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Periprosthetic joint infections in femoral neck fracture patients treated with hemiarthroplasty–should we use antibiotic-loaded bone cement?

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World Journal of Orthopedics 2022年第2期13卷 150-159页

作者： Diana Crego-Vita Daniel Aedo-Martín Rafael Garcia-cañas Andrea Espigares-Correa Coral Sánchez-Pérez Christof Ernst Berberich Department of Orthopaedic and Trauma Surgery Hospital Central de la Defensa Gómez UllaMadrid 28047Spain Department of Orthopaedic and Trauma Surgery Hospital Universitario del HenaresUniversidad Francisco de VitoriaCoslada 28822MadridSpain Department of Orthopeadic and Trauma Surgery Hospital Central de la Defensa Gómez UllaMadrid 28047Spain Department of Orthopeadic and Trauma Surgery General University Hospital Gregorio MaranonMadrid 28007Spain Department of Medical Training Heraeus Medical GmbHWehrheim 612173HessenGermany

BACKGROUND Hemiarthroplasty is the most common treatment in elderly patients with displaced intra-capsular femoral neck fracture(FNF).Prosthetic joint infection(PJI)is one of the most feared and frequent complications post-surgery because of the frail health status of these patients and the need for fast track ***,priorities should lie in effective preventive strategies to mitigate this *** To determine how much the implementation of the routine use of antibioticloaded bone cement(ALBC)as a relatively easy-to-apply amendment to the surgical practice reduces the infection rate in our hemiarthroplasty *** We retrospectively assessed all demographic,health status and treatment-related data of our FNF patients undergoing cemented hemiarthroplasty in the period from 2011 to 2017;241 patients were further analyzed after exclusion of patients with cancer-related sequelae and those who died before the end of the 1-year observation *** PJI rate as diagnosed on basis of the Musculoskeletal Infection Society(MSIS)criteria 2011 was determined for each included patient and compared in function of the bone cement used for hip stem *** were split into a group receiving a plain bone cement in the period from January 2011 to June 2013(non-ALBC group)and into a group receiving an ALBC in the period July 2013 to December 2017(ALBC group).Data analysis was performed with statistical *** further calculated the cost-efficacy of the implementation of routine use of ALBC in the second group balancing the inhospital infection related treatment costs with the extra costs of use of *** In total 241 FNF patients who received cemented hemiarthroplasty in the period from January 2011 to January 2017 were eligible for inclusion in this retrospective *** were 8 PJI cases identified in the ALBC group among n=94 patients,whereas 28 PJI cases were observed in the non-ALBC group among n=147 *** statistical analysis

关键词： prosthetic joint infection Femoral neck fracture patients Hemiarthroplasty Antibiotic-loaded bone cement Prophylaxis Cost-efficacy

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POLES OF ZETA FUNCTIONS OF COMPLETE INTERSECTIONS

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Chinese Annals of Mathematics,Series B 2000年第2期21卷 187-200页

作者： WAN DAQING(Department of Mathematics, University of california, Irvine, ca 92697-3875, USA.) Department of Mathematics University of California Irvine CA 92697-3875 USA

A vanishing theorem is proved for e-adic cohomology with compact support on an affine (singular) complete intersection. As an application, it is shown that for an affine complete intersection defined over a finite field of q elements, the reciprocal "poles" of the zeta function are always divisible by q as algebraic integers. A p-adic proof is also given, which leads to further q-divisibiliy of the poles or equivalently an improvement of the polar part of the AxKatz theorem for an affine complete intersection. Similar results hold for a projective complete intersection.

关键词：极点 ZETA函数完全交叉消没理论

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Optimization of phenol degradation by candida tropicalis Z-04 using Plackett-Burman design and response surface methodology

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Journal of Environmental Sciences 2011年第1期23卷 22-30页

作者： Jiangya Zhou Xiaojuan Yu Cong Ding Zhiping Wang Qianqian Zhou Hao Pao Weimin ca School of Environmental Science and Engineering Shanghai Jiaotong University Dongchuan Road 800 Shanghai 200240 China.

Statistical experimental designs were used to optimize the process of phenol degradation by candida tropicalis Z-04, isolated from phenol-degrading aerobic granules. The most important factors influencing phenol degradation （p 〈 0.05）, as identified by a two-level Plackett-Burman design with 11 variables, were yeast extract, phenol, inoculum size, and temperature. Steepest ascent method was undertaken to determine the optimal regions of these four significant factors. Central composite design （CCD） and response surface analysis were adopted to further investigate the mutual interactions between these variables and to identify their optimal values that would generate maximum phenol degradation. The analysis results indicated that interactions between yeast extract and temperature, phenol and temperature, inocuhim size and temperature affected the response variable （phenol degradation） significantly. The predicted results showed that the maximum removal efficiency of phenol （99.10%） could be obtained under the optimum conditions of yeast extract 0.41 g/L, phenol 1.03 g/L, inoculum size 1.43% （V/V） and temperature 30.04℃. These predicted values were further verified by validation experiments. The excellent correlation between predicted and experimental values confirmed the validity and practicability of this statistical optimum strategy. This study indicated the excellent ability of C. tropicalis Z-04 in degrading high-strength phenol. Optimal conditions obtained in this experiment laid a solid foundation for further use of this microorganism in the treatment of highstrength phenol effluents.

关键词： phenol degradation candida tropicalis Z-04 optimization Plackett-Burman design response surface methodology

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Randomized clinical study of five days apostrophe therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children

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World Journal of Gastroenterology 2006年第39期12卷 6366-6370页

作者： Roberto caete Angel A Escobedo María E González Pedro Almirall Hygiene Epidemiology and Microbiology Centre Matanzas City Cuba Academic Paediatric Hospital "Pedro Borrás" Havana City Cuba Institute of Gastro-enterology Havana City Cuba "Pedro Kourí" Institute Havana City Cuba

AIM: To compare the efficacy and safety of five days apostrophe therapy of mebendazole (MBZ) versus quina- crine (QC) on human giardiasis in children. METHODS: A clinical trial was carried out in paediatric patients (aged 5-15 years) with confirmed symptomatic G. duodenalis mono-infection. Patients were randomly as- signed to receive either MBZ [200 mg taken three times per day (TID) (n = 61)] or QC [2 mg/kg bodyweight tid (n = 61)], both for five days. Follow-up faecal samples were obtained at 3, 5 and 7 d after the end of the treatment. RESULTS: Although the frequency of cure was higher for QC (83.6%) than for MBZ (78.7%), the difference was not statistically significant (P > 0.05). Adverse events were reported more in the QC group (P cacy of MBZ in giardiasis and also indicate that, although comparable to QC, at least in this setting the 5 d course of MBZ did not appear to improve the cure rates in this intestinal parasitic infection.

关键词：甲苯咪唑奎纳克林贾第鞭毛虫病儿童

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ca19-9 antigen levels can distinguish between benign and malignant pancreaticobiliary disease

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Hepatobiliary & Pancreatic Diseases International 2009年第6期8卷 620-626页

作者： Gareth Morris-Stiff Mary Teli Nicky Jardine Malcolm ca Puntis Department of Surgery University Hospital of Wales

BACKGROUND:ca19-9 is a carbohydrate tumor-associated antigen which is frequently upregulated in pancreatobiliary ***,it may also be elevated in patients with jaundice in the absence of a tumor due to biliary obstruction,and in other non-hepato-pancreatico-biliary *** study aimed to evaluate whether ca19-9 levels could accurately differentiate between benign and malignant pancreatobiliary ***:All patients referred to a single surgeon for investigation of pancreaticobiliary disease in 2003 in whom a firm diagnosis had been established were *** malignant disease,a histological diagnosis was required but for benign disease a firm radiological diagnosis was deemed *** patients were divided into 4 categories:pancreatic adenocarcinoma(Pca);cholangiocarcinoma(Cca);chronic pancreatitis(CP)and biliary calculous disease(calc).Bilirubin and alkaline phosphatase levels corresponding to the point of assessment of ca19-9 were also ***:Final diagnoses were made of pancreatic adenocarcinoma(Pca,n=73),cholangiocarcinoma(Cca,n=19),ampullary carcinoma(Amp,n=7),neuroendocrine carcinoma(Neu,n=4),duodenal carcinoma(Duo,n=3),chronic pancreatitis(CP,n=115),and biliary calculous disease(calc,n=27).Median ca19-9 levels(U/ml)were:Pca,653;Cca,408;Duo,403;calc,27;CP,19;Neu,10.5;Amp,8(reference range:0-37).The ca19-9 levels were significantly greater for malignant than for benign disease,could differentiate Pca from Cca/Duo,and were significantly higher in unresectable than in resectable *** sensitivity,specificity,positive predictive value(PPV)and negative predictive value(NPV)for ca19-9 were 84.9%,69.7%,67.7%and 86.1%,respectively.A ROC analysis provided an area under the curve for ca19-9 of 0.871(0.820-0.922),giving an optimal ca19-9 of 70.5 U/ml for differentiating benign from malignant *** this cut-off,the sensitivity was 82.1%,while specificity,PPV and NPV improved to 85.9%,81.3%and 86.5%,*** sta

关键词： ca19-9 antigen pancreatic disease biliary tract disease malignant benign

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Representations of Knot Groups and Twisted Alexander Polynomials

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Acta Mathematica Sinica,English Series 2001年第3期17卷 5+362-380页

作者： Xiao Song LIN Department of Mathematics,University of california,Riversides,ca 92521.USA Department of Mathematics University of California Riverside USA

We present a twisted version of the Alexander polynomial associated with a matrix rep- resentation of the knot *** of two knots with the same Alexander module but different twisted Alexander polynomials are given.

关键词： Twisted Alexander polynomial Representation space Knot group

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ON THE KINEMATIC GEOMETRY OF MANY BODY SYSTEMS

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Chinese Annals of Mathematics,Series B 1999年第1期20卷 11-28页

作者： WU-YI HSIANG(Department of Mathematics,University of caLIFORNIA,berkeley,ca 94720-3840,USA) Department of Mathematics University of California Berkeley CA 94720-3840 USA

***-bodysystemconsistsofthetotalityofallpossibleconfigurationswhichcanbeconvenientlyrepresentedb***-thparticle,bethetotalmassand... 详细信息

***-bodysystemconsistsofthetotalityofallpossibleconfigurationswhichcanbeconvenientlyrepresentedb***-thparticle,bethetotalmassand...

关键词：运动几何学体系统配置空间量子论

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优质化护理在老年慢性支气管炎护理中的应用效果

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中国当代医药 2018年第21期25卷 195-197页

作者：曹晶深圳市宝安中医院集团门诊广东深圳518100

目的研究优质化护理在老年慢性支气管炎护理中的应用效果。方法选取2016年2月~2017年2月我院收治的80例老年慢性支气管炎患者作为研究对象,根据护理干预方式的不同将其分为对照组、观察组,每组40例。对照组中的患者采用常规护理;观察组... 详细信息

目的研究优质化护理在老年慢性支气管炎护理中的应用效果。方法选取2016年2月~2017年2月我院收治的80例老年慢性支气管炎患者作为研究对象,根据护理干预方式的不同将其分为对照组、观察组,每组40例。对照组中的患者采用常规护理;观察组中患者采用优质化护理。对所有患者护理前、护理后的生活质量以及护理满意度进行比较。结果观察组患者护理后的生活质量评分均高于护理前,且观察组患者护理后的生活质量评分高于对照组,差异均有统计学意义(P0.05)。观察组患者的护理总满意度高于对照组,差异有统计学意义(P0.05)。结论优质化护理在老年慢性支气管炎护理中的应用效果显著,改善患者的生活质量,提高护理满意程度,值得推广使用。

关键词：优质化护理老年慢性支气管炎临床效果

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盐碱与冻融耦合作用下再生混凝土耐久性试验研究

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硅酸盐通报 2018年第1期37卷 10-16页

作者：王晨霞郭磊曹芙波内蒙古科技大学土木工程学院包头014000

通过再生混凝土在3.5%Na Cl、3.5%Na_2SO_4、3.5%Na Cl+3.5%Na_2SO_4和水四种溶液中的冻融循环试验,分析再生混凝土在同浓度不同种类盐碱溶液中经过不同冻融次数后(N)的质量变化(△m)和动弹性模量变化(△E),绘制N-△m和N-△E的曲线。同... 详细信息

通过再生混凝土在3.5%Na Cl、3.5%Na_2SO_4、3.5%Na Cl+3.5%Na_2SO_4和水四种溶液中的冻融循环试验,分析再生混凝土在同浓度不同种类盐碱溶液中经过不同冻融次数后(N)的质量变化(△m)和动弹性模量变化(△E),绘制N-△m和N-△E的曲线。同时,设置单掺10%、20%粉煤灰和2%、4%硅灰为对照组,研究粉煤灰和硅灰组分别在3.5%Na Cl和3.5%Na_2SO_4环境下混凝土的抗冻性能规律。结果表明:氯盐环境中,随冻融次数的增加,混凝土表面剥削、开裂现象明显,质量和动弹性模量损失严重,而硫酸盐环境中,冻融前期混凝土内部生成水化产物使质量增加,表面膨胀开裂,后期质量和动弹性模量急剧下降,与浓度3.5%氯盐盐冻相比,硫酸盐盐冻动弹性模量损失更大。冻融破坏强度由强到弱排序为氯盐冻、硫酸盐冻、复合盐冻、水冻;掺入粉煤灰后,氯盐环境下的混凝土抗冻性反而下降,10%掺量优于20%掺量。掺入硅灰后,硫酸盐环境下再生混凝土抗冻性提高,破坏程度要比水冻小,4%掺量优于2%掺量;最后分析了混凝土腐蚀机理。

关键词：盐碱腐蚀再生混凝土冻融循环粉煤灰硅灰

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消费者意愿及地方政府行为对农户种植行为的影响机制

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财经理论与实践 2018年第4期39卷 141-147页

作者：曹裕杜志伟胡韩莉中南大学商学院湖南长沙410083

基于"经济人"假设和外部性原理,建立政府、农户及消费者之间的三方博弈模型,考量地方政府检查策略下的生态补贴与惩罚措施以及质量标签策略对农户种植行为的影响行为。结果表明:地方政府的生态补贴政策与农药超标罚款政策对农户的生态... 详细信息

基于"经济人"假设和外部性原理,建立政府、农户及消费者之间的三方博弈模型,考量地方政府检查策略下的生态补贴与惩罚措施以及质量标签策略对农户种植行为的影响行为。结果表明:地方政府的生态补贴政策与农药超标罚款政策对农户的生态种植行为具有促进作用,其监管效率受上级政府检查力度以及社会舆论的影响;而实施质量标签策略可以提升农户选择生态种植行为的收益,促使农户种植行为的选择转变;消费者对质量安全的敏感性会提高其进行生态产品购买的动因,倒逼农户进行生态种植。

关键词：农产品质量安全监管农产品质量标签消费者行为与认知农户种植行为

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