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Acta Oceanologica Sinica 2019年第2期38卷 96-106页

作者： Yanbing Zhu He Gao Hebin Li Hui ni Zedong Jiang Lijun Li Anfeng Xiao College of Food and Biological Engineering Jimei University Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering Research Center of Food Biotechnology of Xiamen City Key Laboratory of Systemic Utilization and In-depth Processing of Economic Seaweed Xiamen Southern Ocean Technology Center of China Department of Pharmacy Xiamen Medical College

An agarase gene containing 1 302 bp was cloned from Microbulbifer sp. AG1. It encoded a mature protein of 413 amino acids plus a 20-residue signal peptide. The recombinant enzyme without the signal peptide was expressed and purified from Escherichia coli BL21(DE3). When agarose was used as a substrate, the optimal temperature and pH for the enzyme were 60℃ and 7.5, respectively. The recombinant agarase showed excellent thermostability with 67% and 19% of residual activities after incubation at 50℃ and 60℃ for 1 h, *** SDS, the recombinant agarase had a relatively good resistance against the detected inhibitors, detergents and urea denaturant. Thin layer chromatography analysis and enzyme assay using p-nitrophenyl-α/β-Dgalactopyranoside revealed that the recombinant agarase was a β-agarase that degraded agarose into neoagarotetraose as the main end product. The enzymatic hydrolysis products with different degree of polymerization exhibited the antioxidant activities.

关键词： thermostable β-agarase neoagarotetraose Microbulbifer sp.

血清Krüppel样因子2和血管紧张素Ⅱ受体样1内源性配体13对血液透析患者自体动静脉内瘘狭窄的预测价值

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中国医药 2024年第1期19卷 79-83页

作者：王明波倪晓娜朱琳喻珊珊山东省济南市人民医院肾病风湿科济南271100 山东省济南市人民医院血透室济南271100

目的探讨血清Krüppel样因子2(KLF2)、血管紧张素Ⅱ受体样1内源性配体13(Apelin-13)水平对血液透析患者自体动静脉内瘘(AVF)狭窄的预测价值。方法选取2018年6月至2022年12月山东省济南市人民医院收治的214例以AVF为血管通路的血液透析... 详细信息

目的探讨血清Krüppel样因子2(KLF2)、血管紧张素Ⅱ受体样1内源性配体13(Apelin-13)水平对血液透析患者自体动静脉内瘘(AVF)狭窄的预测价值。方法选取2018年6月至2022年12月山东省济南市人民医院收治的214例以AVF为血管通路的血液透析患者为血液透析组,另选取同期53例体检健康者为对照组。血液透析组患者根据是否伴有AVF狭窄分为狭窄组(37例)和非狭窄组(177例)。记录患者临床资料,采用酶联免疫吸附试验法检测血清KLF2、Apelin-13水平。通过多因素Logistic回归方法分析血液透析患者AVF狭窄的影响因素,采用受试者工作特征(ROC)曲线分析血清KLF2、Apelin-13水平对血液透析患者AVF狭窄的预测价值。结果血液透析组血清KLF2、Apelin-13水平均低于对照组(均P<0.001)。狭窄组年龄、透析龄、透析中低血压比例、超滤率、低密度脂蛋白胆固醇水平均大于/长于/高于非狭窄组,体重指数、收缩压、KLF2、Apelin-13水平均低于非狭窄组(均P<0.05)。多因素Logistic回归分析结果显示,透析龄延长、透析中低血压、超滤率增加为血液透析患者AVF狭窄的独立危险因素,体重指数增加、KLF2升高、Apelin-13升高为独立保护因素(均P<0.05)。ROC曲线分析结果显示,血清KLF2、Apelin-13单独与联合预测血液透析患者AVF狭窄的曲线下面积分别为0.797、0.794、0.907,敏感度分别为54.05%、100.00%、91.89%,特异度分别为92.66%、50.85%、83.05%。结论血清KLF2、Apelin-13水平降低与血液透析患者AVF狭窄密切相关,可作为AVF狭窄的辅助预测指标。

关键词：血液透析自体动静脉内瘘狭窄 Krüppel样因子2 血管紧张素Ⅱ受体样1内源性配体13

应对方式在实习护生反刍思维和负性情绪间的中介效应

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卫生职业教育 2024年第14期42卷 144-148页

作者：倪卿囡白桦贾亚萍杨晓宇郑州大学第三附属医院河南郑州450052

了解护理实习生反刍思维、应对方式及负性情绪现状,探讨应对方式在两者间的中介效应。采用方便抽样法,线上发放一般资料问卷、反刍思维量表、简易应对方式量表和抑郁—焦虑—压力量表。采用Amos 24.0构建反刍思维—应对方式—负性情绪... 详细信息

了解护理实习生反刍思维、应对方式及负性情绪现状,探讨应对方式在两者间的中介效应。采用方便抽样法,线上发放一般资料问卷、反刍思维量表、简易应对方式量表和抑郁—焦虑—压力量表。采用Amos 24.0构建反刍思维—应对方式—负性情绪关系模型,并进行中介效应检验。研究表明,实习护生反刍思维可以通过应对方式间接影响负性情绪。建议护理教育者应关注实习护生的反刍思维,帮助其掌握积极应对策略,从而减少不良情绪,促进心理健康。

关键词：实习护生应对方式反刍思维负性情绪

维普期刊数据库博看期刊

Forest height mapping using inventory and multi-source satellite data over Hunan Province in southern China

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Forest Ecosystems 2022年第1期9卷 57-70页

作者： Wenli Huang Wankun Min Jiaqi Ding Yingchun Liu Yang Hu Wenjian ni Huanfeng Shen School of Resource and Environmental Sciences Wuhan UniversityHubei430079China State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijing100101China College of Urban and Environmental Sciences Peking UniversityBeijing100871China Academy of Inventory and Planning National Forestry and Grassland AdministrationBeijing100714China School of Ecology and Environment Ningxia UniversityYinchuan750021China Breeding Base for State Key Laboratory of Land Degradation and Ecological Restoration in Northwest China Ningxia UniversityYinchuan750021China Key Laboratory for Restoration and Reconstruction of Degraded Ecosystem in Northwest China of Ministry of Education Ningxia UniversityYinchuan750021China

Background:Accurate mapping of forest canopy heights at a fine spatial resolution over large geographical areas is *** is essential for the estimation of forest aboveground biomass and the evaluation of forest *** current regional to national scale forest height maps were mainly produced at *** maps lack spatial details for decision-making at local *** advances in remote sensing provide great opportunities to fill this ***:In this study,we evaluated the utility of multi-source satellite data for mapping forest heights over Hunan Province in China.A total of 523 plot data collected from 2017 to 2018 were utilized for calibration and validation of forest height ***,the relationships between three types of in-situ measured tree heights(maximum-,averaged-,and basal area-weighted-tree heights)and plot-level remote sensing metrics(multispectral,radar,and topo variables from Landsat,Sentinel-1/PALSAR-2,and SRTM)were *** types of models(multilinear regression,random forest,and support vector regression)were *** variables were selected by two types of variable selection approaches(stepwise regression and random forest).Model parameters and model performances for different models were tuned and evaluated via a 10-fold cross-validation ***,tuned models were applied to generate wall-to-wall forest height maps for Hunan ***:The best estimation of plot-level tree heights(R2 ranged from 0.47 to 0.52,RMSE ranged from 3.8 to 5.3 m,and rRMSE ranged from 28%to 31%)was achieved using the random forest model.A comparison with existing forest height maps showed similar estimates of mean height,however,the ranges varied under different definitions of forest and types of tree ***:Primary results indicate that there are small biases in estimated heights at the province *** study provides a framework toward establishing regional to national scale maps of

关键词： Forest canopy height Hunan province Landsat ARD PALSAR-2 Sentinel-1

SPACEBORNE SAR REAL-TIME ECHO SIMULATION PLATFORM BASED ON VPX

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Journal of Electronics(China) 2014年第3期31卷 193-199页

作者： ni Chao Hu Xiao Zhang Zhimin Zhao Fengjun Institute of Electronics Chinese Academy of Sciences University of Chinese Academy of Sciences

To perform the ground test of a spaceborne Synthetic Aperture Radar(SAR) system, an echo simulator with the characteristics of multimode, multi-assemblage, and real time is proposed in this paper. A hardware platform of the real-time echo simulator based on the VPX bus is designed. With this platform, real-time multi-point echo generation and scenario targets echo generation can be achieved by the real-time signal processing in Field Programmable Gate Array(FPGA), utilizing the parameters calculated by the industry computers. Furthermore, this platform can output different signals if it is expanded to multi-channels, making it possible for the assignment of echo generation and test in different spaceborne SAR modes. The test results with the actual SAR system show that this platform can satisfy the system requirements and is now used in practice.

关键词： Synthetic Aperture Radar(SAR) Echo simulation Real-time VPX bus

北京市某社区医院高血压处方用药方案及其合理性分析

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中国社区医师 2024年第22期40卷 14-16页

作者：陈磊周林王雅静常庆春王倪北京市海淀区蓟门里社区卫生服务中心药剂科北京102206 中国疾病预防控制中心结核病预防控制中心北京102206

目的:分析北京市某社区医院高血压处方用药方案及其合理性,为规范药品使用、提高诊疗水平提供依据。方法:通过北京市海淀区蓟门里社区卫生服务中心医院管理信息系统收集2022-2023年抗高血压药物处方1 086张,分析处方中抗高血压药种类、... 详细信息

目的:分析北京市某社区医院高血压处方用药方案及其合理性,为规范药品使用、提高诊疗水平提供依据。方法:通过北京市海淀区蓟门里社区卫生服务中心医院管理信息系统收集2022-2023年抗高血压药物处方1 086张,分析处方中抗高血压药种类、抗高血压治疗方案及合理用药情况。结果:2022-2023年1 086份抗高血压药物处方中使用率排在前三位的降压药物类型分别是钙离子拮抗剂(CCB)、血管紧张素Ⅱ受体阻滞剂(ARB)、β-受体阻断剂(β-RB),排在前三位的降压药分别是氨氯地平(28.91%)、硝苯地平(18.88%)、比索洛尔(12.52%),用药方案排在前三位的是单独用药、二联用药、三联用药。治疗方案排在前三位的是单独使用CCB、单独使用ARB、CCB+ARB联合用药,其中合理处方1 066份(98.16%),不合理处方20份(1.84%)。结论:2022-2023年北京市海淀区蓟门里社区卫生服务中心的抗高血压药物选择基本合理,需要控制个别药品最大使用日剂量及其不良反应,加强药物监督,严格按照处方标准用药,增强抗高血压用药的安全性与合理性。

关键词：基层医疗机构高血压处方合理用药

血清AMH、基础LH联合诊断女童中枢性性早熟的临床价值及二者与盆腔超声表现的关系分析

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中国计划生育和妇产科 2024年第2期16卷 101-105页

作者：尹鹏倪卫东赵义勇马兵兵北京京煤集团总医院超声科北京100000

目的探讨血清抗苗勒氏管激素(anti⁃Müllerian hormone,AMH)、基础促黄体生成素(luteinizing hormone,LH)联合诊断女童中枢性性早熟(central precocious puberty,CPP)的临床价值及二者与盆腔超声表现的关系。方法选取2021年1~12月期间... 详细信息

目的探讨血清抗苗勒氏管激素(anti⁃Müllerian hormone,AMH)、基础促黄体生成素(luteinizing hormone,LH)联合诊断女童中枢性性早熟(central precocious puberty,CPP)的临床价值及二者与盆腔超声表现的关系。方法选取2021年1~12月期间于北京京煤集团总医院收治的62例CPP女童为CPP组,选取同期58例健康女童为对照组。所有女童均进行盆腔超声检查,并比较两组血清AMH、基础LH水平。采用Pearson法分析血清AMH、基础LH水平与盆腔超声参数的相关性。采用多因素Logistic回归分析法明确影响CPP女童诊断的危险因素,并采用受试者工作特征(receiver operating characteristic,ROC)曲线分析血清AMH、基础LH及盆腔超声相关参数单独及联合应用对CPP女童诊断的预测价值。结果CPP组子宫横径、长径、前后径及体积,卵巢横径、长径、前后径及体积,内膜厚度,最大卵泡直径及直径>4 mm卵泡数均高于对照组(P4mm卵泡数无相关性(P>0.05);CPP组骨龄、FSH基础值、E_(2)、AMH、LH基础值水平均高于对照组(P<0.05);多因素Logistic回归分析显示,血清AMH、LH基础值高水平,子宫体积、卵巢体积大,子宫内膜厚均是影响女童发生CPP的危险因素(P<0.05)。ROC分析结果显示:血清AMH、LH基础值、超声诊断预测女童发生CPP的AUC值(95%CI)分别为0.673(0.582⁃0.756)、0.689(0.598⁃0.770)、0.832(0.752⁃0.894),二者联合预测效能高于各项单独检测(Z=2.722、2.092,P<0.05)。结论CPP女童血清AMH、基础LH水平升高,血清AMH、LH基础值高水平是影响CPP发生的独立危险因素,二者联合检测对于CPP女童具有更高的诊断价值,血清AMH、LH基础值水平与盆腔超声指标中子宫体积、卵巢体积、内膜厚度均呈正相关。

关键词：中枢性性早熟抗苗勒氏管激素促黄体生成素盆腔超声女童诊断

Olfactory route for cerebrospinal fluid drainage into the cervical lymphatic system in a rabbit experimental model

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Neural Regeneration Research 2012年第10期7卷 766-771页

作者： Haisheng Liu Zhili ni Yetao Chen Dong Wang Yan Qi Qiuhang Zhang Shijie Wang Department of Neurosurgery Yuquan Hospital Tsinghua University Beijing 100049 China Department of Otorhinolaryngology and Head ＆ Neck Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China

The present study analyzed the anatomical association between intracranial subarachnoid space and the cervical lymphatic system. X-ray contrast medium and Microfil （Microfil compounds fill and opacify microvascular and other spaces of non-surviving animals and post-mortem tissue under physiological injection pressure） were injected into the cisterna magna of the rabbit, and perineural routes of cerebrospinal fluid outflow into the lymphatic system were visualized. Under a surgical operating microscope, Microfil was found within the subarachnoid space and along the olfactory nerves. At the nasal mucosa, a lymphatic network was identified near the olfactory nerves, which crossed the nasopharyngeal region and finally emptied into the superficial and deep cervical lymph nodes. Under a light microscope, Microfil was visible around the olfactory nerves and within lymphatic vessels. These results suggested that cerebrospinal fluid drained from the subarachnoid space along the olfactory nerves to nasal lymphatic vessels, which in turn, emptied into the cervical lymph nodes. This anatomical route, therefore, allowed connection between the central nervous system and the lymphatic system.

关键词： central nervous system cerebrospinal fluid lymph subarachnoid space

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浅析动漫元素在商品包装中的应用

绿色包装 2024年第2期 75-77页

作者：陈明红邹苇张滟妮张靖四川音乐学院成都美术学院四川成都610000

近年来,我国的经济文化发展速度和成就令世人瞩目,人们的生活水平持续提升,越来越注重生活品质,对商品包装从单纯满足实用性发展到追求观赏性和舒适性。当下,带有动漫元素的商品包装逐渐受到年轻一代的关注和喜爱。本文对动漫元素在包... 详细信息

近年来,我国的经济文化发展速度和成就令世人瞩目,人们的生活水平持续提升,越来越注重生活品质,对商品包装从单纯满足实用性发展到追求观赏性和舒适性。当下,带有动漫元素的商品包装逐渐受到年轻一代的关注和喜爱。本文对动漫元素在包装中的应用进行研究,分析其能产生的巨大社会价值及经济价值。

关键词：动漫元素经济消费包装设计

维普期刊数据库博看期刊

塔吊基础与深基坑支护结构相结合的设计与施工技术研究

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广州建筑 2024年第4期52卷 13-16页

作者：夏文张凡王倩妮李攀田瑞佳中国建筑第四工程局有限公司深圳分公司深圳518000 中国建筑第四工程局有限公司广州510000

以罗湖食品大厦项目为例,提出了将塔吊基础与深基坑支护体系相结合的设计与施工技术。该技术阐述了一种不在既有内支撑结构范围外单独设置高桩承台塔吊基础的情况下,充分利用深基坑支护结构体系,使塔吊基础与深基坑支护结构体系相结合,... 详细信息

以罗湖食品大厦项目为例,提出了将塔吊基础与深基坑支护体系相结合的设计与施工技术。该技术阐述了一种不在既有内支撑结构范围外单独设置高桩承台塔吊基础的情况下,充分利用深基坑支护结构体系,使塔吊基础与深基坑支护结构体系相结合,并最终完成了塔吊基础与深基坑支护体系相结合的设计与施工。该技术与传统在内支撑结构范围外单独设置塔吊基础的技术相比,不仅减少了单独设置高桩承台塔吊基础的成本,同时有效解决了基坑支护结构施工期间垂直运输难的问题,取得了较好的经济效益,具有较大的推广价值。

关键词：塔吊基础深基坑支护体系高桩承台塔吊基础内支撑结构设计与施工