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Comparison of the.de.ographic characte.istics of pe.iatric and adult colore.tal cance. patie.ts: a national inpatie.t sample.base. analysis

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World Journal of Pe.iatrics 2019年第1期15卷 37-41页

作者： Thomas m.Attard caitlin e.Lawson Unive.sity of missouri Kansas City Kansas CityMOUSA Pe.iatric Gastroe.te.ology Children's Mercy Hospital2401Gillham RdKansas CityMO 64108USA Division of Ge.e.ics Children's Mercy HospitalKansas CityMOUSA

Background Colore.tal cance. in childre. is rare.but characte.ize. by late.pre.e.tation,unfavorable.histology and poor *** factors for colore.tal cance. in childre. ove.lap with those.for adults with gre.te. influe.ce.of he.e.itary *** e.ide.iology of colon cance. in childre. is poorly unde.stood;the.aim of this study was to characte.ize.and compare.the.de.ographics and re.e.ant clinical characte.istics of pe.iatric and adult colon cance.,using a national inpatie.t *** The.AHRQ online.re.ource.HCUPne./KID database.was que.ie. for childre.,unde. the.age.of 18 admitte. with ICD 9 Cm diagnose. re.ating to colore.tal cance.,at the.time.of *** comparison,the.corre.ponding diagnose. in adult patie.ts we.e.que.ie. for e.ch succe.sive.*** de.ographics including re.ide.tial type.and me.ian income.by zip-code.tumor localization;if re.orde.,and me.n hospital charge. we.e.all accrue. and *** Inpatie.t admissions for pe.iatric colore.tal cance. we.e.more.like.y male.(54%),in the.15-17 ye.rs age.bracke. (57%).The. we.e.significantly more.like.y from Southwe.te.n re.ions of the.Unite. State.,and we.e.significantly more.like.y from re.ide.tial zip-code. ide.tifie. as at or be.ow the.lowe.t income.quartile.than adult CRC patie.ts or pe.iatric patie.ts as a *** charge. have.more.than quadruple. ove. the.time.pe.iod studie. (1997-2012).Conclusions Pe.iatric colore.tal cance. is the.most common primary gastrointe.tinal malignancy in *** unde.standing associate. risk factors including those.associate. with ge.de.,ge.graphic re.ion and social e.onomic status may contribute.to future.pre.e.tion or e.rly de.e.tion strate.ie..

关键词： Colore.tal cance. Colore.tal ne.plasms De.ography Inte.national classification of dise.se. Pe.iatric risk factors

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Anxie.y-Inducing Die.ary Supple.e.ts: A Re.ie. of He.bs and Othe. Supple.e.ts with Anxioge.ic Prope.tie.

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Pharmacology & Pharmacy 2014年第10期5卷 966-981页

作者： caitlin e. m.carthy Danie.le.m. Cande.ario me. T. Liu De.artme.t of Pharmacy Practice.and Administration Ernest Mario School of Pharmacy Rutgers The State University of New Jersey Piscataway USA

Anxie.y disorde.s comprise.the.most common group of me.tal disorde.s to affe.t the.ge.e.al population in the.Unite. State.. The.e.disorde.s are.he.e.oge.e.us in nature. highly comorbid with one.anothe., and pose.a de.re. of difficulty re.arding diagnosis and manage.e.t. The.e.act e.iology and pathophysiology of anxie.y re.ains to be.e.ucidate.;howe.e., it is like.y that it is multifactorial, and all pote.tial cause. of anxie.y must be.inve.tigate., including substance.induce. anxie.y. Among substance. that may induce.anxie.y are.die.ary supple.e.ts. As utilization of the.e.products appe.rs to be.high in the.US population, it is important to ide.tify which of available.supple.e.ts may cause.anxie.y. Obje.tive. To re.ie. the.scie.tific lite.ature.to ide.tify die.ary supple.e.ts associate. with induction of anxie.y and re.ate. symptoms. me.hods: A se.rch of Natural me.icine. Compre.e.sive.Database. me.line.lus He.bs and Supple.e.ts, and Natural Standard was pe.forme. to ide.tify die.ary supple.e.ts with anxioge.ic prope.tie.. Die.ary supple.e.ts we.e.include. base. on product availability, utilization tre.ds, and if the.e.was sufficie.t e.ide.ce.that the.substance.could e.icit anxie.y via dire.t pharmacologic e.fe.ts. Age.ts we.e.e.clude. from the.re.ie. if anxie.y was sole.y due.to withdrawal from the.substance.or only occurre. in the.se.ting of intoxication. A se.rch of me.LINe.and PUBme. was pe.forme. to ide.tify re.e.ant pe.r re.ie.e. publications conce.ning induction of anxie.y and/or its associate. symptoms by those.die.ary supple.e.ts chose. for re.ie.. Conclusions: Die.ary supple.e.ts can contribute.to and cause.anxie.y and its re.ate. symptoms via ove.stimulation of the.Ce.tral Ne.vous Syste.. He.lthcare.profe.sionals should scre.n all patie.ts pre.e.ting with symptoms consiste.t with anxie.y for re.e.t or curre.t use.of all products capable.of inducing anxie.y, including die.ary supple.e.ts.

关键词： Anxie.y Adve.se e.fe.ts Die.ary Supple.e.ts St. John’s Wort Caffe.ne

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Conte.porary fe.ale.smoke.s in the.us are.younge. and of lowe. socioe.onomic status

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He.lth 2011年第6期3卷 357-361页

作者： Je.nife. L. Jarvie.Yun Wang caitlin e. Johnson JoAnne.m. Foody Harvard me.ical School Boston USA

Smoking is the.most common cause.of pre.a-ture.cardiovascular dise.se.in wome., but con-te.porary data is lacking. We.sought to inve.-tigate.the.diffe.e.ce. be.we.n fe.ale.smoke.s and nonsmoke.s in the.US. me.hods: Using a re.istry of almost 19,000 wome. who atte.de. fre. public he.rt scre.nings sponsore. by Sis-te. to Siste. be.we.n 2008 and 2009 in 17 large.US citie., we.compare. the.me.ns for lipid val-ue., cardiome.abolic me.sure., and diffe.e.ce. in sociode.ographic information be.we.n smok-e.s and nonsmoke.s. Se.ondary outcome. we.e.age.and race.adjuste. odds for obe.ity, the.me.abolic syndrome. hype.te.sion, a non-HDL > 160 mg/dl, and a se.um glucose.≥ 126 mg/dl be.we.n smoking and nonsmoking wome.. Re.ults: The.final sample.include. 18,892 wome. (49.8 ± 14.3 ye.rs, 37% black, and 32% white. 14% Hispanic), with 1,216 (6.4%) curre.t smoke.s. Smoke.s we.e.younge. than non-smoke.s (45.6 ± 13.0 vs 50.1 ± 14.4 ye.rs, p 160 mg/dl (OR 1.19;1.01 - 1.39). Insurance.and income.data showe. a sig-nificant inve.se.re.ationship be.we.n smoking pre.ale.ce.and incre.sing house.old income. Conclusions: In this richly dive.se.sample.of wome., fe.ale.smoke.s we.e.younge. and of lowe. socioe.onomic status than nonsmoke.s with significant diffe.e.ce. in cardiome.abolic risk factors.

关键词： Cigare.te Smoking Cardiovascular Risk Factors Wome. Pre.e.tion

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Active.Pe.tide. and motifs within Collage. and Othe. e.m Prote.ns

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Ame.ican Journal of mole.ular Biology 2023年第4期13卷 241-260页

作者： Lixin Dai Stanle. W. Lue.Isabe.le.Hanse.ne.Ce.vante. Christina Karas Natalia e. Iyke.Austin Parish Jing Wang caitlin m. Zuilkoski mode.n me.dow Inc. Nutley NJ USA

Collage.s are.the.most abundant prote.ns in mammals and form an e.trace.lular matrix (e.m) with othe. compone.ts as the.structural support of muscle. skin, corne.s and blood ve.se.s e.c. Othe. than providing structural support, the.e.m e.hibits active.communication with ce.ls and influe.ce. many ce.lular proce.se. including migration, wound he.ling, diffe.e.tiation and cance. me.astasis. Though collage. prote.ns contain highly re.e.itive.primary se.ue.ce. and de.ine. te.tiary structure., more.and more.studie. have.shown that many short pe.tide./motifs within collage. prote.ns play ke. role. in various biological proce.se.. The.e.short se.ue.ce. are.e.fe.tive.within triple.he.ical structure. or inde.e.de.tly as stand-alone.mole.ule. re.ulting from prote.lytic de.radation. Be.ide. e.doge.ous e.m-de.ive. pe.tide., many more.functional pe.tide. have.be.n produce. by tissue.proce.sing, che.ical synthe.is, and re.ombinant prote.n production. In this re.ie., we.summarize.diffe.e.t pe.tide./motifs ide.tifie. in collage. and othe. e.m prote.ns and discuss the.r pote.tial for me.ical, pe.sonal care. and cosme.ics applications.

关键词： Collage. e.trace.lular matrix Pe.tide. Re.ombinant Prote.n

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BI-RADS 3类比较:数字乳腺断层摄影筛查前后回访病人的可能良性分类

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国际医学放射学杂志 2018年第1期 99-100页

作者： e.S.mc Donald A.m.mc carthy S.P.We.nste.n m.D.Schnall e.F.Conant 周波 De.artme.t of Radiology Breast Imaging SectionUniversity of PennsylvaniaPerelman School of MedicineHospital of the University of Pennsylvania

摘要目的采用数字乳腺断层摄影(DBT)对大型城市回访病人进行筛查,以总体使用率、发现类型和2年预后的分层使用率评估乳腺成像报告和数据系统(BI-RADS)3类评

关键词：断层摄影 BI-RADS 3

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Four buildings and a flush:Le.sons from de.rade. wate. quality and re.omme.dations on building wate. manage.e.t

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e.vironme.tal Scie.ce.and e.ote.hnology 2024年第2期18卷 104-113页

作者： Kyungye.n Ra caitlin Proctor Christian Le. Danie.le.Ange.t Yoorae.Noh Tolulope.Odimayomi Andre. J.Whe.ton Lyle. School of Civil e.gine.ring Purdue University550 Stadium Mall DriveWest LafayetteIN47907USA Agricultural and Biological e.gine.ring Division of Environmental and Ecological EngineeringPurdue UniversityWest LafayetteIN47907USA Division of e.vironme.tal and e.ological e.gine.ring Purdue UniversityWest LafayetteIN47907USA Civil and e.vironme.tal e.gine.ring University of Colorado1111 Engineering DriveBoulderCO80309USA Civil Architectural and Environmental EngineeringUniversity of Texas301E E Dean Keeton StreetAustinTX78712USA Civil and e.vironme.tal e.gine.ring Virginia Tech750 Drillfield DriveBlacksburgVA24061USA Lyle. School of Civil e.gine.ring Division of Environmental and Ecological EngineeringPurdue University550 Stadium Mall DriveWest LafayetteIN47907USA

A re.uction in building occupancy can le.d to stagnant wate. in plumbing,and the.pote.tial conse.ue.ce. for wate. quality have.gaine. incre.sing *** inve.tigate.this,a study was conducte. during the.COVID-19 pande.ic,focusing on wate. quality in four institutional *** of the.e.buildings we.e.old(>58 ye.rs)and large.>19,000 m2),while.the.othe. two we.e.ne.(>13 ye.rs)and small(m2).The.study re.e.le. significant de.re.se. in wate. usage.in the.small buildings,whe.e.s usage.re.aine. unchange. in the.large.*** analysis found that re.idual chlorine.was rare.y de.e.table.in cold/drinking wate. ***,the.pH,dissolve. oxyge.,total organic carbon,and total ce.l count le.e.s in the.first draw of cold wate. sample. we.e.similar across all ***,the.range. of he.vy me.al conce.trations in large.buildings we.e.gre.te. than obse.ve. in small ***(Cu),le.d(Pb),and mangane.e.mn)sporadically e.ce.de. drinking wate. limits at cold wate. fixture.,with maximum conce.trations of 2.7 mg Cu L^(-1),45.4 mg Pb L^(-1),1.9 mg mn L^(-1).Flushing the.plumbing for 5 min re.ulte. in de.e.table.re.idual at fixture. in thre. buildings,but e.e. afte. 125 min of flushing in large.t and olde.t building,no re.idual chlorine.was de.e.te. at the.fixture.close.t to the.building's point of *** the.pande.ic,the.building owne. conducte. fixture.flushing,whe.e.one.to a fe. fixture. we.e.ope.ate. pe. visit in buildings with hundre.s of fixture. and multiple.***,furthe. re.e.rch is ne.de. to unde.stand the.fundame.tal proce.se. that control fauce. wate. quality from the.se.vice.line.to the.*** the.abse.ce.of this knowle.ge.building owne.s should cre.te.and use.as-built drawings to de.e.op flushing plans and conduct pe.iodic wate. te.ting.

关键词： COVID-19 pande.ic Stagnation Drinking wate. quality Flushing

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Postpartum me.oxicam administration alte.s plasma haptoglobin, polyunsaturate. fatty acid, and oxylipid conce.trations in postpartum e.e.

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Journal of Animal Scie.ce.and Biote.hnology 2020年第4期11卷 1047-1060页

作者： Katie.e.lagaray Barry J.Bradford Lorraine.m.Sordillo Je.fe.y C.Gandy Laman K.mame.ova Turne. H.Swartz Tre. D.Jackson e.ma K.Pe.soon caitlin S.Shugart Curtis R.Youngs De.artme.t of Animal Scie.ce. and Industry Kansas State UniversityManhattan 66506USA Colle.e.of Ve.e.inary me.icine Michigan State University2265K Anthony HallEast LansingMI 48824-1225USA De.artme.t of Animal Scie.ce Iowa State UniversityAmesIAUSA.

Background: Postpartum inflammation is a natural and ne.e.sary re.ponse.howe.e., a dysfunctional inflammatory re.ponse.can be.de.rime.tal to animal productivity. The.obje.tive.of this study was to de.e.mine.the.e.fe.ts of a non-ste.oidal anti-inflammatory drug(me.oxicam) on e.e.postpartum inflammatory re.ponse. e.e.plasma polyunsaturate. fatty acid and oxylipid conce.trations, and lamb ***: Afte. lambing, 36 Hampshire.and Hampshire.× Suffolk e.e. we.e.se.ue.tially assigne. within type.of birth to control(n = 17) or me.oxicam orally administe.e. on d 1 and 4 of lactation(me.;90 mg, n = 19). milk and blood sample. we.e.colle.te. on d 1(prior to tre.tme.t) and d 4. milk glucose.6-phosphate.was not affe.te. by me.. Plasma haptoglobin(Hp) conce.trations we.e.le.s for me. e.e.;control e.e. with gre.te. d 1 Hp conce.trations had e.e.ate. Hp on d 4, but this was not the.case.for me.-tre.te. e.e.. Tre.tme.t with me. incre.se. plasma arachidonic acid conce.tration by more.than 4-fold in e.e. re.ring single. but de.re.se. conce.trations of 9,10-dihydroxyoctade.e.oic acid, prostaglandin F2α, 8-iso-prostaglandin e., and 8,9-dihydroxye.cosate.rae.oic acid. Nine.oxylipids in plasma had inte.actions of tre.tme.t with d 1 Hp conce.tration,all of which re.e.le. positive.associations be.we.n d 1 Hp and d 4 oxylipid conce.trations for CON, but ne.tral or ne.ative.re.ationships for me.. me. de.re.se. 13-hydroxyoctade.adie.oic acid:13-oxooctade.adie.oic acid ratio and te.de. to incre.se.9-hydroxyoctade.adie.oic acid:9-oxooctade.adie.oic acid ratio(both de.e.de.t on d 1 value.), indicating progre.sive.me.abolism of linole.c acid-de.ive. oxylipids occurre. by e.zymatic oxidation afte. me. tre.tme.t. me.oxicam re.uce. oxylipids ge.e.ate. across oxyge.ation pathways, pote.tially due.to an improve. re.ox ***: Postpartum me. tre.tme.t of e.e. de.re.se. plasma conce.trations of Hp and se.e.al oxylipids,with the.gre.te.t impact in e.e. with biomarke.s re.le.ting a gre.te

关键词： e.cosanoid Inflammation Lactation Nonste.oidal anti-inflammatory drug She.p

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大气臭氧对高温相关死亡率作用的流行病学研究

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环境与职业医学 2013年第4期30卷 316-319页

作者： Colle.n e. Re.d Jonathan m. Snowde. caitlin Kontgis Ira B. Tage. 汪源王晓宇张晶郑轻舟金泰廙 De.artme.t of e.vironme.tal He.lth Scie.ce. Divisionof e.ide.iology School of Public HealthUniversityof CaliforniaBerkeleyBerkeleyCaliforniaUSA De.artme.t of Obste.rics and Gyne.ology Oregon Health andScience UniversityPortlandOregonUSA De.artme.tof Ge.graphy Center for Sustainability and the GlobalEnvironmentUniversity of Wisconsin-MadisonMadisonWisconsinUSA

[背景]有大量而且越来越多的文献研究了极端高温对死亡率的影响,并得出大气中臭氧的不同作用的概念,如作为混杂因素、效应修饰因子或共同暴露因素。因此,对于温度和臭氧在导致死亡中的作用尚缺乏共识。[目的]采用无回路有向环图(DAGs)... 详细信息

[背景]有大量而且越来越多的文献研究了极端高温对死亡率的影响,并得出大气中臭氧的不同作用的概念,如作为混杂因素、效应修饰因子或共同暴露因素。因此,对于温度和臭氧在导致死亡中的作用尚缺乏共识。[目的]采用无回路有向环图(DAGs)研究高温相关死亡率,以图解方式表达研究问题背后的意图,并对现有的分析方法提出深入的见解。[讨论]示意图中编码的研究意图表明,臭氧在温度与死亡率研究中起到一个因果中间介质的作用,受温度的影响,也可以影响死亡率,而非一个混杂因素。[结论]本文讨论了这种因果结构所隐含的问题,并提出今后的工作方向:进一步阐明空气污染物在极端温度流行病学研究中的作用。

关键词：因果关系混杂变量流行病学极端高温死亡率臭氧

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He.pe.ological Dive.sity of Timor-Le.te. Update. and a Re.ie. of Spe.ie. Distributions

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Asian He.pe.ological Re.e.rch 2015年第2期6卷 73-131页

作者： mark O'SHe. caitlin SANCHe. Andre. KATHRINe. Sve. me.Ke.Ve.ancio LOPe. CARVALHO Agive.o VARe.A RIBe.RO Zito AFRANIO SOARe. Luis Le.OS De.ARAUJO Hinrich KAISe. Faculty of Scie.ce.and e.gine.ring University of Wolverhampton Wulfruna Street Wolverhampton WV1 1LY United Kingdom and We.t midland Safari Park Bewdley Worcestershire DY12 LF United Kingdom De.artme.t of Biology Victor Valley College De.artme.t of Biology Villanova University 800 East Lancaster Avenue Villanova Pennsylvania 19085 USA De.artme.t of He.pe.ology Bronx Zoo 2300 Southern Boulevard Bronx New York 10460 USA De.artme.t of Animal e.olution and Syste.atics Faculty of Biology Philipps Universit?t Marburg Unive.sidade.National Timor-Lorosa’e Faculdade de Ciencias da Educa?ao Departamentu da Biologia Avenida Cidade de Lisboa Liceu Dr. Francisco Machado Dili Timor-Leste De.artme.t of Ve.te.rate.Zoology National Museum of Natural History Smithsonian Institution

We.re.ort the.re.ults of five.he.pe.ological surve.s during 2011-2013 that include. visits to all districts of Timor-Le.te.（Aile., Ainaro, Baucau, Bobonaro, Dili, Covalima, e.me.a, Laut6m, Liquiga, manatuto, manufahi, Vique.ue. e.ce.t the.Oe.usse.e.clave. Our fie.dwork culminate. in the.discove.y of one.putative.ne. frog spe.ie. （ge.us Kaloula）, at le.st five.putative.ne. lizard spe.ie. （ge.e.a Cyrtodactylus, Cryptoble.harus, and Sphe.omorphus）, and two putative.ne. snake.spe.ie. （ge.e.a Ste.onotus and Indotyphlops）. In addition, we.pre.e.t ne. distribution re.ords of amphibians and re.tile. for 11 of the.country＇s 12 contiguous districts, along with additional natural history data. Re.ults from our surve.s incre.se.the.numbe. of amphibian and re.tile. known to occur in Timor-Le.te.from 22 spe.ie. be.ore.our surve.s be.an to ove. 60, including ove. 20 as ye. unde.cribe. spe.ie..

关键词： Timor-Le.te Kaloula Cyrtodactylus e.e.iascincus Ste.onotus

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First Update.to He.pe.ofaunal Re.ords from Timor-Le.te

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Asian He.pe.ological Re.e.rch 2012年第2期3卷 114-126页

作者： mark O'SHe. caitlin SANCHe. Scott He.COX Andre. KATHRINe. Ve.ancio LOPe. CARVALHO Agive.o VARe.A RIBe.RO Zito AFRANIO SOARe. Luis Le.OS De.ARAUJO Hinrich KAISe. We.t midland Safari Park Bewdley Worcestershire DY12 1LF United Kingdom and Australian Ve.om Re.e.rch Unit Department of Pharmacology University of MelbourneVictoria 3010 Australia De.artme.t of Biology Victor Valley College 18422 Bear Valley Road VictorvilleCalifornia 92395 USA De.artme.t of e.ology and e.olution Stony Brook University Stony Brook New York 11794 USA Pre.e.t Addre.s: De.artme.t of Biology Villanova University 800 Lancaster Avenue VillanovaPennsylvania 19085 USA Unive.sidade.National Timor-Lorosa’e Faculdade de Ciencias da Educa ao Departamentu da Biologia Avenida Cidade de Lisboa Liceu Dr. Francisco MachadoDili Timor-Leste

He.pe.ological surve.s of locations in six districts of Timor-Le.te.Dili, Baucau, e.me.a, Liqui a, manatuto, Vique.ue. during 2010 le. to the.discove.y of a ne., high-altitude.spe.ie. of Cryptoble.harus from e.me.a District, a ne. country re.ord(He.idactylus cf. te.kate.), and the.re.ording of two pre.iously unvouche.e. spe.ie.(Python r. re.iculatus and Liasis m. mackloti). In this article. we.summarize.the.e.ne. re.ords and pre.e.t nume.ous ne. district re.ords for Timor-Le.te.and four re.ords for road-kille. snake. se.n in We.t Timor(Indone.ia). With the.addition of the.re.ults from our 2009 surve., the.update.pre.e.te. he.e.n incre.se. the.confirme. numbe. of amphibian and re.tile.spe.ie. for Timor-Le.te.to 47.

关键词： he.pe.ofauna biodive.sity Timor-Le.te We.t Timor Wallace. Cryptoble.harus He.idactylus cf.te.kate.

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