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Tungsten 2024年第1期6卷 114-123页

作者： Jin-Hui Wang Shao-Wei yang Fu-Bin ma yi-Ke Zhao Shi-Nuo Zhao Zheng-yu Xiong Dong cai Hai-Dong Shen Kai Zhu Qiu-yu Zhang yue-Ling Cao Tian-Shuai Wang He-Peng Zhang Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Xi’an Key Laboratory of Functional Organic Porous materials School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710129China School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China Chongqing Science and Technology Innovation Center of Northwestern Polytechnical University Chongqing 401135China

Developing cost-effective electrocatalysts with high activity and stability especially at high current density is of great significance for the large-scale commercial application of electrochemical water splitting to hydrogen production but still remains ***,we report an effective confinement pyrolysis strategy to fabricate embedded ruthenium-cobalt nanoclusters supported on N-doped porous two-dimensional carbon nanosheets(RuCo@CN).markedly,the embedded structure can effectively prevent the migration,agglomeration,and leaching of nanoparticles,thus endowing the RuCo@CN catalyst with high *** be exact,high stability with up to 650 h can be achieved at high current density(-500 and-1000 ma·cm^(-2)).Besides,the RuCo@CN catalysts also exhibit highly reactive with low overpotentials of only 11mV at-10 ma·cm^(-2).Density functional theory calculations reveal that the introduction of cobalt reduces the decomposition barrier of H_(2)O for RuCo@CN alloy,thus promoting hydrogen evolution reaction.

关键词： Hydrogen evolution reaction Confinement pyrolysis strategy Mosaic structure Stability

Compound heterozygous mutation of AFG3L2 causes autosomal recessive spinocerebellar ataxia through mitochondrial impairment and MICU1 mediated Caoverload

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Science China Life Sciences 2024年

作者： Hongyu Li Qingwen ma yan Xue Linlin cai Liwen Bao Lei Hong yitao Zeng Shuzhen Huang Richard H.Finnell Fanyi Zeng Shanghai Institute of Medical Genetics Shanghai Children's Hospital Shanghai Jiao Tong University School of Medicine Department of Histo-Embryology Genetics and Developmental Biology Shanghai Jiao Tong University School of Medicine NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology Shanghai Key Laboratory of Embryo and Reproduction Engineering Center for Precision Environmental Health Baylor College of Medicine School of Pharmacy Macau University of Science and Technology

Autosomal recessive spinocerebellar ataxias（SCARs） are one of the most common neurodegenerative diseases characterized by progressive ataxia. Although SCARs are known to be caused by mutations in multiple genes, there are still many cases that go undiagnosed or are misdiagnosed. In this study, we presented a SCAR patient, and identified a probable novel pathogenic mutation（c.1A>G, p.M1V） in the AFG3L2 start codon. The proband's genotype included heterozygous mutations of the compound AFG3L2(p.[M1V]; [R632X]（c.[1A>G];[1894.C>T]）), which were inherited from the father（c.1A>G, p.M1V） and mother（c.1894C>T, p.R632X）. Functional studies performed on hiPSCs（human induced pluripotent stem cells） generated from the patients and HEK293T cells showed that the mutations impair mitochondrial function and the unbalanced expression of AFG3L2 mRNA and protein levels. Furthermore, this novel mutation resulted in the degradation of the protein and the reduction of the stability of the AFG3L2 protein, and MCU（mitochondrial calcium uniporter） complex mediated Ca2+overload.

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教师课程转化:意涵、目标及其实现

当代教育科学 2024年第6期 56-63页

作者：马季蔡其全泰山学院教师教育学院泰安271000 山东省教育科学研究院济南250002

教师课程转化是指教师基于对课程方案、课程标准等官方正式课程文件精神与要求的领悟、表征和实际操作,将有价值的抽象教育理念转化为具体可操作的课程设计与教学行为的过程。教师课程转化是课程实施层级中的核心环节,是落实课程政策的... 详细信息

教师课程转化是指教师基于对课程方案、课程标准等官方正式课程文件精神与要求的领悟、表征和实际操作,将有价值的抽象教育理念转化为具体可操作的课程设计与教学行为的过程。教师课程转化是课程实施层级中的核心环节,是落实课程政策的重要途径,也是新时代赋予教师的课程责任。教师课程转化的理念提出和实践推进,对于提升课程运行效率,增进课程方案落实质量意义重大,有助于消减课程落差,减轻教师课程负荷,重塑教师课程文化。推进基础教育课程教学改革,促进基础教育扩优提质,必须依靠教师课程转化。实现教师课程转化,需要增强教师价值认同,培育课程转化意识;提升教师课程素养,生成教学实践智慧;营造专业发展环境,建构专业学习社群。

关键词：教师课程转化课程责任课程落差专业学习社群

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体育教师是谁——角色理论视域下体育教师的形象解构

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上海教育科研 2024年第4期 35-41页

作者：马莉蔡娟北京体育大学教育学院 100084

体育教师作为青少年体育的重要角色,存在形象“扁平化”的危机。为了解学生眼中的体育教师形象,更好地塑造体育教师角色,增强教育强国与体育强国的建设,通过搜集216位来自全国各地体育特长生的教育自传并选取其中16位进行深入访谈,在分... 详细信息

体育教师作为青少年体育的重要角色,存在形象“扁平化”的危机。为了解学生眼中的体育教师形象,更好地塑造体育教师角色,增强教育强国与体育强国的建设,通过搜集216位来自全国各地体育特长生的教育自传并选取其中16位进行深入访谈,在分析体育教师的角色观念和角色行为基础上,进一步提炼体育教师的角色形象。研究发现,在挖掘体育人才、训练、师生关系、考虑体育特长生的未来等方面优秀的体育教师扮演了慧眼识珠的“伯乐”、科学训练师、良师益友和人生规划师;而拙劣的体育教师通常呈现出以貌取人的“庸才”、“三从一大”的曲解者、水火不容的“管教者”、利己主义者的形象。

关键词：体育教师体育教师形象体育教育专业学生教育自传角色理论

Preoperative serum cortisone levels are associated with cognition in preschool‑aged children with tetralogy of Fallot after corrective surgery:new evidence from human populations and mice

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World Journal of Pediatrics 2024年第2期20卷 173-184页

作者： Si-yu ma yu-Ting Liu yue-Shuang Cun Qiang Wang Ming-Cui Fu Ke-De Wu Xin-yu cai Shu-Ting Cheng Nishant Patel Min Da Liang Hu Zhuoga Deqin Xue-Jun Kang Ming yang Xu-Ming Mo Department of Cardiothoracic Surgery Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing 210008China Department of Radiology Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing 210008China Key Laboratory of Child Development and Learning Science Research Center For Learning ScienceSchool of Biological Sciences&Medical EngineeringMinistry of EducationSoutheast UniversityNanjing 210096China Medical School of Nanjing University Nanjing 210093China

Background Tetralogy of Fallot(TOF)is the most common cyanotic congenital heart *** with TOF would be confronted with neurological impairment across their *** study aimed to identify the risk factors for cerebral morphology changes and cognition in postoperative preschool-aged children with *** We used mass spectrometry(MS)technology to assess the levels of serum metabolites,Wechsler preschool and primary scale of intelligence-Fourth edition(WPPSI-Ⅳ)index scores to evaluate neurodevelopmental levels and multimodal magnetic resonance imaging(MRI)to detect cortical morphological *** Multiple linear regression showed that preoperative levels of serum cortisone were positively correlated with the gyrification index of the left inferior parietal gyrus in children with TOF and negatively related to their lower visual spaces index and nonverbal ***,preoperative SpO_(2) was negatively correlated with levels of serum cortisone after adjusting for all ***,after intervening levels of cortisone in chronic hypoxic model mice,total brain volumes were reduced at both postnatal(P)11.5 and P30 *** Our results suggest that preoperative serum cortisone levels could be used as a biomarker of neurodevelopmental impairment in children with *** study findings emphasized that preoperative levels of cortisone could influence cerebral development and cognition abilities in children with TOF.

关键词： Cognition Cortisone MRI Neurodevelopment Tetralogy of Fallot

High-throughput sequencing analysis of differential microRNA expression in the process of blocking the progression of chronic atrophic gastritis to gastric cancer by Xianglian Huazhuo formula(香连化浊方)

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Journal of Traditional Chinese Medicine 2024年第4期44卷 703-712页

作者： GUO yuxi LI Ze CHENG Nan JIA Xuemei WANG Jie ma Hongyu ZHAO Runyuan LI Bolin XUE yucong cai yanru yANG Qian Department of spleen and stomach diseases First Affiliated Hospital of Hebei University of Traditional Chinese MedicineShijiazhuang 050000China Department of Traditional Chinese Medicine Hebei General HospitalShijiazhuang 050051China Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405China College of Integrative Medicine Hebei University of Chinese MedicineShijiazhuang 050011China

OBJECTIVE:To explore the mechanism of Xianglian Huazhuo formula(香连化浊方,XLHZ)blocking the development of chronic atrophic gastritis(CAG)to gastric cancer(GC)through bioinformatics analysis and in ***:Pathological morphology of gastric mucosa of rats were ***-throughput sequencing was used to analyze the miRNA expression profile of gastric *** miRanda,miRDB and miRWalk databases were used to predict the differential target *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis were performed for differential target ***-time quantitative reverse transcription polymerase chain reaction(qRTPCR)was used to verify the differentially expressed miRNAs and target *** blot,EdU,wound healing and flow cytometry were used to observe the effect of XLHZ on epithelial-mesenchymal transition(EMT)markers,proliferation,migration,apoptosis and cell cycle of CAG cells in ***:A total of five differentially expressed miRNAs and four differential target genes were screened in this *** analysis showed that the target genes were enriched in regulation of neuron development,regulation of transcription factor activity and regulation of RNA *** pathways database differences in gene enrichment of target genes in the Wnt signaling pathway,Phospholipase D signaling pathway and mitogen-activated protein kinase signaling *** confirmed that miRNAs and its target genes were consistent with the screening *** vitro,our study revealed that XLHZ could increase the expression of Ecadherin,decrease the expression of transforming growth factorβ1,vimentin andβ-catenin,inhibite the proliferation and migration of CAG cells,cause cell cycle arrest at G0/G1 and G2/M phase,induce the apoptosis of CAG cells,and prevent the progression of CAG to ***:This study provided a new idea for the mechanism of blocking the progression of CAG to GC by XLHZ,which may be related to the expression

关键词： high-throughput nucleotide sequencing gastritis,atrophic stomach neoplasms microRNAs Xianglian Huazhuo formula

Toripalimab in combination with chemotherapy effectively suppresses local recurrence and metastatic sarcomatoid renal cell carcinoma:A case report

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World Journal of Clinical Cases 2024年第28期12卷 6230-6236页

作者： Ming-Zhu Gao Nian-Fei Wang Jin-you Wang Li ma yu-cai yang Department of Oncology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China Department of Urology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China Department of Pathology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China

BACKGROUND Sarcomatoid renal cell carcinoma(SRCC)is a rare variant of renal cell carcinoma associated with an unfavorable *** efficacy of conventional chemo-therapy and targeted therapies are limited,whereas the emergence of immune checkpoint inhibitor has introduced new avenues for managing advanced *** SUMmaRy A 77-year-old female patient was referred to our hospital following the incidental detection of a right kidney tumor without specific *** tumor was successfully resected,and subsequent pathological examination confirmed *** experienced both local recurrence and distant metastasis eight months after the initial laparoscopic *** six cycles of toripalimab combined with pirarubicin chemotherapy,the patient achieved a partial ***-quently,the patient attained an almost-complete continuous response to toripa-limab monotherapy.maintenance for an additional six *** has not experienced disease progression for 15 months,and her overall survival has reached 24 months thus *** Combination therapy with programmed death 1 antibodies and cytotoxic agents may be a recommended first-line treatment approach for SRCC.

关键词： Renal cell carcinoma Sarcomatoid dedifferentiation Immune checkpoint inhibitor Chemotherapy Case report

Pulmonary abscess caused by Streptococcus pseudopneumoniae in a child:A case report and review of literature

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World Journal of Radiology 2024年第8期16卷 362-370页

作者： Ran ma yan-Mei Wang Hua Guan Li Zhang Wei Zhang Ling-cai Chen Department of Pediatrics Shihezi UniversityShihezi 832000Xinjiang Uygur Autonomous RegionChina Department of Pediatrics The First Affiliated Hospital of Shihezi UniversityShihezi 832000Xinjiang Uygur Autonomous RegionChina Department of Pediatrics Corps Fourth Division HospitalYining 844500Xinjiang Uygur Autonomous RegionChina Department of Pediatrics Corps First Division HospitalAksu 842008Xinjiang Uygur Autonomous RegionChina

BACKGROUND Lung abscess found on chest X-ray and computed tomography examinations is rare in infants and young *** pathogens can cause lung abscesses,with the most common pathogens being anaerobes,Streptococci and Staphylococcus *** pseudopneumoniae(***)is a member of the Streptococcaceae family,and is mainly isolated from respiratory tract *** are currently no cases of lung abscess caused by *** in the *** SUMmaRy A 2-year-old boy was admitted to hospital due to persistent cough and *** computed tomography examination suggested the formation of a lung *** diagnosis was not confirmed by testing for serum respiratory pathogens(6 items),respiratory pathogen nucleic acid(27 items),and laboratory ***,metagenomic next-generation sequencing of bronchoalveolar lavage fluid revealed the presence of ***,confirming its role in causing the lung *** receiving antibiotic treatment,reexamination with lung computed tomography showed that the abscess was resorbed and the patient’s outcome was *** This is the first report of a lung abscess in a child caused by *** *** next-generation sequencing of bronchoalveolar lavage fluid is helpful in achieving rapid and accurate pathogen identification.

关键词： Streptococcus pseudopneumoniae Lung abscess Children Bronchoalveolar lavage fluid Metagenomic nextgeneration sequencing Case report

Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第17期30卷 2354-2368页

作者： Kai Zhou cai-Ling Li Hua Zhang Bao-Jun Suo yu-Xin Zhang Xin-Lu Ren yu-Xin Wang Chang-Min Mi Ling-Ling ma Li-ya Zhou Xue-Li Tian Zhi-Qiang Song Department of Gastroenterology Peking University Third HospitalBeijing 100191China

BACKGROUND Difficulty in obtaining tetracycline,increased adverse reactions,and relatively complicated medication methods have limited the clinical application of the classic bismuth quadruple ***,the search for new alternative drugs has become one of the research *** recent years,minocycline,as a semisynthetic tetracycline,has demonstrated good potential for eradicating Helicobacter pylori(***)infection,but the systematic evaluation of its role remains *** To explore the efficacy,safety,and compliance of minocycline in eradicating *** *** We comprehensively retrieved the electronic databases of PubMed,Embase,Web of Science,China National Knowledge Infrastructure,SinoMed,and Wanfang database as of October 30,2023,and finally included 22 research reports on *** eradication with minocycline-containing regimens as per the inclusion and exclusion *** eradication rates of *** were calculated using a fixed or a random effect model,and the heterogeneity and publication bias of the studies were *** The single-arm meta-analysis revealed that the minocycline-containing regimens achieved good overall *** eradication rates,reaching 82.3%[95%confidence interval(CI):79.7%-85.1%]in the intention-to-treat analysis and 90.0%(95%CI:87.7%-92.4%)in the per-protocol *** overall safety and compliance of the minocycline-containing regimens were good,demonstrating an overall incidence of adverse reactions of 36.5%(95%CI:31.5%-42.2%).Further by traditional meta-analysis,the results showed that the minocycline-containing regimens were not statistically different from other commonly used eradication regimens in eradication rate and incidence of adverse *** of the adverse reactions were mild to moderate and well-tolerated,and dizziness was relatively prominent in the minocycline-containing regimens(16%).CONCLUSION The minocycline-containing regimens demonstrated good efficacy,safety,and

关键词： Helicobacter pylori Minocycline Eradication Safety Resistance

Oscillation properties of eigenfunctions for Sturm-Liouville problems with interface conditions via Prufer transformation

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Applied mathematics(A Journal of Chinese Universities) 2024年第2期39卷 191-200页

作者： LI Zhi-yu LI Kun cai Jin-ming QIN Jian-fang ZHENG Zhao-wen School of mathematical Sciences Qufu Normal UniversityQufu 273165China College of mathematics and Systems Science Guangdong Polytechnic Normal UniversityGuangzhou 510665China

A class of Sturm-Liouville problems with discontinuity is studied in this *** oscillation properties of eigenfunctions for Sturm-Liouville problems with interface conditions are *** main method used in this paper is based on Prufer transformation,which is different from the classical ***,we give two examples to verify our main results.

关键词： Sturm-Liouville problem interface condition oscillatory solution