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Tiliroside protects against diabetic nephropathy in streptozotocininduced diabetes rats by attenuating oxidative stress and inflammation

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World Journal of Diabetes 2024年第11期15卷 2220-2236页

作者： yan Shang cai-yun yan Hui Li Na Liu Hui-Feng Zhang Department of Nephrology Shanxi Bethune HospitalShanxi Academy of Medical SciencesThird Hospital of Shanxi Medical UniversityTongji Shanxi HospitalTaiyuan 030032Shanxi ProvinceChina

BACKGROUND Diabetic nephropathy(DN),affecting half of diabetic patients and contributing significantly to end-stage kidney disease,poses a substantial medical challenge requiring dialysis or *** nuanced onset and clinical progression of kidney disease in diabetes involve consistent renal function decline and persistent *** To investigate Tiliroside's(Til)protective effect against diabetic nephropathy(DN)in rats under diabetic *** Five groups of six rats each were included in this study:Rats treated with DMSO by intraperitoneal injection as controls,those treated with STZ by intraperitoneal injection,those treated with STZ+Til(25 mg/kg body weight[bwt])or Til(50 mg/kg bwt),and those treated with anti-diabetic medication glibenclamide(600μg/kg bwt).Biochemical markers,fasting blood glucose,food intake,kidney weight,antioxidant enzymes,inflammatory and fibrotic markers,and renal injury were monitored in different *** docking analysis was performed to identify the interactions between Til and its targeted *** Til significantly reduced biochemical markers,fasting blood glucose,food intake,and kidney weight and elevated antioxidant enzymes in diabetic *** also mitigated inflammatory and fibrotic markers,lessened renal injury,and displayed inhibitory potential against crucial markers associated with DN as demonstrated by molecular docking *** These findings suggest Til's potential as a therapeutic agent for DN treatment,highlighting its promise for future drug development.

关键词： Tiliroside Diabetic nephropathy Antioxidant Diabetes mellitus Oxidative stress Inflammation

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Experimental study on wear failure course of gas-valve/valve-seat in engine

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Journal of Central South University of Technology 2005年第Z1期12卷 243-246页

作者： ZHAO yun-cai yan Hang-zhi School of Mechanical and Electrical Engineering Central South University Changsha 410083 China Department of Mechanical Engineering Jiangxi University Science and Technology Ganzhou 341000 China School of Mechanical and Electrical Engineering Central South University Changsha 410083 China

The wear failure course of gas-valve/valve-seat in engine was investigated with a simulating tester. The results show that the failure of the contact conical surface is mainly caused by the elastic and plastic deformation and the fatigue micro-crack and spalling. The creep-deformation and corrosion atmosphere accelerated wear failure course at the high temperature. The wear failure course of the gas-valve/valve-seat in engine follows general wear rules of mechanical elements, but the rate of wear in the sharp wear stage is faster.

关键词： gas-valve/valve-seat wear failure course micro-crack fatigue spalling

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Reveal the lost entanglement for accelerated atoms in the high-dimensional spacetime

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 48-57页

作者： Jiatong yan Baocheng Zhang Qingyu cai School of Mathematics and Physics China University of GeosciencesWuhan 430074China Physics Department Brown UniversityProvidenceRhode Island 02912USA Center for Theoretical Physics Hainan UniversityHaikou 570228China School of Information and Communication Engineering Hainan UniversityHaikou 570228China Peng Huanwu Center for Fundamental Theory Hefei 230026China

When atoms are accelerated in the vacuum,entanglement among atoms will degrade compared with the initial situation before the *** this study,we propose a novel and interesting view that the lost entanglement can be recovered completely when the high-dimensional spacetime is exploited,in the case that the acceleration is not too large,since the entanglement loss rate caused by the large acceleration is faster than the recovery *** also calculate the entanglement change caused by the anti-Unruh effect and found that the lost entanglement could just be recovered part by the anti-Unruh effect,and the anti-Unruh effect could only appear for a finite range of acceleration when the interaction time scale is approximately shorter than the reciprocal of the energy gap in two dimensional *** limit case of zero acceleration is also investigated,which gives an analytical interpretation for the increase or recovery of entanglement.

关键词： entanglement acceleration high-dimensional spacetime

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Multi-time Collaborative Restoration for Integrated Electrical-gas Distribution Systems Based on Rolling Optimization

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 660-671页

作者： Jingyang yun Zheng yan yun Zhou Peichao Zhang Weidong Hu Key Laboratory of Control of Power Transmission and Conversion of Ministry of Education Department of Electrical EngineeringShanghai Jiao Tong University

This paper proposes a multi-time collaborative restoration model for integrated electricity-gas distribution sys-tems(IEGDSs)considering multiple resources after extreme weather *** on the linearized power flow constraints of the unbalanced electrical distribution system(EDS)and gas distribution system(GDS),this problem can be formulated as a mixed-integer linear programming(MILP)*** improve the efficiency and veracity of the solution,a rolling optimiza-tion based two-stage method is developed with the first stage solved by a linear approximation model,and the second stage solved by real-time updated rolling *** solving the MILP problem using rolling optimization,the proposed model and solution method achieve efficient and reliable collaborative restoration of IEGDS considering multiple resources and unbal-anced operation characteristics of *** effectiveness of the proposed model and method is validated by using an IEGDS made of a 37-bus unbalanced EDS and 11-node *** Terms-Electricity-gas system,mix-integer linear programming,power system restoration.

关键词： Electricity-gas system mix-integer linear programming power system restoration

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Trudinger–Moser Inequalities on a Closed Riemann Surface with a Symmetric Conical Metric

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2263-2284页

作者： Yu FANG yun yan yanG College of Teacher Education Quzhou UniversityQuzhou 324003P.R.China Department of Mathematics Renmin University of ChinaBeijing 100872P.R.China

This is a continuation of our previous work(*** ***.,20,1295–1324,2020).Let(Σ,g)be a closed Riemann surface,where the metric g has conical singularities at finite *** G is a group whose elements are isometries acting on(Σ,g).Trudinger–Moser inequalities involving G are established via the method of blow-up analysis,and the corresponding extremals are also *** extends previous results of Chen(***.,1990),Iula–Manicini(Nonlinear Anal.,2017),and the authors(2020).

关键词： Trudinger-Moser inequality blow-up analysis conical singularity

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BSEC Method for Unveiling Open Clusters and its Application to Gaia DR3:83 New Clusters

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Research in Astronomy and Astrophysics 2024年第5期24卷 169-184页

作者： Zhong-Mu Li cai-yan Mao Institute of Astronomy and Information Dali UniversityDali 671003China

Open clusters(OCs) are common in the Milky Way, but most of them remain undiscovered. There are numerous techniques, including some machine-learning algorithms, available for the exploration of OCs. However, each method has its limitations and therefore, different approaches to discovering OCs hold significant values. We develop a comprehensive approach method to automatically explore the data space and identify potential OC candidates with relatively reliable membership determination. This approach combines the techniques of Hierarchical Density-Based Spatial Clustering of Applications with Noise, Gaussian mixture model, and a novel cluster member identification technique, color excess constraint. The new method exhibits efficiency in detecting OCs while ensuring precise determination of cluster memberships. Because the main feature of this technique is to add an extra constraint(EC) for the members of cluster candidates using the homogeneity of color excess,compared to typical blind search codes, it is called Blind Search-Extra Constraint(BSEC) method. It is successfully applied to the Gaia Data Release 3, and 83 new OCs are found, whose color–magnitude diagrams(CMDs) are fitted well to the isochrones. In addition, this study reports 621 new OC candidates with discernible main sequence or red giant branch. It is shown that BSEC technique can discard some false negatives of previous works, which takes about three percentage of known clusters. It shows that as an EC, the color excess(or twocolor) constraint is useful for removing fake cluster member stars from the clusters that are identified from the positions and proper motions of stars, and getting more precise CMDs, when differential reddening of member stars of a cluster is not large(e.g., ΔE(G_(BP)-G_(RP)) < 0.5 mag). It makes the CMDs of 15% clusters clearer(in particular for the region near turnoff) and therefore is helpful for CMD and stellar population studies. Our result suggests that the color excess con

关键词： Galaxy stellar content-(Galaxy:)open clusters and associations general-stars fundamental parameters

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Preparation and characterization of pH-responsive metal-polyphenol structure coated nanoparticles

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Food Science and Human Wellness 2024年第3期13卷 1303-1310页

作者： Qile Xia yan Liang Ailing Cao yan Cao Luyun cai Key Laboratory of Post-Harvest Handling of Fruits Food Science InstituteZhejiang Academy of Agricultural SciencesHangzhou 310021China Ningbo Research Institute College of Biosystems Engineering and Food ScienceZhejiang UniversityNingbo 315100China School of Biological and Chemical Engineering Zhejiang Engineering Research Center for Intelligent Marine Ranch EquipmentNingboTech UniversityNingbo 315100China College of Food Science and Engineering Bohai UniversityJinzhou 121013China Hangzhou Customs District Hangzhou 310007China

In this paper,tannic acid(TA)and Fe~(3+)were added to form a layer of metal-polyphenol network structure on the surface of the nanoparticles which were fabricated by zein and carbon quantum dots(CQDs)encapsulating phlorotannins(PTN).pH-Responsive nanoparticles were prepared successfully(zein-PTN-CQDs-Fe-~Ⅲ).Further,the formation of composite nanoparticles was confirmed by a series of characterization *** zeta-potential and Fourier transform infrared spectroscopy data proved that electrostatic interaction and hydrogen bonding are dominant forces to form *** encapsulation efficiency(EE)revealed that metal-polyphenol network structure could improve the EE of *** analysis and differential scanning calorimetry experiment indicated the thermal stability of zein-PTN-CQDs-Fe~Ⅲnanoparticles increased because of metal-polyphenol network *** pH-responsive nanoparticles greatly increased the release rate of active substances and achieved targeted release.

关键词： Metal Phlorotannins Nanoparticles pH-Responsive Characterization

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Frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university students

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 374-379页

作者： Jie cai Wen-Wen Fan yun-Hui Zhong cai-Lan Wen Xiao-Dan Wei Wan-Chen Wei Wan-yan Xiang Jin-Mao Chen Department of Ophthalmology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Digital and Intelligent Technology Transformation and Application Research Institute of Visual Function Tianjin 300000China Guangxi Medical University Nanning 530021Guangxi Zhuang Autonomous RegionChina

AIM:To investigate the frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university ***:Totally 158 student volunteers underwent routine vision examination in the optometry clinic of Guangxi Medical *** data were used to identify the different types of accommodation and nonstrabismic binocular vision dysfunction and to determine their *** analysis and logistic regression were used to examine the factors associated with these ***:The results showed that 36.71%of the subjects had accommodation and non-strabismic binocular vision issues,with 8.86%being attributed to accommodation dysfunction and 27.85%to binocular *** insufficiency(CI)was the most common abnormality,accounting for 13.29%.Those with these abnormalities experienced higher levels of eyestrain(χ2=69.518,P<0.001).The linear correlations were observed between the difference of binocular spherical equivalent(SE)and the index of horizontal esotropia at a distance(r=0.231,P=0.004)and the asthenopia survey scale(ASS)score(r=0.346,P<0.001).Furthermore,the right eye's SE was inversely correlated with the convergence of positive and negative fusion images at close range(r=-0.321,P<0.001),the convergence of negative fusion images at close range(r=-0.294,P<0.001),the vergence facility(VF;r=-0.234,P=0.003),and the set of negative fusion images at far range(r=-0.237,P=0.003).Logistic regression analysis indicated that gender,age,and the difference in right and binocular SE did not influence the emergence of these ***:Binocular vision abnormalities are more prevalent than accommodation dysfunction,with CI being the most frequent *** binocular refractive disparity leads to more severe eyestrain symptoms.

关键词： optometry clinic non-strabismic binocular vision dysfunction college students convergence insufficiency

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Strong anisotropy of thermal transport in the monolayer of a new puckered phase of PdSe

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Frontiers of physics 2024年第3期19卷 143-151页

作者： Zheng Shu Huifang Xu Hejin yan Yongqing cai Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoTaipaMacao 999078China

We examine the electronic and transport properties of a new phase PdSe monolayer with a puckered structure calculated by first-principles and Boltzmann transport *** spin−orbit coupling is found to play a negligible effect on the electronic properties of PdSe *** lattice thermal conductivity of PdSe monolayer exhibits remarkable anisotropic characteristic due to anisotropic phonon group velocity along different directions and its intrinsic structure *** compromised electronic mobility despite a relatively low thermal conduction results in a moderate ZT value but significantly anisotropic thermoelectric performance in single-layer *** present work suggests that the remarkable thermal transport anisotropy of PdSe monolayer can be used for thermal management,and enhance the scope of possibilities for heat flow manipulation in PdSe based *** sizeable puckered cages and wiggling lattice implies it an ideal platform for ionic and molecular engineering for thermoelectronic applications.

关键词： 2D materials first-principles calculations phonon

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Module Structures on U(ε^(-))for the Euclidean Algebra

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Algebra Colloquium 2024年第1期31卷 49-56页

作者： Yixin Bao yan'an cai School of Sciences Harbin Institute of Technology ShenzhenGuangdong 518055China Department of Mathematics Soochow University SuzhouJiangsu 215006China

We classify modules which are free of rank 1 when restricted to the negative part for the Euclidean Lie *** and necessary conditions for the simplicity of these modules are *** these modules we construct modules which... 详细信息

关键词： Euclidean algebra free module simple module nonweight module

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