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基于Citespace对健脾法治疗冠心病可视化分析

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光明中医 2024年第8期39卷 1487-1492页

作者：陈向心陆翼郝秀炜张铜五孔德昭辽宁中医药大学辽宁沈阳110032 辽宁中医药大学附属医院中医药循证医学研究中心辽宁沈阳110032

目的分析中医药健脾法治疗冠心病的研究现状及热点,探索研究新趋势。方法检索中国知网近23年收录的健脾法治疗冠心病相关文献,应用CiteSpace ***软件绘制作者、机构、关键词知识图谱。结果共纳入文献257篇。自2000年以来,中医药健脾... 详细信息

目的分析中医药健脾法治疗冠心病的研究现状及热点,探索研究新趋势。方法检索中国知网近23年收录的健脾法治疗冠心病相关文献,应用CiteSpace ***软件绘制作者、机构、关键词知识图谱。结果共纳入文献257篇。自2000年以来,中医药健脾法治疗冠心病的研究总体呈上升趋势。存在2个合作紧密的研究团队,分别以杨关林、张军平为代表;最主要研究机构为辽宁中医药大学;关键词共现分析频次居前3位的为“冠心病”“胸痹”“从脾论治”。结论基于病证结合的中医药治疗冠心病分子机制研究是目前的研究热点,研究趋势从临床观察拓展到实验研究,未来该领域研究方向更多趋向于健脾祛痰化瘀法,从基因、蛋白直至关键病理环节的成链式、系统式研究。

关键词：胸痹冠心病中医药疗法健脾法可视化分析

Profiling of miRNAs in porcine Sertoli cells

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Journal of Animal Science and Biotechnology 2021年第1期12卷 236-249页

作者： Xiaoxu Chen yi Zheng Xueliang Li Qiang Gao Tongying Feng Pengfei Zhang Mingzhi Liao Xiu’e Tian Hongzhao lu Wenxian Zeng College of Biological Science and Engineering Shaanxi University of TechnologyHanzhong 723001China Key Laboratory of Animal Genetics Breeding and Reproduction of the Ministry of AgricultureCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100ShaanxiChina College of Life Science Northwest A&F UniversityYangling 712100ShaanxiChina.

Background: Sertoli cells(SCs) create a specialized environment to support and dictate ***(miRNAs), a kind of ~ 22 nt small noncoding RNAs, have been reported to be highly abundant in mouse SCs and play critical roles in spermatogenesis. However, the miRNAs of porcine SCs remain largely ***: We isolated porcine SCs and conducted small RNA sequencing. By comparing miRNAs in germ cells, we systematically analyzed the miRNA expression pattern of porcine SCs. We screened the highly enriched SC miRNAs and predicted their functions by Gene Ontology analysis. The dual luciferase assay was used to elucidate the regulation of tumor necrosis factor receptor(TNFR)-associated factor 3(TRAF3) by ***: The analysis showed that 18 miRNAs were highly expressed in SCs and 15 miRNAs were highly expressed in germ cells. These miRNAs were predicted to mediate SC and germ cell functions. In addition, ssc-miR-149 played critical roles in SCs by targeting ***: Our findings provide novel insights into the miRNA expression pattern and their regulatory roles of porcine SCs.

关键词： MicroRNAs Pig Sertoli cell Spermatogenesis TRAF3

基于嘌呤环检测Zn^(2+)的荧光探针及其应用

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江苏科技大学学报（自然科学版） 2024年第2期38卷 87-92页

作者：杭懿邵琦鞠立鑫蒋春辉陆鸿飞江苏科技大学环境与化学工程学院镇江212100

基于嘌呤-色酮的席夫碱,设计、合成并论述了一种新型的检测Zn^(2+)的开启式荧光探针(E)-3-((2-(8,9-二(萘-1-基)-9H-嘌呤-6-基)腙)甲基)-4H-铬-4-酮(DPHC).DPHC在DMSO/HEPES(v/v=9:1,pH=7.4)溶液中对Zn^(2+)表现出显著的选择性和快速响应,并且伴随着从无色到淡绿色的颜色变化.DPHC的发射强度与Zn^(2+)的浓度(1-5μmol/L)之间存在良好的线性关系(R^(2)=0.97992),其检出限为150.0 nmol/***′s plot和1H-NMR进一步证明了DPHC对Zn^(2+)的传感机理.

关键词：嘌呤-色酮锌(Ⅱ) 显著选择性快速响应检出限

Artificial liver support in pigs with acetaminophen-induced acute liver failure

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World Journal of Gastroenterology 2017年第18期23卷 3262-3268页

作者： Guo-Lin He Lei Feng Lei cai Chen-jie Zhou Yuan Cheng Ze-Sheng jiang Ming-xin Pan yi Gao Department of Hepatobiliary Surgery Zhujiang Hospital Southern Medical University

AIM To establish a reversible porcine model of acute liver failure(ALF) and treat it with an artificial liver system. METHODS Sixteen pigs weighing 30-35 kg were chosen and administered with acetaminophen(APAP) to induce ALF. ALF pigs were then randomly assigned to either an experimental group(n = 11), in which a treatment procedure was performed, or a control group(n = 5). Treatment was started 20 h after APAP administration and continued for 8 h. Clinical manifestations of all animals, including liver and kidney functions, serum biochemical parameters and survival times were analyzed. RESULTS Twenty hours after APAP administration, the levels of serum aspartate aminotransferase, total bilirubin, creatinine and ammonia were significantly increased, while albumin levels were decreased(P luSION This model is reproducible and allows for quantitative evaluation of new liver systems, such as a bioartificial liver. The artificial liver system(ZHj-3) is safe and effective for the APAP-induced porcine ALF model.

关键词： Hepatic failure Acetaminophen Artificial liver Acute liver failure Liver-assisted device

High-temperature characteristics of SiC module and 100 kW SiC AC–DC converter at a junction temperature of 180 ℃

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Global Energy Interconnection 2019年第6期2卷 522-531页

作者： Juanjuan lu Zhe Zhou Jianhong Hao yi Hao Hao Zhang Ruixiang Hao State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityChangping DistrictBeijing 102206P.R.China State Key Laboratory of Advanced Transmission Technology Global Electricity Interconnection Research Institute Co.Ltd.Changping DistrictBeijing 102211P.R.China University of Bath Claverton DownBath BA27AYUK School of Electrical Engineering Beijing Jiaotong UniversityHaidian DistrictBeijing 100044P.R.China

High-temperature,high-power converters have gained importance in industrial applications given their ability to operate in adverse environments,such as in petroleum exploration,multi-electric aircrafts,and electric *** metaloxide-semiconductor field-effect transistor(MOSFET),a new,wide bandgap,high-temperature device,is the key component of these *** this study,the static and dynamic characteristics of the SiC MOSFET,half-bridge module,are investigated at the junction temperature of 180℃.A simplified experimental method is then proposed pertaining to the power operation of the SiC module at 180℃.This method is based on the use of a thermal resistance test platform and is proven convenient for the study of heat dissipation *** high-temperature characteristics of the module are verified based on the conducted ***,a 100 kW high-temperature converter is built,and the test results show that the SiC converter can operate at a junction temperature of 180℃in a stable manner in compliance with the requirements of high-temperature,high-power applications.

关键词： SiC MOSFET module Static and dynamic characteristics Power operation experimental method Heat dissipation characteristics SiC AC-DC converter

Current improvement in substrate structured Sb2S3 solar cells with MoSe2 interlayer

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Chinese Physics B 2020年第5期29卷 579-585页

作者： lu Liu Sheng-Li Zhang Jian-Yu Wu Wei-Huang Wang Wei Liu Li Wu yi Zhang Institute of Photoelectronic Thin Film Devices and Technology and Tianjin Key Laboratory of Thin Film Devices and Technology Nankai UniversityTianjin 300350China School of Physical Science Nankai UniversityTianjin 300071China

Sb2S3 solar cells with substrate structure usually suffer from pretty low short circuit current(JSC)due to the defects and poor carrier *** Sb2S3,as a one-dimensional material,exhibits orientation-dependent carrier transport *** this work,a thin MoSe2 layer is directly synthesized on the Mo substrate followed by depositing the Sb2S3 thin *** x-ray diffraction(XRD)patterns confirm that a thin MoSe2 layer can improve the crystallization of the Sb2S3 film and induce(hk1)orientations,which can provide more carrier transport *** probe force microscopy(KPFM)results suggest that this modified Sb2S3 film has a benign surface with less defects and dangling *** variation of the surface potential of Sb2S3 indicates a much more efficient carrier ***,the power conversion efficiency(PCE)of the substrate structured Sb2S3 thin film solar cell is improved from 1.36%to 1.86%,which is the best efficiency of the substrate structured Sb2S3 thin film solar cell,and JSC significantly increases to 13.6 mA/cm^*** to the external quantum efficiency(EQE)and C-V measurements,the modified crystallization and elevated built-in electric field are the main causes.

关键词： Sb2S3 thin film super thin MoSe2 built-in electric filed Kelvin probe force microscopy

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基于微网碳计量数据的低压台区协同管理方法

电力需求侧管理 2024年第1期26卷 93-100页

作者：陈影孙毅鲍荟谕王春妍卢达李贺龙华北电力大学电气与电子工程学院北京102206 中国电力科学研究院有限公司北京100192

随着新能源技术的快速发展和广泛应用,电力系统正面临着高比例新能源和多主体互联的趋势。然而,机组主体多样性的调度目标在全时段求解所带来的维度爆炸成为影响系统正常运行的主要问题。为此,提出了一种基于微网碳计量数据的低压台区... 详细信息

随着新能源技术的快速发展和广泛应用,电力系统正面临着高比例新能源和多主体互联的趋势。然而,机组主体多样性的调度目标在全时段求解所带来的维度爆炸成为影响系统正常运行的主要问题。为此,提出了一种基于微网碳计量数据的低压台区协同管理方法,采用碳计量有效监测和控制碳排放量,实现减少碳排放的目标。根据系统的动态内聚性,划分主体进行最优调度的时间范围,均衡求解维度。同时为解决高比例新能源系统的经济运行、环境效益及消纳等问题,构建多目标调度模型,将碳排放量较小的机组优先调度,以达到减排的目的,结合其动态内聚性及动态多目标协同进化求解模型。最后算例分析结果表明,所提的模型及求解方法可有效降低求解的计算维度并实现对低压台区的精细化调度和管理,提升系统的运行效率和稳定性。

关键词：碳计量微电网动态内聚性多目标协同进化多目标调度优化模型

基于TM-Net网络估计的三维人体姿态运动监测算法

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南通职业大学学报 2024年第1期38卷 81-86页

作者：郭意凡陈钲方张路王健汪洋继鸿大连民族大学机电工程学院辽宁大连116650

针对三维人体姿态估计的便捷性与准确性提升需求,提出一种基于TM-Net网络估计算法。该算法以MediaPipe为中心,融合帧率计算、动作检测、动作计数和真实坐标解析等多功能模块,实现对人体运动的精准检测与计数。针对公共数据集LSP(Leeds S... 详细信息

针对三维人体姿态估计的便捷性与准确性提升需求,提出一种基于TM-Net网络估计算法。该算法以MediaPipe为中心,融合帧率计算、动作检测、动作计数和真实坐标解析等多功能模块,实现对人体运动的精准检测与计数。针对公共数据集LSP(Leeds Sports Pose)和自建校园健身房运动数据集使用关键点的正确性概率(Probability of Correct Keypoint,PCK)、关节位置误差平均值(Mean Per Joint Position Error,MPJPE)和普罗克鲁斯对齐后的平均关节位置误差(Procrustes-Aligned Mean Per Joint Position Error,PA-MPJPE)等指标对该算法进行评估,并与目前先进的TP-3D网络估计算法进行对比。结果表明,TM-Net具有更高的准确率。此外,以开合跳为例进行消融实验,结果表明,TM-Net具有更强的泛化能力,能适应不同个体及拍摄角度的变化,满足了运动监测的实际需求。

关键词：三维人体姿态估计 TM-Net网络 MediaPipe LSP数据集运动监测

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微管蛋白α-1B在泛癌中的表达及临床意义

空军军医大学学报 2024年第3期45卷 282-291页

作者：刘艺周晔禄贺文芳卢瑗瑗赵晓迪吴开春国家消化系统疾病临床医学研究中心消化系肿瘤整合防治全国重点实验室空军军医大学西京消化病医院陕西西安710032

目的利用生物信息学分析系统阐述微管蛋白α-1B(TUBA1B)与泛癌特征的关系。方法利用TCGA数据库中的肿瘤患者临床资料,从表达水平、疾病分期、预后、基因突变特征、免疫浸润水平和基因富集分析6个方面探讨TUBA1B与各种肿瘤类型的相关性... 详细信息

目的利用生物信息学分析系统阐述微管蛋白α-1B(TUBA1B)与泛癌特征的关系。方法利用TCGA数据库中的肿瘤患者临床资料,从表达水平、疾病分期、预后、基因突变特征、免疫浸润水平和基因富集分析6个方面探讨TUBA1B与各种肿瘤类型的相关性。结果TUBA1B的表达水平在多数肿瘤中高于癌旁(P<0.05),在包括侵袭性乳腺癌等14种肿瘤中具有早期诊断价值(P<0.05),在肾上腺皮质癌等3种肾脏肿瘤中具有晚期进展监测价值(P<0.05),且高表达TUBA1B在多种肿瘤预示较差预后(P<0.05)。免疫浸润分析提示TUBA1B与泛癌中多数免疫浸润细胞及多种免疫相关基因表达呈正相关(P<0.05)。基因富集分析表明TUBA1B可能通过调控细胞周期、DNA损伤修复、有丝分裂等生物学过程参与肿瘤发生发展。结论TUBA1B参与了多种肿瘤的发生发展和免疫浸润,可作为泛癌的肿瘤标志物和潜在的药物靶点。

关键词：微管蛋白α-1 泛癌肿瘤免疫