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α-catenin expression is decreased in patients with gastric carcinoma

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World Journal of Gastroenterology 2005年第22期11卷 3468-3472页

作者： Yong-NingZhou cai-PuXu YuChen BiaoHan Shi-MingYang dian-ChunFang DepartmentofGastroenterology FirstHospitalLanzhouUniversityLanzhou730000GansuProvinceChina DepartmentofGastroenterology SouthwestHospitalThirdMilitaryMedicalUniversityChongqing400038China InstituteofBumResearch SouthwestHospitalThirdMilitaryMedicalUniversityChongqing400038China

AIM: To assess the expression of α-catenin in gastric carcinoma and to determine the role of α-catenin expression in gastric ***: α-catenin expression was assessed by semi quantitative reverse transcriptase-polymerase chain reaction and immunohistochemical staining in 49 gastric carcinomas,26 adjacent non-cancerous mucosae, and gastric biopsy specimens from 11 healthy ***: mRNA levels of α-catenin were reduced or absent in 34 of 49 (69%) gastric carcinoma tissues and in 5 of 26 (19%) tumor-free gastric mucosae of carcinomapatients, respectively. Of the carcinoma samples with altered α-catenin mRNA levels, α-catenin expression was negative in 20 and decreased in 14 cases. Up to 69% of tumors were stained abnormally for α-catenin. Of the 34 cases whose mRNA expression of α-catenin was reduced, 32 (94%) showed abnormal immunostaining patterns, while only 2 showed a normal α-catenin expression. The frequency of reduced expression of α-catenin mRNA was 14% in well-differentiated carcinomas, higher than that in poorlydifferentiated carcinomas (86%). A significant correlation was not shown between α-catenin expression and bothdepth of invasion and lymph node metastasis. Moreover, there was no statistical difference between loss or down-regulation of α-catenin mRNA and Helicobacter pylori ( H pylori) ***: Downregulation of α-catenin expressionis common in gastric carcinoma, and α-catenin expression may be used as a differentiation marker. Downregulation of α-catenin expression may be an early event in tumorigenesis. Reduced α-catenin expression is not correlated with H pylori infection.

关键词： α-catenin Gastric carcinoma Gastric carcinogenesis

学前教育经历对视力障碍初中生能力发展的影响——基于CEPS数据的实证研究

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现代特殊教育 2024年第18期 57-64页

作者：王典蔡翮飞徐国庆刘新学南京特殊教育师范学院教育科学学院南京210038 江苏省军区第四幼儿园南京210002

基于中国教育追踪调查2013—2014年基线数据,运用倾向得分匹配法,探索了学前教育经历对视力障碍初中生认知和非认知能力发展的影响。结果显示:(1)视力障碍学生的年龄和家庭规模是影响其获取学前教育的重要因素;(2)学前教育经历可以有效... 详细信息

基于中国教育追踪调查2013—2014年基线数据,运用倾向得分匹配法,探索了学前教育经历对视力障碍初中生认知和非认知能力发展的影响。结果显示:(1)视力障碍学生的年龄和家庭规模是影响其获取学前教育的重要因素;(2)学前教育经历可以有效促进视力障碍初中生认知能力和宜人性的发展。鉴于此,政府应积极鼓励普通学前教育机构招收适龄视力障碍儿童,支持特殊教育学校和具备办学条件的残疾儿童福利、康复机构等面向视力障碍儿童提供学前教育服务。教育行政部门应加强宣传,帮助公众深入了解学前教育之于视力障碍儿童发展的重要价值。此外,教育行政部门还可以协同残疾人联合会等职能部门,摸排辖区内适龄视力障碍儿童接受学前教育的情况,并采取捐资助学、送教上门等措施,保障其学前教育机会。

关键词：学前教育视力障碍认知能力非认知能力

Study Pure Annihilation Decays Bs^0（B^-0 s）→D^±π^-＋ in PQCD Approach

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Communications in Theoretical Physics 2005年第4X期44卷 659-664页

作者： lI Ying lUE cai-dian Institute of High Energy Physics the Chinese Academy of Sciences Beijing 100049 China

The rare decays Bs^0（B^-0 s）→D^±π^-＋ can occur only via annihilation-type diagrams in the standard model. In this paper, we calculate branching ratios of these decays in perturbative QCD approach ignoring soft final state interaction. From our calculation, we find that their branching ratios are at O（10^-6） with large CP asymmetry, which may be measured in lHC-b experiment in the future.

关键词： PQCD annihilation decay B meson CP violation

A review of object representation based on local features

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第7期14卷 495-504页

作者： Jian CAO dian-hui MAO Qiang cai Hai-sheng lI Jun-ping DU College of Computer and Information Engineering Beijing Technology and Business University School of Computer Science Beijing University of Posts and Telecommunications

Object representation based on local features is a topical subject in the domain of image understanding and computer vision. We discuss the defects of global features in present methods and the advantages of local features in object recognition, and briefly explore state-of-the-art recognition methods using local features, especially the main approaches of local feature extraction and object representation. To clearly explain these methods, the problem of local feature extraction is divided into feature region detection, feature region description, and feature space optimization. The main components and merits of these steps are presented. Technologies for object presentation are classified into three types: vector space, sliding window, and structure relationship models. Future development trends are discussed briefly.

关键词： Object presentation local feature Image understanding Object recognition Visual words

Physical Properties of 29 sdB+dM Eclipsing Binaries in Zwicky Transient Facility

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Research in Astronomy and Astrophysics 2022年第3期22卷 221-245页

作者： Min Dai Xiao-dian Chen Kun Wang Yang-Ping luo Shu Wang li-cai Deng School of Physics and Astronomy China West Normal UniversityNanchong 637002China CAS Key laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of the Chinese Academy of SciencesBeijing 101408China

The development of large-scale time-domain surveys provides an opportunity to study the physical properties as well as the evolutionary scenario of B-type subdwarfs(sdBs)and M-type dwarfs(dMs).Here,we obtained 33 sdB+dM eclipsing binaries based on the Zwicky Transient Facility(ZTF)light curves and Gaia Early Data Release3(EDR3)*** using the PHOEBE code for light curve analysis,we obtain probability distributions for parameters of 29 sdB+dMs.R1,R2 and i are well determined,and the average uncertainty of mass ratio q is *** parameters are in good agreement with previous works if a typical mass of sdB is *** on parameters of 29 sdB+dMs,we find that both the mass ratio q and the companion’s radius R2 decrease with the shortening of the orbital *** the three sdB+dMs with orbital periods less than 0.075 days,their companions are all brown *** masses and radii of the companions satisfy the mass–radius relation for low-mass stars and brown *** with radii between 0.12 R_(⊙)and 0.15 R_(⊙)seem to be missing in the *** more short-period sdB+dM eclipsing binaries are discovered and classified in the future with ZTF and Gaia,we will have more information to constrain the evolutionary ending of sdB+dMs.

关键词： (stars:)binaries:eclipsing stars:evolution (stars:)subdwarfs (stars:)brown dwarfs

Factors Affecting Temperature Distribution Along Thickness of Plate During Cooling Process and Their Control Strategies

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Journal of Iron and Steel Research International 2010年第5期17卷 17-22页

作者： cai Xiao-hui ZHANG dian-hua lIU Xiang-hua WANG Guo-dong State Key laboratory of Rolling and Automation Northeastern University Shenyang 110819 Liaoning China

On the basis of the finite difference method, the factors affecting the temperature distribution along the thickness of plate during cooling process were analyzed, which include transformation heat, coefficient of heat conduction, specific heat, carbon content, cooling time, plate thickness, and unit of water flow volume. To ensure the homogenous temperature distribution along the thickness of plate, some cooling strategies, such as interval cooling, stepped cooling, and unsymmetrical cooling of upper and lower surfaces, were applied online. The online results showed that the cooling strategies can improve the temperature homogeneity greatly and the finite difference method can correctly simulate the cooling process.

关键词： temperature distribution thermophysical parameter cooling strategy

The Electronic Structures and Optical Properties of Substituted Rare-Earth Manganite Tb_(1−x)Yb_(x)MnO_(3)

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Chinese Physics letters 2013年第5期30卷 52-55页

作者： cai lu-Gang lIU Fa-Min ZHONG Wen-Wu ZHANG dian School of Physics and Nuclear Energy Engineering Key Laboratory of Micro-nano Measurement-Manipulation and PhysicsBeihang UniversityBeijing 100191

The electronic structures and optical properties of Tb_(1−x)Yb_(x)MnO_(3) as a function of Yb element content x are investigated by employing the first-principles method. The calculation results indicate that the electronic states associated with the Yb element are dominated gradually and the inner electronic states move to the lower energy level with the increasing x. The dielectric function and other optical properties of Tb_(1−x)Yb_(x)MnO_(3) such as the reflectance spectra are obtained and the results indicate that the static dielectric function reaches a maximum at about x=0.75, while the fitting expression predicts a maximum when x=0.69. In addition, it is found that one peak appearing at about 3.60 eV in the reflectance spectra of TbMnO_(3) is driven to shift linearly towards higher energy level with the increasing x. However, another peak at about 29.63 eV moves nonlinearly in the same situation.

关键词： method dielectric element

Effects of geometrical characteristics on defect distributions in alloy components produced by selective laser melting

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China Foundry 2021年第4期18卷 369-378页

作者： Yao cai Tao lu Gui-dian Ma Wang li Ye Pan Hui Ding School of Materials Science and Engineering Southeast UniversityJiangsu Key Laboratory of Advanced Metallic MaterialsNanjing 211189China Nanjing Cham lion laser Technology Co. LtdNanjing 210039China

Selective laser melting(SlM)has been applied to manufacture various alloy components with excellent properties,but its further application is restricted by the intrinsic *** this work,the internal defect distributions in samples of three alloys(316l stainless steel,AlSi10Mg and Inconel 718)were investigated respectively,considering the effects of geometrical characteristics of the *** defects in the 316l stainless steel sample tend to be formed densely in the central part with large wall thickness,indicating a strong sensitivity to heat ***,the Inconel 718 sample shows a higher relative density with homogeneous defect distribution,indicating better formability for the SlM *** the AlSi10Mg sample,the defect density keeps increasing as the deposition goes ***,the defect density located at sample edges shows an abnormally high level comparing with the inner part,especially in the top sections of AlSi10Mg and Inconel 718 *** results are helpful for the geometrical design,the adjustment of building orientation and the further optimization of process parameters in the SlM process.

关键词： selective laser melting defect 316l stainless steel AlSi10Mg Inconel 718 geometrical characteristics formability

Structural and Functional Changes of Immune System in Aging Mouse Induced by D-Galactose

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Biomedical and Environmental Sciences 2006年第6期19卷 432-438页

作者： HONG-BIN DENG CHUN-lEI CHENG DA-PENG CUI dian-DONG lI lI CUI NIAN-SHENG cai Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China Preclinical Medicine College Jilin University Changchun 130021 Jilin China

Objective To investigate the role of D-galactose, especially in the structural and functional changes of the immune system in aging. Methods Serum levels of advanced glycation end-products （AGE） were determined by ElISA method. Ultra-structures of thymus and spleen were detected by transmission electron microscopy. MTT method was used to determine the lymphocyte proliferation. Il-2 activity was determined by bioassay. Northern blot was used to detect the Il-2 mRNA levels. Results Serum AGE levels of D-galactose- （P〈0.01） and AGE-treated （P〈0.05） mice （n=8） were increased significantly. The ultra-structures of thymus and spleen in D-galactose- and AGE-treated mice showed regressive changes similar to those in the aged control group. The lymphocyte mitogenesis and Il-2 activity of spleen were also decreased significantly （P〈0.01, n=8）. The change of Il-2 activity shown by Northern blot resulted from the change of mRNA expression. The AGE plus aminoguanidine group, however, showed no significant change in these parameters in comparison with the young control group （P〈0.01 or P〈0.05, n=8）. Conclusion D-galactose and AGE lead to a mimic regression change of aging in the immune system in vivo.

关键词： D-galactose Aging-mimetic model Advanced glycation end-products Ultra-structure Nonenzyme glycation Aminoguanidine