定手段AlderHey伤员拣别分类中疼痛评分(AHTPS)应用于遭受意外或急诊(A&e)患儿以进行拣别分类的可靠性和有效性进行评估。方法:由于现有工具无法满足需要,且在伤员拣别分类时应用自评评分的可靠性较低,故而研究... 详细信息

目的:对将一种新的疼痛评定手段AlderHey伤员拣别分类中疼痛评分(AHTPS)应用于遭受意外或急诊(A&e)患儿以进行拣别分类的可靠性和有效性进行评估。方法:由于现有工具无法满足需要,且在伤员拣别分类时应用自评评分的可靠性较低,故而研究出一种新的行为观察性疼痛评定标准。本研究对1所较大儿科A&

关键词： Alder Hey 现有工具观察性 validity analgesia rater nurse assessed 知组出院诊断

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预测儿童手术前焦虑：谁最准确？

麻醉与镇痛 2010年第5期6卷 74-80页

作者： Jill e. MacLaren, PhD caitlin Thompson, BA Megan Weinberg, MA Michele A. Fortier, PhD Debra e. Morrison, MD DanieUe Perret, MD Zeev N. Kain, MD, MBA 谢珺田(译) 宋文阁(校) Center for the Advancement of Perioperative Health University of California Irvine California Department of Anesthesiology and Perioperative Care University of California Irvine California Department of Pediatric Psychology Children's Hospital Orange County Orange California Departments of Child Psychiatry Yale University School of Medicine New Haven Connecticut Departments of Anesthesiology Yale University School of Medicine New Haven Connecticut 不详

背景本研究旨在评价全麻诱导期间小儿麻醉主治医师、住院医师及患儿母亲三者预测2．16岁儿童（n=125）手术前焦虑的能力。方法麻醉医师及患儿母亲运用视觉模拟评分对患儿的手术前焦虑提供预测，患儿的实际焦虑状况则使用有效行为观测工... 详细信息

背景本研究旨在评价全麻诱导期间小儿麻醉主治医师、住院医师及患儿母亲三者预测2．16岁儿童（n=125）手术前焦虑的能力。方法麻醉医师及患儿母亲运用视觉模拟评分对患儿的手术前焦虑提供预测，患儿的实际焦虑状况则使用有效行为观测工具——改良耶鲁手术前焦虑量表进行评估。所有患儿母亲在全麻诱导期间均在场，所有患儿均不接受手术前镇静用药。采集数据后进行相关分析。结果125例2—16岁的患儿、患儿母亲及实施麻醉的主治医师和住院医师共同参与了此项研究。相关分析显示全麻诱导期间麻醉主治医师对患儿手术前焦虑的预测与患儿实际焦虑状况之间存在显著相关性（rs=0.38，P〈0.001）。而诱导期间麻醉住院医师和患儿母亲的预测与患儿客观焦虑状况之间无显著相关（rs分别为0.01及0.001）。就预测的准确性而言，在麻醉主治医师所提供的预测中，47．2％与患儿的客观焦虑状况在一个标准差误差范围内，70．4％在2个标准差误差范围内。结论相比患儿母亲，参与实施儿科麻醉的主治医师在全麻诱导期间更能准确地预测儿童患者的手术前焦虑。虽然这一结论具有重要的临床意义，但是否可将其推广至其他较少从事儿科麻醉的麻醉主治医师尚未知。

关键词：手术前焦虑儿童患者预测主治医师小儿麻醉诱导期间焦虑状况住院医师

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Nuss修补术前后漏斗胸对肺功能的影响

世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 51-52页

作者： lawson M. L. Mellins R. B. Tabangin M. 肖莉 Center for Pediatric Research Children’sHosp. King’s Daughters E. Norfolk VA 23507 United States

Patient reports of preoperative exercise intolerance and improvement after surgical repair of pectus excavatum (Pex) have been documented but not substantiated in laboratory studies. This may be because no study has been large enough to determine if pulmonary function tests (PFTs)-in the Pex population are significantly different from the normal population, and none has assessed improvement in pulmonary function after Nuss bar removal. The authors studied PFT results in 408 Pex patients before repair and in a subset of 45 patients after Nuss procedure and bar removal. Significance of differences in percent predicted (using Knudson’s equations) was tested using t tests (parametric) or sign tests (nonparametric). Normal was defined as 100%of predicted for forced vital capacity (FVC), forced expired volume in 1 second (FeV1), and forced expiratory flow (FeF25%-75%). Preoperatively, FVC and FeV 1 medians were lower than the normal by 13%, whereas the FeF 25%-75%median was lower than normal by 20%(all P e postoperative group had statistically significant improvement after surgery for all parameters. Patients older than 11 years at the time of surgery had lower preoperative values and larger mean postbar removal improvement than the younger patients. An older patient with a preoperative FeF25-75 score of 80%of normal would be predicted by these data to have a postoperative FeF25-75 of 97%, indicating almost complete normalization for this function. These results demonstrate that preoperatively Pex patients as a group have decreased lung function relative to normal patients. After Nuss procedure and bar removal, we show a small but significant improvement in pulmonary function. These results are consistent with patient reports of clinical improvement and indicate the need for more in-depth tests of cardiopulmonary function under exercise conditions to elucidate the mechanism.

关键词：漏斗胸 Nuss 研究规模有显著性差异患者群临床改善用力呼气量用力肺活量试验研究所符号检验

CGH-based microarray detection of cryptic and novel copy number alterations and balanced translocations in cytogenetically abnormal cases of b-cell all

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Health 2013年第5期5卷 23-40页

作者： Roger A. Schultz Karen Tsuchiya Aubry Furrow Marilyn L. Slovak Lisa D. McDaniel Meaghan Wall eric Crawford Yi Ning Reza Saleki Min Fang Victoria Cawich caitlin e. Johnson Sara L. Minier Nicholas J. Neill S. Annie Morton Steve Byerly Urvashi Surti Theresa C. Brown Blake C. Ballif Lisa G. Shaffer Department of Molecular and Human Genetics Baylor College of Medicine Houston USA empire Genomics Buffalo USA Fred Hutchinson Cancer Research Center Seattle USA Genetics Associates Inc. Nashville USA Johns Hopkins University School of Medicine Baltimore USA Magee-Womens Hospital University of Pittsburgh Medical Center Pittsburgh USA Pathology Associates Medical Laboratories (PAML) Spokane USA Paw Print Genetics Genetic Veterinary Sciences Inc. Spokane USA Seattle Children’s Hospital Seattle USA Signature Genomic Laboratories PerkinElmer Inc. Spokane USA Signature Genomic Laboratories PerkinElmer Inc. Spokane USA Sonora Quest Laboratories Tempe USA Victorian Cancer Cytogenetics Service St. Vincent’s Hospital Melbourne Fitzroy Australia

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, with the majority of cases being of precursor B-cell phenoltype. Conventional cytogenetic analysis plays an important role in the diagnosis of B-cell ALL, identifying characteristic chromosomal abnormalities associated with a given prognosis therein facilitating optimized treatment. The more recent introduction of microarray technology to the analysis of B-cell ALL has afforded both higher resolution for the detection of known abnormalities and an ability to identify novel copy number abnormalities (CNAs) with potential clinical relevance. In the current study, microarray analysis was performed on 20 cytogenetically abnormal B-cell ALL cases (10 pediatric and 10 adult), while a novel microarray-based balanced-translocation detection methodology (translocation CGH or tCGH) was applied to that subset of cases with a known or suspected recurrent balanced translocation. Standard microarray analysis identified that CNAs was not detected by previous conventional cytogenetics in 75% (15/20) cases. tCGH identified 9/9 (100%) balanced translocations defining BCR/ABL1 (x4), eTV6/RUNX1 (x3), and MLL/AFF1 (x2) breakpoints with high resolution. The results illustrate the improved molecular detail afforded by these technologies and a comparison of translocation breakpoints, CNAs and patient age offers new insights into tumor biology with potential prognostic significance.

关键词： Acute Lymphoblastic Leukemia B-Cell ALL Microarray Balanced Translocation Translocation CGH Hematologic Malignancies

*** impact of visual impairment on the Montreal Cognitive Assessment

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Annals of eye Science 2019年第1期 208-208页

作者： elliott Morrice Zoey Stark caitlin Murphy Walter Wittich Aaron Johnson Department of Psychology Concordia UniversityMontrealQCCanada CRIR/Centre de Réadaptation MAB-Mackay du CIUSSS du Centre Ouest del’Île de Montréal QCCanada Optometry University of MontrealQCCanada

Background:Cognitive assessments,such as the Montreal Cognitive Assessment(MoCA),use components that assume intact sensory abilities,however,adults show concomitant decreases in visual acuity with increasing *** on cognitive assessments are typically lower for individuals with visual impairments compared to individuals with normal/corrected to normal *** it is not clear if lowers scores on cognitive assessments are due to the assessments relying on visual stimuli,or if individuals with visual impairments are actually more likely to have cognitive *** we simulated visual impairments,i.e.,reduced visual acuity and contrast sensitivity,in young healthy adults to determine how this impacts their scores on a measure of cognitive ability,i.e.,the ***:Participants(n=19)completed one of the three version of the MoCA under three conditions(20/20,simulated 20/80,simulated 20/200).The MoCA was administered following the clinical *** participants that scored>26(i.e.,normal cognitive function)at 20/20 were included in the *** comparison,we included MoCA data from a sample of older adults with normal vision(n=19,Mage=74,Acuity M=0.04 logMAR,SD=0.16)or visual impairment(n=19,Mage=79,Acuity M=0.35 logMAR,SD=0.3).Results:Acuity of participants at 20/20(M=0.06 LogMAR,SD=0.1),simulated 20/80(M=0.63,SD=0.18)and simulated 20/200(M=0.88,SD=0.19)showed that the participants experienced simulated acuity loss with the *** the MoCA scores,we found a main effect of acuity(F=16.22,Ped post hoc comparisons showed a significant difference between scores with a 20/20 acuity(M=27.26,SD=0.93)and 20/80(M=24.74,SD=1.66,t=5.62,ptukeyetween 20/20 and 20/200(M=25.63,SD=1.46,t=3.63,ptukey=0.002,Cohen’s d=1.33).However,no difference was observed between 20/80 and 20/200(t=−1.99,ptukey=0.125,d=0.572).The MoCA scores in older adults with normal vision(M=27.32,SD=2.41)and with visual impa

关键词： Visual impairment cognitive assessment simulated visual impairment Montreal Cognitive Assessment(MoCA)

降低日粮粗蛋白并添加单体氨基酸对断奶——育肥猪生长性能和营养排泄的影响(下)

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猪业科学 2022年第12期39卷 18-20页

作者：何颖朱威力(编译) caitlin e.Vonderohe Kayla M.Mills Shule Liu Matthew D.Asmus emily R.Otto-Tice Brian T.Richert Ji-Qin Ni John Scott Radcliffe 重庆工商大学长江上游经济研究中心重庆400067 焦作禾丰饲料有限公司河南焦作454584 不详

综合来看,在生长第2阶段(d84)结束之前,NH3排放量无显著差异(P>0.05),其中饲喂对照组日粮的猪只每头排放的NH_(3)总量高于2X组,而IX组排放量介于二者之间(P<0.05)。在生长第3阶段,饲喂2X组日粮的猪只相较于对照组继续产生更少NH_(3)累积... 详细信息

综合来看,在生长第2阶段(d84)结束之前,NH3排放量无显著差异(P>0.05),其中饲喂对照组日粮的猪只每头排放的NH_(3)总量高于2X组,而IX组排放量介于二者之间(P<0.05)。在生长第3阶段,饲喂2X组日粮的猪只相较于对照组继续产生更少NH_(3)累积量,而IX组介于二者之间(P=0.0057)。

关键词：猪生长性能日粮粗蛋白累积量

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在中学运动员中女运动员三联征的患病率

世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 27-28页

作者： Nichols J. F. Rauh M. J lawson M. J. 俞晓梅(译) - ARCH. PeDI-ATR. ADOLeSC. MeD. 2006 160/2 (137 -142) 不详

Objective:To estimate the prevalence of the female athlete triad(disordered eating,menstrual irregularity,and low bone mass)among high school athletes.D esign:Observational cross-sectional ***:High ***:Female athletes(n=170)representing 8 sports were recruited from 6 high school s in southern *** Outcome Measures:Disordered eating and menstrual status were determined by interviewer-assisted *** mineral de nsity was measured by dual-energy x-ray absorptiometry of the hip,spine(L1-L4),and total ***:Among all athletes,18.2%,23.5%,and 21.8%met the criteria for disordered eating,menstrual irregularity,and low bone mass,r *** girls(5.9%)met criteria for 2 components of the triad,and 2 girls(1.2%)met criteria for all 3 ***/amenorrheic at hletes had higher mean ± SD eating restraint(1.55±1.60 vs 1.04±1.27;P=.02)-and eating Disorder exa mination Questionnaire global scores(1.68±1.20 vs 1.33±1.14;P=.03)than eume norrheic *** controlling for age,age at menarche,body mass index,race/ethnicity,and sport type,athletes with oligomenorrhea/amenorrhea had sign ificantly lower mean ±SD bone mineral densities for the trochanter(0.884±0.09 0 g·cm-2)than eumenorrheic athletes(0.933±0.130 g·cm-2;P=0.04).Conclusi ons:The prevalence of the full female athlete triad was low in our sample;howe ver,a substantial percentage of the athletes may be at risk for long-term heal th consequences associated with disordered eating,menstrual irregularity,or lo w bone *** screening to identify these components should be e ncouraged as a preventive approach to identify high-risk athletes.

关键词：女运动员中学生三联征患病率进食障碍调查问卷月经失调横断面研究加利福尼亚骨矿物密度观察指标

趋磁细菌磁小体及其相关MRI报告基因分子影像学研究

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中国医学影像技术 2019年第4期35卷 625-629页

作者：张薇薇 Donna e.Goldhawk 李海龙甘肃中医药大学医学影像教研室甘肃兰州730000 罗森健康研究所医学影像项目组西安大略大学医学生物物理学系甘肃中医药大学临床诊断检验教研室甘肃兰州730000 甘肃中医药大学甘肃省中医方药挖掘与创新转化重点实验室甘肃兰州730000

趋磁细菌受基因调控形成纳米Fe_3O_4颗粒——磁小体,自带天然脂性包膜,其独特结构与特性受到分子影像学研究的重视,特别是纯化磁小体在磁性粒子成像中的应用和磁小体相关调控基因在MRI报告基因的分子影像学中的应用。相关研究逐年增多,... 详细信息

趋磁细菌受基因调控形成纳米Fe_3O_4颗粒——磁小体,自带天然脂性包膜,其独特结构与特性受到分子影像学研究的重视,特别是纯化磁小体在磁性粒子成像中的应用和磁小体相关调控基因在MRI报告基因的分子影像学中的应用。相关研究逐年增多,但有关MRI报告基因的研究尚处于初级阶段。本文对趋磁细菌磁小体及其相关基因在MRI报告基因的分子影像学研究进行综述。

关键词：磁小体磁共振报告基因分子影像学

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猪增生性肠炎的病原学研究

中国兽药杂志 1989年第1期 46-47页

作者： M·e·Mapotter 陈永红

猪增生性肠炎是一种以未成熟的上皮细胞噌生,引起肠壁变厚、细胞内有弯曲杆菌为特征的疾病(Rowland 和 Rowntee1972、Rowland 和 lawson1975a·b)。用同源性腺瘤粘膜组织给猪口服进行实验性感染人工发病,表明了本病的自然传染性。本试验通

关键词：增生性肠炎弯曲杆菌细胞内天后小猪增生性出血性肠炎病原学病因学