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Journal of Clinical and Translational Hepatology 2022年第4期10卷 740-747页

作者： Shen Zhang Wan-Sheng Wang Bin-Yan Zhong cai-fang ni Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina

Transarterial chemoembolization(TACE)is widely applied for the treatment of hepatocellular *** TACE is often required in clinical practice because a satisfactory tumor response may not be achieved with a single ***,repeated TACE procedures can impair liver function and increase treatment-related adverse events,all of which prompted the introduction of the concept of“TACE failure/refractoriness”.Mainly based on evidence from two retrospective studies conducted in Japan,sorafenib is recommended as the first choice for subsequent treatment after TACE failure/*** studies have investigated the outcomes of other subsequent treatments,including locoregional,other molecular targeted,anti-programmed death-1/anti-programed death ligand-1 therapies,and combination therapies after TACE failure/*** this review,we summarize the up-to-date information about the outcomes of several subsequent treatment modalities after TACE failure/refractoriness.

关键词： Transarterial chemoemboization Failure Refractoriness Subsequent treatment

Transarterial chemoembolization failure/refractoriness: A scientific concept or pseudo-proposition

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World Journal of Gastrointestinal Surgery 2022年第6期14卷 528-537页

作者： Shen Zhang Bin-Yan Zhong Lei Zhang Wan-Sheng Wang cai-fang ni Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

Multi-session transarterial chemoembolization(TACE)is usually needed for the treatment of intermediate-stage hepatocellular carcinoma(HCC),but it may not always have a positive influence on prognosis due to high heterogeneity of *** avoid ineffective repeated TACE,the concept of TACE failure/refractoriness has been proposed by several organizations and is being addressed using tyrosine kinase *** concept of TACE failure/refractoriness is controversial due to ambiguous definitions and low evidence-based *** date,only a few studies have examined the rationality concerning the definition of TACE failure/refractoriness,although the concept has been introduced and applied in many TACE-related clinical *** review focuses on some of the issues related to different versions of TACE failure/refractoriness,the rationality of related definitions,and the feasibility of continuing TACE after so-called failure/refractoriness based on published evidence.A suggestion to re-define TAEC failure/refractoriness is also put forward.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Failure Refractoriness

Upregulation of PD-L1 expression promotes epithelial-to-mesenchymal transition in sorafenib-resistant hepatocellular carcinoma cells

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Gastroenterology Report 2020年第5期8卷 390-398,I0002,I0003页

作者： Gui-Li Xu cai-fang ni Han-Si Liang Yun-Hua Xu Wan-Sheng Wang Jian Shen Ming-Ming Li Xiao-Li Zhu Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuP.R.China Jiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuP.R.China

Background:The epithelial-to-mesenchymal transition(EMT)status is associated with programmed death-1 ligand 1(PDL1)expression in various ***,the role and molecular mechanism of PD-L1 in the EMT of sorafenib-resistant hepatocellular carcinoma(HCC)cells remain *** this study,we aimed to investigate the regulation of PD-L1 on the EMT in sorafenib-resistant HCC ***:Initially,the sorafenib-resistant HCC cell lines HepG2 SR and Huh7 SR were ***-blot assays were used to detect the expression of PD-L1,E-cadherin,and *** intervention and overexpression of PD-L1 were used to explore the role of PD-L1 in the regulation of EMT in HepG2 SR and Huh7 SR *** migration and invasion were assessed by transwell ***-L1 or Sterol regulatory element-binding protein 1(SREBP-1)overexpression and knockdown were performed in order to study the mechanism of PD-L1 in sorafenib-resistant HCC ***:PD-L1 expression was upregulated,whereas E-cadherin levels were downregulated and N-cadherin expression was increased in HepG2 SR and Huh7 SR *** cell viabilities of HepG2 and Huh7 cells were lower than those of HepG2 SR and Huh7 SR ***-L1 overexpression reduced E-cadherin expression and increased N-cadherin levels,whereas PD-L1 knock-down increased E-cadherin expression and decreased N-cadherin ***-L1 expression promoted EMT and the migratory and invasive abilities of HepG2 SR and Huh7 SR ***-L1 promoted the EMT of sorafenib-resistant HCC cells via the PI3K/Akt pathway by activating SREBP-1 expression in HepG2 SR and Huh7 SR ***:The findings reveal that PD-L1 expression promotes EMT of sorafenib-resistant HCC cells.

关键词： programmed death-1 ligand 1(PD-L1) sorafenib-resistant hepatocellular carcinoma(HCC)cells epithelial-tomesenchymal transition(EMT)

Re-evaluating Transarterial Chemoembolization Failure/Refractoriness:A Survey by Chinese College of Interventionalists

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 521-527页

作者： Bin-Yan Zhong Wan-Sheng Wang Shen Zhang Hai-Dong Zhu Lei Zhang Jian Shen Xiao-Li Zhu Gao-Jun Teng cai-fang ni Department of Interventional Radiology the First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjingJiangsuChina

Background and Aims:The recognition of transarterial chemoembolization(TACE)failure/refractoriness among Chinese clinicians remains *** an online survey conducted by the Chinese College of Interventionalists(CCI),the aim of this study was to explore the recognition of TACE failure/refractoriness and review TACE application for hepatocellular carcinoma(HCC)treatment in clinical ***:From 27 August 2020 to 30 August 2020 during the CCI 2020 annual meeting,a survey with 34 questions was sent by email to 264 CCI clinicians in China with more than 10 years of experience using TACE for HCC ***:A total of 257 clinicians participated and responded to the *** participants agreed that the concept of“TACE failure/refractoriness”has scientific and clinical significance(n=191,74.3%).Nearly half of these participants chose TACE-based combination treatment as subsequent therapy after so-called TACE failure/refractoriness(n=88,46.1%).None of the existing TACE failure/refractoriness definitions were widely accepted by the participants;thus,it is necessary to re-define this concept for the treatment of HCC in China(n=235,91.4%).Most participants agreed that continuing TACE should be performed for patients with preserved liver function,presenting portal vein tumor thrombosis(n=242,94.2%)or extrahepatic spread(n=253,98.4%),after the previous TACE treatment to control intrahepatic lesion(s).Conclusions:There is an obvious difference in the recognition of TACE failure/refractoriness among Chinese clinicians based on existing *** work should be carried out to re-define TACE failure/refractoriness.

关键词： Hepatocellular carcinoma TACE Failure Refractoriness Survey

Research progress of bariatric embolization for treatment of obesity

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Chinese Medical Journal 2019年第7期132卷 880-882页

作者： Bin-Yan Zhong Pei-Cheng Li cai-fang ni Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006China

To the Editor:The prevalence of obesity,defined as body mass index(BMI)≥30 kg/m^2,is increasing worldwide and has been identified that obesity is a risk factor for several kinds of chronic diseases.[1]According to the severity of obesity,associated coexisting chronic diseases,and functional limitations,therapies for obesity include lifestyle intervention(eg,diet and exercise),pharmacotherapy,endoscopic bariatric therapies,bariatric surgery,and bariatric embolization(BAE).

关键词： bariatric embolization treatment obesity

Application of Cone-beam Computed Tomography in Interventional Therapies for Liver Malignancy:A Consensus Statement by the Chinese College of Interventionalists

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Journal of Clinical and Translational Hepatology 2024年第10期12卷 886-891页

作者： Bin-Yan Zhong Zhong-Zhi Jia Wen Zhang Chang Liu Shi-Hong Ying Zhi-Ping Yan cai-fang ni Clinical Guidelines Committee of Chinese College of Interventionalists Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Department of Interventional and Vascular Surgery The Affiliated Changzhou Second People’s Hospital of Nanjing Medical UniversityChangzhouJiangsuChina Department of Interventional Radiology Zhongshan HospitalFudan University Shanghai Institution of Medical ImagingFudan UniversityShanghaiChina Division of Liver Department of General SurgeryWest China HospitalSichuan UniversityChengduSichuanChina Department of Minimal Invasive Surgery Shangjin Nanfu HospitalChengduSichuanChina Department of Radiology First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina 不详

Despite its crucial role in interventional therapies for liver malignancy,cone-beam computed tomography(CBCT)has not yet been fully integrated into clinical practice due to several complicating factors,including nonstandardized operations and limited recognition of CBCT among interventional *** response,the Chinese College of Interventionalists has released a consensus statement aimed at standardizing and promoting the application of CBCT in the interventional therapies for liver *** statement summarizes CBCT scanning techniques,and operational standards,and highlights its potential applications in clinical practice.

关键词： Cone-beam computed tomography Interventional radiology Liver malignancy Consensus statement Chemoembolization Ablation

Prognostic Performance of the China Liver Cancer Staging System in Hepatocellular Carcinoma Following Transarterial Chemoembolization

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Journal of Clinical and Translational Hepatology 2023年第6期11卷 1321-1328页

作者： Bin-Yan Zhong Jian-Qiang Jiang Jun-Hui Sun Jin-Tao Huang Wei-Dong Wang Qi Wang Wen-Bin Ding Xiao-Li Zhu cai-fang ni Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Department of Interventional Therapy Nantong Tumor HospitalNantongJiangsuChina Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Interventional Radiology The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxiJiangsuChina Department of Interventional Radiology Third Affiliated Hospital of Soochow UniversityChangzhou First HospitalChangzhouJiangsuChina Department of Interventional Radiology Nantong First People’s HospitalNantongJiangsuChina

Background and Aims:To validate prognostic performance of the China liver cancer(CNLC)staging system as well as to compare these parameters with those of the Barcelona Clinic Liver Cancer(BCLC)staging system for Chinese hepatocellular carcinoma(HCC)treated with transarterial chemoembolization(TACE).Methods:This multicenter retrospective study included 1,124 patients with HCC between January 2012 and December 2020 from six Chinese *** on overall survival(OS),the prognostic performance outcomes for the CNLC and BCLC staging systems were compared by model discrimination[C statistic and Akaike information criterion(AIC)],monotonicity of the gradient(linear trend chi-square test),homogeneity(likelihood ratio chisquare test),and calibration(calibration plots).A prospective cohort of 44 patients receiving TACE-based therapy included between January 2021 and December 2022 was used to prospectively validate the ***:Median OS was 19.1(18.2–20.0)months,with significant differences in OS between stages defined by the CNLC and BCLC observed(pnicity of the gradient(linear trend chi-square test:66.107 vs.57.418;pning model discrimination,gradient monotonicity,homogeneity,and calibration,the CNLC performed better than the BCLC for Chinese HCC patients receiving TACE.

关键词： Hepatocellular carcinoma CNLC BCLC TACE

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射频消融联合肝动脉栓塞治疗兔肝癌的安全性

世界华人消化杂志 2008年第32期16卷 3677-3680页

作者：李绍钦倪才方蒋国民陈珑南京医科大学附属常州二院介入科江苏省常州市213003 苏州大学附属第一医院介入科江苏省苏州市215006

目的:研究射频消融(RFA)与肝动脉栓塞(TAE)联合治疗VX2兔肝移植瘤的安全性.方法:将VX2肿瘤块植入实验兔的肝脏内,建立兔肝癌模型.将36只兔肝癌模型随机分为4组,每组9只,A组行单纯RFA治疗,B、C、D组分别在TAE治疗后1、4、7d行RFA治疗;术... 详细信息

目的:研究射频消融(RFA)与肝动脉栓塞(TAE)联合治疗VX2兔肝移植瘤的安全性.方法:将VX2肿瘤块植入实验兔的肝脏内,建立兔肝癌模型.将36只兔肝癌模型随机分为4组,每组9只,A组行单纯RFA治疗,B、C、D组分别在TAE治疗后1、4、7d行RFA治疗;术前及术后检查实验兔肝、肾功能和存活情况.结果:实验兔术后出现精神萎靡、纳差、嗜睡,以B组及C组最重,A组最轻.A组及D组无动物死亡,B、C组分别死亡3、2只.各组ALT值均在治疗后第1天最高.A组(178.4±49.2U/L)、D组(208.2±65.5U/L)分别与B组(385.0±213.1U/L)和C组(289.2±192.6U/L)比较,差异有统计学意义(P<0.05),B组与C组,D组与A组之间比较,均无统计学意义;各组治疗后4、7dALT值比较均无统计学意义.各组UREA值组间比较差异也无统计学意义.结论:栓塞后1、4d行射频治疗对肝脏功能将产生严重的影响,栓塞后7d进行射频治疗相对比较安全.单纯射频及联合治疗对肾功能无明显影响.

关键词：兔鳞癌细胞株肝癌射频消融冷循环电极肝动脉栓塞碘化油

Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru cai Dongge Yin Tingting Fu Jing Liu Yuji Du Jiahui Kong Rongrong Chang Jian ni Xingbin Yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

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相关因素对中风病中经络急性期证候的影响

中国中医基础医学杂志 2017年第3期23卷 354-356页

作者：胡龙涛蔡芳妮王亚丽周望张柳婧张赛赛安康市中医院陕西安康725000 陕西中医药大学陕西咸阳712000 延安大学咸阳医院陕西咸阳712000

目的:研究相关因素对中风病中经络急性期证候的影响。方法:调查242例中风病中经络急性期住院患者的相关信息及中医证候进行统计分析。结果:年龄小、合并高血压、不合并冠心病者风火上炎证发生率高,发病时间长者风痰瘀阻证发生率高,女性... 详细信息

目的:研究相关因素对中风病中经络急性期证候的影响。方法:调查242例中风病中经络急性期住院患者的相关信息及中医证候进行统计分析。结果:年龄小、合并高血压、不合并冠心病者风火上炎证发生率高,发病时间长者风痰瘀阻证发生率高,女性患者痰热腑实证发生率高,发病时间短者风火上炎证、痰热腑实证发生率高,年龄大者气虚血瘀证发生率高。结论:中风病的证候受多种因素的影响,临床在中风病的预防中应遵循"未病先防、既病防变"的原则,可在治疗原发病的基础上依据相关因素进行中医证候学预防,一旦发生中风应综合患者所有信息进行准确的辨证论治。

关键词：中风病证候年龄高血压