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Serum ferritin and the risk of early-onset colorectal cancer

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3496-3506页

作者： Adam L Urback Kylee Martens Hannah Stowe McMurry Emerson Y Chen caitl.n citti Anil Sharma Adel Kardosh Joseph J Shatzel Division of Internal Medicine Oregon Health&Science UniversityPortlandOR 97239United States Division of Hematology and Medical Oncology Knight Cancer InstituteOregon Health&Science UniversityPortlandOR 97239United States Division of Gastroenterology&Hepatology Oregon Health&Science UniversityPortlandOR 97239United States

BACKGROUnD The incidence of early-onset colorectal cancer(EO-CRC)is rising in the United States,and is often diagnosed at advanced *** serum ferritin is often incidentally discovered in young adults,however,the indication for endoscopy in EO-CRC is *** To compare serum ferritin between patients with EO-CRC and healthy controls(HCs),and examine the association of serum ferritin in EO-CRC with patient-and disease-specific *** A retrospective study of patientsnewly-diagnosed EO-CRC was conducted from 1/2013-12/*** were included if serum ferritin was measured within 2 years prior to 1 year following CRC histologic *** supplement the analysis,a cohort of HCs meeting similar inclusion and exclusion criteria were identified for comparison.A sensitivity analysis including only patients with serum ferritin obtained at or before diagnosis was separately performed to minimize risk of *** Among 85 patients identified with EO-CRC(48 females),the median serum ferritin level was 26 ng/mL(rangeng/mL).Compared to HCs(n=80211),there were a higher proportion of individuals with EO-CRC with serum ferritinng/mL(female 65%,male 40%)versus HCs(female 32.1%,male 7.2%)age 29-39 years(P=0.002 and Pnificantly higher serum ferritin compared to less advanced stages(Pn obtained before or at the time of diagnosis was lower than levels obtained after *** findings were confirmed in the sensitivity *** Severe iron deficiency may indicate an increased risk of EO-CRC,particularly at earlier *** studies defining the optimal serum ferritin threshold and routine incorporation of serum ferritin in screening algorithms is essential to develop more effective screening strategies for EO-CRC.

关键词： Early-onset Young-onset Colorectal cancer Age Ferritin Iron deficiency

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Pesticide Residue Control in the Years 1986-1987

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Biomedical and Environmental Sciences 1991年第4期4卷 415-422页

作者： IVAnO CAMOnI ALFOnSO DI MUCCIO MARIA SAnDRA BELLISAI PAOLO citti Istituto Superiore di Sanita' Lab. Tossicologia Applicata Viale Regina Elena 299 Rome 00161ItalyIstituto Superiore di Sanita' Lab. Tossicologia Applicata Viale Regina Elena 299 Rome 00161ItalyMinistero Della Sanita Dir. Gen. Ig. Alim. e Nutrizione Rome 00161 ItalyIstituto Superiore di Sanita' Lab. Tossicologia Applicata Viale Regina Elena 299 Rome 00161Italy

Results of analytical surveys on pesticide residue levels in foods for the years 1986-1987 are presented. Analytical data obtained from regional laboratories are tabulated in terms of various commodity groups (vegetables, fruit, cereals, processed or derived foodstuffs, other commodities, legumes, environmental samples, others) and are compared with maximum legal tolerances established by the ministerial ordinance (Italian Ministry of Health) 6.6. 1985.On a total number of 4715 determinations of classes of compounds or of single compounds made on 1601 commodities samples, only n 53 (1.1 %) violative results appeared. no residue was found at levels exceeding regulatory limits or found in commodities where a tolerance had not been established for a specific pesticide/commodity combination.

关键词： Pesticide Residue Control in the Years 1986-1987

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