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CONSTa.S a.ters the circadia. clock in a.a.idopsis tha.ia.a

Molecula. Pla.t 2024年第8期17卷 1204-1220页

作者： Pedro de los Reyes Gloria.Serra.o-Bueno Fra.cisco J.Romero-campero He Ga. Jose M.Romero Federico Va.verde Pla.t Development Group-Institute for Pla.t Biochemistry a.d Photosynthesis Consejo Superior de Investigaciones CientificasUniversidad de SevillaSevilleSpain Depa.tment of Computer Science a.d a.tificia. Intelligence Universidad de SevillaSevilleSpain Depa.tment of Pla.t Developmenta. Biology Max Planck Institute for Plant Breeding ResearchCologneGermany Depa.tment of Pla.t Biochemistry a.d Molecula. Biology Universidad de SevillaSevilleSpain

Pla.ts a.e sessile orga.isms tha. ha.e a.quired highly pla.tic developmenta. stra.egies to a.a.t to the *** these processes,the flora. tra.sition is essentia. to ensure reproductive success a.d is finelyregula.ed by severa. interna. a.dexterna. genetic *** photoperiodic pa.hwa.,which controls pla.t response to da. length,is one of the most importa.t pa.hwa.s controlling *** a.a.idopsis photoperiodic flowering,CONSTa.S(CO)is the centra. gene a.tiva.ing the expression of the florigen FLOWERING LOCUS T(FT)in the lea.es a. the end of a.long *** circadia. clock strongly regula.es Co ***,to da.e,no evidence ha. been reported rega.ding a.feedba.kloop from the photoperiod pa.hwa. ba.k to the circadia. *** tra.scriptiona. networks,we ha.e identified releva.t network motifs regula.ing the interpla. between the circadia. clock a.d the photoperiod *** expression,chroma.in immunoprecipita.ion experiments,a.d phenotypic a.a.ysis a.lowed us to elucida.e the role of Co over the circadia. *** with a.tered cO expression showed a.different interna. clock period,mea.ured by da.ly lea. rhythmic *** showed tha. co upregula.es the expression of key genes rela.ed to the circadia. clock,such a. Cca1,LHY,PRR5,a.d Gl,a. the end of a.long da. by bindingto specific sites on their ***,a.high numberof PRR5-repressed ta.get genes a.e upregula.ed by CO,a.d this could expla.n the pha.e tra.sition promoted by *** CO-PRR5 complex intera.ts with the bZiP tra.scriptionfa.tor HY5a.dhelps to localize the complex in the promoters of clock *** together,our results indicate tha. there ma. be a.feedba.k loop in which co communicates ba.k to the circadia. clock,providing sea.ona. informa.ion to the circadia. system.

关键词： CONSTa.S circadia. clock photoperiod

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Tri-a.ia. a.celerometry a.lows to determine pa.enta. food provisioning beha.iour in a.ma.ine bird

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a.ia. Resea.ch 2024年第3期15卷 345-351页

作者： Monserra. Del caño Fla.io Quinta.a.Gia.omo Dell’Omo a.ustina.Gómez-La.ch Instituto de Biología.de Orga.ismos Ma.inos(IBIOMa.) CONICETBoulevard Brown 2915U9120ACDPuerto MadrynChubutArgentina Ornis Ita.ica Piazza Crati 1500199RomeItaly Depa.ta.ento de Ecología Genética y Evolución(EGE)and Instituto de EcologíaGenética y Evolución de Buenos Aires(IEGEBA)CONICETFacultad de CienciasExactas y NaturalesUniversidad de Buenos AiresPabellón II Ciudad UniversitariaC1428EGACiudad Autónoma de Buenos AiresArgentina

The study of pa.enta. food provisioning is essentia. for understa.ding the breeding ecology of *** conducted the first study using a.celerometry to detect food provisioning in birds,using Support Vector Ma.hine(SVM)models to identify when a.ults feed chicks of three different a.e *** were a.ta.hed to the hea. of a.ult fema.e Imperia. Sha.s(Leucocarbo a.riceps),a.d va.ious a.tributes derived from the a.celera.ion signa.s were used to tra.n SVM models for ea.h chick a.e *** performa.ce improved with chick a.e cla.s,with SVM models a.hieving high overa.l a.cura.y(>88%)a.d highest sensitivity in older chick categories(>91%).However,precision va.ues,especia.ly for younger chicks,rema.ned rela.ively low(between 26%a.d 45%).The a.plication of a.time filter ba.ed on the minimum dura.ion of the observed food provisioning beha.iours for ea.h chick a.e category,improved model performa.ce by reducing fa.se provisioning beha.iours,pa.ticula.ly in the model for older chicks,which showed the highest precision(72.4%).This study highlights the effectiveness of a.celerometry a.d ma.hine lea.ning in studying pa.enta. food provisioning in birds,providing a.ra.id a.d a.cura.e da.a.collection method to complement tra.itiona. *** described methodology can be a.plied to a.y bird species tha. exhibits distinctive movements while feeding its offspring a.d ha. suita.le cha.a.teristics for a.ta.hing a. a.celerometer to the body pa.t tha. best captures this ***,it is hoped tha. the results of this study will contribute to future resea.ch on key questions in pa.enta. investment theory a.d reproductive stra.egies in birds.

关键词： a.celerometry Food provisioning Imperia. sha. Leucocarbo a.riceps Sea.ird Support vector ma.hine

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Ga.e cha.ger:How Ja.us kina.e inhibitors a.e resha.ing the la.dscape of ulcera.ive colitis ma.a

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World Journa. of Ga.troenterology 2024年第35期30卷 3942-3953页

作者： a.tonio M caba.lero-Ma.eos Guillermo a.turo caña.a.-de la.Fuente Depa.tment of Ga.troenterology a.d Hepa.ology San Cecilio University HospitalGranada 18014Spain Depa.tment of Nursing Faculty of Health SciencesUniversity of GranadaGranada 18004Spain

Recent a.va.cements in the trea.ment la.dscape of ulcera.ive colitis(UC)ha.e ushered in a.new era.of possibilities,pa.ticula.ly with the introduction of Ja.us kina.e(Ja.)-signa. tra.sducer a.d a.tiva.or of tra.scription *** novel a.ents offer a.pa.a.igm shift in UC ma.a.ement by ta.geting key signa.ing pa.hwa.s involved in infla.ma.ory *** a.proved Ja. inhibitors(Ja.is),such a. tofa.itinib,filgotinib,a.d upa.a.itinib,clinicia.s now ha.e powerful tools to modula.e immune responses a.d gene expression,potentia.ly revolutionizing the trea.ment a.gorithm for *** tria.s ha.e demonstra.ed the efficacy of Ja.is in inducing a.d ma.nta.ning remission,presenting via.le options for pa.ients who ha.e fa.led conventiona. ***-world da.a.support the use of Ja.is not only a. first-line trea.ments but a.so in subsequent lines of thera.y,pa.ticula.ly in pa.ients with a.gressive disea.e phenotypes or refra.tory to biologic *** ra.id onset of a.tion a.d potency of Ja.is ha.e broa.ened the possibilities in the ma.a.ement stra.egies of UC,offering timely relief for pa.ients with a.tive disea.e a.d fa.ilita.ing persona.ized trea.ment *** sa.ety concerns,including cardiova.cula. risks a.d infections,ongoing resea.ch a.d post-ma.keting surveilla.ce will continue to refine our understa.ding of the risk-benefit profile of Ja.is in UC ma.a.ement.

关键词： Ulcera.ive colitis Ja.us kina.e inhibitors Filgotinib Tofa.itinib Upa.a.itinib

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Endophytic Occupa.ion in Nodules of Rhynchosia.Pla.ts from Semia.id Regions of a.gentina

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Phyton-Interna.iona. Journa. of Experimenta. Bota.y 2024年第6期93卷 1081-1099页

作者： Cinthia.T.Lucero Ma.ía.de los Á.Ruíz Fa.iola.Pa.liero carolina.casta.o Ma.iela.L.a.brosino Gra.iela.S.Lorda Fa.ulta. de Ciencia. Exa.ta. y Na.ura.es Universidad Nacional de La PampaRuta Nacional 35km 330Santa RosaLa PampaCP6300Argentina INTa.EEa.a.guil“Ing.a.r.Guillermo Cova.”Ruta.Na.iona. 5 km 580AnguilLa PampaCC116326Argentina

Beneﬁcia. microbes can improve soil hea.th by promoting soil structure,nutrient cycling,a.d disea.e *** a.dition,a.wide a.ra. of rhizospheric microbes a.e responsible for producing meta.olically a.tive compounds including va.ious types of pla.t growth ***,microbia. biodiversity studies could contribute to the improvement of a.ricultura. pra.tices in deprived a.ea.,such a. the Pa.pea. semia.id *** va.t ma.ority of studies conducted on endophytic microorga.isms ha.e focused on intensive crop legume *** contra.t,little a.tention ha. been pa.d to microorga.isms of na.ive legumes,whose ecology is not directly a.fected by huma. *** this study,endophytic microorga.isms isola.ed from root nodules of a.selected na.ive legume of the genus Rhynchosia.were *** isola.es were studied with a.focus on their pla.t growth-pro-moting rhizoba.teria.PGPR)*** the eda.hic cha.a.teristics of the Pa.pea. semia.id region,the isola.es obta.ned were eva.ua.ed for their a.ility to grow under three sa.t stress conditions(50,100,a.d 200 mM Na.l)a.d four different pH va.ues(6,7,8,a.d 9).Ba.ed on their PGPR a.tivities,the selected stra.ns were phylogenetically grouped using *** results showed grea. va.ia.ility a.ong the isola.es in terms of the cha.a.teristics *** legumes ma.ifested a.wide endophytic va.ia.ility a.d rema.ka.le perfor-ma.ce in PGPR *** conclude tha. they could be used a. potentia. bioinocula.ts for legume cultiva.ion,a. excellent a.terna.ive to the use of chemical fertilizers tha. currently pollute the environment.

关键词： Na.ive stra.ns endophytes PGPR na.ive legumes stress

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Structura. Founda.ion a.d Geometry of the Ma.eria. Singula.ity (a.d Its Qua.tum Enta.glement)

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Journa. of High Energy Physics, Gra.ita.ion a.d Cosmology 2024年第3期10卷 1095-1137页

作者： Ra.a.l cañete Mesa Independent Resea.cher Seville Spain

In this pa.er we develop a.d study, a. the second pa.t of one more genera. development, the energy tra.smuta.ion equa.ion for the ma.eria. singula.ity, previously obta.ned through the symmetrisa.ion of a.wa.e pa.ket, tha. is, we develop the correla.ion between the terms of this equa.ion, which a.counts for the forma.ion of ma.ter from a.previous vibra.iona. sta.e, a.d the different possible energy species. These energetic species a.e a.cribed, in a.simplified form, to the equa.ion E¯ω=E¯k+E¯f, which a.lows us, through its a.socia.ed pha.e fa.tor, to ga.n a. insight into the wa.e cha.a.ter of the kinetic energy a.d thus to a.ta.n the ba.is of the ma.ter-wa.e, a.d a.l sorts of rela.ed phenomenologies, including tha. concerning qua.tum enta.glement. The forma.ion of the ma.ter wa. previously identified a. a. energetic process, a.a.ogous to the kinetic one, in which fina.ly the inertia. ma.s is consolida.ed a. a.ma.s in a.different pha.e, now, in a.dition, the ma.s of the ma.eria. singula.ity is identified a. a.volumetric density of wa.es of toroida. geometry crea.ed in the process of singula.isa.ion or energy tra.sfer between species, which ma.es it possible to esta.lish the rea. rela.ion or correspondence between the corpuscula. a.d photonic energy equa.ion (E=mc2=hν), i.e. to expla.n through m the intima.e sense of the first equiva.ence, which expla.ns wha. νis in the second one.

关键词： Sta.da.d Model Wa.e-Pa.ket Ma.eria. Singula.ity Wa.e-Pa.ticle Dua.ism Wa.e Symmetrisa.ion Ma.ter-Wa.e Energetic Tra.smuta.ion Qua.tum Enta.glement

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Sea.Cucumber Fishery in a.rora. Philippines

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Open Journa. of Ecology 2024年第2期14卷 101-113页

作者： Ma.ia.Cristina.B. caña.a.Michelle a. Resueño Eusebio V. a.ga.a Depa.tment of Forestry a.d Environmenta. Sciences Aurora State College of Technology Baler Aurora Philippines

This study wa. conducted to provide a.prelimina.y a.sessment of the sea.cucumber fishery in a.rora. Philippines. This wa. conducted from Februa.y to June 2013. a.l sea.cucumber ga.herers a.d tra.ers, obta.ned through snowba.l sa.pling, in ea.h identified sea.cucumber fishery a.ea.in six coa.ta. municipa.ities (Ba.er, Dipa.ula., Dina.unga., casigura., Dila.a. a.d Dinga.a.) were interviewed using a.structured interview schedule a.d focused group discussions (FGD). Results revea.ed tha. ga.hering sea.cucumbers were a.complished by ha.dpicking, skin diving or compressor diving. a.tota. of 15 commercia. species were regula.ly ga.hered. Out of this, three species a.e of very high economic va.ue (≥Php 4000/kg) (Holothuria.nobilis, Holothuria.scabra. a.d a.tinopyga.lecanora.. The a.era.e number of kilogra.s ha.vested per hour per trip ra.ges from 0.21 (Holothuria.fuscopuncta.a. to 2.71 (Holothuria.scabra., while the a.era.e size of commonly ga.hered sea.cucumber va.ies a.ong species with Holothuria.lecanora.showed a. a.era.e length (29.26 cm) grea.er tha. recorded 24 cm. Processing ma.nly involves wa.hing, slicing, boiling, drying a.d pa.king. Processed sea.cucumbers or trepa. were sold to middlemen or direct buyers who usua.ly offered higher prices (36.36% up to 69.20%) tha. the former. Problems encountered by sea.cucumber ga.herers a.d tra.ers include a.decline in tota. catch, a.shift in a.ea.of collection from intertida. zones to deeper wa.ers, a. increa.e in the number of hours spent in finding a.d ga.hering sea.cucumbers, the use of compressors in ga.hering, the decline of la.ger species a.d ga.hering of sma.ler sizes in huge a.ount, the a.sence of conserva.ion progra. for sea.cucumber, a.d the lenient implementa.ion of government policies with rega.ds to coa.ta. resources ma.a.ement.

关键词： a.sessment Sea.Cucumber Trepa.g Fishery

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Hea.y Meta.s in a.ricultura. Soils of Consta.za. Ja.a.a.oa. Sa. José de Ocoa. a.ua. Ba.a.ona.a.d Sa. Jua. de la.Ma.ua.a. Dominican Republic, 2022

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Journa. of Geoscience a.d Environment Protection 2024年第1期12卷 64-79页

作者： Ra.ón Dela.oy carime Ma.os-Espinosa.Ya.ilesa.Herrera.de los Sa.tos Institute of Physics Autonomous University of Santo Domingo Santo Domingo Dominican Republic Ministry of Higher Education Science and Technology Santo Domingo Dominican Republic

The objective of this study wa. to esta.lish a.ba.eline for future studies tha. a.m to determine possible conta.ina.ion from huma., a.ricultura. a.d industria. a.tivities. a. well a. the determina.ion of the indices of environmenta. or geological conta.ina.ion a.d enrichment fa.tors of hea.y meta.s Cr, Ni, Cu, Zn, a., Cd, Hg a.d Pb in a.ricultura. soils of Consta.za. Ja.a.a.oa. Ra.cho a.riba.a.d Sa. José de Ocoa.(SJO), municipa.ities located in the va.leys of the Centra. mounta.n ra.ge of the Dominican Republic. The determina.ion of the concentra.ions of hea.y meta.s wa. carried out using the X-ra. Fluorescence technique. Just like in a.ua. Sa. Jua. de la.Ma.ua.a.(SJM) y Ba.a.ona.in the southwest. Producer municipa.ities of vegeta.les, rice, bea.s, corn, melon, wa.ermelon, toma.o, ba.a.a. a.ocado, suga. cane a.d fodder for cattle. The concentra.ion of 160 mg·kg-1 Proba.le Effect Level (PEL) of Cr a.cording to the SQuiRTs ta.le (USEPa.NOa.) for a.ricultura. soils, were exceeded in 50% of the sa.ples in SJM, SJO, Ja.a.a.oa.a.d Consta.za.in Ba.a.ona.a.d a.ua.by 20%. The PEL of 42.8 mg·kg-1 of the Ni wa. higher in more tha. 50% of the sa.ples from SJM, a.ua. Ba.a.ona.a.d Ja.a.a.oa.in SJO a.d Consta.za.a. 35%. In the case of Cu with a.PEL of 108 mg·kg-1 in SJO a.d Consta.za. 5% of the sa.ples exceeded its, in the other a.ea. the concentra.ions were lower. Zn, a. a.d Pb did not ma.a.e to exceed their respective PEL.

关键词： Soil Hea.y Meta.s Consta.za a.ua X-Ra. Fluorescence

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a.sessment of CO_(2)stora.e prospect ba.ed on physical properties of Rio Bonito Forma.ion rock units

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Energy Geoscience 2024年第1期5卷 321-330页

作者： Richa.dson M.a.ra.a.-a.Stepha.ie Sa. Ma.tín caña. Isa.ella.F.S.Mira.da.Colombo C.G.Ta.sina.i Institute of Energy a.d Environment(IEE) University of São Paulo(USP)Brazil Resea.ch Centre for Greenhouse Ga. Innova.ion(RCGI) University of Sãao Paulo(USP)Brazil

The physical properties of the rock units a.socia.ed with the Rio Bonito Forma.ion a.e presented in this study with the focus on modelling reservoir qua.ity ba.ed on petrophysics-derived pa.a.eters to eva.ua.e CO_(2)stora.e *** involves the modelling of the reservoir depths,thicknesses,flow zone indicators(FZI),a.d effective permea.ility(Keff)a.d presenting the CO_(2)stora.e efficiency fa.tors peculia. to the rock units of the study *** results presented by this study for the sta.ed objectives a.e not quite common in the *** va.ues ra.ge from 200 mD to higher tha. 2000 mD,a.d FZI va.ues a.e genera.ly a.ove 1.0 mm a.d up to 13.0 mm within the portions covered by the drilled *** sa.dstone units recorded a.e up to 20 m thick in some *** Keff a.d FZI models indicate the sa.dstone reservoirs a. permea.le units to support the injection a.d circula.ion of CO_(2)within the potentia. reservoir units of the Rio Bonio Forma.ion a.ross São Pa.lo *** from some points in the southea.tern pa.t of the study location,where the Rio Bonito a.e delinea.ed a. depths less tha. 800 m(minimum CO_(2)stora.e depth ba.ed on best pra.tices),other portions a.e deeper,ra.ging from 950 m to 3500 ***-bedded la.ers will a.fect the integrity of the rocks a. CO_(2)stora.e ta.ks or reservoir sea.s/tra.s/overburden within the *** bed thicknesses a.e up to 20 m in some ***,hybrid CO_(2)reservoir units a.e fea.ible,especia.ly in portions where thin siltstone la.ers a.e sa.dwiched between sa.dstone units to provide considera.le thicknesses ba.ed on CO_(2)stora.e *** current study shows tha. usea.le a.ea. considering reservoir thickness,depth,a.d other physical qua.ities will significantly control the CO_(2)stora.e efficiency of the study *** studies fea.uring a.deta.led geophysical explora.ion of the site to confirm the a.a.la.ility a.d sa.ura.ions of preexisting fluid(hydrocarbon a.d wa.er)a.e encoura.ed

关键词： Rio Bonito Effective permea.ility Fluid tra.smissibility CO_(2)stora.e prospect Reservoir qua.ity Overburden integrity Flow zones

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a.new oxida.ive pa.hwa. of nitric oxide production from oximes in pla.ts

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Molecula. Pla.t 2024年第1期17卷 178-198页

作者： Pedro Lopez-Gomez Ja.ier Buezo Ma.ina.Urra.a.fonso Cornejo Ra.uel Esteba. Jorge Ferna.dez de los Reyes Estiba.iz Ura.te Estefa.ia.Rodriguez-Dobreva.a.eja.dro Cha.izo-a.pudia.a.eja.dro Egua.a. Seba.tia. Wolf Da.iel Ma.ino Victor Ma.tinez-Merino Jose F.Mora. Institute for Multidisciplina.y Resea.ch in a.plied Biology(IMa.) Department of SciencesPublic University of Navarre(UPNA)Avda.de Pamplona 12331192 MutilvaSpain Institute for a.va.ced Ma.eria.s a.d Ma.hema.ics(INa.a.2) Department of SciencesPublic University of Navarre(UPNA)Campus de Arosadia31006 PamplonaSpain Depa.tment of Pla.t Biology a.d Ecology University of the Basque Country(UPV/EHU)Sarriena s/nApdo.64448080 BilbaoSpain Center for Pla.t Molecula. Biology(ZMBP) University of TubingenGeschwister-Scholl-Platz72074 TubingenGermany Institute of Na.ura. Resources a.d a.robiology of Sa.a.a.ca(IRNa.a. Department of Plant-Microorganism InteractionsSpanish National Research Council(CSIC)Cordel de Merinas40-5237008SalamancaSpain Depa.tment of Biochemistry Area of Molecular BiologyVeterinary FacultyUniversity of LeonCampus de Vegazanas/n.24071 LeonSpain

Nitric oxide(NO)is a. essentia. rea.tive oxygen species a.d a.signa. molecule in *** severa. studies ha.e proposed the occurrence of oxida.ive NO production,only reductive routes for NO production,such a. the nitra.e(NO_(3)^(-))-upper-reducta.e pa.hwa.,ha.e been evidenced to da.e in la.d ***,pla.ts grown a.enically with a.monium a. the sole source of nitrogen exhibit contents of nitrite a.d NO3−,evidencing the existence of a.meta.olic pa.hwa. for oxida.ive production of *** hypothesized tha. oximes,such a. indole-3-a.eta.doxime(Ia.x),a.precursor to indole-3-a.etic a.id,a.e intermedia.e oxida.ion products in NO *** detected the production of NO from Ia.x a.d other oximes cata.yzed by peroxida.e(POD)enzyme using both 4-a.ino-5-methyla.ino-2′,7′-difluorescein fluorescence a.d *** stimula.ed the rea.tion,while superoxide dismuta.e inhibited ***,mouse NO syntha.e can a.so use Ia.x to produce NO a. a.lower ra.e tha. *** provided a.full mecha.ism for POD-dependent NO production from Ia.x consistent with the experimenta. da.a.a.d supported by density functiona. theory *** showed tha. the a.dition of Ia.x to extra.ts from Medicago truncatula.increa.ed the in vitro production of NO,while in vivo supplementa.ion of Ia.x a.d other oximes increa.ed the number of la.era. roots,a. shown for NO donors,a.d a.more tha. 10-fold increa.e in Ia.x dehydra.a.e ***,we found tha. in vivo supplementa.ion of Ia.x increa.ed NO production in a.a.idopsis tha.ia.a.wild-type pla.ts,while prx33-34 muta.t pla.ts,defective in POD33-34,ha. reduced *** da.a.show tha. the relea.e of NO by Ia.x,a. well a. its a.xinic effect,expla.n the superroot ***,our study revea.s tha. pla.ts produce NO utilizing diverse molecules such a. oximes,POD,a.d fla.ins,which a.e widely distributed in the pla.t kingdom,thus introducing a.long-a.a.ted oxida.ive pa.hwa. to NO production in pla.ts.T

关键词： a.monium oxida.ion a.xin nitric oxide oxime peroxida.e root phenotype

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a.sessment of progra.med dea.h-liga.d 1 expression in prima.y tumors a.d pa.red lymph node meta.ta.es of ga.tric a.enocarcinoma

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World Journa. of Ga.trointestina. Oncology 2024年第3期16卷 883-893页

作者： Brendha.cação Coimbra.Ma.ina.a.essa.dra.Pereira.Leona.do cardili Vena.cio a.a.cini Ferreira.a.ves Eva.dro Sobroza.de Mello Ulysses Ribeiro Jr Ma.cus Ferna.do Koda.a.Pertille Ra.os Depa.tment of Ga.troenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Depa.tment of Pa.hology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

Ba.KGROUND a.ti-progra.med dea.h-1/progra.med dea.h-liga.d 1(PD-1/PD-L1)immuno-thera.y ha. demonstra.ed promising results on ga.tric cancer(GC).However,PD-L1 can express differently between meta.ta.ic sites a.d prima.y tumors(PT).a.M To compa.e PD-L1 sta.us in PT a.d ma.ched lymph node meta.ta.es(LNM)of GC pa.ients a.d to determine the correla.ion between the PD-L1 sta.us a.d clinicopa.hological *** We retrospectively reviewed 284 GC pa.ients who underwent ***-L1 wa. eva.ua.ed by immunohistochemistry(clone SP142)using the com-bined positive *** PD-L1+PT sta.ed a. pN+were a.so tested for PD-L1 expression in their ***-L1(-)GC with pN+served a. the compa.ison *** a.ong 284 GC pa.ients included,45 ha. PD-L1+PT a.d 24 of them ha. pN+.For compa.ison,44 PD-L1(-)cases with pN+were included(sa.ple loss of 4 cases).Of the PD-L1+PT,54.2%(13/24 cases)were a.so PD-L1+in the *** PD-L1(-)PT,9.1%(4/44)ha. PD-L1+in the *** a.reement between PT a.d LNM ha. a.ka.pa.va.ue of *** tumor size a.d modera.e/severe peritumora. infla.ma.ory response were a.socia.ed with PD-L1 positivity in both *** wa. no sta.istical difference in overa.l surviva. for PT a.d LNM a.cording to the PD-L1 sta.us(P=0.166 a.d P=0.837,respectively).CONCLUSION Intra.pa.ient heterogeneity in PD-L1 expression wa. observed between the PT a.d ma.ched *** disa.reement in PD-L1 sta.us ma. empha.ize the importa.ce of considering different tumor sites for a.a.yses to select pa.ients for immunothera.y.

关键词： Ga.tric cancer Lymph node Progra.med dea.h liga.d 1 Stoma.h neopla.ms Immunohistochemistry Meta.ta.is

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