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Association between glucose-lowering drugs and circulating insulin antibodies induced by insulin therapy in patients with type 2 diabetes

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World Journal of Diabetes 2024年第7期15卷 1489-1498页

作者： Peng Zhang Qing Jiang Bo Ding Reng-Na Yan Yun Hu Jian-Hua ma Department of Endocrinology Nanjing First HospitalNanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Department of Endocrinology The Affiliated Wuxi People's Hospital of Nanjing Medical UniversityWuxi Medical CenterWuxi 214000Jiangsu ProvinceChina

BACKGROUND Insulin antibodies(ias)affect blood glucose control in patients receiving insulin *** To investigate the relationship between different hypoglycemic treatments and ias in patients with type 2 diabetes mellitus(T2DM).METHODS This cross-sectional,retrospective study included 1863 patients with T2DM who were receiving exogenous insulin *** patients received stable antidiabetic therapy in the last 3 months and ia levels were measured using an iodine-125 *** A total of 1863 patients were *** were 902(48.4%)patients who had positive ias(ia level>5%),with a mean ia level of 11.06%(10.39%-11.72%).ia levels were positively correlated with high fasting blood glucose(odds ratio=1.069,Pias was lowest in patients using glargine only(31.9%)and highest in patients using human insulin only(70.3%),Pia levels in patients using sulfonylureas/glinides(8.3%),metformin(9.6%),and dipeptidyl peptidase-4 inhibitors(8.2%)were all lower than in patients without these drugs(all Pia antibodies,and ia antibody levels are associated with blood glucose *** glargine and a combination of oral glucose-lowering drugs were correlated with lower ia levels.

关键词： Insulin antibodies Insulin therapy Glucose-lowering drugs Glargine Type 2 diabetes

Population genomic analysis reveals key genetic variations and the driving force for embryonic callus induction capability in maize

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Journal of Integrative Agriculture 2024年第7期23卷 2178-2195页

作者： Peng Liu Langlang ma Siyi Jian Yao He Guangsheng Yuan Fei Ge Zhong Chen Chaoying Zou Guangtang Pan Thomas Lübberstedt Yaou Shen State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China/maize Research Institute Sichuan Agricultural UniversityChengdu 611130China Department of Agronomy Iowa State UniversityAmesIA 50011USA

Genetic transformation has been an effective technology for improving the agronomic traits of ***,it is highly reliant on the use of embryonic callus(EC)and shows a serious genotype *** this study,we performed genomic sequencing for 80 core maize germplasms and constructed a high-density genomic variation map using our newly developed pipeline(MQ2Gpipe).Based on the induction rate of EC(REC),these inbred lines were categorized into three *** low-REC germplasms displayed more abundant genetic diversity than the high-REC *** integrating a genome-wide selective signature screen and region-based association analysis,we revealed 95.23 Mb of selective regions and 43 REC-associated *** variants had phenotypic variance explained values ranging between 21.46 and 49.46%.In total,103 candidate genes were identified within the linkage disequilibrium regions of these REC-associated *** genes mainly participate in regulation of the cell cycle,regulation of cytokinesis,and other functions,among which MYB15 and EMB2745 were located within the previously reported QTL for EC *** leaf area-associated variants with large effects were closely linked to several REC-related loci,implying a potential synergistic selection of REC and leaf size during modern maize breeding.

关键词： maize genetic transformation embryonic callus selective signal association analysis

Two-dimensional atomically thin Pt layers on MXenes: The role of electronic effects during catalytic dehydrogenation of ethane and propane

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Nano Research 2024年第3期17卷 1251-1258页

作者： Zhe Li Tobias K.Misicko Fan Yang Xiaopeng Liu Zhenwei Wu Xiaoyang Gao Tao ma Jeffrey T.Miller Daniela S.mainardi Collin D.Wick Zhenhua Zeng Yang Xiao Yue Wu Department of Chemical and Biological Engineering Iowa State University618 Bissell RoadAmesIA 50011USA Institute for Micromanufacturing Louisiana Tech University505 Tech DriveRustonLA 71272USA Davidson School of Chemical Engineering Purdue University480 Stadium Mall DriveWest LafayetteIN 47907USA Michigan Center for materials Characterization University of Michigan2800 Plymouth RdAnn Arbor MI 48109USA College of Engineering and Science Louisiana Tech UniversityRustonLA 71272USA

Atomically thin Pt nanolayers were synthesized on the surface of Mo2TiC2 MXenes and used for the catalytic dehydrogenation of ethane and propane into ethylene and propylene,two important chemicals for the petrochemical *** compared with Pt nanoparticles,the atomically thin Pt nanolayer catalyst showed superior coke-resistance(no deactivation for 24 h),high activity(turnover frequencies(TOFs)of 0.4–1.2 s^(-1)),and selectivity(>95%)toward ethylene and *** unique Pt nanolayer has a similar geometric surface to Pt nanoparticles,enabling the investigations of the electronic effect on the catalytic performance,where the geometric effect is *** is found that the electronic effect plays a critical role in dehydrogenative product selectivity and catalyst *** metal–support interaction is found dependent on the substrate and metal components,providing wide opportunities to explore high-performance MXene-supported metallic catalysts.

关键词： MXene catalysis alkane dehydrogenation nanolayers

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黄河流域碳排放的时空格局演变及驱动机制

北方民族大学学报（哲学社会科学版） 2024年第4期 137-147页

作者：马明德北方民族大学学报编辑部宁夏银川750021

黄河流域是我国资源能源富集区,也是碳排放较为集中的区域,实现碳减排任务十分艰巨。宁夏是黄河流域重要省区,随着经济社会的发展,碳排放呈现不断增加的趋势。影响宁夏各县域碳排放的原因复杂,其中,第二产业和能源消耗是造成碳排放的主... 详细信息

黄河流域是我国资源能源富集区,也是碳排放较为集中的区域,实现碳减排任务十分艰巨。宁夏是黄河流域重要省区,随着经济社会的发展,碳排放呈现不断增加的趋势。影响宁夏各县域碳排放的原因复杂,其中,第二产业和能源消耗是造成碳排放的主要原因,人口规模、城镇居民可支配收入、人均GDP、建设用地、固定资产投资等因素对碳排放的影响系数有正值有负值,这些因素与碳排放之间可能存在类似环境库兹涅茨曲线关系,人口对碳排放逐渐表现出抑制作用。因此,宁夏应该升级产业结构,提高资源利用效率,优化人口空间分布格局,提高居民收入水平,加快清洁能源使用,促进经济与生态环境协调发展。

关键词：黄河流域碳排放时空格局驱动机制

中国西部旅游城镇化与人居环境的时空耦合协调性及驱动力

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地理科学 2024年第3期44卷 463-473页

作者：马梦瑶唐健雄湖南师范大学旅游学院湖南长沙410081

本文在构建旅游城镇化与人居环境耦合协调理论框架的基础上,运用耦合协调模型、空间引力模型、地理探测器等方法,实证分析2005-2019年中国西部旅游城镇化与人居环境的时空耦合协调性及驱动力。结果表明:①旅游城镇化与人居环境综合指数... 详细信息

本文在构建旅游城镇化与人居环境耦合协调理论框架的基础上,运用耦合协调模型、空间引力模型、地理探测器等方法,实证分析2005-2019年中国西部旅游城镇化与人居环境的时空耦合协调性及驱动力。结果表明:①旅游城镇化与人居环境综合指数均值呈上升态势,旅游城镇化发展水平增速快于人居环境,但人居环境指数整体高于旅游城镇化。②旅游城镇化与人居环境耦合协调度的中级协调区域居多,2017年以后演变为高级协调,耦合协调类型逐渐由旅游产业滞后型向同步发展型转变。③旅游城镇化与人居环境耦合协调度空间趋势极不均衡,空间联系强度呈现出以宁夏–陕西–重庆–贵州为主轴的链状式空间关联格局。④耦合协调度差异是不同驱动因素共同作用的结果,国际旅游收入是主导性驱动,人均社会固定资产投资是根本性驱动,A级景区数量是原生性驱动,其中国际旅游收入与A级景区的交互影响作用解释力最强。

关键词：旅游城镇化人居环境空间引力模型地理探测器中国西部

乡村聚落与耕地共生理论模型及案例区情景模拟

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地理学报 2024年第5期79卷 1265-1285页

作者：马利邦张文博王祥陈贤斐白静西北师范大学地理与环境科学学院兰州730070 甘肃省绿洲资源环境与可持续发展重点实验室兰州730070 西北师范大学西北城乡发展与协同治理研究院兰州730070

乡村聚落与耕地作为描述乡村发展的重要子系统,两者互利共生对于乡村可持续发展至关重要。在甘肃省环境异质性背景下,以1384个乡(镇)为研究单元,引入共生理论构建乡村聚落与耕地共生框架,构建乡村聚落、耕地、共生环境评价指标体系,借助... 详细信息

乡村聚落与耕地作为描述乡村发展的重要子系统,两者互利共生对于乡村可持续发展至关重要。在甘肃省环境异质性背景下,以1384个乡(镇)为研究单元,引入共生理论构建乡村聚落与耕地共生框架,构建乡村聚落、耕地、共生环境评价指标体系,借助Lotka-Volterra模型识别其共生模式。新一轮国土空间规划背景下,借助SD-FLUS耦合模型对比分析2035年惯性发展情景(BD)和规划发展情景(PD)下共生模式演变趋势。研究发现:(1) 2000—2020年甘肃省乡村聚落、耕地发展水平呈先增后减趋势,共生环境容量呈持续下降趋势;五大农业区划3个指标差异显著,河西灌溉农业区(ia)具有明显发展优势。(2) 2000—2020年甘肃省乡村聚落与耕地共生模式整体呈互利共生向互害共生转变,互利共生占比由59.80%下降至38.97%;区域间主导模式差异显著,高寒牧区(AP)、陇南山地农业区(ma)、ia以互利共生为主,陇中旱作农业区(DA)、陇东雨养农业区(RA)分别以聚落偏害、耕地偏利为主;2000—2020年各区域主导模式均趋于多元化且呈现出由互利共生向互害共生转移的发展共性。(3)不同情景下共生模式差异显著,BD情景下五大区域延续历史粗放发展模式,互利共生模式占比均持续减少,而PD情景下因共生单元、环境容量水平的提升,共生模式向互利共生进化。

关键词：乡村聚落耕地共生模式多维情景模拟甘肃省

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新发现《雅俗通音》手稿本音系研究

语言研究 2024年第2期44卷 55-63页

作者：马重奇叶晓芳闽南师范大学闽南文化研究院福建漳州363000

《雅俗通音》是最近新发现的一部漳州地区的方言韵书。《雅俗通音》有18个声母,86个韵母和7个调类。《雅俗通音》与《汇集雅俗通十五音》声母和声调基本相同,韵母则比《汇集雅俗通十五音》少了2个字母、3个韵母,即糜[uei/uei?]和牛[lu]... 详细信息

《雅俗通音》是最近新发现的一部漳州地区的方言韵书。《雅俗通音》有18个声母,86个韵母和7个调类。《雅俗通音》与《汇集雅俗通十五音》声母和声调基本相同,韵母则比《汇集雅俗通十五音》少了2个字母、3个韵母,即糜[uei/uei?]和牛[lu],但比《汇集雅俗通十五音》则多了4个韵母,即爻[au?]、惊[ia]、光[ui]、姆[m?]。《雅俗通音》的方言基础是清代末年漳州府漳浦县的方言音系。

关键词：雅俗通音共时比较历时比较音系性质

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融合先验信息的单株植物三维结构点云配准方法

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山东科技大学学报（自然科学版） 2024年第4期43卷 74-83页

作者：王太阳张熙空马楠曾宝秀东华理工大学测绘与空间信息工程学院江西南昌330006 山东科技大学大学测绘与空间信息学院山东青岛266590 青岛星科瑞升信息科技有限公司山东青岛266590 中科卫星(山东)科技集团有限公司山东济南250000

针对样本一致性初始对化(SAC-ia)点云配准算法在处理样本抽样和误差计算时存在的高计算成本和鲁棒性不足的问题,提出一种融合先验信息的单株植物三维结构点云粗配准方法。该方法首先采用“体素下采样+直通滤波+统计离群点去除”的点云... 详细信息

针对样本一致性初始对化(SAC-ia)点云配准算法在处理样本抽样和误差计算时存在的高计算成本和鲁棒性不足的问题,提出一种融合先验信息的单株植物三维结构点云粗配准方法。该方法首先采用“体素下采样+直通滤波+统计离群点去除”的点云预处理策略,在有效降低点云数据量的同时保留植物结构的关键特征信息。通过引入基于先验知识的初始姿态约束,对SAC-ia算法进行改进,减少不合理变换矩阵的迭代次数,从而提高配准效率,降低误匹配风险。实验结果证明,所提方法配准均方根误差为6.242,时间为0.902 s,相比SAC-ia方法节省了1.407 s,显著提升了单株植物三维结构点云配准的运算效率和鲁棒性。

关键词： SAC-ia方法点云配准先验信息单株植物

Hybrid scheme for three-cell multi-user MIMO cellular networks

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The Journal of China Universities of Posts and Telecommunications 2014年第5期21卷 37-42页

作者： ma Yan-jun School of Communication Engineering Xi'an University of Science and Technology

Orthogonal schemes are usually adopted for cell-edge users in a cellular network, where the spectrum is poorly utilized. A new interference alignment （ia） based space-division hybrid （ia-SDH） scheme is proposed by joint design transmit precoding matrices and beamforming matrices for a three-cell constant cellular network, where users at cell-center work with a conventional scheme while users at cell-edge utilize an ia scheme. Therefore, the cell-edge users suffer no interference and cell-center users are only affected by negligible inter-cell interference. Analysis simulation shows that more users can be served simultaneously than that of a conventional scheme in certain user distributions.

关键词： iterference alignment degree of freedom interference channel