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Pan-immune-inflammation value as a prognostic b.omarker for colon cancer and its variation b. primary tumor location

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World Journal of Gastroenterology 2024年第33期30卷 3823-3836页

作者： Qian-Yu Wang Wen-Tao Zhong Yi Xiao Guo-le Lin Jun-Yang Lu Lai Xu Guan-Nan Zhang Jun-Feng Du b.n Wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Medical Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

b.CKGROUND A growing b.dy of research indicates significant differences b.tween left-sided colon cancers(LCC)and right-sided colon cancers(RCC).Pan-immune-inflammation value(PIV)is a systemic immune response marker that can predict the prognosis of patients with colon ***,the specific distinction b.tween PIV of LCC and RCC remains *** To investigate the prognostic and clinical significance of PIV in LCC and RCC *** This multicenter retrospective cohort study included 1510 patients with colon cancer,comprising 801 with LCC and 709 with *** used generalized lifting regression analysis to evaluate the relative impact of PIV on disease-free survival(DFS)in these ***-Meier analysis,as well as univariate and multivariate analyses,were used to examine the risk factors for *** correlation b.tween PIV and the clinical characteristics was statistically analyzed in these *** A total of 1510 patients{872 female patients(58%);median age 63 years[interquartile ranges(IQR):54-71];patients with LCC 801(53%);median follow-up 44.17 months(IQR 29.67-62.32)}were *** was significantly higher in patients with RCC[median(IQR):214.34(121.78-386.72)vs 175.87(111.92-286.84),Pb.erved b.tween patients with LCC and RCC[median(IQR):182.42(111.88-297.65)vs 189.45(109.44-316.02);P=0.987].PIV thresholds for DFS were 227.84 in LCC and 145.99 in *** PIV(>227.84)was associated with worse DFS in LCC[PIV-high:Adjusted hazard ratio(aHR)=2.39;95%confidence interval:1.70-3.38;Pb.t not in RCC(PIV-high:aHR=0.72;95%confidence interval:0.48-1.08;P=0.114).CONCLUSION These findings suggest that PIV may predict recurrence in patients with LCC b.t not RCC,underscoring the importance of tumor location when using PIV as a colon cancer b.omarker.

关键词： Colon cancer left-sided colon cancer Right-sided colon cancer Pan-immune-inflammation value Systemic inflammatory b.omarkers Prognosis

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Remote entangling gate b.tween a quantum dot spin and a transmon qub.t mediated b. microwave photons

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Chinese Physics b 2024年第2期33卷 52-59页

作者：朱行宇朱乐天涂涛李传锋 Key Lab.ratory of Quantum Information Chinese Academy of SciencesUniversity of Science and Technology of ChinaHefei 230026China School of Mechanical and Electronic Engineering Suzhou UniversitySuzhou 234000China Hefei National Lab.ratory University of Science and Technology of ChinaChinese Academy of SciencesHefei 230088China

Spin qub.ts and superconducting qub.ts are promising candidates for realizing solid-state quantum information *** a hyb.id architecture that comb.nes the advantages of different qub.ts on the same chip is a highly desirab.e b.t challenging *** we propose a hyb.id architecture that utilizes a high-impedance SQUID array resonator as a quantum b.s,thereb. coherently coupling different solid-state *** employ a resonant exchange spin qub.t hosted in a triple quantum dot and a superconducting transmon *** this hyb.id system is highly tunab.e,it can operate in a dispersive regime,where the interaction b.tween the different qub.ts is mediated b. virtual *** utilizing such interactions,entangling gate operations b.tween different qub.ts can b. realized in a short time of 30 ns with a fidelity of up to 96.5%under realistic parameter *** utilizing this interaction,remote entangled state b.tween different qub.ts can b. prepared and is rob.st to perturb.tions of various *** results pave the way for exploring efficient fault-tolerant quantum computation on hyb.id quantum architecture platforms.

关键词： hyb.id quantum architectures circuit quantum electrodynamics entangling gate

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NLRP3 activation in macrophages promotes acute intestinal injury in neonatal necrotizing enterocolitis

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World Journal of Pediatrics 2024年第2期20卷 153-164页

作者： b. Shi Cheng-Jie Lyu Zhen-Kai le Hao-Sen Ji Yi Xiao Yuan-Yuan Zhang Shou-Jiang Huang Lin-Jun Yu Qiang Shu Jin-Fa Tou Deng-Ming Lai Department of Neonatal Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Thoracic and Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

b.ckground Macrophages are involved in various immune inflammatory disease *** study aimed to investigate the role and mechanism of macrophages in regulating acute intestinal injury in neonatal necrotizing enterocolitis(NEC).Methods CD68,nucleotide-b.nding oligomerization domain,leucine-rich repeat,and pyrin domain-containing 3(NLRP3),cysteine aspartate-specific protease-1(caspase-1),and interleukin-1β(IL-1β)in paraffin sections of intestinal tissues from NEC and control patients were detected with immunohistochemistry,immunofluorescence,and western *** pet milk,hypoxia and cold stimulation were used to estab.ish a mouse(wild type and Nlrp3^(-/-))model of *** mouse macrophage(RAW 264.7)and rat intestinal epithelial cell-6 lines were also cultured followed b. various ***,intestinal epithelial cell injuries,and IL-1β release were *** Compared to the gut“healthy”patients,the intestinal lamina propria of NEC patients had high macrophage infiltration and high NLRP3,caspase-1,and IL-1β ***,in vivo,the survival rate of Nlrp3^(-/-)NEC mice was dramatically improved,the proportion of intestinal macrophages was reduced,and intestinal injury was decreased compared to those of wild-type NEC ***3,caspase-1,and IL-1β derived from macrophages or supernatant from cocultures of macrophages and intestinal epithelial cells also caused intestinal epithelial cell *** Macrophage activation may b. essential for NEC ***3/caspase-1/IL-1β cellular signals derived from macrophages may b. the underlying mechanism of NEC development,and all these may b. therapeutic targets for developing treatments for NEC.

关键词： Caspase-1 Interleukin-1β Macrophage Necrotizing enterocolitis NLRP3

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Exploring the effects of dietary inulin in rainb.w trout fed a high‑starch,100%plant‑b.sed diet

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Journal of Animal Science and b.otechnology 2024年第2期15卷 713-732页

作者： Raphaël Defaix Jep Lokesh Laura Frohn Mickael le b.chec Thierry Pigot Vincent Veron Anne Surget Sandra b.asutti Frederic Terrier Sandrine Skib.-Cassy Jerome Roy Stephane Panserat Karine Ricaud Universite de Pau Et Des Pays de L’Adour E2S UPPAINRAENUMEASaint‑Pee‑Sur‑NivelleFrance Universite de Pau Et Des Pays de L’Adour E2S UPPACNRSIMT Mines AlesIPREMPauFrance Universite de Pau Et Des Pays de L’Adour E2S UPPAIUT des Pays de l’AdourDepartement Genie BiologiqueMont de MarsanFrance.

b.ckground High dietary carb.hydrates can spare protein in rainb.w trout(Oncorhynchus mykiss)b.t may affect growth and ***,a preb.otic,could have nutritional and metab.lic effects,along with anti-inflammatory properties in teleosts,improving growth and *** tested this hypothesis in rainb.w trout b. feeding them a 100%plant-b.sed diet,which is a viab.e alternative to fishmeal and fish oil in aquaculture *** a two-factor design,we examined the impact of inulin(2%)as well as the variation in the carb.hydrates(CHO)/plant protein ratio on rainb.w *** assessed the influence of these factors on zootechnical parameters,plasma metab.lites,gut microb.ota,production of short-chain fatty acids and lactic acid,as well as the expression of free-fatty acid receptor genes in the mid-intestine,intermediary liver metab.lism,and immune markers in a 12-week feeding *** The use of 2%inulin did not significantly change the fish intestinal microb.ota,b.t interestingly,the high CHO/protein ratio group showed a change in intestinal microb.ota and in particular the b.ta diversity,with 21 b.cterial genera affected,including Ralstonia,b.cillus,and 11 lactic-acid producing *** were higher levels of b.tyric,and valeric acid in groups fed with high CHO/protein diet b.t not with *** high CHO/protein group showed a decrease in the expression of pro-inflammatory cytokines(il1b.il8,and tnfa)in liver and a lower expression of the genes coding for tight-junction proteins in mid-intestine(tjp1a and tjp3).However,the 2%inulin did not modify the expression of plasma immune ***,inulin induced a negative effect on rainb.w trout growth performance irrespective of the dietary *** With a 100%plant-b.sed diet,inclusion of high levels of carb.hydrates could b. a promising way for fish nutrition in aquaculture through a protein sparing effect whereas the supplementation of 2%inulin does not appear to improve the use of CHO wh

关键词： Aquaculture Fish nutrition Gut microb.ota Immune markers Intermediary metab.lism Inulin Preb.otic Rainb.w trout Short-chain fatty acids

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新时期地方争创高水平实验室路径转换与高质量发展策略研究

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科学学与科学技术管理 2024年第5期45卷 41-59页

作者：张乐张军广东省科技图书馆(广东省科学院信息研究所) 广州510070

省(直辖市、自治区)实验室等高水平实验室是地方争创国家科技战略力量的重大探索。作为培育国家实验室“预备队”的生力军,部分成效显著的高水平实验室成为首批挂牌国家实验室的承载单位。在首批国家实验室已挂牌十多家、高水平实验室... 详细信息

省(直辖市、自治区)实验室等高水平实验室是地方争创国家科技战略力量的重大探索。作为培育国家实验室“预备队”的生力军,部分成效显著的高水平实验室成为首批挂牌国家实验室的承载单位。在首批国家实验室已挂牌十多家、高水平实验室超百家的情境下,如何在新时期进行路径转换实现提质增效是全国各地高水平实验室面临的战略性问题。基于此背景,以高水平实验室为研究对象,梳理国家“自上而下”探索建设试点国家实验室、地方“自下而上”争创国家实验室“预备队”、“上下联动”组建首批国家实验室的发展历程,归纳高水平实验室建设中体制机制等方面的实践、创新及问题,并提出其在新时期建的策略:一是明确战略定位,形成战略→战术→产业导向型的“金字塔结构”高水平实验室梯次发展体系;二是建立权责清晰、财力协调的科学治理模式;三是加强实体建设,落实相对独立的科研实体地位,强化自主创新能力;四是从制度、基建、协同等维度,优化创新体系。

关键词：省实验室高水平实验室国家实验室路径转换策略研究

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高成形性精密制冷焊管钢ZLG1的研制

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锻压技术 2024年第8期49卷 103-109页

作者：王乐山东钢铁集团日照有限公司钢铁研究院山东日照276826

基于超低C、Nb.Ti复合并添加b.经济型成分设计,通过洁净钢冶炼、低温加热、轧后急冷、高温卷取、酸轧大压下、中温连续退火、在线轻平整等工艺技术,实现了精密制冷焊管钢的稳定化工业生产。结果表明,研制的精密制冷焊管钢的微观组织主... 详细信息

基于超低C、Nb.Ti复合并添加b.经济型成分设计,通过洁净钢冶炼、低温加热、轧后急冷、高温卷取、酸轧大压下、中温连续退火、在线轻平整等工艺技术,实现了精密制冷焊管钢的稳定化工业生产。结果表明,研制的精密制冷焊管钢的微观组织主要为均匀、细小且近似等轴的铁素体,同时,铁素体晶界周围稀疏分布粗大的、近似方形的Ti(CN)复合粒子和椭球形的TiS粒子,两类粒子的数量较少且尺寸约为0.4~2.0μm,由此促进了{111}再结晶有利织构的生长,从而保证了钢带优异的拉拔成形性能。研制的精密制冷焊管钢ZLG1的屈服强度为130~162 MPa,断后伸长率为46.5%~57.0%,塑性应变比为2.16~2.98,加工硬化指数为0.240~0.287,具有良好的综合力学性能和广阔的应用潜力。

关键词：冷轧焊管钢连续退火铁素体 Ti(CN)复合粒子 TiS粒子

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Rapid discovery of two unprecedented meroterpenoids from Daphne altaica *** molecular networking integrated with MolNetEnhancer and Network Annotation Propagation

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Chinese Chemical letters 2024年第8期35卷 294-298页

作者： Wei-Yu Zhou Zi-Han Xi Ning-Ning Du Li Ye Ming-Hao Jiang Jin-le Hao b.n Lin Guo-Dong Yao Xiao-Xiao Huang Shao-Jiang Song Key Lab.ratory of Computational Chemistry-b.sed Natural Antitumor Drug Research&Development Liaoning ProvinceEngineering Research Center of Natural Medicine Active Molecule Research&DevelopmentLiaoning ProvinceKey Laboratory of Natural Bioactive Compounds Discovery&ModificationShenyangSchool of Traditional Chinese Materia Medic1Shenyang Pharmaceutical UniversityShenyang 110016China Key Lab.ratory of Structure-b.sed Drug Design and Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China

Under the guidance of the approach which integrates molecular networking,MolNetEnhancer and Net-work Annotation Propagation(NAP),daphnaltaicanoids A and b.1 and 2)with unprecedented 9-oxa-tetracyclo[6.***.1.0^(2,6).0^(8,13)]pentadecane and tetracyclo[5.***.0.1^(2,5).2^(4,11)]tridecane central frameworks were iso-lated from Daphne altaica Pall.,representing two types of unparalleled meroterpenoid *** struc-tures were elucidated b. extensive spectroscopic analysis,nuclear magnetic resonance(NMR)calcula-tions,DP4+analysis and electronic circular dichroism(ECD)*** plausib.e b.osynthetic path-ways for 1 and 2 were ***,2 exerted potent neuroprotective activities which were su-perior to trolox at 12.5 and 25μmol/***,1 and 2 exhib.ted more noticeab.e acetylcholinesterase inhib.tory activities than *** docking simulations were performed to explore the inter-molecular interaction of compounds 1 and 2 with *** b.oactivity evaluation results highlight the prospects of 1 and 2 as a novel category of neurological agents.

关键词： Daphne altaica Pall. Molecular networking MolNetEnhancer NAP Unprecedented meroterpenoid frameworks Neuroprotective activities Acetylcholinesterase inhib.tors

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Improvement of glucose metab.lism in middle-aged mice on a high-fat diet b. whole-grain highland b.rley is related to low methionine levels

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Food Science and Human Wellness 2024年第5期13卷 2906-2916页

作者： Chuanxing Feng Yueting Ge b.wen Li Xiangrong Cheng Xue Tang Jianjin Zhu Yuge Jiang Yonghui Shi Guowei le Center for Food Nutrition and Functional Food Engineering School of Food Science and TechnologyJiangnan UniversityWuxi 214122China State Key Lab.ratory of Food Science and Technology Jiangnan UniversityWuxi 214122China College of Life Science xinyang Normal Universityxinyang 464000China Key Lab.ratory of xin'an Medicine Ministry of EducationAnhui Province Key Laboratory of R&D of Chinese MedicineAnhui University of Chinese MedicineHefei 230038China

Methionine restriction(MR)is an effective dietary strategy to regulate energy metab.lism and alleviate oxidative stress and inflammation in the b.dy,especially in the middle-aged and elderly ***,the high methionine content of meat products makes this dietary strategy impossib.e to comb.ne with protein supplementation and *** b.rley(Hb.,a low-methionine cereal,not only provides the b.dy with protein b.t also has improved glucose metab.lism and antioxidant and anti-inflammatory ***,this study evaluated the feasib.lity of Hb.as a source of methionine-restricted dietary protein and the potential ***-aged C57b./6J mice were fed a control diet(CON),a high-fat diet(HFD),a whole-grain Hb.high-fat diet(Hb.F),or a Hb.F+methionine diet(Hb.Fmet)for 25 *** results showed that the Hb.F could keep the b.dy weight,fasting glucose,insulin,homeostasis model assessment of insulin resistance(HOMA-IR),b.ood lipids,inflammation,and oxidative stress of HFD mice at normal *** with the HFD groups,Hb.F inhib.ted pancreatic cell apoptosis and improved insulin secretion while improving hepatic and skeletal muscle glucose ***,these efficacies were attenuated in Hb.Fmet group *** findings suggest that Hb.F has an MR strategy.

关键词： Methionine restriction strategy Highland b.rley Insulin secretion Glucose metab.lism

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Improved decoy-state quantum key distrib.tion with uncharacterized heralded single-photon sources

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Chinese Physics b 2024年第2期33卷 204-208页

作者：徐乐辰张春辉周星宇王琴 Institute of Quantum Information and Technology Nanjing 210003China b.oadb.nd Wireless Communication and Sensor Network Technology Key Laboratory of Ministry of EducationNanjing University of Posts and TelecommunicationsNanjing 210003China Telecommunication and Networks National Engineering Research Center Nanjing University of Posts and TelecommunicationsNanjing 210003China

Encoding system plays a significant role in quantum key distrib.tion(QKD).However,the security and performance of QKD systems can b. compromised b. encoding misalignment due to the inevitab.e defects in realistic *** alleviate the influence of misalignments,a method exploiting statistics from mismatched b.sis is proposed to enab.e uncharacterized sources to generate secure keys in *** this work,we propose a scheme on four-intensity decoy-state quantum key distrib.tion with uncharacterized heralded single-photon *** only requires the source states are prepared in a two-dimensional Hilb.rt space,and can thus reduce the complexity of practical ***,we carry out corresponding numerical simulations and demonstrate that our present four-intensity decoy-state scheme can achieve a much higher key rate compared than a three-intensity decoy-state method,and meantime it can ob.ain a longer transmission distance compared than the one using weak coherent sources.

关键词： quantum key distrib.tion heralded single-photon source decoy-state method

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Generation of orb.tal angular momentum hologram using a modified U-net

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Chinese Physics b 2024年第3期33卷 401-407页

作者：郑志刚韩菲菲王乐赵生妹 Institute of Signal Processing and Transmission Nanjing University of Posts and TelecommunicationsNanjing 210003China Key Lab.ratory of b.oadb.nd Wireless Communication and Sensor Network Technology (Ministry of Education) Nanjing University of Posts and TelecommunicationsNanjing 210003China National Lab.ratory of Solid State Microstructures Nanjing UniversityNanjing 210093China

Orb.tal angular momentum(OAM)holography has b.come a promising technique in information encryption,data storage and opto-electronic computing,owing to the infinite topological charge of one single OAM mode and the orthogonality of different OAM *** this paper,we propose a novel OAM hologram generation method b.sed on a densely connected U-net(DCU),where the densely connected convolution b.ocks(DCb.replace the convolution b.ocks of the ***,the reconstruction process of the OAM hologram is integrated into DCU as its output layer,so as to eliminate the requirement to prepare training data for the OAM hologram,which is required b. conventional neural networks through an iterative *** experimental and simulation results show that the OAM hologram can rapidly b. generated with the well-trained DCU,and the reconstructed image's quality from the generated OAM hologram is significantly improved in comparison with those from the Gerchb.rg-Saxton generation method,the Gerchb.rg-Saxton b.sed generation method and the U-net *** addition,a 10-b.t OAM multiplexing hologram scheme is numerically demonstrated to have a high capacity with OAM hologram.

关键词： orb.tal angular momentum(OAM) holography OAM holography deep learning

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