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Platelet-based bioactive systems guided precision targeting and immune regulation for cancer therapy

Nano Research 2024年第9期17卷 8269-8284页

作者： Xinyi cai Long Qiu Zhenying Diao Lintao cai Ting Yin Hong Pan Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China School of pharmacy Guangdong Medical UniversityDongguan 523808China Sino-Euro Center of Biomedicine and Health Shenzhen 518024China

The antitumor effects of conventional drug carriers are often attenuated and limited in application by biological barriers associated with tumor heterogeneity and resistance brought about by low tumor *** the rapid development of nanotechnology,naturally derived bioactive materials,and live cell carriers,a promising strategy emerges for targeting the tumor microenvironment(TME)for precision cancer *** unique injury-targeting properties of platelets can significantly extend functional activity,which cannot be achieved with conventional *** this review,three strategies based on platelet-engineered materials are systematically described,namely nanoparticles for platelet membrane camouflage,engineered activated platelets,and targeted-platelets ***-based nanomaterials can effectively coordinate local and distant tumor-host crosstalk with controlled active tumor site recognition and killing effects due to the presence of specific membrane proteins on the surface and the self-secretion of a large number of *** advances in platelets for effectively overcoming biological barriers and reducing immune resistance in cancer immunotherapy applications will be discussed in future clinical *** review provides an overview of recent research advances in platelet-based bioactive material-directed immunotherapy and chemotherapy to inform future antitumor combination therapies.

关键词： platelets bionic targeting immune modulation precision therapy deep penetration

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Optimized silicon fertilization regime weakens cadmium translocation and increases its biotransformation in rice tissues

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The Crop Journal 2024年第4期12卷 1041-1053页

作者： Bogui Pan Yixia cai Kunzheng cai Jihui Tian Wei Wang College of Natural Resources and Environment South China Agricultural UniversityGuangzhou 510642GuangdongChina Guangdong Provincial Key Laboratory of Eco-Circular Agriculture Guangzhou 510642GuangdongChina Key Laboratory of Tropical Agricultural Environment in South China Ministry of Agriculture and Rural AffairsGuangzhou 510642GuangdongChina College of Agriculture South China Agricultural UniversityGuangzhou 510642GuangdongChina

In acidic paddy fields of South China,rice(Oryza sativa L.)faces the dual challenges of cadmium(Cd)toxicity and silicon(Si)*** previous studies have highlighted the functions of Si application timing and strategies in mitigating Cd-stressed rice,the precise mechanisms underlying the health restoration of Cd-toxic rice and the assurance of grain safety remain *** study explored Cd translocation and detoxification in the shoots of rice regulated by various Si fertilization regimes:Si(T)(all Si added before transplanting),Si(J)(all Si added at jointing),and Si(TJ)(half Si added both before transplanting and at jointing).The findings revealed that the regime of Si(TJ)was more beneficial to rice health and grain safety than Si(T)and Si(J).The osmotic regulators such as proline,soluble sugars,and soluble proteins were significantly boosted by Si(TJ)compared to other Si treatments,and which enhanced membrane integrity,balanced intracellular pH,and increased Cd tolerance of ***,Si(TJ)was more effective than Si(T)and Si(J)on the Cd sequestration in the cell wall,Cd bio-passivation,and the down-regulated expression of the Cd transport *** concentrations of Cd in the xylem and phloem treated with Si(TJ)were reduced ***,Si(TJ)facilitated much more Cd bound with the outer layer proteins of grains,and promoted Cd chelation and complexation by phytic acid,phenolics,and ***,Si(TJ)outperformed Si(T)and Si(J)in harmonizing the phycological processes,inhibiting Cd translocation,and enhancing Cd detoxification in rice *** the split Si application strategy offers potential for reducing Cd toxicity in rice grain.

关键词： Cadmium Silicon Growth stages Translocation and accumulation Rice Safe production

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Novel method for measuring surface residual stress using flat-ended cylindrical indentation

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Chinese Journal of Aeronautics 2024年第8期37卷 486-495页

作者： Guangzhao HAN Lixun cai Xiaokun LIU Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province School of Mechanics and Aerospace EngineeringSouthwest Jiaotong UniversityChengdu 610031China Zhengzhou Machinery Research Institute Transmission Technology Co. LtdZhengzhou 518115China

Instrumented indentation is a promising technique for estimating surface residual stresses and mechanical properties in engineering *** relative difference between the indentation loads for unstressed and stressed specimens was selected as the key parameter for measuring surface residual stresses in flat-ended cylindrical *** on the equivalent material method and finite element simulations,a dimensionless mapping model with six constants was established between the relative load difference,constitutive model parameters,and normalized residual stress.A novel method for measuring the surface residual stress and constitutive model parameters of metallic material through flat-ended cylindrical indentations was proposed using this model and a mechanical properties determination *** simulations were conducted using numerous elastoplastic materials with different residual stresses to verify the proposed model;good agreements were observed between the predicted residual stresses and those previously applied in finite element ***-ended cylindrical indentation tests were performed on four metallic materials using cruciform specimens subjected to various equibiaxial *** results exhibited good conformance between the stress–strain curves obtained using the proposed method and those from traditional tensile tests,and the absolute differences between the predicted residual stresses and applied stresses were within 40 MPa in most cases.

关键词： Instrumented indentation Residual stress Finite element simulation Equivalent material method Mechanical property

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Pathway Planning of Nuclear Power Development Incorporating Assessment of Nuclear Event Risk

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 500-513页

作者： Xinxin Yang Yusheng Xue Bin cai School of Electrical Engineering Southeast UniversityNanjingChinaand they are also with State Grid Electric Power Research Institute(NARI Group Corporation)NanjingChina State Key Laboratory of Smart Grid Protection and Operation Control NanjingChina State Grid Electric Power Research Institute(NARI Group Corporation) NanjingChina

The nuclear event risk(NER)is an important and disputed factor that should be reasonably considered when planning the pathway of nuclear power development(NPD)to assess the benefits and risks of developing nuclear power more *** paper aims to explore the impact of nuclear events on NPD pathway *** influence of nuclear events is quantified as a monetary risk component,and an optimization model that incorporates the NER in the objective function is *** optimize the pathway of NPD in the lowcarbon transition course of power supply structure evolution,a simulation model is built to deduce alternative NPD pathways and corresponding power supply evolution scenarios under the constraint of an exogenously assigned carbon emission pathway(CEP);moreover,a method is proposed to describe the CEP by superimposing the maximum carbon emission space and each carbon emission reduction(CER)component,and various CER components are clustered considering the emission reduction characteristics and resource endowments of different power generation technologies.A case study is conducted to explore the impact of NER and its risk valuation uncertainty on NPD pathway *** method presented in this paper allows the impact of nuclear events on NPD pathway planning to be quantified and improves the level of coordinated optimization of benefits and risks.

关键词： Low-carbon transition power supply structure evolution nuclear power development(NPD) quantitative analysis nuclear event risk evaluation

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Optimization of resource allocation in FDD massive MIMO systems

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Digital Communications and Networks 2024年第1期10卷 117-125页

作者： Jun cai Chuan Yin Youwei Ding School of Artificial Intelligence and Information Technology Nanjing University of Chinese MedicineNanjing 210046China School of Electronic and Information Hangzhou Dianzi UniversityHangzhou 310018ZhejiangChina

The performance of massive MIMO systems relies heavily on the availability of Channel State Information at the Transmitter(CSIT).A large amount of work has been devoted to reducing the CSIT acquisition overhead at the pilot training and/or CsI feedback *** fact,the downlink communication generally includes three stages,i.e.,pilot training,CsI feedback,and data *** three stages are mutually related and jointly determine the overall system ***,there exist few studies on the reduction of csIT acquisition overhead from the global point of *** this paper,we integrate the Minimum Mean Square Error(MMSE)channel estimation,Random Vector Quantization(RVQ)based limited feedback and Maximal Ratio Combining(MRC)precoding into a unified framework for investigating the resource allocation *** particular,we first approximate the covariance matrix of the quantization error with a simple expression and derive an analytical expression of the received Signal-to-Noise Ratio(SNR)based on the deterministic equivalence *** the three performance metrics(the spectral efficiency,energy efficiency,and total energy consumption)oriented problems are formulated *** practical system requirements,these three metrics can be collaboratively ***,we propose an optimization solver to derive the optimal partition of channel coherence *** results verify the benefits of the proposed resource allocation schemes under three different scenarios and illustrate the tradeoff of resource allocation between three stages.

关键词： Massive MIMO FDD CSIT Resource allocation

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Value Iteration-Based Cooperative Adaptive Optimal Control for Multi-Player Differential Games With Incomplete Information

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 690-697页

作者： Yun Zhang Lulu Zhang Yunze cai the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240 the Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai 200240China

This paper presents a novel cooperative value iteration(VI)-based adaptive dynamic programming method for multi-player differential game models with a convergence *** players are divided into two groups in the learning process and adapt their policies *** method removes the dependence of admissible initial policies,which is one of the main drawbacks of the PI-based ***,this algorithm enables the players to adapt their control policies without full knowledge of others’ system parameters or control *** efficacy of our method is illustrated by three examples.

关键词： Adaptive dynamic programming incomplete information multi-player differential game value iteration

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Segment-wise learning control for trajectory tracking of robot manipulators under iteration-dependent periods

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Science China(Information Sciences) 2024年第3期67卷 155-166页

作者： Fan ZHANG Deyuan MENG Kaiquan cai The Seventh Research Division Beihang University School of Automation Science and Electrical Engineering Beihang University School of Electronics and Information Engineering Beihang University

This paper is concerned with the amplitude boundedness problem of adaptive iterative learning control(AILC) for robot manipulators operating with iteration-dependent periods. By introducing virtual memory slots for storing historical data, a practical AILC method is proposed to achieve the segmentwise learning. This method requires less memory storage for historical information of previous iterations,especially in comparison with that of the conventional AILC methods using point-wise learning *** is shown that not only the energy boundedness but also the amplitude boundedness of estimates and inputs of practical AILC can be guaranteed. Moreover, the practical AILC method can achieve the perfect tracking objective regardless of iteration-dependent periods when the robot manipulators have a persistent full learning property. In addition, a solution to the visual manipulator platform is provided and deployed based on Coppeliasim and Matlab, which helps to show the amplitude boundedness of learning results and the perfect tracking performances of the proposed practical AILC method for robot manipulators.

关键词： amplitude boundedness iteration-dependent period iterative learning control robot manipulator segment-wise virtual memory slot

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Reveal the lost entanglement for accelerated atoms in the high-dimensional spacetime

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 48-57页

作者： Jiatong Yan Baocheng Zhang Qingyu cai School of Mathematics and Physics China University of GeosciencesWuhan 430074China Physics Department Brown UniversityProvidenceRhode Island 02912USA Center for Theoretical Physics Hainan UniversityHaikou 570228China School of Information and Communication Engineering Hainan UniversityHaikou 570228China Peng Huanwu Center for Fundamental Theory Hefei 230026China

When atoms are accelerated in the vacuum,entanglement among atoms will degrade compared with the initial situation before the *** this study,we propose a novel and interesting view that the lost entanglement can be recovered completely when the high-dimensional spacetime is exploited,in the case that the acceleration is not too large,since the entanglement loss rate caused by the large acceleration is faster than the recovery *** also calculate the entanglement change caused by the anti-Unruh effect and found that the lost entanglement could just be recovered part by the anti-Unruh effect,and the anti-Unruh effect could only appear for a finite range of acceleration when the interaction time scale is approximately shorter than the reciprocal of the energy gap in two dimensional *** limit case of zero acceleration is also investigated,which gives an analytical interpretation for the increase or recovery of entanglement.

关键词： entanglement acceleration high-dimensional spacetime

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Defect engineering on constructing surface active sites in catalysts for environment and energy applications

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 11-32页

作者： Yawen cai Baowei Hu Xiangke Wang School of Life Science Shaoxing UniversityShaoxing 312000China College of Environmental Science and Engineering North China Electric Power UniversityBeijing 102206China

The precise engineering of surface active sites is deemed as an efficient protocol for regulating surfaces and catalytic properties of *** engineering is the most feasible option to modulate the surface active sites of *** specific active sites on the catalyst allows precise modulation of its electronic structure and physicochemical ***,we outlined the engineering of several types of defects,including vacancy defects,void defects,dopant-related defects,and defect-based single atomic *** overview of progress in fabricating structural defects on catalysts via de novo synthesis or post-synthetic modification was ***,the applications of the well-designed defective catalysts in energy conversion and environmental remediation were carefully ***,current challenges in the precise construction of active defect sites on the catalyst and future perspectives for the development directions of precisely controlled synthesis of defective catalysts were also proposed.

关键词： defect engineering vacancy void defects doping single atomic sites

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Comprehensive analysis of clinical and biological value of ING family genes in liver cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2592-2609页

作者： Shi-cai Liu School of Medical Information Wannan Medical CollegeWuhu 241002Anhui ProvinceChina

BACKGROUND Liver cancer(LIHC)is a malignant tumor that occurs in the liver and has a high mortality in *** ING family genes were identified as tumor suppressor *** expression of these genes can lead to cell cycle arrest,senescence and/or *** family genes are promising targets for anticancer ***,their role in LIHC is still not well *** To have a better understanding of the important roles of ING family members in *** A series of bioinformatics approaches(including gene expression analysis,genetic alteration analysis,survival analysis,immune infiltration analysis,prediction of upstream microRNAs(miRNAs)and long noncoding RNAs(lncRNAs)of ING1,and ING1-related gene functional enrichment analysis)was applied to study the expression profile,clinical relationship,prognostic significance and immune infiltration of ING in *** relationship between ING family genes expression and tumor associated immune checkpoints was investigated in *** molecular mechanism of ING1 mediated hepatocarcinogenesis was preliminarily *** mRNA/protein expression of different ING family genes in LIHC was analyzed in different databases,showing that ING family genes were highly expressed in *** 47 samples from 366 LIHC patients,the ING family genes were altered at a rate of 13%.By comprehensively analyzing the expression,clinical pathological parameters and prognostic value of ING family genes,ING1/5 was ***1/5 was related to poor prognosis of LIHC,suggesting that they may play key roles in LIHC tumorigenesis and *** of the target miRNAs of ING1 was identified as *** upstream lncRNAs of hsa-miR-214-3p,U91328.1,and HCG17,were *** the same time,we found that the expression of ING family genes was correlated with immune cell infiltration and immune checkpoint *** This study lays a foundation for further research on the potential mechanism and clinical v

关键词： Liver cancer ING family genes Noncoding RNAs Immune cell infiltration Prognosis

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