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Single-cell RNA-seq reveals the immune escape and drug resistance mechanisms of mantle cell lymphoma

Cancer Biology & Medicine 2020年第3期17卷 726-739页

作者： Liang Wang Steven mo Xin Li Yingzhi He jing Yang Department of Hematology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang University and Capital Medical UniversityBeijing Tongren HospitalBeijing 100730China Nanning Life-Ontology Biotechnology Co. Ltd.Nanning 530000China Department of Hematology Zhujiang Hospital of Southern Medical UniversityGuangzhou 510280China

Objective:Mantle cell lymphoma(MCL)is a rare subtype of non-Hodgkin lymphoma(NHL)with high heterogeneity and a high recurrence *** heterogenous cell populations contribute to relapse remains to be ***:We performed single cell RNA sequencing(scRNA-seq)on approximately 4,000 bone marrow cells sampled from one patient with multidrug resistant *** identified 10 subpopulations comprising 4 malignant B cell subtypes,3 T cell subtypes,2 dendritic cell subtypes and 1 natural killer(NK)cell ***,we identified cell markers,including a series of genes associated with immune escape and drug *** addition,we explored the roles of these genes in the mechanism of immune escape and drug resistance,and we verified the expression imbalance and clinical prognostic potential by using GEO datasets including 211 MCL ***:The major immune escape mechanisms of MCL included anti-perforin activity,decreased immunogenicity and direct inhibition of apoptosis and cell killing,as mediated by type I and II B *** drug resistance mechanisms of different cell clusters included drug metabolism,DNA damage repair,apoptosis and survival *** III B cells closely communicate with other *** key genes involved in the resistance mechanisms showed dysregulated expression and may have significant clinical prognostic ***:This study investigated potential immune escape and drug resistance mechanisms in *** results may guide individualized treatment and promote the development of therapeutic drugs.

关键词： Cell heterogeneity immune escape mantle cell lymphoma multidrug resistance scRNA-seq

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Ni segregation and thermal stability of reversed austenite in a Fe–Ni alloy processed by QLT heat treatment

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Rare Metals 2015年第11期34卷 776-782页

作者： Tao Pan jing Zhu Hang Su cai-Fu Yang Division of Structural Materials Central Iron and Steel Research Institute School of Materials Science and Engineering Tsinghua University

High-resolution transmission electron microscopy(HRTEM) and X-ray diffraction(XRD) were used to investigate Ni segregation and thermal stability of reversed austenite(RA) in a Fe–Ni alloy processed by quench–lamellarize–temper(QLT) heat treatment. The results show that the 77 K impact energy of the alloy increases with RA content increasing. As an austenite-stabilizing element, Ni is found to segregate in RA, though Ni is not evenly distributed within RA. The amount of segregations increases near the boundary(twice as high as the balanced content)and decreases to some extent in the center of the RA regions. Ni concentration in matrix near the boundary is lower than that in matrix far from the boundary because of Ni atom transportation from a to c near the boundary. RA in this alloy has high heat and mechanical stability but is likely to lose its stability and transform to martensite when a mechanical load is applied at ultralow temperatures(77 K), which induces plasticity.

关键词： Reversed austenite Quench–lamellarize–temper Compo

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Shape Optimization for A Conventional Underwater Glider to Decrease Average Periodic Resistance

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China Ocean Engineering 2021年第5期35卷 724-735页

作者： LI jing-lu WANG Xin-jing WANG Peng DONG Hua-chao CHEN cai-hua School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072China

As a type of autonomous underwater vehicle(AUV),underwater gliders(UG)are getting increasing attention in ocean *** save energy and satisfy the mission requirements of a longer voyage,shape optimization for UGs has become a key technique and research *** this paper,a conventional UG,including its fuselage and hydrofoil,is optimized,which aims to decrease the average resistance in one motion *** operate the optimization progress for the complex object,multiple free form deformation(FFD)volumes are established for geometric ***-fidelity simulation models are employed for objective function evaluation and gradients *** sequential quadratic programming(SQP)method is adopted as an optimization *** optimization results show that there exists a UG with symmetrical and non-horizontal hydrofoils that has lower resistance.

关键词： underwater glider shape optimization conventional configuration free form deformation

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基于反应气混合物的ICP-MS/MS测定原油中的钒和镍

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光谱学与光谱分析 2025年第1期45卷 101-106页

作者：蔡松韬黄莹秀袁亮代宇宣莫垚坤黄建华湖南工学院材料科学与工程学院湖南衡阳421002 湖南省中医药研究院中药研究所湖南长沙410013

原油中金属元素钒和镍(V和Ni)的含量和比值可为深入了解原油的沉积环境特征和有机质类型发挥重要作用。在原油炼制过程中,V和Ni作为原油催化裂化过程中的有害金属元素,会降低催化剂的活性,严重时会导致催化剂中毒,会严重腐蚀设备,在精... 详细信息

原油中金属元素钒和镍(V和Ni)的含量和比值可为深入了解原油的沉积环境特征和有机质类型发挥重要作用。在原油炼制过程中,V和Ni作为原油催化裂化过程中的有害金属元素,会降低催化剂的活性,严重时会导致催化剂中毒,会严重腐蚀设备,在精炼之前必须对原油中的V和Ni进行脱除处理。V和Ni具有致突变性和致癌性,识别或监测原油中V和Ni进入环境的潜在危险变得越来越重要,对原油中V和Ni的含量进行高灵敏精准测定具有重要意义。采用电感耦合等离子体串联质谱(ICP-MS/MS)测定原油中V和Ni的新策略。原油样品经航空煤油简单稀释后直接采用ICP-MS/MS进行分析,针对V和Ni受到的质谱干扰,在MS/MS模式下,采用由NH_(3)/He(He为缓冲气)和H_(2)组成的反应气混合物(NH_(3)/He/H_(2))作为反应气,基于V^(+)与NH_(3)/He/H_(2)不发生反应,而V^(+)的干扰离子与NH_(3)/He/H_(2)发生反应,采用原位质量法消除干扰,选择V^(+)进行测定;基于Ni^(+)与NH_(3)/He/H_(2)发生反应,采用质量转移法消除干扰,选择无干扰团簇离子Ni(NH_(3))_(3)^(+)进行测定。通过与NH_(3)/He反应模式进行对比研究发现,对于V的测定,加入H_(2)为反应气能快速去除氩基离子的干扰,并能协同NH_(3)消除氧化物离子的干扰;对于Ni的测定,加入H_(2)为反应气能促进全氢加合物(-NH_(3))的形成,从而提高生成Ni(NH_(3))_(3)^(+)的产率。在NH_(3)/He/H_(2)反应模式下,V和Ni的背景等效浓度(BEC)更低,Ni的灵敏度更高,V和Ni的检出限(LOD)分别低至0.83和3.76 ng·kg^(-1),定量限(LOQ)分别为2.77和12.5 ng·kg^(-1)。通过分析标准参考物质NIST SRM 1634c并进行加标回收实验评价方法的准确度和精密度,结果显示,方法的测定结果与标准参考物质的认证值基本一致,V和Ni的加标回收率分别为97.7%和103%,相对标准偏差(RSD)分别为1.8%和1.9%。所建立的分析方法避免了繁琐的样品预处理过程,具有操作简单快速、灵敏度高、准确度和精密度好的特点,适用于原油中V和Ni的检测,能为原油深加工中V和Ni的脱除提供理论依据。

关键词：原油电感耦合等离子体串联质谱钒(V) 镍(Ni) 氨气/氦气/氢气(NH_(3)/He/H_(2))

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Effect of Micro-Dimples on Hydrodynamic Lubrication of Textured Sinusoidal Roughness Surfaces

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Chinese Journal of Mechanical Engineering 2018年第4期31卷 160-167页

作者： jing-Hu Ji cai-Wei Guan Yong-Hong Fu School of Mechanical Engineering Jiangsu University

Surface texturing has been applied to improving the tribological performance of mechanical components for many years. Currently, the researches simulate the film pressure distribution of textured rough surfaces on the basis of the average flow model, and however the influence of roughness on the film pressure distribution could not be precisely expressed. Therefore, in order to study the hydrodynamic lubrication of the rough textured surfaces, sinusoidal waves are employed to characterize untextured surfaces. A deterministic model for hydrodynamic lubrication of microdimple textured rough surfaces is developed to predict the distribution of hydrodynamic pressure. By supplementing with the JFO cavitation boundary, the load carrying capacity of the film produced by micro-dimples and roughness is obtained. And the geometric parameters of textured rough surface are optimized to obtain the maximum hydrodynamic lubrication by specifying an optimization goal of the load carrying capacity. The effect of roughness on the hydrodynamic pressure of surface texture is significant and the load carrying capacity decreases with the increase of the roughness ratio because the roughness greatly suppresses the hydrodynamic effect of dimples. It shows that the roughness ratio of surface may be as small as possible to suppress the effect of hydrodynamic lubrication. Additionally,there are the optimum values of the micro-dimple depth and area density to maximize the load carrying capacity for any given value of the roughness ratio. The proposed approach is capable of accurately reflects the influence of roughness on the hydrodynamic pressure, and developed a deterministic model to investigate the hydrodynamic lubrication of textured surfaces.

关键词： Hydrodynamic lubrication Surface texturing Micro-dimple Roughness surface Sinusoidal wave

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International Journal of Minerals,Metallurgy and Materials 2009年第2期16卷 135-142页

作者： Zhuo-ying Tan Si-jing Wang Mei-feng cai State Key Laboratory of High-Efficient Mining and Safety of Metal Mines Ministry of Education of China Beijing 100083 China School of Civil and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China School of Civil Engineering Tsinghua University Beijing 100084 China

An instrumented drilling system can be applied for the acquisition of drilling process parameters. The system can provide continuous and huge data for geotechnical engineering. However, due to the complexity of ground strata, the variation in the drilling parameters with stratigraphical characteristics is great and the correlation between likely comparable parameters is not high, which limits the use of conventional correlation approaches in this field. How to use the data for engineering and how to get a reasonable interpretation for the relationships among the drilling parameters, as well as between a drilling parameter and formational characteristics, become a technical choke point for the development and application of the instrumented drilling system. Based on similarity criteria, the extraction of sample data and characteristics, the pretreatment of data and feature matching algorithms have been analyzed and an approach of slope coefficient searching identification has been established. A case study was carried out for the similarity between the rotational speed of the drill bit, flushing pressure, and effective thrust force graphics in general weathered granite. The result shows that the similarity coefficients between the rotational speed of the drill bit, flushing pressure, and effective thrust force are 0.72 and 0.83, respectively. Although there are differences between the distances of the graphics, the curves of both rotational speed and flushing pressure agree with the effective thrust curve in shape, which provides a possible method for the identification of various formations by use of the similarity between feature drilling parameters.

关键词： rock drilling process parameters similarity identification slope coefficient

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The role of TGF-beta3 in cartilage development and osteoarthritis

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Bone Research 2023年第1期11卷 108-123页

作者： Xinmei Du Linyi cai jing Xie Xuedong Zhou State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan University610041ChengduChina National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan University610041ChengduChina

Articular cartilage serves as a low-friction,load-bearing tissue without the support with blood vessels,lymphatics and nerves,making its repair a big *** growth factor-beta 3(TGF-β3),a vital member of the highly conserved TGF-βsuperfamily,plays a versatile role in cartilage physiology and ***-β3 influences the whole life cycle of chondrocytes and mediates a series of cellular responses,including cell survival,proliferation,migration,and *** TGF-β3 is involved in maintaining the balance between chondrogenic differentiation and chondrocyte hypertrophy,its regulatory role is especially important to cartilage *** TGF-β3 plays a dual role:in healthy tissues,it can facilitate chondrocyte viability,but in osteoarthritic chondrocytes,it can accelerate the progression of ***,TGF-β3 has been recognized as a potential therapeutic target for osteoarthritis(OA)owing to its protective effect,which it confers by enhancing the recruitment of autologous mesenchymal stem cells(MSCs)to damaged ***,the biological mechanism of TGF-β3 action in cartilage development and OA is not well *** this review,we systematically summarize recent progress in the research on TGF-β3 in cartilage physiology and pathology,providing up-to-date strategies for cartilage repair and preventive treatment.

关键词： cartilage protective versatile

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Purifying Fe-based amorphous alloys to enhance glass-forming ability by designing a novel refining slag

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Journal of Materials Science & Technology 2023年第12期143卷 189-197页

作者： Shuai mo jing Zeng Hua Zhang Yinan Wu Tao Liu Hongwei Ni The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China The Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Wuhan Research Institute of Metallurgical Construction Ltd.MCCWuhan 430081China

Designing low melting point and low basicity refining slag suitable for Fe-based amorphous alloys and understanding the inclusions’formation,removal,influencing mechanisms are quite vital in the fields of metallurgy and *** this study,a novel 13%SiO_(2)-32%CaO-30%Al_(2)O_(3)-25%B_(2)O_(3)(wt.%)refining slag was designed after careful calculations of the liquid phase region,slag-metal equilibrium,surface tension,viscosity,deoxidation capability and sulfur distribution *** refining with our designed slag,the content of impurities and the number density of inclusions in a representative Fe_(83)Si_(2)B_(15)(at.%)amor-phous alloy were significantly ***,the glass-forming ability(GFA)of the alloy was also enhanced,enabling the preparation of amorphous ribbons with a lower cooling *** on the impu-rities in Fe-based amorphous alloys as well as the calculated oxide and sulfide free energy diagrams,CaO,SiO_(2),Al_(2)O_(3) oxides and CaS,TiS,MnS sulfides will form in the master *** high melting point in-clusions in the melt are generally removed via a floatation-separation-absorption process and the Mn,Ti,S impurities are removed via slag-metal interface reactions during *** for the detrimental effect of inclusions on glass formation,the small lattice disregistry between Ti,Mn-containing inclusions and primaryα-Fe gains reveal that these inclusions are effective in promoting the heterogeneous nucleation,and therefore greatly deteriorate the *** findings are important and provide an ideal solution to purifying the Fe-based amorphous alloys by refining and enhancing the GFA for industrial production.

关键词： Fe-based amorphous alloy Refining slag design Inclusion Lattice disregistry Heterogeneous nucleation

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DNA Nanotechnology-Enabled Fabrication of Metal Nanomorphology

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Research 2022年第4期2022卷 189-204页

作者： mo Xie Yang Hu Jue Yin Ziwei Zhao jing Chen Jie Chao State Key Laboratory of Organic Electronics and Information Displays e Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing 210023China The Interdisciplinary Research Center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

In recent decades,DNA nanotechnology has grown into a highly innovative and widely established *** nanostructures have extraordinary structural programmability and can accurately organize nanoscale materials,especially in guiding the synthesis of metal nanomaterials,which have unique advantages in controlling the growth morphology of metal *** review started with the evolution in DNA nanotechnology and the types of DNA ***,a DNA-based nanofabrication technology,DNA metallization,was *** this section,we systematically summarized the DNA-oriented synthesis of metal nanostructures with different morphologies and ***,the applications of metal nanostructures constructed from DNA templates in various fields including electronics,catalysis,sensing,and bioimaging were figured ***,the development prospects and challenges of metal nanostructures formed under the morphology control by DNA nanotechnology were discussed.

关键词： materials template synthesis

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Anti-breast cancer effect of quercetin nanoparticles based on moFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru cai Dongge Yin Tingting Fu jing Liu Yuji Du Jiahui Kong Rongrong Chang Jian Ni Xingbin Yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (moF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(moFs) phototherapy anti-cancer heat shock proteins inhibition

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