检索结果-南通市图书馆

Effects of supplemental xylanase and xylooligosaccharides on production performance and gut health variables of broiler chickens

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2022年第1期13卷 166-180页

作者： Amit K.Singh Birendra Mishra Michael r.Bedford rajesh Jha Department of Human Nutrition Food and Animal SciencesUniversity of Hawaii at ManoaHonoluluHI 96822USA AB Vista Feed Ingredients MarlboroughWiltshireUK

Background:This study evaluated the effects of supplemental xylanase and xylooligosaccharides(XOS)in a cornsoybean meal(SBM)-based diet on growth performance and intestinal health of broilers.A total of 288 day-old chicks(Cobb 500)were allocated to 36 floor pens(8 birds/pen)equally in 9 dietary treatments in a 3×3 factorial *** treatments were combinations of 3 levels of xylanase(0,0.005% and 0.01% Econase XT)and 3 levels of prebiotics(0,0.005% and 0.01% XOS)added to basal mash diets formulated in three phases(starter,d 0-14;grower,d 15-28;finisher,d 29-42).The feed intake and body weights were recorded *** d 42,ileal sections were collected for histomorphometric and gene expression analysis,and cecal content was collected for determining short-chain fatty acids(SCFA)and ***:Xylanase linearly(Preased the average daily gain(ADG)in both the finisher and total period and the final body weight gain(FBWG,2940&2932 vs.2760 g)of *** did not significantly increase either ADG or FBWG(P>0.05).Supplemental xylanase and XOS did not affect average daily feed intake and feed conversion ratio(P>0.05).Xylanase and XOS did not change villus height(VH)or crypt depth(CD)ratio(P>0.05).However,xylanase exhibited a trend(P=0.097)on VH:CD *** inclusion of 0.01%XOS without xylanase increased the level of IL-10(a marker of anti-inflammatory cytokine)and IL-4(a T-cell differentiation cytokine)genes compared with control(Production was increased by xylanase(Preased total SCFA(Prease(P=0.052).Alpha and beta diversity of microbiota among treatments were not different(P>0.05).However,the mean proportion of family ruminococcaceae was increased by the supplemental 0.01% xylanase(Pcan be concluded that XOS can enhance cecal fermentation,while xylanase can increase the body weight gain along with the ferment

关键词： Gene expression Histomorphology Microbiota Poultry Prebiotics Short-chain fatty acid Xylooligosaccharide

Luteolin attenuates diabetic nephropathy via inhibition of metalloenzymes in rats

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2023年第12期13卷 507-520,I0002,I0003页

作者： r.B.Daude rajendra Bhadane J.S.Shah Department of Pharmacy Government PolytechnicJalgaon-425001MaharashtraIndia Structural Bioinformatics Laboratory Faculty of Science and EngineeringBiochemistryAbo Akademi UniversityFI-20520 TurkuFinland Pharmaceutical Sciences Laboratory Faculty of Science and EngineeringPharmacyÅbo Akademi UniversityFI-20520 TurkuFinland Institute of Biomedicine Research Unit for Infection and ImmunityUniversity of TurkuFI-20520 TurkuFinland Department of Pharmacology Institute of PharmacyNirma UniversityAhmedabad-382481GujratIndia

Objective:To investigate the renoprotective effects of luteolin on diabetes in ***:One week after administration of streptozotocin 55 mg/kg intraperitoneally,rats were given 25,50,and 75 mg/kg/day of luteolin orally for another eight *** the end of the experiment,body weight,blood glucose level,biochemical parameters for renal function(serum creatinine,blood urea nitrogen,uric acid,serum albumin,and total protein),kidney histology,matrix metalloproteinase(MMP)-2,MMP-9,and histone deacetylase 2(HDAC-2)expression,and malondialdehyde,myeloperoxidase,and hydroxyproline content in renal tissue were *** glucose-induced damage using NrK-52E cell line was studied to evaluate cell viability and metalloenzyme ***,in silico studies including docking and molecular dynamics simulations were ***:MMP-2,MMP-9,and HDAC-2 expressions were significantly increased in high glucose-induced NrK-52E cells and the renal tissue of diabetic ***,these changes were reversed by luteolin at the administered ***,luteolin significantly reduced oxidative stress,inflammation,and fibrosis,as well as improved biochemical parameters in diabetic ***,luteolin at the examined doses markedly alleviated diabetes-induced histopathological changes in renal ***:Luteolin effectively attenuates streptozotocin-induced diabetic nephropathy in rats by inhibiting MMP-2,MMP-9,and HDAC-2 expression,and reducing oxidative stress and inflammation.

关键词： MMPs HDAC-2 Luteolin NrK-52E Diabetic nephropathy Docking Molecular dynamic simulations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

共生蓝藻的遗传多态性研究(摘要)

共生蓝藻的遗传多态性研究(摘要)

Topology impacts TrAIL therapy: Differences in primary cancer growth and liver metastasis between orthotopic and subcutaneous xenotransplants of pancreatic ductal adenocarcinoma cells

中国藻类学会第十一次学术讨论会

作者：郑伟文陈坚宋铁英包晓东 ulla rasmussen Birgitta Bergman 福建省农科院生物技术中心福建省农科院生物技术中心福建省农科院生物技术中心福建省农科院生物技术中心瑞典斯德哥尔摩大学植物学系瑞典斯德哥尔摩大学植物学系

＜正＞念珠藻科（Nostocaceae）的某些具异形胞的丝状蓝藻可与不同进化阶段的植物代表种形成固氮共生体。本研究涉及的共生蓝藻可与蕨类植物满江红（Azolla）、裸子植物苏铁（ Cycad）和被子植物根乃拉草（Gunnera）共生固氮。而宿主...

＜正＞念珠藻科（Nostocaceae）的某些具异形胞的丝状蓝藻可与不同进化阶段的植物代表种形成固氮共生体。本研究涉及的共生蓝藻可与蕨类植物满江红（Azolla）、裸子植物苏铁（ Cycad）和被子植物根乃拉草（Gunnera）共生固氮。而宿主植物分别形成叶腔、珊瑚状根和茎腺三种特殊的共生构造供共生藻栖息。从分子水平探讨共生蓝藻的遗传多态性不仅有利于揭示共生藻本身的进化规律及其与宿主植物的共进化机制,对建立作物-蓝藻的人工固氮共生体（或联合体）也将有所启示。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2021年第3期20卷 279-284页

作者： Bastian Kettler Anna Trauzold Christian röder Jan-Hendrik Egberts Holger Kalthoff Clinic for General- Abdominal-and Transplant-SurgeryMedical School HannoverCarl-Neuberg-Str.130625 HannoverGermany Institute for Experimental cancer research University of Kiel and University Clinic of Schleswig-HolsteinCampus KielHs.U30Arnold-Heller-Str.324105 KielGermany Clinic for General VisceralThoracicTransplantation-and Pediatric SurgeryUniversity Clinic of Schleswig-HolsteinCampus KielHs.CArnold-Heller-Str.324105 KielGermany

Background: To study novel treatment modalities for pancreatic ductal adenocarcinoma(PDAC), we need to transfer the knowledge from in vitro to in vivo. It is important to mirror the clinical characteristics of the typically local invasive growth of pancreatic cancer and the distant spread resulting in liver metastasis. Notably, for xenotransplant studies using human specimen, two models, i.e. subcutaneous(s.c.) and orthotopic(o.t.) transplantation are widely used. Methods: The subcutaneously and orthotopically inoculated Colo357 Bcl-x L cell-derived tumors were directly compared with and without TNF-related apoptosis inducing ligand(TrAIL) treatment. The size of primary tumors, number of liver metastasis and the histologic markers Ki67, M30, TNF-α and CD31 were assessed. results: Upon TrAIL treatment, the primary tumors did not change their size, neither in the s.c. nor in the o.t. approaches. But when s.c. was compared to o.t., the size of the s.c. tumors was more than twofold bigger than that of the o.t. tumors( Pr, mice with orthotopically inoculated PDAC cells developed liver metastasis upon TrAIL treatment much more frequently( n=13/17) than mice with subcutaneously inoculated PDAC cells( n=1/11)( Priving force for this increased metastasis, a higher TNF-α staining intensity in the o.t. tumors was observed by immunohistochemistry. Conclusions: These data from a direct side-by-side comparison underline the importance of the proper inoculation site of the PDAC cells. Local invasion and liver metastases are a hallmark of PDAC in the clinic;the o.t. model is clearly superior in reflecting this setting. Moreover, a serious side-effect of a possible new therapeutic compound became obvious only in the o.t. model.

关键词： Pancreatic cancer Animal models Immunohistochemistry Subcutaneous metastasis

Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2023年第2期16卷 65-71页

作者： Govind r.Patel Indu Thanvi Mohammad Nadeem rahul Kanwaria Department of Clinical Hematology Dr.SN Medical CollegeJodhpurRajasthanIndia Department of General Medicine Dr.SN Medical CollegeJodhpurRajasthanIndia

Objective:To evaluate coagulation abnormalities and their relationship with bleeding manifestations among patients with ***:This observational study was conducted on 292 adult dengue patients who were admitted to a tertiary care hospital of Western India from July 2021 to June *** tests including prothrombin time(PT),international normalized ratio(INr),activated partial thromboplastin time(aPTT),fibrinogen,and D-dimer were *** were monitored for bleeding ***:Coagulation abnormalities were reported in 42.8%of the ***,prolonged aPTT was the most common coagulation abnormality(40.8%),followed by low fibrinogen(38.7%),raised D-dimer(31.2%),raised INr(26.0%)and prolonged PT(19.2%).Bleeding manifestations were present in 19.9%***,INr,aPTT and D-dimer levels were significantly higher(Prinogen level was significantly lower(Pred to patients without *** with bleeding had a significantly higher rate of all coagulation abnormalities than patients without bleeding(Pcantly higher frequency of coagulation abnormalities compared to patients without *** with dengue should be assessed for coagulation abnormalities.

关键词： Dengue Coagulation abnormalities Coagulation parameters Prothrombin time Activated partial thromboplastin time Bleeding manifestations

Friction transitions and connections to third bodies for a Cd coating on steel substrate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Friction 2020年第4期8卷 784-801页

作者： Priyadarshi BEHErA Lisa LEE Sriraman K.rAJAGOPALAN richard r.CHrOMIK Stephen YUE Department of Mining&Materials Engineering McGill UniversityMontrealQC H3A 0C5Canada

Cd coating is used in aerospace industries from last five decades due to its sacrificial protection and lubrication properties. Although Cd coating is primarily used due to its sacrificial corrosion protection when applied on steel substrate, the added benefit of modifying the tribological behavior by acting as a lubricious layer gives it a leading-edge than other coatings. Often the measurement of friction coefficient (CoF) is reported as a value generated after full sliding cycle. This measurement of average CoF generally limits the study of local variation in CoF occurring within one sliding cycle, which can be significantly different with change in spatial position due to change in third body morphology. In this study, a linearly reciprocating sliding test is used to measure the CoF at a sampling rate of 800 Hz along the track length to generate triboscopic image with steel countersphere. The instantaneous CoF obtained with triboscopy is correlated with the wear track morphology using scanning electron microscope (SEM) and optical profilometer for variation in contact conditions. Tribological test performed in dry atmosphere shows an average CoF of 0.4 till the end of the test whereas with increase in relative humidity to 60%, the average CoF changes from 0.4 to 0.8 at the end of the test due to change in contact conditions. Soft Cd coating on low carbon steel substrate is used to study these variations in third body morphology.

关键词： tribology Cd coating triboscopy third body aerospace coating humidity

Screening for probiotic characters in lactobacilli isolated from chickens revealed the intra-species diversity of Lactobacillus brevis

在线全文

学校读者我要写书评

暂无评论

作者： r.·夸克(r. Quirk)

学校读者我要写书评

暂无评论

Animal Nutrition 2021年第1期7卷 119-126页

作者： Nasrin Noohi Moslem Papizadeh Mahdi rohani Malihe Talebi Mohammad r.Pourshafie research Center for Conservation of Cultural relics Research Center of Iranian Cultural Heritage and Tourism OrganizationTehranIran Department of Microbiology Pasteur Institute of IranTehranIran Department of Microbiology School of MedicineIran University of Medical SciencesTehranIran

Considering the importance of the poultry industry and the increasing interest in alternative growth promoters,probiotics are considered as a potential candidate for use in the poultry *** this study,Lactobacillus species were isolated from 21 rectal swabs of 11 healthy 6-day-old and 10 healthy 21-day-old chickens and their fecal and feed *** isolates were characterized and their probiotic characteristics,including resistance to gastric acid and bile salts,biofilm formation and adherence to epithelium or mucus,amylase and protease activity and production of inhibitory compounds,were *** 31 acid and bile resistant lactobacilli,only 2 Lactobacillus brevis and 1 Lactobacillus reuteri strains showed significant probiotic *** isolates indicated detectable attachment to caco-2 cells and significant antibacterial activities against Gram-positive and Gram-negative ***,phenotypic and genotypic diversity of lactobacilli isolates were studied by Phene Plate(PhP)system(PhP-LB)and random amplified polymorphic DNA(rAPD)-PCr,***-LB results of 24 *** isolates showed a high phenotypic variation among the *** comparison,results of rAPD-PCr highlighted a low ***,it seems that combination of the 2 techniques(PhP and rAPD-PCr)could result in a significant discriminatory power than each of them used alone.

关键词： Probiotic Lactobacilli Poultry Feed Fecal

在线全文

学校读者我要写书评

暂无评论

城市地区灾害评价和沉积学模式的应用

国外第四纪地质 1989年第3期 14-24页

作者： M‘Kr.,ga 王伍云