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Comprehensive analysis of clinical and biological value of ING family genes in liver cancer

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2592-2609页

作者： shi-cai Liu School of Medical Information Wannan Medical CollegeWuhu 241002Anhui ProvinceChina

BACKGROUND Liver cancer(LIHC)is a malignant tumor that occurs in the liver and has a high mortality in *** ING family genes were identified as tumor suppressor *** expression of these genes can lead to cell cycle arrest,senescence and/or *** family genes are promising targets for anticancer ***,their role in LIHC is still not well *** To have a better understanding of the important roles of ING family members in *** A series of bioinformatics approaches(including gene expression analysis,genetic alteration analysis,survival analysis,immune infiltration analysis,prediction of upstream microRNAs(miRNAs)and long noncoding RNAs(lncRNAs)of ING1,and ING1-related gene functional enrichment analysis)was applied to study the expression profile,clinical relationship,prognostic significance and immune infiltration of ING in *** relationship between ING family genes expression and tumor associated immune checkpoints was investigated in *** molecular mechanism of ING1 mediated hepatocarcinogenesis was preliminarily *** mRNA/protein expression of different ING family genes in LIHC was analyzed in different databases,showing that ING family genes were highly expressed in *** 47 samples from 366 LIHC patients,the ING family genes were altered at a rate of 13%.By comprehensively analyzing the expression,clinical pathological parameters and prognostic value of ING family genes,ING1/5 was ***1/5 was related to poor prognosis of LIHC,suggesting that they may play key roles in LIHC tumorigenesis and *** of the target miRNAs of ING1 was identified as *** upstream lncRNAs of hsa-miR-214-3p,U91328.1,and HCG17,were *** the same time,we found that the expression of ING family genes was correlated with immune cell infiltration and immune checkpoint *** This study lays a foundation for further research on the potential mechanism and clinical v

关键词： Liver cancer ING family genes Noncoding RNAs Immune cell infiltration Prognosis

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Circulating tumor DNA in liquid biopsy: Current diagnostic limitation

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World Journal of Gastroenterology 2024年第15期30卷 2175-2178页

作者： shi-cai Liu School of Medical Information Wannan Medical CollegeWuhu 241002Anhui ProvinceChina

With the rapid development of science and technology,cell-free DNA(cfDNA)is rapidly becoming an important biomarker for tumor diagnosis,monitoring and prognosis,and this cfDNA-based liquid biopsy technology has great potential to become an important part of precision *** is the total amount of free DNA in the systemic circulation,including DNA fragments derived from tumor cells and all other somatic *** cells release fragments of DNA into the bloodstream,and this source of cfDNA is called circulating tumor DNA(ctDNA).cfDNA detection has become a major focus in the field of tumor research in recent years,which provides a new opportunity for non-invasive diagnosis and prognosis of *** this paper,we discuss the limitations of the study on the origin and dynamics analysis of ctDNA,and how to solve these problems in the *** the future faces major challenges,it also con-tains great potential.

关键词： Cell-free DNA Circulating tumor DNA Liquid biopsy Cancer Diagnosis Prognosis

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A Moment Characterization of B-Valued Generalized Functionals of White Noise

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Acta Mathematica Sinica,English Series 2006年第1期22卷 157-168页

作者： cai shi WANG Zhi Yuan HUANG School of Mathematics and Information Science Northwest Normal University Lanzhou 730070 P. R. China Department of Mathematics Huazhong University of Science and Technology Wuhan 430074 P. R. China

Kernel theorems are established for Bananch space-valued multilinear mappings, A moment characterization theorem for Banach space-valued generalized functionals of white noise is proved by using the above kernel theorems. A necessary and sufficient condition in terms of moments is given for sequences of Banach space-valued generalized functionals of white noise to converge strongly. The integration is also discussed of functions valued in the space of Banach space-valued generalized functionals.

关键词： White noise analysis B-valued generalized functionals Moment characterization

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A Filtration of Wick Algebra and Its Application to Quantum SDEs

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Acta Mathematica Sinica,English Series 2004年第6期20卷 999-1008页

作者： cai shi WANG Zhi Yuan HUANG School of Mathematics and Information Science Northwest Normal University Department of Mathematics Huazhong University of Science & Technology

A family of closed subalgebras, indexed by R (the set of real numbers), of the Wick algebra is constructed. Fundamental properties of the family are shown including the increasing property and the right–continuity. The notion of adaptedness to the family is defined for quantum stochastic processes in terms of generalized operators. The existence and uniqueness of solutions adapted to the family is established for quantum stochastic differential equations in terms of generalized operators.

关键词： White noise Wick algebra Filtration

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Terahertz superconducting kinetic inductance detectors demonstrating photon-noise-limited performance and intrinsic generation-recombination noise

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Science China(Physics,Mechanics & Astronomy) 2022年第3期65卷 106-113页

作者： Qing shi Jing Li Qiang Zhi Zheng Wang Wei Miao Sheng-cai shi Purple Mountain Observatory Chinese Academy of SciencesNanjing 210034China School of Astronomy&Space Science University of Science and Technology of ChinaHefei 230026China

The development of large-format detector arrays with background-limited performance is of particular interest at the terahertz(THz) band, which is a unique band in search of our cosmic origins. With high sensitivity and being more promising in the pixel number and multiplexing technology, superconducting kinetic inductance detectors(KID) are emerging as a major choice of detectors of this type. Here we fabricate three-THz-band(0.35/0.85/1.4 THz) KIDs on a single chip from a 120-nm-thick aluminum(Al) superconducting film and measure photon-noise-limited performance and intrinsic generation-recombination noise at high(>1 p W) and low(<1 f W) optical radiation power, respectively. Their responses to blackbody(optical) radiation are proven to be purely from photons compared with the responses of two dark KIDs intentionally arranged on the same detector chip. The lowest optical noise equivalent power(NEP) reaches 6×10^(-18)W/Hz^(0.5)and the optical coupling efficiency is in the range of 49%-56% for the three KIDs, which are in good agreement with the simulation results.

关键词： terahertz kinetic inductance detectors(KID) photon-noise generation-recombination noise

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Early diagnostic strategies for colorectal cancer

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World Journal of Gastroenterology 2024年第33期30卷 3818-3822页

作者： shi-cai Liu Han Zhang School of Medical Information Wannan Medical CollegeWuhu 241002Anhui ProvinceChina School of Basic Medical Sciences Wannan Medical CollegeWuhu 241002Anhui ProvinceChina

At present,cancer is still an important factor threatening human *** cancer(CRC)is one of the top three most common cancers worldwide and one of the deadliest malignancies in *** latest data showed that CRC incidence and mortality rank third and second,respectively,among global *** and accurate diagnosis is crucial to reduce the morbidity,mortality and improve survival of patients with CRC,but the current early diagnostic methods have *** effectiveness and compliance of diagnostic methods have a certain impact on whether people choose *** this editorial,we explore strategies for the early diagnosis of CRC,including stool-based,blood-based,direct visualization,and imaging examinations.

关键词： Colorectal cancer Diagnostic markers Colonoscopy Fecal immunochemical test Fecal occult blood test Circulating tumor cells Circulating tumor DNA

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Analytic Characterization for Hilbert-Schmidt Operators on Fock Space

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Acta Mathematica Sinica,English Series 2005年第4期21卷 787-796页

作者： cai shi WANG Zhi Yuan HUANG Xiang Jun WANG School of Mathematics and Information Science Northwest Normal University Lanzhou 730070 P. R. China Department of Mathematics Huazhong University of Science & Technology Wuhan 430074 P. R. China

In this paper we first introduce and investigate some special classes of nonlinear maps and get several useful results. Then, by using these results, we obtain analytic criteria for checking whether or not an operator defined only on the exponential vectors of a symmetric Fock space becomes a Hilbert-Schmidt operator on the whole space. Additionally, as an application, we also get an analytic criterion for Hilbert-Schmidt operators on a Gaussian probability space through the Wiener-Ito-Segal isomorphism.

关键词： Fock space Hilbert-Schmidt operator Frěchet entire map

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Is FOLFOX-HAIC superior to transarterial chemoembolization in treating large hepatocellular carcinoma?

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 164-165页

作者： Yun-shi cai Hong Wu Department of Liver Surgery&Liver Transplantation State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduChina

We read with interest the recent article by Li et al.(1)reported a randomized phase III trial that compared the efficacy of hepatic artery infusion(HAIC)with oxaliplatin,fluorouracil,and leucovorin with transarterial chemoembolization(TACE)for large hepatocellular carcinoma(HCC)(diameter≥7 cm).The authors found a lower incidence of serious adverse events in the FOLFOX-HAIC group;furthermore,the overall and progression-free survival was better in the FOLFOX-HAIC group than in the TACE ***,HAIC provided survival benefits in various ***,although the authors discussed some limitations,several fundamental flaws have yet to be fixed.

关键词： FOLFOX HAI arterial

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Development and validation of a predictive model for spinal fracture risk in osteoporosis patients

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World Journal of Clinical Cases 2023年第20期11卷 4824-4832页

作者： Xu-Miao Lin Zhi-cai shi Department of Orthopedics Changhai HospitalShanghai 200433China

BACKGROUND Spinal osteoporosis is a prevalent health condition characterized by the thinning of bone tissues in the spine,increasing the risk of *** its high incidence,especially among older populations,it is critical to have accurate and effective predictive models for fracture ***,clinicians have relied on a combination of factors such as demographics,clinical attributes,and radiological characteristics to predict fracture risk in these ***,these models often lack precision and fail to include all potential risk *** is a need for a more comprehensive,statistically robust prediction model that can better identify high-risk individuals for early *** To construct and validate a model for forecasting fracture risk in patients with spinal *** The medical records of 80 patients with spinal osteoporosis who were diagnosed and treated between 2019 and 2022 were retrospectively *** patients were selected according to strict criteria and categorized into two groups:Those with fractures(n=40)and those without fractures(n=40).Demographics,clinical attributes,biochemical indicators,bone mineral density(BMD),and radiological characteristics were collected and compared.A logistic regression analysis was employed to create an osteoporotic fracture risk-prediction *** area under the receiver operating characteristic curve(AUROC)was used to evaluate the model’s *** Factors significantly associated with fracture risk included age,sex,body mass index(BMI),smoking history,BMD,vertebral trabecular alterations,and prior vertebral *** final risk-prediction model was developed using the formula:(logit[P]=-3.75+0.04×age-1.15×sex+0.02×BMI+0.83×smoking history+2.25×BMD-1.12×vertebral trabecular alterations+1.83×previous vertebral fractures).The AUROC of the model was 0.93(95%CI:0.88-0.96,P<0.001),indicating strong discriminatory *** The fracture risk-pr

关键词： Spinal osteoporosis Fracture risk prediction Bone mineral density Vertebral trabecular alterations Previous vertebral fractures

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Characterizing the Microenvironment Surrounding Phosphorylated Protein Sites

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Genomics, Proteomics & Bioinformatics 2005年第4期3卷 213-217页

作者： shi-cai Fan Xue-Gong Zhang The Key Laboratory of the Ministry of Education for Bioinformatics Department of Automation Tsinghua University Beijing 100084 China.

Protein phosphorylation plays an important role in various cellular processes. Due to its high complexity, the mechanism needs to be further studied. In the last few years, many methods have been contributed to this field, but almost all of them investigated the mechanism based on protein sequences around protein sites. In this study, we implement an exploration by characterizing the microenvironment surrounding phosphorylated protein sites with a modified shell model, and obtain some significant properties by the rank-sum test, such as the lack of some classes of residues, atoms, and secondary structures. Furthermore, we find that the depletion of some properties affects protein phosphorylation remarkably. Our results suggest that it is a meaningful direction to explore the mechanism of protein phosphorylation from microenvironment and we expect further findings along with the increasing size of phosphorylation and protein structure data.

关键词： protein phosphorylation microenvironment modified shell model rank-sum test

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