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Presynaptic endoplasmic reticulum architecture and hereditary spastic paraplegia

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Neural Regeneration Research 2024年第3期19卷 485-486页

作者： Juan JoséPérez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary spastic paraplegia(HSP)is a clinically and genetically heterogeneous neurodegenerative disorder,characterized primarily by progressive spasticity and weakness in the lower *** ients can also experience peripheral neuropathy,cognitive impairment,and other neurological *** date,more than 80 genes have been implicated in HSP,encompassing various cellular components,although mutations in genes encoding endoplasmic reticulum(ER)-shaping proteins are the most prevalent(Parodi et al.,2017).ER-shaping proteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autophagy,lipid droplet synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the complexity of studying the role of these proteins and the link between ER function and HSP.

关键词： reticulum endoplasmic

Non-participation of asymptomatic candidates in screening protocols reduces early diagnosis and worsens prognosis of colorectal cancer

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World Journal of Gastroenterology 2024年第26期30卷 3198-3200页

作者： Sergio Pérez-Holanda Office of Regional Viceministry of Health Regional Viceministry of HealthOviedo 33005AsturiasSpain

The Agatsuma et al’s study shows that despite the evidence of the benefits of an early colorectal cancer(CRC)diagnosis,through screening in asymptomatic subjects,up to 50%of candidates reject this option and many of those affected are diagnosed later,in advanced *** efficacy of screening programs has been well-established for several years,which reduces the risk of CRC morbidity and mortality,without taking into account the test used for screening,or other ***,a significant proportion of patients remain unscreened,so understanding the factors involved,as well as the barriers of the population to adherence is the first step to possibly modify the participation *** barriers could include a full range of social and political aspects,especially the type of financial provision of each health *** Japan,health services are universal,and this advantageous situation makes it easier for citizens to access to these services,contributing to the detection of various diseases,including ***,the symptomatic CRC group had a lower early-stage diagnosis rate than the patients detected during follow-up for other comorbidities,and symptomatic and cancer screening groups showed similar early-stage diagnosis.

关键词： Colorectal neoplasms cancer registry Diagnostic route cancer screening Stage at diagnosis

An Adaptive Data-driven Method Based on Fuzzy Logic for Determining Power System Voltage Status

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 707-718页

作者： Sirwan Shazdeh Hêmin Golpîra Hassan Bevrani the SMGRC University of KurdistanSanandajIran Power Systems Modeling&Simulation Lab Department of Electrical EngineeringUniversity of KurdistanKurdistanSanandaj 66177-15175Iran

This paper proposes an adaptive method based on fuzzy logic that utilizes data from phasor measurement units(PMUs) to assess and classify generating-side voltage trajectories. The voltage variable and its associated derivatives are used as the input variables of a fuzzy-logic block. In addition, the voltage trajectory is compared with the pre-selected pilot-bus voltage to make a reliable decision about the voltage operational state. Different types of short-term voltage dynamics are considered in the proposed method. The fuzzy membership functions are determined using a systematic method that considers the current situation of the voltage trajectory. Finally, the voltage status is categorized into four classes to determine appropriate remedial actions. The proposed method is validated on a IEEE 73-bus power system in a MATLAB environment.

关键词： Fuzzy logic fault-induced delayed voltage recovery phasor measurement unit(PMU) short-term voltage stability situational awareness voltage classification

calibration of the DEM sliding friction and rolling friction parameters of a cohesionless bulk material

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Particuology 2024年第9期92卷 126-139页

作者： Jonatan Marín Pérez Tugrul Comlekci Yevgen Gorash Donald MacKenzie University of Strathclyde 75 Montrose StreetG11XJGlasgowUnited Kingdom

The discrete element method(DEM)has become a valuable tool for understanding the mechanical behaviour of granular assemblies,however,the accuracy of the DEM simulations depends on several interaction parameters such as the sliding friction and rolling friction ***,these parameters are estimated using bulk calibration approach(Bca)where the draw down test has been suggested as an effective way to approach these *** test provides up to four bulk criteria,the angle of repose,shear angle,mass flow rate and the mass loss which are used to narrow down the possible ***,there is still more research needed around it to fully understand how this methodology *** experimental and numerical study was carried out using the draw down test to assess the influence of different mass flow rates and particle shapes on DEM parameters for a cohesionless bulk *** is concluded that use of multi-sphere particles and three aperture sizes in the draw down test to calibrate the sliding and rolling friction parameters of a cohesionless bulk material can converge to a small feasible region in which a single combination of the friction coefficients can be *** calibrated sliding and rolling friction coefficients were validated using multi-sphere particles,where the maximum deviation was 5.9%from the experimental values.

关键词： Discrete element method calibration Draw down Sliding friction Rolling friction Particle shape

Navigating the controversy regarding antibiotic prophylaxis in acute variceal bleeding

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World Journal of Gastroenterology 2024年第18期30卷 2485-2487页

作者： David Aguirre-Villarreal Ignacio García-Juárez Department of Gastroenterology and Liver Transplant Unit Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico

Antibiotic prophylaxis in patients with cirrhosis and acute variceal bleeding is part of the standard of care according to most clinical ***,with recent evidence arguing against antibiotic prophylaxis,the role of this... 详细信息

关键词： Cirrhosis Acute variceal bleeding Antibiotic prophylaxis Endoscopic band ligation Spontaneous bacterial peritonitis

HVSR analysis of pumice sands for sediment depth characterization:A case study for Guadalajara,Mexico

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 577-591页

作者： Hafid Salgado M. Alejandro ramírez-Gaytan Adolfo Preciado Christian R.Escudero Departamento de Ciencias Exactas Centro Universitario de la CostaUniversidad de GuadalajaraCP.48280 Puerto VallartaJaliscoMéxico Departamento de Ciencias Computacionales Centro Universitario de Ciencias Exactas e IngenieríaUniversidad de GuadalajaraCP.44430 GuadalajaraJaliscoMéxico Departamento del Hábitat y Desarrollo Urbano Instituto Tecnológico y de Estudios Superiores de Occidente(ITESO)CP.45604 TlaquepaqueMéxico

The horizontal to vertical spectral ratio(HVSR)methodology is used here to characterize pumice soils and to image the three-dimensional surface geometry of Guadalajara,*** to other Latin American cities,Guadalajara is exposed to high seismic risk,with the particularity of being the largest urban settlement in Latin America built on pumice *** has not yet been tested to characterize subsoil depths in pumice *** to the questionable use of traditional geotechnical tests for the analysis of pumice soils,HVSR provides an alternative for its characterization without altering its fragile and porous *** this work,resonance frequency(F0)and peak amplitude(A0)are used to constrain the depth of the major impedance contrast that represents the interface between bedrock and pumice *** were compared with borehole depths and other available geotechnical and geophysical data and show good *** of the profiles estimated on the riverbanks that cross the city,reveals different subsoil thickness that could have an impact on different site responses on riverine areas to an eventual *** and academic efforts are combined in this work to characterize depth sediments,an important parameter that impacts the regulations for construction in the city.

关键词： subsoil of Guadalajara shallow soil thickness bedrock depth pumice soil characterization

Development and Optimization of Universal Bone Conduction Hearing Spectacles

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第5期13卷 344-358页

作者： Johannes Burkart Mona Kirstin Fehling Saadu Adamu raúl Pérez ramos Daniel Häussler Department of Otorhinolaryngology Head and Neck Surgery University Hospital Mannheim Mannheim Germany National Ear care Centre Kaduna Nigeria School of Advanced Education Research and Accreditation University Isabel I Castelln de la Plana Spain

Background: Non-implantable bone anchored hearing devices (BCHDs) are utilized for patients with conductive or mixed hearing loss who are unsuitable for conventional hearing aids or have unresolved middle ear issues. These devices can be surgically implanted or attached using adhesive plates, dental sticks, elastic headbands, or bone conduction spectacles. Optimal fitting of bone conduction spectacles requires appropriate frame selection and contact pressure in the temporal and mastoid areas. The ANSI S3.6 and DIN EN ISO 389-3 standards recommend a contact area of approximately 1.75 cm2 and a maximum force of 5.4 N for effective sound transmission and comfort. Methods: This study aimed to evaluate the technical fit and mechanical stability of universal bone conduction hearing spectacles compared to established systems. A Sen-Pressure 02 thin-film sensor connected to an Arduino Uno R3 board measured contact force in the temporal and mastoid areas. Several BCHDs were tested, including the Bruckhoff la belle BC D50/70, radioear B71 headset, radioear B71 elastic headband, Cochlear Baha SoundArc M, and Cochlear Baha elastic headband, on a PVC artificial head, with data analyzed using ANOVA and LSD post hoc tests. Results: The la belle BC D50/70 spectacles showed comparable contact force to established BCHDs, ensuring adequate sound transmission and comfort. Significant differences were observed between the systems, with the radioear B71 headset exhibiting the highest forces. The la belle BC D50/70 had similar forces to the radioear B71 elastic headband. Conclusion: The la belle BC D50/70 universal bone conduction hearing spectacles are a technically equivalent alternative to established BCHDs, maintaining pressure below 5.4 N. Future research should explore the impact of different contact forces on performance and comfort, and the integration of force control in modified spectacles. This study indicates that the la belle BC D50/70 is a viable alternative that meets audio

关键词： Bone Conduction Hearing Devices (BCHD) Universal Bone Conduction Hearing Spec-Tacles Non-Implantable Hearing Aids Contact Pressure Optimization

Assessment of energy consumption,environmental effects and fuel costs of the bus rapid transit system in Bogotá(Colombia)

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Clean Energy 2024年第3期8卷 34-47页

作者： Jhon Jairo Pérez Luis Hernando Correa Poul AlbergØstergaard Pedro cabrera Universidad de La Salle-Engineering Faculty Electrical DepartmentCampus La CandelariaBogota D.C.Colombia Aalborg University Department of PlanningRendsburggade 149000 AalborgDenmark University of Las Palmas de Gran canaria Department of Mechanical EngineeringCampus Universitario de TafiraLas Palmas de Gran CanariaSpain

Colombia aims to boost the utilization of mass transportation systems in its major cities while simultaneously reducing greenhouse gas emissions by 20%,in alignment with the commitments of the COP21 *** 2020,the transport sector in Colombia accounted for 34.4%of the country’s energy demand and was responsible for~49%of its total CO_(2) *** article presents an assessment of energy consumption,environmental effects and the fuel costs of Bogotá’s bus rapid transit system based on the Activity,Share,Intensity,Fuel methodology.A long-term analysis spanning from 2021 to 2040 was developed using the long-range energy alternatives planning *** conduct this assessment,the tool was calibrated using data from 2019 and *** distinct scenarios based on energy policies implemented in Bogotáwere examined:Business as Usual,Fast Transition,High Growth and Low *** energy consumption and environmental effects,the results underscore the pivotal role of diversifying energy sources and reducing reliance on fossil fuels such as ***,the analysis emphasizes the urgent need to accelerate the transition to alternative energy sources such as natural gas and electricity.

关键词： ASIF energy consumption environmental effects LEAP long-term energy model public transport

Primary repair of esophageal atresia Gross type C via thoracoscopic magnetic compression anastomosis:Is it the best option?

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1474-1481页

作者： Sonia Pérez-Bertólez Jorge Godoy-Lenz Department of Pediatric Surgery Sant Joan de Deu HospitalUniversity of BarcelonaBarcelona 08950Spain Department of Pediatric Surgery Clínica Alemana of SantiagoSantiago 7650568Chile

Magnetic compression anastomosis is a promising treatment option for patients with complex esophageal atresia;but,at the present time,should not be the first therapeutic option in those cases where the surgeon can per... 详细信息

关键词： Esophageal atresia Tracheoesophageal fistula Thoracoscopy Magnamosis Magnetic anastomosis