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Sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2716-2726页

作者： cai-jing mo Xiao-Yuan Deng Ru-Lan Ma Kun Zhu Lei Shi Kang Li Department of Surgical Oncology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND The role of Sm-like 5(LSM5)in colon cancer has not been *** this study,we investigated the role of LSM5 in progression of colon cancer and the potential underlying mechanism *** To determine the role of LSM5 in the progression of colon cancer and the potential underlying mechanism *** The Gene Expression Profiling Interactive Analysis database and the Human Protein Atlas website were used for LSM5 expression analysis and prognosis ***-time quantitative polymerase chain reaction and Western blotting were utilized to detect the expression of mRNAs and proteins.A lentivirus targeting LSM5 was constructed and transfected into colon cancer cells to silence LSM5 *** and apoptosis assays were also conducted to evaluate the growth of the colon cancer *** GeneChip assay and bioinformatics analysis were performed to identify the potential underlying mechanism of LSM5 in colon *** LSM5 was highly expressed in tumor tissue and colon cancer cells.A high expression level of LSM5 was related to poor prognosis in patients with colon *** of LSM5 suppressed proliferation and promoted apoptosis in colon cancer *** of LSM5 also facilitates the expression of p53,cyclin-dependent kinase inhibitor 1A(CDKN1A)and tumor necrosis factor receptor superfamily 10B(TNFRSF10B).The inhibitory effect of LSM5 knockdown on the growth of colon cancer cells was associated with the upregulation of p53,CDKN1A and *** LSM5 knockdown inhibited the proliferation and facilitated the apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B.

关键词： Sm-like 5 Colon cancer Proliferation Apoptosis Knockdown

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Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan cai Lianghui Meng Meina Quan Ling Wang jing Ren Chenguang Zheng Jiajia Yang Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

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Anti-breast cancer effect of quercetin nanoparticles based on moFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru cai Dongge Yin Tingting Fu jing Liu Yuji Du Jiahui Kong Rongrong Chang Jian Ni Xingbin Yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (moF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(moFs) phototherapy anti-cancer heat shock proteins inhibition

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moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang jing-Shui Zhen Bo-Cheng Li De-Cheng cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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Fabrication and Characterization of Chitosan-Silk Fibroin/Hydroxyapatite Composites via in situ Precipitation for Bone Tissue Engineering

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Chinese Journal of Polymer Science 2015年第12期33卷 1661-1671页

作者： jing-xiao Hu Xuan cai Shao-bo mo Li Chen Xin-yu Shen 童华 Key Laboratory of Analytical Chemistry for Biology and Medicine Ministry of Education College of Chemistry and Molecular Sciences Wuhan University

Homogeneous chitosan-silk fibroin/hydroxyapatite （CS-SF/HA） composites were prepared by in situ precipitation method driven by a multiple-order template. The morphology of the composites was investigated by scanning electron microscope （SEM） and transmission electron microscope （TEM）. The compositional analysis was carried out by X-ray diffraction analysis （XRD） and Fourier transformed infrared spectroscopy （FTIR）. The mechanical properties and biocompatibility of the composites were also determined. The results indicated that the inorganic particles of uniform size （50 nm） were well-dispersed among the CS-SF matrices. The compressive modulus of the CS-SF/HA composites was enhanced with the increasing amount of SF. The in vitro results suggested that the MC3T3-E1 osteoblast-like cells on CS-SF/HA composite disks displayed strong bonding and spreading, and the cell proliferation cultured on each composite disk increased throughout the culture period for up to 7 days. Especially, the samples with higher content of SF had much better biological properties. The evidences proved that the CS-SF/HA composites possessed excellent biocompatibility. By using the freeze-drying technique, hierarchical porous scaffolds with pores ranging from 50 μm to 200 μm were obtained. This work presented the advantages of in situ precipitation method to prepare the organic/inorganic composites, and a multiple-order template was introduced in the system to improve the properties of the composites by combining the merits of each organic template.

关键词： Composites In situ precipitation Biocompatibility Mechanical properties.

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Estimation of pollutant sources in multi-zone buildings through different deconvolution algorithms

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Building Simulation 2022年第5期15卷 817-830页

作者： mo Li Fei Li Yuanqi jing Kai Zhang Hao cai Lufang Chen Xian Zhang Lihang Feng College of Urban Construction Nanjing Tech UniversityNanjing210009China Institute of Defense Engineering Academy of Military SciencePLABeijing100850China College of Electrical Engineering and Control Science Nanjing Tech UniversityNanjing210009Chino

Effective identification of pollution sources is particularly important for indoor air *** estimation of source strength is the basis for source effective *** paper proposes an optimization method for the deconvolution process in the source strength inverse *** the scheme,the concept of time resolution was defined,and combined with different filtering positions and filtering *** measures to reduce effects of measurement noise were quantitatively ***,the performances of nine deconvolution inverse algorithms under experimental and simulated conditions were evaluated and *** hybrid algorithms were proposed and compared with single algorithms including Tikhonov regularization and iterative *** showed that for the filtering position and algorithm,Butterworth filtering performed better,and different filtering positions had little effect on the inverse *** the calculation time step,the optimal Tr(time resolution)was 0.667%and 1.33%in the simulation and experiment,*** hybrid algorithms were found to not perform better than the single algorithms,and the SART(simultaneous algebraic reconstruction technique)algorithm from CAT(computer assisted tomography)yielded better performances in the accuracy and stability of source strength *** relative errors of the inverse calculation for source strength were typically below 25%using the optimization scheme.

关键词： pollutant source measurement noise inverse algorithm indoor air algorithm ranking

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Inspection interval optimization for aircraft composite structures with dent and delamination damage

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Journal of Systems Engineering and Electronics 2021年第1期32卷 252-260页

作者： cai jing DAI Dingqiang College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 211106China

The optimization of inspection intervals for composite structures has been proposed,but only one damage type,dent damage,has been addressed so *** present study focuses on the two main damage types of dent and delamination,and a model for optimizing the inspection interval of composite structures is proposed to minimize the total maintenance cost on the premise that the probability of structure failure will not exceed the acceptable *** order to analyze the damage characteristics and the residual strength of the composite structure,the frequency,energy,size,and depth of the damage are studied,and the situation of missing detection during the inspection is *** structural residual strength and total maintenance cost are quantified corresponding to different inspection *** proposed optimization method relieves the constraints in previous simulation methods,and is more consistent with the actual ***,the outer wing of aircraft is taken as an example,and with the historical cases and experimental data,the optimization method is *** optimal inspection interval is shorter than the actually implemented inspection interval,and the corresponding maintenance cost is reduced by 23.3%.The result shows the feasibility and effectiveness of the proposed optimization method.

关键词： civil aircraft composite structure accidental impact damage failure probability inspection interval

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Evidential method to identify influential nodes in complex networks

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Journal of Systems Engineering and Electronics 2015年第2期26卷 381-387页

作者： Hongming mo cai Gao Yong Deng School of Computer and Information Science Southwest University Department of the Tibetan Language Sichuan University of Nationalities School of Automation Northwestern Polytechnical University School of Engineering Vanderbilt University

Identifying influential nodes in complex networks is still an open issue. In this paper, a new comprehensive centrality mea- sure is proposed based on the Dempster-Shafer evidence theory. The existing measures of degree centrality, betweenness centra- lity and closeness centrality are taken into consideration in the proposed method. Numerical examples are used to illustrate the effectiveness of the proposed method.

关键词： Dempster-Shafer evidence theory (D-S theory) belief function complex networks influential nodes evidential centrality comprehensive measure

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Accuracy analysis of a single-fault Markov model for FADEC system

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Journal of Systems Engineering and Electronics 2019年第5期30卷 1044-1052页

作者： cai jing HU Wei cai Kunye College of Civil Aviation Nanjing University of Aeronautics and Astronautics

Time-limited dispatching(TLD)analysis of the full authority digital engine control(FADEC)systems is an important part of the aircraft system safety analysis and a necessary task for the certification of commercial aircraft and *** the time limited dispatch guidance document ARP5107B,a single-fault Markov model(MM)approach is proposed for TLD ***,ARP5107B also requires that the loss of thrust control(LOTC)rate error calculated by applying the single-fault MM must be less than 5%when performing airworthiness ***,the sources of accuracy errors in three kinds of MM are analyzed and specified through a case study of the general FADEC system,and secondly a two-fault MM considering maintenance policy is established through analyzing and calculating the expected repair time when two related faults ***,a specific FADEC system is given to study on the influence factors of accuracy error in the single-fault MM,and the results show that the accuracy error of the single-fault MM decreases with the increase of short or long prescribed dispatch time,and the range values of short time(ST)and long time(LT)are determined to satisfy the requirement of accuracy error within 5%.

关键词： full authority digital engine control(FADEC)system Markov model(MM) accuracy analysis loss of thrust control(LOTC)

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定向电场下W_(6)C_(6)团簇的超卤素调制及非线性光学特性

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原子与分子物理学报 2025年第3期42卷 72-76页

作者：蔡璧钧段宇静魏强重庆理工大学理学院重庆400050

本文采用密度泛函(DFT)方法研究了定向外电场(OEEF)对W_(6)C_(6)团簇几何结构、电子性质以及非线性光学响应(NLO)的影响.计算结果表明W_(6)C_(6)的结构在一定OEEF强度下可以保持稳定.OEEF可以增大W_(6)C_(6)团簇的电子亲和能(EA值),且... 详细信息

本文采用密度泛函(DFT)方法研究了定向外电场(OEEF)对W_(6)C_(6)团簇几何结构、电子性质以及非线性光学响应(NLO)的影响.计算结果表明W_(6)C_(6)的结构在一定OEEF强度下可以保持稳定.OEEF可以增大W_(6)C_(6)团簇的电子亲和能(EA值),且在特定强度下,OEEF可以将W_(6)C_(6)团簇转变为超卤素.通过对EA值的非线性拟合可以实现对W_(6)C_(6)团簇的连续调制.进一步对不同外电场下W_(6)C_(6)团簇的最高占据分子轨道(HOmo)和最低未占据分子轨道(LUmo)能级进行分析,发现OEEF降低了W_(6)C_(6)团簇LUmo能级是其EA值增大的主因.此外,OEEF可以显著增大W_(6)C_(6)团簇的平均极化率和第一超极化率,尤其是第一超极化率,改变其非线性光学性质.

关键词：定向外电场超原子密度泛函理论 NLO W_(6)C_(6)团簇

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