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Generalized McKay Quivers of Rank Three

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Acta Mathematica Sinica,English Series 2013年第7期29卷 1351-1368页

作者： xiao Li HU Naihuan JING Wu Xing cai School of Sciences South China University of Technology Department of Mathematics North Carolina State University

For each finite subgroup G of SLn（C）, we introduce the generalized Cartan matrix AG in view of McKay correspondence from the fusion rule of its natural representation. Using group theory, we show that the generalized Cartan matrices have similar favorable properties such as positive semi- definiteness as in the classical case of affine Cartan matrices. The complete McKay quivers for SL3 （C） are explicitly described and classified based on representation theory.

关键词： McKay correspondence McKay quivers generalized Dynkin diagrams

Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy

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Cellular & Molecular Immunology 2021年第9期18卷 2083-2100页

作者： cai Zhang Yuan Hu Weihua xiao Zhigang Tian NK CellTech Co. Ltd.Shanghai International Medical ParkShanghaiChina Institute of Immunology University of Science and Technology of ChinaHefeiAnhuiChina Research Unit of NK Cell Study Chinese Academy of Medical SciencesBeijingChina

Chimeric antigen receptor(CAR)-engineered T-cell(CAR-T)therapy has demonstrated impressive therapeutic efficacy against hematological malignancies,but multiple challenges have hindered its application,particularly for the eradication of solid *** killer cells(IKCs),particularly NK cells,NKT cells,andγδT cells,employ specific antigen-independent innate tumor recognition and cytotoxic mechanisms that simultaneously display high antitumor efficacy and prevent tumor escape caused by antigen loss or *** are associated with a low risk of developing GVHD,thus offering new opportunities for allogeneic“off-the-shelf”cellular therapeutic *** unique innate features,wide tumor recognition range,and potent antitumor functions of IKCs make them potentially excellent candidates for cancer immunotherapy,particularly serving as platforms for CAR *** this review,we first provide a brief summary of the challenges hampering CAR-T-cell therapy applications and then discuss the latest CAR-NK-cell research,covering the advantages,applications,and clinical translation of CAR-and NK-cell receptor(NKR)-engineered *** in synthetic biology and the development of novel genetic engineering techniques,such as gene-editing and cellular reprogramming,will enable the further optimization of IKC-based anticancer therapies.

关键词： Innate killer cells Chimeric antigen receptor Natural killer cell receptor Genetic engineering Adoptive cell therapy Tumor microenvironment

Manipulating spatial alignment of donor and acceptor in host–guest MOF for TADF

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National Science Review 2022年第8期9卷 80-88页

作者： xiao-Ting Liu Weijie Hua Hong-Xiang Nie Mingxing Chen Ze Chang Xian-He bu School of Materials Science and Engineering TKL of Metal and Molecule-Based Material ChemistryNankai University MIIT Key Laboratory of Semiconductor Microstructure and Quantum Sensing Department of Applied PhysicsSchool of ScienceNanjing University of Science and Technology Analytical Instrumentation Center Peking University State Key Laboratory of Elemento-Organic Chemistry College of ChemistryNankai University

Thermally activated delayed fluorescence(TADF) was achieved when electron-rich triphenylene(Tpl)donors were confined to a cage-based porous metal-organic framework(MOF) host(NKU-111)composed of electron-deficient 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine(Tpt) acceptor as the ligand. The spatially separated donor and acceptor molecules in a face-to-face stacking pattern generated strong through-space charge transfer(CT) interactions with a small energy splitting between the singlet and triplet excited states(～0.1 eV), which enabled TADF. The resulting Tpl@NKU-111 exhibited an uncommon enhanced emission intensity as the temperature increased. Extensive steady-state and time-resolved spectroscopic measurements and first-principles simulations revealed the chemical and electronic structure of this compound in both the ground and low-lying excited states. A double-channel(T1, T2) intersystem crossing mechanism with S1was found and explained as single-directional CT from the degenerate HOMO-1/HOMO of the guest donor to the LUMO+1 of one of the nearest acceptors. The rigid skeleton of the compound and effective through-space CT enhanced the photoluminescence quantum yield(PLQY). A maximum PLQY of 57.36% was achieved by optimizing the Tpl loading ratio in the host framework. These results indicate the potential of the MOFs for the targeted construction and optimization of TADF materials.

关键词： donor-acceptor through-space charge transfer thermally activated delayed fluorescence(TADF) host-guest MOF

Orbital Stability of Solitary Waves of Compound KdV-type Equation

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Acta Mathematicae Applicatae Sinica 2015年第4期31卷 1033-1042页

作者： Wei-guo ZHANG Hui-wen Li xiao-shuang bu Lan-yun BIAN School of Science University of Shanghai for Science and Technology

In this paper, we study the orbital stability of solitary waves of compound KdV-type equation in the form of ut ＋ auPux ＋ bu2pux ＋ Uzzz = 0 （b 〉 0, p 〉 0）. Our results imply that orbital stability of solitary waves is affected not only by the highest-order nonlinear term bu2pux, but also the nonlinear term auPux. For the case of b 〉 0 and 0 〈 p ≤ 2, we obtain that the positive solitary wave Ul（X - ct） is stable when a 〉 0, while that unstable when a 〈 0. The stability for negative solitary wave u2（x - ct） is on the contrary. In particular, we point that the nonlinear term with coefficient a makes contributes to the stability of the solitary waves when p= 2 and a〉0.

关键词： orbital stability compound KdV-type equation solitary waves spectral analysis

Novel 2H-pyrazolo[4,3-c]hexahydropyridine derivatives: Synthesis, crystal structure, fluorescence properties and cytotoxicity evaluation against human breast cancer cells

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Science China Chemistry 2013年第6期56卷 702-715页

作者： PANG ChunCheng SUN ChuanWen WANG Jing xiao Di DING Li bu HongFei College of Life and Environment Sciences Shanghai Normal University

A series of novel 2H-pyrazolo[4,3-c]hexahydropyridine derivatives （II） have been designed and synthesized. The target com- pounds have been identified by elemental analysis and spectral （1H NMR, IR, and MS） data and the absolute configuration of compound （IIl） was confirmed by single crystal X-ray diffraction. The cytotoxicity of the target compounds have been evalu- ated in vitro against two human breast cancer cell lines MCF-7 and MDA-MB-231 by MTT assay. Most compounds exhibited good inhibition, and compounds II21 （IC50 = 4.7 μM for MCF-7 and IC50 = 9.3 μM for MDA-MB-231）, 1133 （IC50 = 2.4 μM for MCF-7 and IC50 = 4.2 gM for MDA-MB-231） and 114o （IC50 = 3.3 μM for MCF-7 and IC5o =8.6 μM for MDA-MB-231） dis- played better inhibitory activity than 5-fluorouracil （IC50 = 4.8 μM for MCF-7 and IC50 = 9.6 I, tM for MDA-MB-231, respec- tively）. Flow cytometric analysis and DNA fragmentation suggest that II33 is cytotoxic and able to induce the apoptosis of MCF-7 cells. The fluorescence properties of compounds IIl, II6, II11,II16, II23, Il2s, and II3s were also studied and compound Ilzs afforded the highest photoluminescence quantum yield （38%）.

关键词： pyrazolopyridine synthesis crystal structure breast cancer cells cytotoxicity evaluation apoptosis fluorescence prop-erties

Creep rupture behavior and microstructural evolution of modified 9Cr-1Mo heat-resistant steel

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Journal of Iron and Steel Research International 2018年第12期25卷 1303-1310页

作者： Fa-cai Ren He Wang xiao-ying Tang Fei Chen Shanghai Institute of Special Equipment Inspection and Technical Research Shanghai 200062China Capital Aerospace Machinery Corporation Limited Beijing 100076China National Engineering Research Centre of Die &Mold CAD Shanghai Jiao Tong UniversityShanghai 200030China

High-temperature creep rupture behavior of modified 9Cr-lMo steel used for steam cooler was investigated at temperature of 838 and 923 K and stress ranging from 100 to 250 *** on the analysis of creep rate-time curves,it is found that the creep rupture life decreases with the increase in the applied stress and *** creep damage tolerance factor has been identified as a value of *** the normalized and tempered condition,the studied steel shows typical martensitic microstructure with Cr-rich M23C6 and Nb-or V-rich MX ***,the Laves phase has been found along the grain *** fracture morphology characterized by field emission scanning electron microscope is adopted to reveal the creep failure *** investigated results indicate the occurrence of the transgranular fracture under all the creep test conditions.

关键词： Creep rupture behavior Modified 9Cr-1Mo steel Microstructural evolution Fractography

Combining Multiple Factors to Predict Alzheimer’s Disease

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Neuroscience bulletin 2022年第8期38卷 969-972页

作者： xiao-Lin Gao Jun Wang Yan-Jiang Wang Xian-Le bu Department of Neurology and Centre for Clinical Neuroscience Daping HospitalThird Military Medical University400042ChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases 400042ChongqingChina Institute of Brain and Intelligence Third Military Medical University400042ChongqingChina State Key Laboratory of Trauma Burns and Combined InjuryThird Military Medical University400042ChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences200031ShanghaiChina

Alzheimer's disease(AD)is the most common type of dementia that imposes a high burden on caregivers and has substantial economic cost for *** there are no drugs available to reverse the progression of AD,a large number of studies have shown that intervention for the risk factors for AD or administration of disease-modifying therapy at the preclinical/prodromal stage yields better ***,early diagnosis or accurate prediction of AD in healthy populations and preclinical AD is an important prerequisite for effective intervention.

关键词： Alzheimer diagnosis drugs

Geometry of Motion for Video Shakiness Detection

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Journal of Computer Science & Technology 2018年第3期33卷 475-486页

作者： xiao-Qun Wu Hai-Sheng Li Jian Cao Qiang cai School of Computer and Information Engineering Beijing Technology and Business University Beijing 100048 China Beijing Key Laboratory of Big Data Technology for Food Safety Beijing Technology and Business University Beijing 100048 China

This paper presents a novel algorithm for automatically detecting global shakiness in casual videos. Per-frame amplitude is computed by the geometry of motion, based on the kinematic model defined by inter-frame geometric transformations. Inspired by motion perception, we investigate the just-noticeable amplitude of shaky motion perceived by the human visual system. Then, we use the thresholding contrast strategy on the statistics of per-frame amplitudes to determine the occurrence of perceived shakiness. For testing the detection accuracy, a dataset of video clips is constructed with manual shakiness label as the ground truth. The experiments demonstrate that our algorithm can obtain good detection accuracy that is in concordance with subjective judgement on the videos in the dataset.

关键词： video shakiness kinematic model motion perception

Spatial-temporal coupling between high-quality source rocks and reservoirs for tight sandstone oil and gas accumulations in the Songliao Basin, China

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International Journal of Mining Science and Technology 2019年第3期29卷 387-397页

作者： Laixing cai Guolin xiao Shuangfang Lu Jiao Wang Zhiqiang Wu Qingdao Institute of Marine Geology Qingdao 266071China Laboratory for Marine Mineral Resources Pilot National Laboratory for Marine Science and Technology (Qingdao)Qingdao 266237China Research Institute of Unconventional Petroleum and Renewable Energy China University of Petroleum (East China)Qingdao 266580China

The spatial-temporal relationship between high-quality source rocks and reservoirs is a key factor when evaluating the formation,occurrence,and prospectivity of tight oil and gas *** this study,we analyze the fundamental oil and gas accumulation processes occurring in the Songliao Basin,contrasting tight oil sand reservoirs in the south with tight gas sand reservoirs in the *** is done using geochemical data,constant-rate and conventional mercury injection experiments,and fluid inclusion *** results demonstrate that as far as fluid mobility is concerned,the expulsion center coincides with the overpressure zone,and its boundary limits the occurrence of tight oil and gas *** addition,the lower permeability limit of high-quality reservoirs,controlled by pore-throat structures,is 0.1×10^-3μm^2 in the fourth member of the Lower Cretaceous Quantou Formation(K1q^4)in the southern Songliao Basin,and 0.05×10^-3μm^2 in the Lower Cretaceous Shahezi Formation(K1sh)in the northern Songliao ***,the results indicate that the formation of tight oil and gas reservoirs requires the densification of reservoirs prior to the main phase of hydrocarbon expulsion from the source ***“sweet spots”develop at the intersection of high-quality source rocks(with high pore pressure)and reservoirs(with high permeability).

关键词： Spatial-temporal coupling High-quality source rock High-quality sandstone Tight sandstone reservoir Songliao Basin