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Effect of alpine hypoxic environment on intestinal flora

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Microenvironment & Microecology Research 2021年第2期3卷 1-2页

作者： Jiali Cai caijuan bai Jinbang Zhang Zixuan Li New Campus of Tibet University No.10Zangda East Road

The external environment plays a decisive role in the changes of the intestinal *** low oxygen environment of the plateau disturbs the barrier function of the intestinal mucosa,altered flora structure exacerbates intestinal mucosal barrier *** is possible that the mechanism of intestinal mucosal injury is the upregulation of the expression of hypoxia-inducible factor HIF-1αin the intestine under hypoxic environment,along with the sustained expression of inducible nitric oxide synthase(iNOS),which triggers intestinal mucosal injury.

关键词： Altitude hypoxia Intestinal flora Dysfunction

De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation

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National Science Review 2020年第2期7卷 391-402页

作者： Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao Wangshan Zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li caijuan bai baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su High Altitude Medical Research Center School of Medicine Tibetan University Fukang Obstetrics Gynecology and Children Branch Hospital Tibetan Fukang Hospital State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences Chinese Academy of Sciences Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational Biology Shanghai Institute of Nutrition and Health Shanghai Institutes for Biological SciencesUniversity of Chinese Academy of Sciences School of Life Science and Technology Shanghai Tech University Center for Disease Control Tibet Autonomous Region National Key Laboratory of High Altitude Medicine High Altitude Medical Research Institute Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Collaborative Innovation Center of Genetics and Development

Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence—a662-bp intronic insertion in the SCUBE2 gene—is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies.

关键词： long-read sequencing Tibetan structural variants genetic adaptation reference genome

Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia

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National Science Review 2018年第4期5卷 516-529页

作者： Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang baimakangzhuo caijuan bai Wangshan Zheng Yongbo Guo Duojizhuoma baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui State Key Laboratoryof Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences High Altitude Medical Research Center School of Medicine Tibetan University National Key Laboratory of High Altitude Medicine High Altitude Medical Research Institute Fukang International Medical Examination Center Fukang Obstetrics Gynecologyand Children Branch Hospital Tibetan Fukang Hospital 7. Yunnan Key Laboratory of Primate Biomedicine ResearchInstitute of PrimateTranslational MedicineKunming University of Science andTechnology

Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in ***, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct ***, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia.

关键词： adaptation high altitude Tibetan nitric oxide GCH1

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迭代去噪收缩阈值算法重构压缩全息

上海交通大学学报 2017年第12期51卷 1435-1442页

作者：白彩娟刘静蒋晓瑜张国贤黄开宇西安交通大学电子与信息工程学院西安710049 中国人民解放军装甲兵工程学院信息工程系北京100072

为了解决全息图像数据在传输过程中占用大量内存并在一定程度上增加设计成本的问题,在数字全息成像技术中,应用压缩感知理论,提出了一种基于迭代去噪收缩阈值算法(IDNST)的数字全息重构方法.IDNST算法引入了去噪迭代因子和正则化收缩因... 详细信息

为了解决全息图像数据在传输过程中占用大量内存并在一定程度上增加设计成本的问题,在数字全息成像技术中,应用压缩感知理论,提出了一种基于迭代去噪收缩阈值算法(IDNST)的数字全息重构方法.IDNST算法引入了去噪迭代因子和正则化收缩因子,利用前2次迭代的值、不断更新的迭代参数以及不断收缩的正则化参数来获得新的迭代值,加快了收敛速度,提高了全息图像的重构精度.仿真结果表明,所提出方法能够高概率地恢复出原始图像.

关键词：压缩感知数字全息全息图的稀疏表示观测矩阵迭代去噪收缩阈值算法

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开放实验室中交叉组合培养方法探索

实验室研究与探索 2019年第10期38卷 179-181页

作者：罗超叶唐进杨光白彩娟西藏大学医学院拉萨850000 西藏大学工学院拉萨850000 西南交通大学医学院成都610031

为了适应新时期国家从制造大国向创新大国转型对人才培养的需求,高校急需培养知识面广、专业技能扎实、实践能力强、综合素质高以及具有一定创新能力的各类高级人才。该文结合4年来学科融合方法,分析了开放实验室中对学生进行交叉组合... 详细信息

为了适应新时期国家从制造大国向创新大国转型对人才培养的需求,高校急需培养知识面广、专业技能扎实、实践能力强、综合素质高以及具有一定创新能力的各类高级人才。该文结合4年来学科融合方法,分析了开放实验室中对学生进行交叉组合式培养的创新探索。研究表明,不同专业、不同年级和不同学历层次的学生进行交叉组合培养对学生知识面的扩展、创新能力的培养、综合素质提高等方面具有明显的提升。

关键词：开放实验室跨学科组合培养创新能力

铭记关怀坚定信念不负期望立德树人——学习领会习近平总书记给西藏大学医学院学生回信精神

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高原科学研究 2020年第2期4卷 1-4页

作者：白彩娟扎堆西藏大学医学院 850000

2020年2月21日,习近平总书记给西藏大学医学院临床医学专业本科班在北京大学首钢医院实习的17名学生回信,肯定了收获,提出了期望,并向全区各族群众送出了藏历新年祝福。文章立足回信内容,以西藏大学医学院教师的角度,从学校发展、育人... 详细信息

2020年2月21日,习近平总书记给西藏大学医学院临床医学专业本科班在北京大学首钢医院实习的17名学生回信,肯定了收获,提出了期望,并向全区各族群众送出了藏历新年祝福。文章立足回信内容,以西藏大学医学院教师的角度,从学校发展、育人使命、感恩关怀等方面进行了深入学习。总书记回信的殷殷关切,温暖着藏大人的心怀;深深期许,汇聚成砥砺前行的力量。在党中央高度重视西藏教育事业发展的前提下,回信精神无疑是一剂催人奋进的助力剂,作为人民教师更应牢记重托,努力培养“靠得住、用得上、留得下”的社会主义建设者和接班人,书写实现西藏人民对美好生活向往的西藏篇章。

关键词：西藏大学医学院学生回信精神

Negative enthalpy alloys and local chemical ordering:a concept and route leading to synergy of strength and ductility

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National Science Review 2024年第4期11卷 172-184页

作者： Zibing An Tao Yang caijuan Shi Shengcheng Mao Lihua Wang Ang Li Wei Li Xianmeng Xue Ming Sun Yifan bai Yapeng He Fuzeng Ren Zhouguang Lu Ming Yan Yang Ren Chain-Tsuan Liu Ze Zhang Xiaodong Han Beijing Key Lab of Microstructure and Property of Advanced Materials College of Materials Science &Engineering Beijing University of Technology Department of Materials Science and Engineering City University of Hong Kong Key Laboratory of Partial Acceleration Physics& Technology Institute of High Energy PhysicsChinese Academy of Sciences Department of Materials Science &Engineering Southern University of Science and Technology Department of Physics City University of Hong Kong State Key Laboratory of Silicon Materials Department of Materials Science and Engineering Zhejiang University

Solid solutions are ubiquitous in metals and alloys. Local chemical ordering(LCO) is a fundamental sub-nano/nanoscale process that occurs in many solid solutions and can be used as a microstructure to optimize strength and ductility. However, the formation of LCO has not been fully elucidated, let alone how to provide efficient routes for designing LCO to achieve synergistic effects on both superb strength and ductility. Herein, we propose the formation and control of LCO in negative enthalpy alloys. With engineering negative enthalpy in solid solutions, genetic LCO components are formed in negative enthalpy refractory high-entropy alloys(RHEAs). In contrast to conventional ‘trial-and-error' approaches, the control of LCO by using engineering negative enthalpy in RHEAs is instructive and results in superior strength(1160 MPa) and uniform ductility(24.5%) under tension at ambient temperature, which are among the best reported so far. LCO can promote dislocation cross-slip, enhancing the interaction between dislocations and their accumulation at large tensile strains; sustainable strain hardening can thereby be attained to ensure high ductility of the alloy. This work paves the way for new research fields on negative enthalpy solid solutions and alloys for the synergy of strength and ductility as well as new functions.

关键词： negative enthalpy alloys local chemical ordering strength ductility dislocation

一株红树来源真菌Penicillium citrinum HL-5126中两个新异香豆素化合物（英文）

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有机化学 2019年第5期39卷 1479-1482页

作者：梅荣清黄国雷王斌白猛罗由萍陈光英郑彩娟热带药用植物化学教育部重点实验室海南省热带药用植物化学重点实验室海南师范大学化学与化工学院

综合运用多种现代色谱学分离方法对红树来源真菌Penicillium citrinum HL-5126中的次级代谢产物进行了研究,从中分离获得2个新的异香豆素类化合物,通过1D NMR,2D NMR和HR-ESI-MS等波谱鉴定技术确定结构分别为penicimarin J(1)和penicima... 详细信息

综合运用多种现代色谱学分离方法对红树来源真菌Penicillium citrinum HL-5126中的次级代谢产物进行了研究,从中分离获得2个新的异香豆素类化合物,通过1D NMR,2D NMR和HR-ESI-MS等波谱鉴定技术确定结构分别为penicimarin J(1)和penicimarin K(2).通过测定圆二色谱并与文献数据对照,确定了化合物1和2的绝对构型.化合物1和2对α-Glucosidase显示一定的抑制活性,IC50值分别为18.37和25.86μg/mL.

关键词： Penicillium citrinum 异香豆素抗菌活性 α-Glucosidase抑制活性

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壳聚糖定量分析方法的研究进展

广东药学院学报 2016年第6期32卷 805-810页

作者：马彩娟张伟爱白研广东药科大学公共卫生学院广东广州510310

壳聚糖(chitosan)是目前自然界唯一带阳离子的碱性多糖,具有减肥降脂、增强免疫力等生物活性,使其在医药和功能性食品领域都备受关注,因此,以壳聚糖为核心成分的产品质量控制是一个重要的研究课题。本文综述了近年来壳聚糖定量分析的主... 详细信息

壳聚糖(chitosan)是目前自然界唯一带阳离子的碱性多糖,具有减肥降脂、增强免疫力等生物活性,使其在医药和功能性食品领域都备受关注,因此,以壳聚糖为核心成分的产品质量控制是一个重要的研究课题。本文综述了近年来壳聚糖定量分析的主要方法,包括光谱法、电化学法和高效液相色谱法等,并对其分析测定的发展进行展望,旨在为各类产品中壳聚糖的定量分析提供新的思路。

关键词：壳聚糖定量分析光谱法电化学法高效液相色谱法