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Debaryomyces hansenii supplementation in low fish meal diets promotes growth,modulates microbiota and enhances intestinal condition in juvenile marine fish

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Journal of Animal Science and biotechnology 2024年第1期15卷 253-276页

作者： Ignasi Sanahuja Alberto Ruiz Joana P.Firmino Felipe E.Reyes-López Juan b.Ortiz-Delgado Eva vallejos-vidal Lluis Tort Dariel Tovar-ramírez Isabel M.Cerezo Miguel A.Moriñigo carmen Sarasquete Enric Gisbert Aquaculture Program Institute of Agrifood Research and Technology(IRTA)La Rapita 43540Spain Centro de biotecnologia Acuicola Universidad de Santiago de ChileSantiagoChile Instituto de Ciencias Marinas de Andalucia(ICMAN-CSIC) Avda.Republica Saharaui no 2Campus Universitario Rio San PedroPuerto RealCadiz 11510Spain Nucleo de Investigaciones Aplicadas en Ciencias veterinarias y Agronomicas Facultad de Medicina Veterinaria y AgronomiaUniversidad de Las AmericasSantiagoChile Department of Cell biology Physiologyand ImmunologyUniversitat Autonoma de BarcelonaBarcelonaSpain Centro de Investigaciones biologicas del Noroeste SC CIBNORLa PazMexico Department of Microbiology Instituto de Biotecnologia Y Desarrollo Azul(IBYDA)Faculty of SciencesUniversity of Malaga29010 MalagaSpain SCbI Bioinformatic UnitUniversity of Malaga29590 MalagaSpain

background The development of a sustainable business model with social acceptance,makes necessary to develop new strategies to guarantee the growth,health,and well-being of farmed *** hansenii is a yeast species that can be used as a probiotic in aquaculture due to its capacity to i)promote cell proliferation and differen-tiation,ii)have immunostimulatory effects,iii)modulate gut microbiota,and/or iv)enhance the digestive *** provide inside into the effects of *** on juveniles of gilthead seabream(Sparus aurata)condition,we inte-grated the evaluation of the main key performance indicators coupled with the integrative analysis of the intestine condition,through histological and microbiota state,and its transcriptomic *** After 70 days of a nutritional trial in which a diet with low levels of fishmeal(7%)was supplemented with 1.1%of ***(17.2×10^(5) CFU),an increase of ca.12%in somatic growth was observed together with an improve-ment in feed conversion in fish fed a yeast-supplemented *** terms of intestinal condition,this probiotic modu-lated gut microbiota without affecting the intestine cell organization,whereas an increase in the staining intensity of mucins rich in carboxylated and weakly sulphated glycoconjugates coupled with changes in the affinity for certain lectins were noted in goblet *** in microbiota were characterized by the reduction in abundance of several groups of Proteobacteria,especially those characterized as opportunistic *** microarrays-based transcrip-tomic analysis found 232 differential expressed genes in the anterior-mid intestine of ***,that were mostly related to metabolic,antioxidant,immune,and symbiotic *** Dietary administration of *** enhanced somatic growth and improved feed efficiency param-eters,results that were coupled to an improvement of intestinal condition as histochemical and transcriptomic tools *** probiotic ye

关键词： Debaryomyces hansenii Intestine condition Low fish meal diet Microbiota Transcriptomics Yeast probiotic

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Music Genre Classification Using African buffalo Optimization

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Computer Systems Science & Engineering 2023年第2期44卷 1823-1836页

作者： b.Jaishankar raghunathan Anitha Finney Daniel Shadrach M.Sivarathinabala v.balamurugan KPR Institute of Engineering and Technology Coimbatore641407India Government Engineering College Palakkad678633India velammal Institute of Technology Chennai601204India Sathyabama Institute of Science and Technology Chennai600119India

In the discipline of Music Information Retrieval(MIR),categorizing musicﬁles according to their genre is a difﬁcult *** genre classiﬁca-tion is an important multimedia research domain for classiﬁcation of music *** the proposed method music genre classiﬁcation using features obtained from audio data is *** classiﬁcation is done using features extracted from the audio data of popular online repository namely GTZAN,ISMIR 2004 and Latin Music Dataset(LMD).The features highlight the differences between different musical *** the proposed method,feature selection is per-formed using an African buffalo Optimization(AbO),and the resulting features are employed to classify the audio using back Propagation Neural Networks(bPNN),Support vector Machine(SvM),Naïve bayes,decision tree and kNN classiﬁ*** evaluation reveals that,AbO based feature selection strategy achieves an average accuracy of 82%with mean square error(MSE)of 0.003 when used with neural network classiﬁer.

关键词： Genre african buffalo optimization neural network SvM audio data music

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calcium-Magnesium ca/Mg ratios and Their Agronomic Implications for the Optimization of Phosphate Fertilization in rainfed Rice Farming on Acidic Ferralsol in the Forest Zone of Ivory Coast

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Open Journal of Soil Science 2024年第1期14卷 81-96页

作者： Fernand G. Yao brahima Kone Franck M. L. bahan Kouadio Amani Jean L. Essehi Mamadou b. Ouattara Konan E. b. Dibi brou Kouame François Lompo Albert Yao-Kouame Central Laboratory Soils Water and Plants (LCSEP) National Center for Agronomic Research (CNRA) Bouaké Ivory Coast Soil Water and Geomaterials Sciences Laboratory (LS2EG) Cocody-Abidjan Earth Sciences and Mining Resources Training and Research Unit (UFR STRM) Félix Houphou&#235t-Boigny University Abidjan Ivory Coast Department of Rice Program Man Research Station National Center for Agronomic Research (CNRA) Man Ivory Coast Department of Geography Unit of Training and Research (UFR) Communication Environment and Society University Alassane Ouattara Bouaké Ivory Coast Food Crops Research Station (SRCv) National Agricultural Research Center (CNRA) Bouaké Ivory Coast Institute of the Environment and Agricultural Research (INEra) Ouagadougou Burkina Faso

This study is a contribution to improving rice productivity on acidic plateau soils of the tropical rainforest zone. It is based on taking into account the cationic balances of the soil in order to optimize the phosphorus (P) nutrition of rice on these acidic soils, where this nutrient constitutes a limiting factor for agricultural production. Three (3) pot trials were conducted in Adiopodoumé in the forested south of Côte d’Ivoire. The interactive effects of calcium carbonate (0, 25, 50 and 75 kg ca ha−1) and magnesium sulfate (0, 25, 50 and 75 kg Mg ha−1) were evaluated on the response of NERIca 5 rice at doses 0, 25, 50 and 75 kg P ha−1 of natural phosphate from Togo, applied only once at the start of the experiment. Additional fertilizers of nitrogen (N) (100 kg N ha−1) and potassium (K) (50 kg KCl ha−1) were added to each of the tests in a split-plot device. The test results revealed a paddy production potential of approximately 3 to 5 t⋅ha−1 for NERIca 5 on an acidic soil, under the effect of the interaction of P, ca and Mg. The quadratic response of rice yield to the doses of these fertilizers would be more dependent on their balance, itself influenced by ca nutrition. For the sustainability and maintenance of rice production in agro-ecology studied, it was recommended doses of 38 kg ca ha−1, 34 kg Mg ha−1 in a ca/Mg ratio (1/1) with intakes of 41 kg P ha−1, overall in a ratio 1/1/1 (P/ca/Mg) more favorable to the availability of free iron considered a guiding element of mineral nutrition. Thus, these promising results should be confirmed in a real environment for better management of the fertilization of rice cultivated on acidic plateau soils in Côte d’Ivoire.

关键词： Soil Acidity ca/Mg ratios Phosphate Fertilization Rice Growing Ivory Coast

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Efficient mid-infrared single-photon detection using superconducting NbTiN nanowires with high time resolution in a Gifford-McMahon cryocooler

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Photonics Research 2022年第4期10卷 1063-1070页

作者： Jin Chang Johannes W.N.los Ronan Gourgues Stephan Steinhauer S.N.Dorenbos Silvania F.Pereira HPaul Urbach val Zwiller Iman Esmaeil Zadeh Optics Research Group ImPhys DepartmentFaculty of Applied SciencesDelft University of TechnologyDelft 2628 CJThe Netherlands Single Quantum b.v. Delft 2628 CJThe Netherlands KTH Royal Institute of Technology Department of Applied PhysicsAlbanova University Centre10691 StockholmSweden

Shortly after their inception, superconducting nanowire single-photon detectors(SNSPDs) became the leading quantum light detection technology. With the capability of detecting single-photons with near-unity efficiency,high time resolution, low dark count rate, and fast recovery time, SNSPDs outperform conventional single-photon detection techniques. However, detecting lower energy single photons(v) with high efficiency and low timing jitter has remained a challenge. To achieve unity internal efficiency at mid-infrared wavelengths, previous works used amorphous superconducting materials with low energy gaps at the expense of reduced time resolution(close to a nanosecond), and by operating them in complex milli Kelvin(mK) dilution refrigerators. In this work,we provide an alternative approach with SNSPDs fabricated from 5 to 9.5 nm thick NbTiN superconducting films and devices operated in conventional Gifford-McMahon cryocoolers. by optimizing the superconducting film deposition process, film thickness, and nanowire design, our fiber-coupled devices achieved >70% system detection efficiency(SDE) at 2 μm and sub-15 ps timing jitter. Furthermore, detectors from the same batch demonstrated unity internal detection efficiency at 3 μm and 80% internal efficiency at 4 μm, paving the road for an efficient mid-infrared single-photon detection technology with unparalleled time resolution and without mK cooling requirements. We also systematically studied the dark count rates(DCRs) of our detectors coupled to different types of mid-infrared optical fibers and blackbody radiation filters. This offers insight into the trade-off between bandwidth and DCRs for mid-infrared SNSPDs. To conclude, this paper significantly extends the working wavelength range for SNSPDs made from polycrystalline NbTiN to 1.5–4 μm, and we expect quantum optics experiments and applications in the mid-infrared range to benefit from this far-reaching technology.

关键词： nanowires technology SNSPD

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vanadium mineralization at los Chihuidos sediment-hosted Cu-v deposit,Neuquén basin,Argentina:An approach to vanadium ore forming processes

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Geoscience Frontiers 2024年第1期15卷 225-246页

作者： Ana L.rainoldi Daniel beaufort Marta b.Franchini Adolfo Giusiano Sabine Petit Patricia Patrier M.Josefina Pons Dpto.de Geología Universidad Nacional del Sur(UNS)8000 Bahía BlancaArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Centro Patagónico de Estudios MetalogenéticosArgentina Universitéde Poitiers IC2MPCNRS-UMR 7285HydrasaF-86022 Poitiers CedexFrance Universidad Nacional del Comahue Facultad de IngenieríaDepartamento de Geología y Petróleo8300 NeuquénArgentina Consultant Geologist 8300 NeuquénArgentina Universidad Nacional de Río Negro Instituto de Investigación en Paleobiología y GeologíaRío NegroArgentina

vanadium mineralization at los Chihuidos deposit of the Neuquén basin is linked to the development of a redox front system related to the inflow of hydrocarbons into the red sandstone of the Huincul *** of hydrocarbons with oxidized red beds and connate water generated redox reactions where hematite was dissolved due to iron reduction resulting in the discoloration of the red *** the contact between oxidized red sandstone and reduced white sandstone,precipitation of specific mineral phases resulted in the v ore with minor amounts of *** the implementation of the redox interface,abundant v-montmorillonite and v-hematite precipitated at the more oxidizing conditions and Cu-v-corrensite-type at the more reducing conditions of the redox *** the redox front advanced with fluids constantly migrating into the reservoir,more reducing conditions were stablished,promoting chloritization and minor illitization with v-Cu incorporation and continuous upgrading of the *** ore mineralogy consists of clay minerals including v-bearing montmorillonite,Cu-v-corrensite-type,v-di-trioctahedral chlorite and Cu-tri-trioctahedral chlorite with minor v-illite-smectite mixed-layer minerals and associated secondary *** over illitization was favored due to high amounts of Fe and Mg in detrital clasts and in connate fluids and by low K availability related to low amounts of detrital *** spatial transition of v and/or Cu bearing clay minerals observed through the mineralized redox front at los Chihuidos deposit(kaolinite→smectite→illite/smectite→corrensite-type→di-trioctahedral-chlorite→tri-trioctahedral-chlorite)and the related variation of v-Cu concentrations in bulk rock are indicative of increasing pH and decreasing Eh of resident solutions from red to white sandstones during the hypogene mineralization *** influx of Cu-rich oxidized basinal brines precipitated main copper ore with Cu-sulfides in the white sandst

关键词： Clay minerals v-chlorite Redox front bleaching Hydrocarbons

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Confirmation of a Sub-Saturn-size Transiting Exoplanet Orbiting a G Dwarf:TOI-1194 b and a very Low Mass Companion Star: TOI-1251 b from TESS

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Research in Astronomy and Astrophysics 2024年第3期24卷 129-143页

作者： Jia-Qi Wang Xiao-Jun Jiang Jie Zheng Hanna Kellermann Arno Riffeser Liang Wang Karen A.Collins Allyson bieryla Lars A.buchhave Steve b.Howell Elise Furlan Eric Girardin Joao Gregorio Eric Jensen Felipe Murgas Mesut Yilmaz Sam Quinn Xing Gao Ruo-Yu Zhou Frank Grupp Hui-Juan Wang caS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy Of SciencesBeijing 10010China University of Chinese Academy of Sciences Beijing 100049China University Observatory Munich Scheinertrsse 1.D-81679 MunichGemany Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1D-85748 GarchingGermany National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing210042China caS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China Center for Astrophysics Harvard&Smithsonian60 Garden Street.CambridgeMA 02138USA National Space Institute Technical University of DenmarkElektrovejDK-2800 KgsLyngbyDenmark NASA Ames Research Center Moffett FieldCA 94035USA NASA Exoplanet Science Institute Caltech/IPACMail Code 100-221200 E.California Blvd.PasadenaCA91125USA Grand Pra Observatory Switzerland Department of Physics Washington UniversitySt.LouisMO 63130.USA Department of Physics and Astronomy Swarthmore CollegeSwarthmorePA 19081USA Instituto de Astrofísica de canarias(IAC) E-38205 La Laguna.TenerifeSpain Departamento de Astrofísica Universidad de La LagunaSpain Dept.of Astronomy and Space Sciences Ankara UniversityTandogan 06100AnkaraTurkey Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Urumqi No.1 Senior High School Urumqi 830002China Lijiang Gemini Observatory Lijiang 674199China

We report the confirmation of a sub-Saturn-size exoplanet,TOI-1194 b,with a mass of about 0.456+0.055-0.051M_(J),and a very low mass companion star with a mass of about 96.5±1.5 MJ,TOI-1251 *** candidates provided by the Transiting Exoplanet Survey Satellite(TESS)are suitable for further follow-up observations by ground-based telescopes with small and medium *** analysis is performed based on data from several telescopes worldwide,including telescopes in the Sino-German multiband photometric campaign,which aimed at confirming TESS Objects of Interest(TOIs)using ground-based small-aperture and medium-aperture telescopes,especially for long-period ***-1194 b is confirmed based on the consistent periodic transit depths from the multiband photometric *** measure an orbital period of 2.310644±0.000001 days,the radius is 0.767+0.045-0.041RJ and the amplitude of the Rv curve is 69.4_(-7.3)^(+7.9)m s^(-1).TOI-1251 b is confirmed based on the multiband photometric and high-resolution spectroscopic data,whose orbital period is 5.963054+0.000002-0.000001days,radius is 0.947+0.035-0.033 R_(J) and amplitude of the Rv curve is 9849_(-40)^(+42)ms^(-1).

关键词： planets and satellites fundamental parameters-planets and satellites gaseous planets-stars fundamental parameters-stars low-mass-methods data analysis-techniques photometric-techniques spectroscopic

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The Holocene environmental changes revealed from the sediments of the Yarkov sub-basin of Lake Chany,south-western Siberia

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Geoscience Frontiers 2023年第2期14卷 133-153页

作者： S.K.Krivonogov A.N.Zhdanova P.A.Solotchin A.Y.Kazansky v.v.Chegis Z.Liu M.Song S.v.Zhilich N.A.Rudaya X.cao O.v.Palagushkina L.b.Nazarova L.S.Syrykh Institute of Geology and Mineralogy Russian Academy of SciencesSiberian BranchNovosibirskRussia Novosibirsk State University NovosibirskRussia Korkyt Ata Kyzylorda University KyzylordaKazakhstan Moscow State University MoscowRussia Geological Institute Russian Academy of SciencesMoscowRussia Pushkov Institute of Terrestrial Magnetism Ionosphere and Radio Wave PropagationRussian Academy of SciencesTroitskRussia Department of Earth Sciences The University of Hong KongHong KongChina State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’anChina Institute of Archaeology and Ethnography Russian Academy of SciencesSiberian BranchNovosibirskRussia Tomsk State University TomskRussia Alpine Paleoecology and Human Adaptation Group(ALPHA) State Key Laboratory of Tibetan Plateau Earth SystemEnvironment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijingChina volga Region Federal University KazanRussia Krasnoyarsk Science Center Russian Academy of SciencesSiberian BranchKrasnoyarskRussia Herzen State Pedagogical University St.PetersburgRussia

Lake Chany is the largest endorheic lake in Siberia whose catchment is entirely on the territory of *** geographical location on the climate-sensitive boundary of wet and dry landscapes provides an opportunity to gain more knowledge about environmental changes in the West Siberian interior during the Holocene and about the evolution of the lake *** cores obtained from the Yarkov subbasin of the lake in 2008 have been comprehensively studied by a number of approaches including sedimentology and AMS dating,pollen,diatom and chironomid analyses(with statistical interpretation of the results),mineralogy of authigenic minerals and geochemistry of plant lipids(biomarker analysis.).Synthesis of new results presented here and published data provides a good justification for our hypothesis that Lake Chany is very young,no older than 3.6 ka *** that,between 9 and 3.6 ka bP,the Chany basin was a swampy landscape with a very low sedimentation rate;it could not be identified as a water *** the early lake phase,between 3.6 and 1.5 ka bP,the lake was shallow,1.2–3.5 m in depth,and it rose to its modern size,up to 6.5 m in depth,during the last *** data reveal important changes in the understanding of the history of this large endorheic lake,as before it was envisioned as a large lake with significant changes in water level since ca.14 ka *** addition to hydrology,our proxies provide updates and details of the regional vegetation and climate change since ca.4 ka bP in the WestSiberian forest-steppe and *** evolution of the Chany basin is dependent on hydroclimatic changes in a large region of southern West Siberia,we compare lake-level change and climate-change proxies from the other recently and most comprehensively studied lakes of the region.

关键词： Saline lake Multiproxy study Holocene Climate Environment West Siberia

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Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

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Nano Research 2023年第5期16卷 7119-7133页

作者： Alexander v.Romashchenko Dmitrii v.Petrovskii Sergey Yu.Trotsky Ksenia N.Morozova Nina b.Illarionova Maria v.Zhukova Elena v.Kiseleva Marina b.Sharapova Daniil S.Zuev Konstantin E.Kuper Sergey Yu.Taskaev Anna I.Kasatova Dmitrii A.Kasatov Olga I.Solovieva Ivan A.razumov Ludmila A.Gerlinskaya Mikhail P.Moshkin Yuri M.Moshkin The Federal Research Center Institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia International tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.boreskov Institute of catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center budker Institute of Nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia Institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia Institute of Gene biology Russian Academy of SciencesMoscow 117334Russia Institute of Molecular and Cellular biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

Nanoparticles(NPs)can be transported via the nose-to-brain(N_(2)b)***,quantitative data on their spatiotemporal dynamics and regulation of the N_(2)b transport are largely *** surveyed metal oxide/hydroxide NPs as magnetic resonance imaging(MRI)contrasts for quantitative N_(2)b *** containing divalent transition metals were the only ones capable of N_(2)b *** T1-weighted(T1W)MRI,we showed that Mn_(3)O_(4)-NPs were readily engulfed by olfactory receptor neurons(ORNs)without disrupting olfactory sensing,we mapped their N_(2)b *** neurons,the Mn_(3)O_(4)-NPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** NPs’axonal transport is dependent on neuronal activity and microtubule *** Mn_(3)O_(4)-NPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the NPs was dependent on N-type ca^(2+)channels and NMDA receptors but blocked by GAbAb receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W MRI data allowed for estimating kinetic parameters of Mn_(3)O_(4)-NP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORNs,indicating a coupling of the NPs’N_(2)b transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the Mn_(3)O_(4)-NP N_(2)b transport odor ***,the NPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling N_(2)b drug delivery.

关键词： Mn_(3)O_(4)nanoparticles magnetic resonance imaging(MRI) nose-to-brain transport trans-synaptic transmission olfactory stimulation

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Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

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World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li brittney O baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini valvi Michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A baccarelli Rob McConnell David v Conti Lida Chatzi Department of Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

bACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation ballooning degeneration

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Anti-N-methyl-D-aspartate receptor-associated encephalitis: A review of clinicopathologic hallmarks and multimodal imaging manifestations

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World Journal of radiology 2024年第1期16卷 1-8页

作者： bryce David beutler Alastair E Moody Jerry Mathew Thomas benjamin Phillip Sugar Mark b Ulanja Daniel Antwi-Amoabeng Lucas Anthony Tsikitas Department of radiology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States Department of Anesthesiology University of UtahSalt Lake CityUT 84132United States Department of Internal Medicine Christus Ochsner St.Patrick HospitalLake CharlesLA 70601United States

Anti-N-methyl-D-aspartate receptor-associated encephalitis(NMDARE)is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic *** mechanism of pathogenesis remains incompletely understood,but is thought to be related to antibodies targeting the GluN1 subunit of the NMDA receptor with resultant downstream dysregulation of dopaminergic *** adults are most frequently affected;the median age at diagnosis is 21 *** is a strong female predilection with a female sex predominance of 4:*** often develops as a paraneoplastic process and is most commonly associated with ovarian ***,NMDARE has also been described in patients with small cell lung cancer,clear cell renal carcinoma,and other benign and malignant *** is based on correlation of the clinical presentation,electro-encephalography,laboratory studies,and *** tomography,positron emission tomography,and magnetic resonance imaging are essential to identify an underlying tumor,exclude clinicopathologic mimics,and predict the likelihood of long-term functional *** imaging may be of value for prognostication and to assess the response to *** may involve high-dose corticosteroids,intravenous immunoglobulin,and plasma ***,we review the hallmark clinicopathologic features and imaging findings of this rare but potentially devastating condition and summarize diagnostic criteria,treatment regimens,and proposed pathogenetic mechanisms.

关键词： Anti-N-methyl-D-aspartate receptor-associated encephalitis Autoimmune encephalitis Encephalitis Ovarian teratoma Paraneoplastic syndrome Teratoma

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