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信息系统开发中的代码设计

辽宁工程技术大学学报（自然科学版） 2000年第2期19卷 174-176页

作者：李石山张菁田彩华辽宁工程技术大学工商管理学院辽宁工程技术大学职业技术学院营口市工业学校

针对信息系统开发中代码设计存在的不符合标准、结构不合理、内容不完全等问题．提出了严格按国家标准设计、处理好代码的可扩充性与简明性原则的统一，代码结构的合理性与稳定原则的统一、设计内容必须包括代码校验等具体的处理意见。

关键词：代码标准化代码校验信息系统代码结构开发

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两相溶胶－凝胶法制备微米二氧化硅

无机盐工业 2009年第6期41卷 37-39页

作者：赵贝贝田彩华王克宇雷武夏明珠王风云南京理工大学工业化学研究所江苏南京210094 南京师范大学分析测试中心

采用两相溶胶-凝胶法,以正硅酸乙酯、氨水、乙醇、水、微量电解质为原料,制备出微米级单分散性二氧化硅微球,着重研究了微量电解质加入量、加料时间、加料方式、不同溶剂配比对二氧化硅微球粒径的影响。结果表明,二氧化硅微球粒径随着... 详细信息

采用两相溶胶-凝胶法,以正硅酸乙酯、氨水、乙醇、水、微量电解质为原料,制备出微米级单分散性二氧化硅微球,着重研究了微量电解质加入量、加料时间、加料方式、不同溶剂配比对二氧化硅微球粒径的影响。结果表明,二氧化硅微球粒径随着电解质浓度的增大先减小后增大;随着加料时间的延长,二氧化硅微球粒径逐渐增大;连续加料比间歇加料制得的二氧化硅微球单分散性好;溶剂类型对二氧化硅微球粒径有很大影响,通过不同溶剂配比调控二氧化硅微球粒径,最终制备出单分散性好的微米二氧化硅微球。

关键词：单分散性二氧化硅微球两相溶胶-凝胶法

Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer’s disease by neurotoxin neutralization and immune recognition suppression

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Bioactive Materials 2023年第8期26卷 337-352页

作者： Meng Cheng caihua Ye Chunxiao tian Dongju Zhao Haonan Li Zuhao Sun Yuyang Miao Qiang Zhang Junping Wang Yan Dou Department of Radiology and tianjin Key Laboratory of Functional Imaging Tianjin Medical University General HospitalTianjin300052PR China School of Biomedical Engineering and Technology Tianjin Medical UniversityTianjin300070PR China School of Life Sciences Tianjin UniversityTianjin300072PR China Department of Geriatrics Tianjin Medical University General HospitalTianjin Geriatrics InstituteTianjin300052PR China

Immune recognition of excessive neurotoxins by microglia is a trigger for the onset of neuroinflammation in the brain,leading to neurodegeneration in Alzheimer’s disease(AD).Blocking active recognition of microglia while removing neurotoxins holds promise for fundamentally alleviating neurotoxin-induced immune responses,but is very ***,an engineered macrophage-biomimetic versatile nanoantidote(OT-Lipo@M)is developed for inflammation-targeted therapy against AD by neurotoxin neutralization and immune recognition *** macrophage membranes can not only endow OT-Lipo@M with anti-phagocytic and inflammation-tropism capabilities to target inflammatory lesions in AD brain,but also efficiently reduce neurotoxin levels to prevent them from activating *** loaded oxytocin(OT)can be slowly released to downregulate the expression of immune recognition site Toll-like receptor 4(TLR4)on microglia,inhibiting TLR4-mediated pro-inflammatory signalling *** from this two-pronged immunosuppressive strategy,OT-Lipo@M exhibits outstanding therapeutic effects on ameliorating cognitive deficits,inhibiting neuronal apoptosis,and enhancing synaptic plasticity in AD mice,accompanied by the delayed hippocampal atrophy and brain microstructural disruption by in vivo 9.4T MR *** work provides new insights into potential AD therapeutics targeting microglia-mediated neuroinflammation at the source.

关键词： Alzheimer’s disease Biomimetic nanomedicine Biological neutralization Immune recognition and response Neuroinflammation-targeted therapy 9.4T MR imaging

Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor

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Chinese Science Bulletin 2009年第6期54卷 1050-1057页

作者： LIU DaZhen YIN caihua ZHANG YingMei tian LinJie LI Ting LI Dan MA DaLong GUO YingLu WANG Ying Department of Urology First Hospital of Peking University Beijing 100034 China Department of Medical Immunology School of Basic Medical Science Peking University Health Science Center Beijing 100083 China Center for Human Disease Genomics Peking University Beijing 100083 China Department of Urology General Hospital of Tianjin Medical University Tianjin 300052 China

CKLF (chemokine-like factor)-like MARVEL (MAL and related proteins for vesicle trafficking and mem-brane link domain) transmembrane domain containing (CMTM) is a novel gene family. One member of this family, CMTM2, also named chemokine-like factor superfamily 2 (CKLFSF2), is expressed highly in the testis and moderately in the prostate, marrow and peripheral blood cells. However, the function of human CMTM2 remains unknown. Here, we found that CMTM2 was upregulated in 5α-dihydrotestos- terone (DHT)-treated LNCaP cells. We investigated the relationship between CMTM2 and the androgen receptor. Our results showed that CMTM2 enhanced DHT-mediated androgen receptor (AR) transacti-vation and the expression of prostate specific antigen (PSA). We also observed that CMTM2 enhanced the AR protein level, which was reversed by silencing endogenous CMTM2 expression, which sug-gested that CMTM2 might play an important role in maintaining the AR protein level. We also found that CMTM2 suppressed Akt activation. A previous study showed that Akt could phosphorylate AR at Ser210 and Ser790 and lead to AR ubiquitylation and degradation as well as suppression of AR activity. Taken together, suppressing Akt activation and increasing the AR protein level might be one of the mechanisms for the CMTM2-mediated enhancement of AR transactivation.

关键词：雄激素受体转录人类 LNCaP细胞诱导配体蛋白水平外周血细胞

Research progress on the health status and community management service needs of mobile elderly people

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Journal of Translational Neuroscience 2023年第3期8卷 10-13页

作者： Min Mo Ran tian Jiuxue Li caihua Yang Department of Clinical Psychology The Affiliated Mental Hospital of Kunming Medical UniversityKunming 650000China

The health status of the floating elderly population and the need of community management services are complex and important *** to the change of living environment and the insecure medical care,the mobile elderly people have more health and psy-chological problems compared to the rest of the elderly ***,the community should take a variety of measures to meet their needs and help them to better adapt to the new living environment,and maintain their physical and mental *** paper aims to summarize recent studies on the physical and emotional health problems of mobile elderly people and related community management service needs.

关键词： mobile elderly people health status community management services

High-Sensitivity Tunnel Magnetoresistance Sensors Based on Double Indirect and Direct Exchange Coupling Effect

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Chinese Physics Letters 2021年第12期38卷 80-84页

作者： Xiufeng Han Yu Zhang Yizhan Wang Li Huang Qinli Ma Houfang Liu caihua Wan Jiafeng Feng Lin Yin Guoqiang Yu tian Yu Yu Yan Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China College of Physical Science and Technology Sichuan UniversityChengdu 610065China Key Laboratory of Physics and Technology for Advanced Batteries(Ministry of Education) Department of PhysicsJilin UniversityChangchun 130012China

Detection of ultralow magnetic field requires magnetic sensors with high sensitivity and low noise level,especially for low operating frequency *** investigated the transport properties of tunnel magnetoresistance(TMR)sensors based on the double indirect exchange coupling *** TMR ratio of about 150%was obtained in the magnetic tunnel junctions and linear response to an in-plane magnetic field was successfully achieved.A high sensitivity of 1.85%/Oe was achieved due to a designed soft pinned sensing layer of CoFeB/NiFe/Ru/***,the voltage output sensitivity and the noise level of 10.7 mV/V/Oe,10 nT/Hz^(1/2)at 1 Hz and3.3 nT/Hz^(1/2)at 10 Hz were achieved in Full Wheatstone Bridge *** kind of magnetic sensors can be used in the field of smart grid for current detection and sensing.

关键词： configuration effect Coupling

聚α-C14烯烃/酯类润滑油基础油合成和性能研究

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润滑与密封 2019年第11期44卷 90-93页

作者：祁天倪才华江南大学食品胶体与生物技术教育部重点实验室江南大学化学与材料工程学院

将α-C14烯烃先与马来酸酐进行无规共聚,再与季戊四醇进行酯化反应,制得一种新型的聚α-C14烯烃/酯类润滑基础油。采用红外光谱、核磁共振谱1H-NMR、热重分析仪、油品运动黏度测定仪、酸值测定仪对产物进行表征和性能测试。结果表明:随... 详细信息

将α-C14烯烃先与马来酸酐进行无规共聚,再与季戊四醇进行酯化反应,制得一种新型的聚α-C14烯烃/酯类润滑基础油。采用红外光谱、核磁共振谱1H-NMR、热重分析仪、油品运动黏度测定仪、酸值测定仪对产物进行表征和性能测试。结果表明:随着马来酸酐用量增加,合成的基础油的运动黏度、热分解温度、酸值均先增大后减小,随着季戊四醇用量增加,合成的基础油的运动黏度、热分解温度先增大后减小,酸值逐渐降低;当马来酸酐与α-C14烯烃质量比为1∶5.14,季戊四醇占α-C14烯烃质量4.17%时,润滑基础油的黏度指数为114,酸值为0.082 mg/g(以KOH计),热分解温度大于249.3℃,40℃运动黏度为276.31 mm^2/s,100℃运动黏度为25.91 mm^2/s。因此,与AIP类润滑油相比,合成的基础油具有更好的低温流动性和耐高温稳定性,与传统的酯类润滑油相比具有较低的酸值,对器件腐蚀性较低。

关键词：合成润滑油热稳定性运动黏度季戊四醇

花棒沙柳根与土及土与土界面直剪摩擦试验与数值模拟

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农业工程学报 2015年第13期31卷 149-156页

作者：田佳曹兵及金楠赵元宵李才华郭婷宁夏大学农学院银川750021 北京林业大学水土保持与荒漠化防治教育部重点实验室北京100083

花棒和沙柳是毛乌素沙地中分布最广泛的优良防风固沙树种,在固定流动沙丘和半流动沙丘上效果明显。为了探索花棒和沙柳根-土界面的摩擦特性,该文选取毛乌素沙地5 a生人工种植花棒、沙柳的根系为研究对象,通过直剪摩擦试验研究界面类型... 详细信息

花棒和沙柳是毛乌素沙地中分布最广泛的优良防风固沙树种,在固定流动沙丘和半流动沙丘上效果明显。为了探索花棒和沙柳根-土界面的摩擦特性,该文选取毛乌素沙地5 a生人工种植花棒、沙柳的根系为研究对象,通过直剪摩擦试验研究界面类型、土壤含水率和垂直荷载对花棒、沙柳根-土界面以及素土-素土界面摩擦特性的影响,并采用有限元软件对直剪摩擦试验进行数值模拟。结果表明:花棒和沙柳根系对土壤抗剪强度的提高作用与根-土界面的黏聚力无关,与摩擦角有关。花棒根-界面的摩擦角显著高于素土-素土和沙柳根-土界面(P<0.05)。土壤含水率的变化对根-土界面的黏聚力与摩擦角的影响规律相似,旱季和雨季对根系提高土壤抗剪强度的作用有显著影响(P<0.05)。根-土界面的抗剪强度与垂直荷载的关系同样满足莫尔-库伦准则,本构关系为双曲线。花棒根-土界面抗剪强度极显著高于素土-素土界面和沙柳根-土界面(P<0.01),从抵抗根-土位移的角度,花棒的固沙效果优于沙柳。该文所采用的应力、位移边界条件和Coulomb摩擦模型,模拟计算的根-土界面和素土-素土界面的抗剪强度与试验结果基本一致(最大相对误差<10%),因此根-土界面的直剪摩擦试验可以通过本文所建立的有限元数值模型来模拟。研究结果可为根系固土作用的理论研究和防风固沙树种的筛选提供参考。

关键词：摩擦土界面数值分析根直剪摩擦试验花棒沙柳

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防风固沙灌木花棒沙柳根系生物力学特性

农业工程学报 2014年第23期30卷 192-198页

作者：田佳曹兵及金楠李才华朱莉马尼园宁夏大学农学院银川750021 北京林业大学水土保持与荒漠化防治教育部重点实验室北京100083

为了揭示花棒和沙柳的根系生物力学特性,该文选取毛乌苏沙地5 a生人工种植花棒、沙柳的根系为研究对象,通过室内单根拉伸试验,得到沙柳（直径0.78~7.44 mm）的平均最大拉力、抗拉强度和杨氏模量分别比花棒（直径0.91~6.46 mm）高42.07%... 详细信息

为了揭示花棒和沙柳的根系生物力学特性,该文选取毛乌苏沙地5 a生人工种植花棒、沙柳的根系为研究对象,通过室内单根拉伸试验,得到沙柳（直径0.78~7.44 mm）的平均最大拉力、抗拉强度和杨氏模量分别比花棒（直径0.91~6.46 mm）高42.07%、44.52%和90.00%。花棒、沙柳单根根系的最大拉力随直径增大以幂函数增大,抗拉强度和杨氏模量随直径增大以幂函数减小。花棒与沙柳单根根系的平均抗拉强度能达到Ⅰ级钢筋（370MPa）的6.86%和9.91%,对土壤有一定的加筋作用。采用自制根系拉力测试系统进行野外原位整株根系垂直拉拔试验,得到花棒（地径17.65~42.68 mm）和沙柳（地径20.35~48.07 mm）的整株根系最大垂直拉拔力为（1.71±0.16）k N和（1.18±0.16）k N,花棒比沙柳高出44.92%。花棒整株根系的生物力学特性要优于沙柳,整体固沙能力更强。该研究可为根系固土作用理论研究和防风固沙树种的筛选提供参考。

关键词：生物力学抗拉强度土壤根系固土垂直拉拔力花棒沙柳