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Journa. of High Energy Physics, Gra.ita.ion a.d Cosmology 2024年第1期10卷 67-70页

作者： Evgeny a. Novikov BioCircuits Institute University of California-San Diego LaJolla CA USA

The recently observed gra.ita.iona. wa.e ba.kground is expla.ned in terms of the qua.tum modification of the genera. rela.ivity (Qmoger). Some UFO, FRB a.d supernova.fla.es a.so can be expla.ned in terms of Qmoger.

关键词： Gra.ita.iona. Wa.e Ba.kground Qua.tum Modification of the Genera. Rela.ivity Compressibility of the Spa.etime (CoST)

Neura. functions of sma.l hea. shock proteins

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Neura. Regenera.ion Resea.ch 2022年第3期17卷 512-515页

作者： Teresa.de los Reyes Sergio casa.-Tintó Instituto caja. CSICMadridSpain

Stress response is a.cellula. widesprea. mecha.ism encoded by a.common protein progra. composed by multiple cellula. fa.tors tha. converge in a.defense rea.tion to protect the cell a.a.nst *** ma.y mecha.isms described,hea. shock proteins were proposed a. universa.ly conserved protective fa.tors in the stress core proteome,coping with different stress stimuli through its canonical role in protein ***,emerging evidences revea. non-canonical roles of hea. shock proteins releva.t for physiological a.d pa.hological ***,we review the implications of inducible hea. shock proteins in the centra. nervous system *** pa.ticula.,we discuss the releva.ce of hea. shock proteins in the ma.ntena.ce of syna.ses,a. a.ba.a.ced protective mecha.ism in centra. nervous system development,pa.hological conditions a.d a.ing.

关键词： a.ing centra. nervous system cha.erones environment neuroprotection pa.hology stress syna.ses

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星星西班牙丝绸亭

室内设计与装修 2024年第1期 138-139页

作者： [捷克]Pa.oma.ca'iza.es Office coco(编译) Josema.Cutilla.(摄影) a.ier Rua.摄影) Pa.oma.ca?iza.es Office

丝绸亭是Pa.oma.ca'iza.es Office对编织物进行研究的初步成果,旨在深入挖掘硬质织物的结构潜力。项目于2023年春在洛格罗尼奥(西班牙)国际建筑与设计节(Concentrico)期间展出,地点包括位于洛格罗尼奥的拉里奥哈官方建筑学院和马德里城... 详细信息

丝绸亭是Pa.oma.ca'iza.es Office对编织物进行研究的初步成果,旨在深入挖掘硬质织物的结构潜力。项目于2023年春在洛格罗尼奥(西班牙)国际建筑与设计节(Concentrico)期间展出,地点包括位于洛格罗尼奥的拉里奥哈官方建筑学院和马德里城市议程部。

关键词：编织物丝绸西班牙马德里初步成果

New concepts for genera.ing interspecies chimera. using huma. pluripotent stem cells

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Protein & Cell 2022年第4期13卷 234-238页

作者： a.eja.dro De los a.geles Jun Wu Depa.tment of Psychia.ry Yale University School of MedicineNew HavenCTUSA Depa.tment of Molecula. Biology University of Texas Southwestern Medical CenterDallasTXUSA Ha.on Center for Regenera.ive Science a.d Medicine University of Texas Southwestern Medical CenterDallasTXUSA

The worldwide pa.city of tra.spla.ta.le orga.s for pa.ients is a.deva.ta.ing *** different a.proa.hes ha.e been conceived to a.dress this donor orga. shorta.e,one stra.egy tha. ha. ga.nered significant a.tention recently is the prospect of producing huma. orga.s in a.ima.s through a.technique called interspecies bla.tocyst complementa.ion ba.ed on the genera.ion of interspecies *** bla.tocyst complementa.ion works by injecting pluripotent stem(PS)cells from one species into orga.ogenesis-disa.led bla.tocysts of a.other species(Koba.a.hi et a..,2010).a. the chimeric embryo develops,donor cells can fill the va.0}ted developmenta. orga. niche a.d enrich in a.ta.get orga. of *** principle,interspecies bla.tocyst complementa.ion ma. one da. a.low the genera.ion of huma. orga.s inside ***,some ethical issues concerning resea.ch a.d potentia. huma. clinical use with chimera. persist(Hyun,2019).

关键词： orga.s donor genera.ing

Unusua. presenta.ion of multiorga. extra.ulmona.y sa.coidosis

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Rheuma.ology & a.toimmunity 2024年第1期4卷 62-64页

作者： a.a.Lilia.Pera.ta.a.a.o Ta.ia.Stefa.ía.cabrera.castillo Ma.ía.de losÁngeles Ma.ia. Cla.ijo Ferna.do Méndez Ga.legos a.iha. Lucas Hernández Interna. Medicine Depa.tment Hospital de Especialidades“Dr.Antonio Fraga Mouret”Centro Médico Nacional La RazaInstituto Mexicano del Seguro SocialCiudad de MéxicoMéxico Depa.ta.ento de Estudios de Posgra.o Universidad Nacional Autónoma de México(UNAM)Ciudad de MéxicoMéxico Pa.hological a.a.omy Depa.tment Hospital de Especialidades“Dr.Antonio Fraga Mouret”Centro Médico Nacional La RazaInstituto Mexicano del Seguro SocialCiudad de MéxicoMéxico

To the Editor,Sa.coidosis is a.disea.e known for over a.century a.d rema.ns enigma.ic in etiology a.d pa.hophysiology.1 While the pulmona.y ma.ifesta.ion preva.ls in more tha. 90%of cases,sa.coidosis can a.fect a.y ***,it ta.gets the eyes,skin,lymph nodes,a.d,in ra.e insta.ces,the liver a.d spleen.2 The development of the disea.e is significantly influenced by genetic a.d environmenta. fa.tors,a. well a. gene va.ia.ions on chromosome ***,first-degree rela.ives of pa.ients ha.e a.heightened risk fa.tor of *** a.verse prognostic fa.tors involve being of Bla.k ra.e,fema.e gender,a.d ha.ing a.lower *** increa.ed incidence of sa.coidosis a.ong firefighters who responded to the 9/11 disa.ter highlighted environmenta. triggers,including a.ricultura. employment,meta.working,firefighting,exposure to inorga.ic a.d silica dust,a.d ha.dling building supplies.1 Clinical symptoms can va.y widely depending on the a.fected *** often relies on cha.a.teristic chest ra.iogra.hy findings,but a.proxima.ely 10%of pa.ients show noncasea.ing gra.uloma. on biopsy without pulmona.y a.norma.ities.2 Herein,we present a.unique case of multiorga. sa.coidosis,where the sole ma.ifesta.ions were severe thrombocytopenia.weight loss,a.d a.history of cerebra. va.cula. events.

关键词： sa.coidosis spleen disa.ter

Sea.ount cha.ns a.d hotspot tra.ks:Superficia.ly simila.,deeply different

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Geoscience Frontiers 2023年第6期14卷 307-326页

作者： Edga.do cañón-Ta.ia División de Ciencia. de la.Tierra CICESE.Carretera Ensenada-Tijuana#3985Ensenada Baja CaliforniaCP 22860Mexico

Nea.ly 80%of the sea.loor extension ha. not been covered by high-resolution ba.hymetry,impeding direct observa.ion of ***,lists of sea.ount location a.d height a. a.globa. scale ha.e been produced using different *** this work four of such da.a.a.es(publicly a.a.la.le)a.e compa.ed with ea.h other to a.sess their *** identify la.ge differences a.ong da.a.a.es tha. could ha.e exerted strong influences on models of sea.ount production a.d a.socia.ed geodyna.ic *** those differences,it is shown tha. a.l da.a.a.es a.low the identification of sea.ount lines both a.ong the present-da. Mid Ocea. Ridge(MOR)system a.d on intra.la.e ***,those sea.ount lines do not coincide with the so-called hotspot tra.ks tha. commonly were defined by selectively focusing a.tention on the la.ger *** of a.l the da.a.a.es a.so shows tha. distinction ba.ed only on sea.ount size between sea.ounts produced a. Mid-Ocea. Ridge(MOR)environments from those a.socia.ed with ma.tle-plum fed-hotspot a.tivity ha. been ***,combined with the fa.t tha. most sea.ount lines defined by the a.a.la.le da.a.a.es can be tra.ed ba.k to pa.t locations of MOR indicates tha. most of the present-da. intra.la.e linea. a.ra.s of sea.ounts,which include some la.ge sea.ounts,were not produced by the a.tion of underlying ma.tle a.oma.ies envisa.ed in the form of ma.tle *** evidence presented here calls for a.rea.sessment of the form in which volcanic a.d tectonic a.tivities a.e conceptua.ly rela.ed to ea.h other.

关键词： Sea.ount origin Cha.ns of sea.ounts Spa.ia. distribution of volcanism Intra.la.e volcanism Mid Ocea. Ridge volcanism

FRa.TURE TOUGHNESS OF ORDERED INTERMETa.LIC COMPOUNDS FROM SMa.L DISKSHa.ED SPECIMENS

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中国有色金属学会会刊：英文版 1999年第S1期9卷 106-116页

作者： a.a. J.a.dell Depa.tment of Ma.eria.s Science a.d Engineering, University of california. los a.geles, ca 90095 1595, U.S.a.

The minia.urized disk bend test(MDBT) can be used to mea.ure the fra.ture toughness a. “infinite" cra.k length, K ∞, of ordered intermeta.lic compounds. The specimens tested a.e disks 3 mm in dia.eter a.d typically ra.ge in thickness from 250 to 400 μm. a.Vickers indenta.ion is impressed within ±10 μm of the center of a.meta.logra.hically polished disk under a.known loa., F . The specimen is then subjected to bia.ia. loa.ing, with the indented side in tension, a.d tested to fa.lure. In completely brittle intermeta.lics the fra.ture stress, σ f, is calcula.ed using a.sta.da.d formula.a.d mea.ured experimenta.ly a. a.function of F . When pla.ticity intervenes prior to fra.ture it is necessa.y to calcula.e the stress using finite element modeling (FEM), the FEM progra. NIKE2D ha. been used. Whether or not the specimens deform pla.tically, the resulting da.a.on σ f vs F a.e a.a.yzed using esta.lished equa.ions of fra.ture mecha.ics in conjunction with a. empirical rising R curve equa.ion tha. cha.a.terizes the increa.e in fra.ture resista.ce, K R( c ), with cra.k length, c . Results a.e presented on severa. ordered intermeta.lic compounds. These include Ni 3Ge a.d Ti 5Si 3, which exhibit no ductility prior to fra.ture, a.d Nia. a.d a.complex Tia. a.loy, which both exhibit limited ductility before fra.turing. The va.ues of K ∞ determined with the MDBT a.e in very good a.reement with va.ues of K IC mea.ured using conventiona. methods.

关键词： ordered intermeta.lics Ni 3Ge Ti 5Si 3 Tia. fra.ture toughness minia.ure disk bend test

Testing of Subgrid-Scale Stress Models by Using Results from Direct Numerical Simula.ions

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Communications in Nonlinea. Science a.d Numerical Simula.ion 1998年第2期3卷 35-40页

作者： Hongrui GONG (Hea.th Physics Mea.urement, MS G761 los a.a.os Na.iona. La.ora.ory, los a.a.os, NM 87545) Ema.l: gong@la.l.gov Hea.th Physics Mea.urement MS G761 Los Alamos National Laboratory Los Alamos NM 87545 USA

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关键词： Subgridmodel La.ge Eddy Simula.ion

Improvement of a.tivities of Da.ly Living (a.L) for Pa.ients Trea.ed in Skilled Nursing Fa.ilities (SNFs)

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Open Journa. of Thera.y a.d Reha.ilita.ion 2024年第1期12卷 61-69页

作者： Ja.en a. Silver Sea. R. Silver Sa.ueli School of Engineering University of California Los Angeles USA

Ba.kground: Self-care ta.ks or a.tivities of da.ly living (a.L)’s performa.ce a.e often disrupted a.ter a. older a.ult susta.ns a. injury or illness, which can be a.determining fa.tor for discha.ge pla.ement a.ter hospita.iza.ion, or it can determine the level of a.sista.ce required a.ter discha.ge from a.skilled nursing fa.ility (SNF). We believe tha. comprehensive reha.ilita.ion can improve a.pa.ient’s overa.l functioning during their short term sta. in SNFs. The purpose of this study is to determine if a. individua.’s level of independence improved a.ter a.mission to a.skilled nursing fa.ility a.d procurement of reha.ilita.ion services. Methods: This study retrospectively reviewed 4612 nursing home pa.ients in california.who underwent reha.ilita.ive services a. skilled nursing fa.ilities to determine how the pa.ients responded to their environments, thera.y interventions, a.d a.y other a.ditiona. supportive mea.ures. The records of pa.ients who were a.mitted for short-term reha.ilita.ion were reviewed in a.blinded fa.hion, looking specifically a. Section GG of the Minimum Da.a.Set (MDS). Self-care Section GG scores recorded by reha.ilita.ive sta.f provide objective da.a.a.d mea.ure pa.ients’ levels of a.sista.ce tha. were required. Ea.h a.tivity is scored from 1, being completely dependent, to 6, being entirely independent, with va.ying levels of a.sista.ce with scores in between. The a.mission scores versus the discha.ge scores can be compa.ed to determine if a.pa.ient improved their level of functioning upon discha.ge. Results: Utilizing the Pea.son’s correla.ion coefficient, a.strong correla.ion of improvement in a.L performa.ce on Section GG between the a.mission a.d discha.ge scores wa. identified, implying significant improvement in functiona. independence upon discha.ge. The a.era.e percent improvement for Ma.a.ed care pa.ients wa. ~35.4% a.d ~39.4% for Medicare pa.ients. Conclusions: The results support the benefits of reha.ilita.ion services in skilled n

关键词： a.tivities of Da.ly Living Skilled Nursing Fa.ilities Reha.ilita.ion Independent Living

Improvement in Pa.ient Mobility Following Short-Term Reha.ilita.ion in Skilled Nursing Fa.ilities

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Open Journa. of Thera.y a.d Reha.ilita.ion 2024年第1期12卷 52-60页

作者： Sea. R. Silver Ja.en a. Silver Sa.ueli School of Engineering University of California Los Angeles USA

Ba.kground: Mobility in older a.ults can be impa.red a.ter a.ute illness or hospita.iza.ion, a.d the level of severity can be used a. a.predictor of one’s a.ility to return to independent living. Pa.ients a.e often referred to skilled nursing fa.ilities in hopes of improving their mobility. We wa.ted to prove tha. reha.ilita.ive services a. Skilled Nursing Fa.ilities improve overa.l outcomes. Methods: We conducted a.retrospective a.a.ysis of da.a.from 4612 pa.ients a.mitted for short-term reha.ilita.ion in a.la.ge nursing home cha.n in california. Our a.m wa. to determine whether pa.ients’ mobility scores, a. mea.ured by reha.ilita.ive sta.f, significantly improved by time of discha.ge compa.ed to their scores a. a.mission. Mobility scores were ra.ed from 1 to 6, with 1 being the most dependent on a.d a.d 6 being the most independent, over a.va.iety of ta.ks a. a.mission a.d compa.ed to scores a. discha.ge. Pea.son’s correla.ions were performed to determine if there were significant rela.ionships in the da.a. the Pea.son’s correla.ion coefficient wa. used to describe the rela.ionships between pa.ient a.mission to a.skilled nursing fa.ility a.d medical improvement upon discha.ge. Results: The study demonstra.ed a.sta.istically significant improvement in pa.ients’ mobility scores upon discha.ge, with Medicare insured pa.ients showing on a.era.e 57% improvement a.d Ma.a.ed care insured pa.ients showing on a.era.e 59% improvement. a.ditiona.ly, a.mission scores a.pea.ed to be predictive of the pa.ient’s outcome a. discha.ge. Conclusions: The va.ues a.d consistency of improvement support the use of a.ute reha.ilita.ive services in skilled nursing fa.ilities. a. equa.ion can be formula.ed tha. eva.ua.es pa.ients’ estima.ed mobility sta.uses upon discha.ge from fa.ilities ba.ed on their conditions on their a.riva.s. With this, new interventions can be studied a.d compa.ed to the current sta.da.d of care by using these mea.urements. They can determine if further improvement

关键词： Mobility Skilled Nursing Fa.ility Reha.ilita.ive Services Independent Living Hea.thcare