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Towards Practical Application of li-S Battery with High Sulfur Loading and Lean Electrolyte:Will Carbon-Based Hosts Win This Race?

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Nano-Micro Letters 2023年第9期15卷 384-422页

作者： Yi Gong Jing li kai Yang Shaoyin li Ming Xu Guangpeng Zhang Yan Shi qiong cai Huanxin li Yunlong Zhao Advanced Technology Institute University of SurreyGuildfordSurrey GU27XHUK Department of Chemical and Process Engineering University of SurreyGuildford GU27XHUK Department of Chemistry Physical and Theoretical Chemistry LaboratoryUniversity of OxfordOxford OX13QZUK Department of Engineering University of Cambridge9 JJ Thomson AvenueCambridge CB30FAUK State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082HunanPeople’s Republic of China College of Materials and Metallurgy Guizhou UniversityGuiyang 550025People’s Republic of China

As the need for high-energy–density batteries continues to grow, lithium-sulfur(li–S) batteries have become a highly promising next-generation energy solution due to their low cost and exceptional energy density compared to commercially available li-ion batteries. Research into carbon-based sulfur hosts for li–S batteries has been ongoing for over two decades, leading to a significant number of publications and ***, the commercialization of li–S batteries has yet to be realized. This can be attributed, in part, to the instability of the li metal anode. However, even when considering just the cathode side, there is still no consensus on whether carbon-based hosts will prove to be the best sulfur hosts for the industrialization of li–S batteries. Recently, there has been controversy surrounding the use of carbon-based materials as the ideal sulfur hosts for practical applications of li–S batteries under high sulfur loading and lean electrolyte conditions. To address this question, it is important to review the results of research into carbon-based hosts, assess their strengths and weaknesses, and provide a clear perspective. This review systematically evaluates the merits and mechanisms of various strategies for developing carbon-based host materials for high sulfur loading and lean electrolyte conditions. The review covers structural design and functional optimization strategies in detail, providing a comprehensive understanding of the development of sulfur hosts. The review also describes the use of efficient machine learning methods for investigating li–S batteries. Finally, the outlook section lists and discusses current trends, challenges, and uncertainties surrounding carbon-based hosts, and concludes by presenting our standpoint and perspective on the subject.

关键词： li-S batteries Carbon materials Structural design Functional modification Machine learning

Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer

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Cancer Biology & Medicine 2022年第8期19卷 1193-1210页

作者： qiong Wang Zean li Jin Yang Shirong Peng Qianghua Zhou kai Yao Wenli cai Zhongqiu Xie Fujun Qin Hui li Xu Chen kaiwen li Hai Huang Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Pathology School of MedicineUniversity of VirginiaCharlottesvilleVA 22908USA Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Radiation Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Urology Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Radiology Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Department of Urology The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China

Objective:To explore the genetic changes in the progression of castration-resistant prostate cancer(CRPC)and neuroendocrine prostate cancer(NEPC)and the reason why these cancers resist existing ***:We employed our CRPC cell line microarray and other CRPC or NEPC datasets to screen the target gene *** transfection and RNA interference were used to construct overexpression and knockdown cell *** and animal models of radiotherapy were established by using a medical electron linear *** cytometry was used to detect apoptosis or cell cycle *** blot and qPCR were used to detect changes in the protein and RNA ***:TCGA and clinical patient datasets indicated that NEIL3 was downregulated in CRPC and NEPC cell lines,and NEIL3 was correlated with a high Gleason score but a good *** functional studies demonstrated that NEIL3 had no effect on the proliferation and migration of PCa ***,cell and animal radiotherapy models revealed that NEIL3 could facilitate the radiotherapy sensitivity of PCa cells,while loss of NEIL3 activated radiotherapy ***,we found that NEIL3 negatively regulated the expression of ATR,and higher NEIL3 expression repressed the ATR/CHK1 pathway,thus regulating the cell ***:We demonstrated that NEIL3 may serve as a diagnostic or therapeutic target for therapy-resistant patients.

关键词： CRPC NEIL3 NEPC prostate cancer radiotherapy resistance

Qishen capsule safely boosts cardiac function and angiogenesis via the MEK/ERK pathway in a rat myocardial infarction model

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Journal of Geriatric Cardiology 2019年第10期16卷 764-774页

作者： cai-Xia GUO Zhi-yuan li Jin-Bang NIU Shuan-Cheng FAN Si-Yu YAN pei-pei LU Yan-Ni SU li-Hong MA State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Shanghai kai Bao Pharmaceutical Co. LtdShanghaiChina

Background Qishen(QS) capsules, a Traditional Chinese Medicine, has been widely used to treat coronary heart disease in China. However, evidence of its effectiveness remains unclear. Methods To explore whether QS has cardioprotective efficacy and/or promotes angiogenesis after myocardial infarction (MI), we performed experiments in a preclinical rat MI model. One month after left anterior descending coronary artery ligation, the rats received either QS solution (0.4 g/kg/day) or the same volume of saline by intragastric injection for four weeks. Results Echocardiographic and hemodynamic analyses demonstrated relatively preserved cardiac function in MI rats administered QS. Indeed, QS treatment was associated with reduced infarct scar size and heart weight index, and these beneficial effects were responsible for enhancing angiogenesis. Mechanistically, QS treatment increased phosphorylation of protein kinase B (Akt) and downregulated phosphorylation of mitogen-activated protein kinase/extracellular-regulated kinase (MEK/ERK). Conclusions QS therapy can improve the cardiac function of rats after MI by an underlying mechanism involving increased angiogenesis, at least partially via activation of the Akt signaling pathway and inhibition of MEK/ERK phosphorylation.

关键词： Angiogenesis Cardioprotective efficacy Qishen capsule

面向乡村振兴的中国传统村落保护与利用:挑战与展望

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自然资源学报 2024年第8期39卷 1735-1759页

作者：程叶青胡守庚杨忍陶伟李红波李伯华刘沛林魏峰群郭文唐承财顾康康唐雪琼海南师范大学地理与环境科学学院海口571158 中国地质大学(武汉)公共管理学院武汉430074 中山大学地理科学与规划学院广州510006 华南师范大学地理科学学院广州510631 南京师范大学地理科学学院南京210023 衡阳师范学院地理与旅游学院衡阳421002 长沙学院乡村振兴研究院长沙410022 陕西师范大学地理科学与旅游学院西安710119 南京农业大学人文与社会发展学院南京210095 北京第二外国语学院旅游科学学院北京100024 安徽建筑大学建筑与规划学院合肥230601 西南林业大学园林园艺学院昆明650224

传统村落保护与利用既是实现中国乡村振兴与中国式现代化的重大实践问题,也是地理学、社会学、规划学、经济学等多学科关注和融合交叉研究的热点议题。为系统探索中国传统村落保护与利用的理论认知、政策机制、实践经验和实现路径,特邀... 详细信息

传统村落保护与利用既是实现中国乡村振兴与中国式现代化的重大实践问题,也是地理学、社会学、规划学、经济学等多学科关注和融合交叉研究的热点议题。为系统探索中国传统村落保护与利用的理论认知、政策机制、实践经验和实现路径,特邀传统村落相关研究领域的11位专家开展访谈。访谈主要从政策变迁与典型模式、宏观机制与核心主题、理论认知与实践路径三个视角,以中国传统村落保护与利用的理论认知到具体空间实践为主线,聚焦政策变迁、机制机理、经验模式、村落分类、产业转型、景观保护、有机更新、活态化、价值实现、主体驱动、空间治理和地方性等核心主体及其前沿性理论和实践问题进行深入对话。结合各位专家主要观点,新时期中国传统村落保护与利用需重点关注:(1)面向快速城镇化与现代化冲击的中国传统村落保护与利用的机制体制创新与实现路径。针对中国传统村落面临的现代文明与农耕文明的冲突和面向国家乡村振兴与中国式现代化的重大战略需求,需采用“自上而下”和“自下而上”相结合的方式,构建多元主体参与、农文旅有机融合和全面统筹协调的多元融合机制,通过挖掘传统村落内生增长因素和传统村落历史传承和文脉肌理、发挥村民主体作用、重塑传统村落公共文化空间体系和全方位数字孪生建模等,打造符合现代化发展与生态文明建设的人居环境和协同共建文化图谱。(2)面向乡村振兴与中国式现代化发展的中国传统村落保护与利用的核心主题与具体空间实践。聚焦传统村落分类施策、产业转型、有机更新、景观保护、活态化、价值实现、主体驱动、空间治理和地方性重构等核心主题,强化基于“生计、水、粮食、能源、土地”等关键要素耦合的传统村落划分及分类施策;关注传统村落产业转型时间维度、空间维度和属性维度的意义内涵及影响机制;重点围绕“保护发展对策、改善民生措施、活化利用策略”三大任务推进传统聚落有机更新;重视传统人居文化景观基因保护与内在精神价值挖掘和传统居住空间“活态”保护与利用及传统文化遗产“活化”;关注传统村落活态多样化,推进“共建共治共享”和美乡村建设;重视自然非人类要素和人类作为传统村落空间秩序建构和地方营造的重要作用及其能动性实践;关注传统文化底蕴挖掘和集约高效物质空间、塑造和谐舒适社会空间与保护传承传统文化空间打造;聚焦“生态、文化、主体、产业”等乡村要素,强化生态底色、传承发展地方文化和平衡地方、跨地方主体间的资本优势和地方性嵌入,以实现中国传统村落地方性重构和特色重塑。

关键词：乡村振兴传统村落保护与利用有机更新内生机制地方性重构

Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth

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Science China(life Sciences) 2022年第10期65卷 2017-2030页

作者： Xuan pei kai-Yue li yuan Shen Jin-Tao li Ming-Zhu Lei cai-Yun Fang Hao-Jie Lu Hui-Juan Yang Wenyu Wen Miao Yin Jia Qu Qun-Ying Lei Fudan University Shanghai Cancer Center&Institutes of Biomedical Sciences Cancer InstitutesKey Laboratory of Breast Cancer in ShanghaiShanghai Key Laboratory of Radiation OncologyThe Shanghai Key Laboratory of Medical EpigeneticsShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Gynecological Oncology Fudan University Shanghai Cancer CenterShanghai 200032China State Key Laboratory of Medical Neurobiology Fudan UniversityShanghai 200032China

Epithelial ovarian cancer(EOC) exhibits strong dependency on the tricarboxylic acid(TCA) cycle and oxidative phosphorylation to fuel anabolic ***,we show that malate dehydrogenase 2(MDH2),a key enzyme of the TCA cycle,is palmitoylated at cysteine 138(C138) residue,resulting in increased activity of *** next identify that ZDHHC18 acts as a palmitoyltransferase of *** deprivation enhances MDH2 palmitoylation by increasing the binding between ZDHHC18 and ***2 silencing represses mitochondrial respiration as well as ovarian cancer cell proliferation both in vitro and in ***,re-expression of wild-type MDH2,but not its palmitoylation-deficient C138 S mutant,sustains mitochondrial respiration and restores the growth as well as clonogenic capability of ovarian cancer ***,MDH2 palmitoylation level is elevated in clinical cancer samples from patients with high-grade serous ovarian *** observations suggest that MDH2 palmitoylation catalyzed by ZDHHC18 sustains mitochondrial respiration and promotes the malignancy of ovarian cancer,yielding possibilities of targeting ZDHHC18-mediated MDH2 palmitoylation in the treatment of EOC.

关键词： EOC MDH2 cysteine palmitoylation ZDHHC18 glutamine

Layered barium vanadate nanobelts for high-performance aqueous zinc-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2021年第10期28卷 1684-1692页

作者： Xing-hua Qin Ye-hong Du Peng-chao Zhang Xin-yu Wang qiong-qiong Lu Ai-kai Yang Jun-cai Sun Institute of Materials and Technology Dalian Maritime UniversityDalian 116026China Institute for Complex Materials Leibniz Institute for Solid State and Materials Research(IFW Dresden e.V.HelmholtzstraBe 2001069 DresdenGermany Materials Synthesis and Processing(IEK-1) Institute of Energy and Climate ResearchForschungszentrum Julich GmbH52425 JulichGermany

Aqueous zinc-ion batteries(ZIBs)are deemed as the idea option for large-scale energy storage systems owing to many alluring merits including low manufacture cost,environmental friendliness,and high operations ***,to develop high-performance cathode is still significant for practical application of ***,Ba_(0.23)V_(2)O_(5)·1.1H_(2)O(BaVO)nanobelts were fabricated as cathode materials of ZIBs by a typical hydrothermal synthesis *** from the increased interlayer distance of 1.31 nm by Ba2+ and H2O pre-intercalated,the obtained BaVO nanobelts showed an excellent initial discharge capacity of 378 mAh·g^(-1) at 0.1 A·g^(-1),a great rate performance(e.g.,172 mAh·g^(-1) at 5 A·g^(-1)),and a superior capacity retention(93% after 2000 cycles at 5 A·g^(-1)).

关键词： aqueous zinc-ion batteries barium vanadate nanobelts increased interlayer distance long cycle life

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua cai Wenyong cai Wujun cai Yijian cai Yizhou cai Yuchen cai Haiying cai Huacheng cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-yuan Chen kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu kaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Development and Identification of Introgression lines from Cross of Oryza sativa and Oryza minuta

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Rice science 2013年第2期20卷 95-102页

作者： GUO Si-bin WEI Yu li Xiao-qiong liU kai-qiang HUANG Feng-kuan CHEN cai-hong GAO Guo-qing Rice Research Institute Guangxi Academy of Agricultural Sciences Guangxi Crop Genetic Improvement and Biotechnology Laboratory Plant Protection Research Institute Guangxi Academy of Agricultural Sciences

Introgression line population is effectively used in mapping quantitative trait loci（QTLs）,identifying favorable genes,discovering hidden genetic variation,evaluating the action or interaction of QTLs in multiple conditions and providing the favorable experimental materials for plant breeding and genetic *** this study,an advanced backcross and consecutive selfing strategy was used to develop introgression lines（ILs）,which derived from an accession of Oryza minuta（accession No.101133） with BBCC genome,as the donor,and an elite indica cultivar IR24（***）,as the *** segments from *** were screened using 164 polymorphic simple sequence repeat（SSR） markers in the genome of each *** segments carried by 131 ILs covered the whole *** *** average number of homozygous *** segments per introgression line was about *** average length of introgressed segments was approximate 14.78 cM,and about 79.64% of these segments had sizes less than 20 *** the genome of each introgression line,the *** chromosomal segments harbored chromosomal fragments of *** ranging from 1.15% to 27.6%,with an overall average of 8.57%.At each locus,the ratio of substitution of *** alleles had a range of 1.5% 25.2%,with an average of 8.3%.Based on the evaluation of the phenotype of these ILs,a wide range of alterations in morphological and yield-related traits were *** inoculation,ILs 41,11 and 7 showed high resistance to bacterial blight,brown planthopper and whitebacked planthopper,*** *** ILs will serve as genetic materials for identifying and using favorable genes from ***.

关键词： Oryza sativa Oryza minuta introgression line bacterial blight brown planthopper whitebacked planthopper

Quantum computing and the security of public key cryptography

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Fundamental Research 2021年第1期1卷 85-87页

作者： kai li pei-Gen Yan Qing-Yu cai State Key Laboratory of Magnetic Resonances and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Department of Physics University of New BrunswickFrederictonNew Brunswick E3B 5A3Canada

Compared with electronic computers,quantum parallelism has led to a significant increase in the computing power of quantum ***,the computing power of quantum computers will also be limited by the laws of physics,and hence there is no doubt that the com-puting power of quantum computers is not *** an algorithm,we need to consider both its space complexity and time *** not only requires quantum computers to achieve large-scale integration,but also requires the quantum coherence time to be sufficiently *** either of the above two conditions is not met,the task cannot be com-pleted.

关键词： complexity. quantum hence