检索结果-南通市图书馆

Efficacy and safety of low-dose cyclophosphamide combined with lenvatinib, pembrolizumab and TACE for unresectable hepatocellular carcinoma:A single-center, prospective,single-arm clinical trial

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2024年第2期36卷 114-123页

作者： Yupeng Ren Yuxuan Li Mingbo Cao Yongchang Tang feng Yuan Gaoyuan Yang Zhiwei He Zheng Shi Xiaorui Su Zhicheng Yao Meihai deng Department of Hepatobiliary Surgery the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Department of General Surgery Qilu HospitalShandong UniversityJinan 250012China Department of Hepatobiliary Surgery the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Hepatobiliary and Pancreatic Surgery the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China

Objective: Unresectable hepatocellular carcinoma(uHCC) continues to pose effective treatment options. The objective of this study was to assess the efficacy and safety of combining low-dose cyclophosphamide with lenvatinib, pembrolizumab and transarterial chemoembolization(TACE) for the treatment of ***: From February 2022 to November 2023, a total of 40 patients diagnosed with uHCC were enrolled in this small-dose, single-center, single-arm, prospective study. They received a combined treatment of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE. Study endpoints included progression-free survival(PFS), objective response rate(ORR), and safety assessment. Tumor response was assessed using the modified Response Evaluation Criteria in Solid Tumors(mRECIST), while survival analysis was conducted through KaplanMeier curve analysis for overall survival(OS) and PFS. Adverse events(AEs) were evaluated according to the National Cancer Institute Common Terminology Criteria for Adverse Events(version 5.0).Results: A total of 34 patients were included in the study. The median follow-up duration was 11.2 [95% confidence interval(95% CI), 5.3-14.6] months, and the median PFS(mPFS) was 15.5(95% CI, 5.4-NA) *** OS(mOS) was not attained during the study period. The ORR was 55.9%, and the disease control rate(DCR) was 70.6%. AEs were reported in 27(79.4%) patients. The most frequently reported AEs(with an incidence rate >10%) included abnormal liver function(52.9%), abdominal pain(44.1%), abdominal distension and constipation(29.4%), hypertension(20.6%), leukopenia(17.6%), constipation(17.6%), ascites(14.7%), and insomnia(14.7%). Abnormal liver function(14.7%) had the most common grade 3 or higher ***: A combination of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE is safe and effective for u HCC, showcasing a promising therapeutic strategy for managing uHCC.

关键词： Hepatocellular carcinoma lenvatinib low-dose cyclophosphamide pembrolizumab transarterial chemoembolization

Liquid-like polymer lubricating surfaces:Mechanism and applications

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第2期17卷 476-491页

作者： Dagui Wang Jinglong Yang Junchang Guo Zhijuan Duan Deihui Wang Fan Xia Fei deng Xu deng Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China State Key Laboratory of Biogeology and Environmental Geology Engineering Research Center of Nano-Geomaterials of Ministry of EducationFaculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430070China Department of Nephrology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610054China Department of Nephrology Sichuan Provincial People’s Hospital Jinniu HospitalChengdu Jinniu District People’s HospitalChengdu 610054China Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen 518110China

Liquid-like polymer lubricating surfaces(LPLSs)are solid substrates with highly flexible polymer chains grafted via covalent *** unique modification enables ultralow contact-angle hysteresis,repellency of various liquids and bulk ice,and *** distinctive wettability and universality of LPLSs have potential applications in liquid motion,biological detection,and environmental *** this review,we summarize the mechanisms,preparation,and applications of *** discuss the wettability and lubrication mechanisms of liquid droplets on *** then categorize LPLS fabrication into“grafted onto”and“grafted from”groups,depending on the type of *** highlight representative applications with recent developments in anti-complex liquid,anti-icing,anti-biological adhesions,biosensing,and photocatalytic ***,we discuss future challenges and outlooks for LPLSs.

关键词： liquid-like polymer surface lubricating wettability

Efficacy of radiofrequency ablation combined with sorafenib for treating liver cancer complicated with portal hypertension and prognostic factors

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第11期30卷 1533-1544页

作者： Li-Min Yang Hong-Juan Wang Shan-Lin Li Guan-Hua Gan Wen-Wen deng Yong-Sheng Chang Lian-feng Zhang Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Gastroenterology Zhoukou Central Hospital of Henan ProvinceZhoukou 466000Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453000Henan ProvinceChina

BACKGROUND Patients with liver cancer complicated by portal hypertension present complex challenges in *** To evaluate the efficacy of radiofrequency ablation in combination with sorafenib for improving liver function and its impact on the prognosis of patients with this *** Data from 100 patients with liver cancer complicated with portal hypertension from May 2014 to March 2019 were analyzed and divided into a study group(n=50)and a control group(n=50)according to the treatment *** research group received radiofrequency ablation(RFA)in combination with sorafenib,and the control group only received *** short-term efficacy of both the research and control groups was *** function and portal hypertension were compared before and after ***-fetoprotein(AFP),glypican-3(GPC-3),and AFP-L3 levels were compared between the two groups prior to and after *** occurrence of adverse reactions in both groups was *** 3-year survival rate was compared between the two *** data were compared between the survival and non-surviving *** identify the independent risk factors for poor prognosis in patients with liver cancer complicated by portal hypertension,multivariate logistic regression analysis was *** When comparing the two groups,the research group's total effective rate(82.00%)was significantly greater than that of the control group(56.00%;P<0.05).Following treatment,alanine aminotransferase and aspartate aminotransferase levels increased,and portal vein pressure decreased in both *** degree of improvement for every index was substantially greater in the research group than in the control group(P<0.05).Following treatment,the AFP,GPC-3,and AFP-L3 levels in both groups decreased,with the research group having significantly lower levels than the control group(P<0.05).The incidence of diarrhea,rash,nausea and vomiting,and fatigue in the research group was significantly great

关键词： Radiofrequency ablation Sorafenib Liver cancer Portal hypertension Efficacy Prognosis analysis

Performance of physical-informed neural network (PINN) for the key parameter inference in Langmuir turbulence parameterization scheme

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2024年第5期43卷 121-132页

作者： Fangrui Xiu Zengan deng School of Marine Science and Technology Tianjin UniversityTianjin 300072China

The Stokes production coefficient(E_(6))constitutes a critical parameter within the Mellor-Yamada type(MY-type)Langmuir turbulence(LT)parameterization schemes,significantly affecting the simulation of turbulent kinetic energy,turbulent length scale,and vertical diffusivity coefficient for turbulent kinetic energy in the upper ***,the accurate determination of its value remains a pressing scientific *** study adopted an innovative approach by leveraging deep learning technology to address this challenge of inferring the E_(6).Through the integration of the information of the turbulent length scale equation into a physical-informed neural network(PINN),we achieved an accurate and physically meaningful inference of E_(6).Multiple cases were examined to assess the feasibility of PINN in this task,revealing that under optimal settings,the average mean squared error of the E_(6) inference was only 0.01,attesting to the effectiveness of *** optimal hyperparameter combination was identified using the Tanh activation function,along with a spatiotemporal sampling interval of 1 s and 0.1 *** resulted in a substantial reduction in the average bias of the E_(6) inference,ranging from O(10^(1))to O(10^(2))times compared with other *** study underscores the potential application of PINN in intricate marine environments,offering a novel and efficient method for optimizing MY-type LT parameterization schemes.

关键词： Langmuir turbulence physical-informed neural network parameter inference

Precipitates Generation Mechanism and Surface Quality Improvement for Aluminum Alloy 6061 in Diamond Cutting

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 150-159页

作者：王海龙 deng Wenping 王素娟 State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Key Laboratory of Micro-Nano Manufacturing Technology and Equipment School of Electromechanical EngineeringGuangdong University of TechnologyGuangzhou 510006China

To improve the surface quality for aluminum alloy 6061(Al6061) in ultra-precision machining, we investigated the factors affecting the surface finish in single point diamond turning(SPDT)by studying influence of the precipitates generation of Al6061 on surface integrity and surface *** on the Johnson-Mehl-Avrami solid phase transformation kinetics equation, theoretical and experimental studies were conducted to build the relationship between the aging condition and the type, size and number of the precipitates for Al6061. Diamond cutting experiments were conducted to machine Al6061 samples under different aging conditions. The experimental results show that, the protruding on the chip surface is mainly Mg_(2)Si and the scratches on the machined surface mostly come from the iron-containing phase(α-, β-AlFeSi).Moreover, the generated Mg_(2)Si and α-, β-AlFeSi affect the surface integrity and the diamond turned surface roughness. Especially, the achieved surface roughness in SPDT is consistent with the variation of the number of AlFeSi and Mg_(2)Si with the medium size(more than 1 μm and less than 2 μm) in Al6061.

关键词： Al6061 precipitates aging treatment diamond cutting surface roughness

Preparation of tungsten-particle-reinforced Zr-based bulk metallic glass composites by two-step spark plasma sintering:microstructure evolution,densification mechanism and mechanical properties

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第4期43卷 1793-1808页

作者： Yun-Fei Ma Pan Gong Mao Zhang Hui-EHu Zhen Peng Xiao Xu Xin Wang Mehdi Malekan Xue-feng Tang Lei deng Jun-Song Jin Xin-Yun Wang State Key Laboratory of Materials Processing and Die and Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China Research Institute of Huazhong University of Science and Technology in Shenzhen Shenzhen518057China Department of Chemistry and Materials Naval University of EngineeringWuhan430032China School of Materials Science and Engineering Jiangsu UniversityZhenjiang212013China College of Machine Shanghai Dianji UniversityShanghai201306China School of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehran 11155-4563Iran

A new two-step spark plasma sintering(TSS)process with low-temperature pre-sintering and high-temperature final sintering has been successfully applied to prepare the tungsten-particle(Wp)-reinforced bulk metallic glass composites(Wp/BMGCs).Compared to normal spark plasma sintering(NS),the densification rate and relative density of Wp/BMGCs can be improved by selecting TSS with appropriate sintering pressure in the low temperature pre-sintering ***,the compressive strength and plastic strain of 30%Wp/BMGCs prepared by TSS are both higher than those of the samples prepared by *** TSS process can significantly enhance the compressive strength of 30%Wp/BMGCs by 12%and remarkably increase the plastic strain by 50%,while the trend is completely opposite for 50%Wp/***-in situ experiments and finite element simulations reveal that uneven temperature distribution among particles during low-temperature pre-sintering causes local overheating at contact points between particles,accelerating formation of sintering neck between particles and plastic deformation of *** the volume fraction of Wp is low,TSS can improve the interface bonding between particles by increasing the number of sintering *** makes the fracture mode of Wp/BMGCs being predominantly transgranular ***,as the volume fraction of Wp increases,the adverse effects of Wp plastic deformation are becoming more and more *** aggregated Wp tends to form a solid"cage structure"that hinders the bonding between particles at the interface;correspondingly,the fracture behavior of Wp/BMGCs is mainly dominated by intergranular ***,reducing the sintering pressure during the low-temperature pre-sintering stage of TSS has been shown to effectively decrease plastic deformation in Wp,resulting in a higher degree of densification and better mechanical properties.

关键词： Bulk metallic glass composites Tungsten particle Two-step spark plasma sintering Densification mechanism Mechanical properties

Osteotomy combined with anterior cruciate ligament reconstruction for anterior cruciate ligament injury and biplanar deformity

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第22期12卷 4897-4904页

作者： Fu-Yuan deng Jun-cai Liu Zhong Li Department of Orthopedics Deyang People’s Hospital/Orthopedic Center of Deyang CityDeyang 618000Sichuan ProvinceChina Department of Orthopedics The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Sichuan Provincial Laboratory of Orthopaedic Engineering Luzhou 646000Sichuan ProvinceChina

BACKGROUND It has been confirmed that the increased posterior tibial slope over 12 degrees is a risk factor for anterior cruciate ligament injury,and varus deformity can aggravate the progression of medial *** To evaluate the efficacy of modified high tibial osteotomy(HTO)and anterior cruciate ligament reconstruction(ACLR)in the treatment of anterior cruciate ligament(ACL)injuries with varus deformities and increased posterior tibial slope(PTS)based on clinical and imaging *** The patient data in this retrospective study were collected from 2019 to 2021.A total of 6 patients were diagnosed with ACL injury combined with varus deformities and increased *** patients underwent modified open wedge HTO and *** degree of correction of varus deformity and the PTS was evaluated by radiography and magnetic resonance *** All 6 patients(6 knee joints)were followed up for an average of 20.8±3.7 *** average age at surgery was 29.5±3.8 *** the last follow-up,all patients resumed competitive *** International Knee Documentation Committee score increased from 50.3±3.1 to 87.0±2.8,the Lysholm score increased from 43.8±4.9 to 86±3.1,and the Tegner activity level increased from 2.2±0.7 to 7.0±*** average movement distance of the tibia anterior translation was 4.8±1.1 mm,medial proximal tibial angle(MPTA)was 88.9±1.3°at the last follow-up,and the PTS was 8.4±1.4°,both of which were significantly higher than those before surgery(P<0.05).CONCLUSION Modified open wedge HTO combined with ACLR can effectively treat patients with ACL ruptures with an associated increased PTS and varus *** short-term effect is significant,but the long-term effect requires further follow-up.

关键词： Anterior cruciate ligament reconstruction Varus deformity High tibial osteotomy Posterior tibial slope Biplanar deformity

Study of 26 Galactic Open Clusters with Extended Main-sequence Turnoffs

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第6期24卷 28-37页

作者： Yang-Yang deng Zhong-Mu Li Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Institute of Astronomy and Information Dali UniversityDali 671003China

Recent studies indicate that some Galactic open clusters(OCs)exhibit extended main-sequence turnoff(eMSTO)in their color–magnitude diagrams(CMDs).However,the number of Galactic OCs with eMSTO structures detected so far is limited,and the reasons for their formation are still *** work identifies 26 Galactic OCs with undiscovered eMSTOs and investigates the causes of these *** population types and fundamental parameters of cluster samples are acquired using CMD fitting *** them,the results of 11 OCs are reliable as the observed CMDs are *** propose the crucial role of stellar binarity and confirm the importance of stellar rotation in reproducing eMSTO *** results also show that the impact of age spread is important,as it can adequately explain the structure of young OCs and fit the observed CMDs of intermediate-age OCs better.

关键词： (stars:)binaries:general Galaxy:fundamental parameters (Galaxy:)open clusters and associations:general (stars:)Hertzsprung Russell and C-M-diagrams

Functional decoration on a regenerable bifunctional porous covalent organic framework probe for rapid detection and adsorption of copper ions

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第2期43卷 758-769页

作者： Yu-Long Li Xi-Lang Jin Yi-Ting Ma Jing-Rui Liu Fazal Raziq Peng-Yuan Zhu Zhi-feng deng Hong-Wei Zhou Wei-Xing Chen Wen-Huan Huang School of Materials and Chemical Engineering Xi’an Technological UniversityXi’an710021China Yulin Boyi-Jingking Research Institute of Industrial Technology Development Research Yulin719054China KAUST Catalysis Center King Abdullah University of Science and Technology23955-6900ThuwalKingdom of Saudi Arabia Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi’an710021China National and Local Joint Engineering Laboratory for Slag Comprehensive Utilization and Environmental Technology School of Materials Science and EngineeringShaanxi University of TechnologyHanzhong723001China

Developing fluorescence porous probe for detecting and eliminating Cu^(2+) contamination in water or biosystem is an essential research project that has attracted considerable ***,improving the fluorescence detecting efficiency while enhancing the adsorption capacity of the porous probe is of great ***,a bifunctional two-dimensional imine-based porous covalent organic framework(TTP-COF)probe was designed and synthesized from 1,3,5-tris(4-aminophenyl)benzene(TAPB)and 2,4,6-Triformylphloroglucinol(TP)***-COF displayed rapid detection of Cu^(2+)(limit of detection(LOD)=10 nmol·L^(−1) while achieving a high adsorption capacity of 214 mg·g^(−1)(pH=6)at room temperature with high reusability(>5 cycles).The key roles and contributions of highπ-conjugate and delocalized electrons in TABP and functional–OH groups in TP were *** importantly,the fluorescence quenching mechanism of TTP-COF was studied by density functional theory theoretical calculations,revealing the crucial role of intramolecular hydrogen bonds among C=N and–OH groups and the blocking of the excited state intramolecular proton transfer process in detecting process of Cu^(2+).

关键词： Covalent organic framework(COF) Excited-state intramolecular proton transfer(ESIPT) Copper ion detection Copper ion adsorption Renewability