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Combining prognostic value of serum ca.bohydrate antigen 19-9 and tumor size reduction ratio in pancreatic ductal adenoca.cinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 798-809页

作者： dong-Qin Xia Yong Zhou Shuang Yang Fang-Fei Li Li-Ya tian Yan-Hua Li Hai-Yan Xu ca.-Zhi Xiao Wei Wang Oncology Treatment Center of Traditional Chinese Medicine Chongqing University Cancer HospitalChongqing 400030China Department of Oncology Chongqing Weisiteng Biotech Translational Research InstituteChongqing 430039China Chongqing Key Laboratory on Big Data for Bio Intelligence Chongqing University of Posts and TelecommunicationsChongqing 430065China

BACKGROUND Pancreatic ductal adenoca.cinoma(PDAC)is a common ca.cer with increasing morbidity and mortality due to changes of social *** To evaluate the significa.ce of serum ca.bohydrate antigen 19-9(ca.9-9)and tumor size changes pre-and post-neoadjuvant therapy(NAT).METHODS This retrospective study was conducted at the Chongqing Key Laboratory of Translational Research for ca.cer Metastasis and Individualized Treatment,Chongqing University ca.cer *** study specifica.ly assessed ca.9-9 levels and tumor size before and after *** A total of 156 patients who completed NAT and subsequently underwent tumor resection were included in this *** average age was 65.4±10.6 years and 72(46.2%)patients were *** survival analysis,we defined the post-NAT serum ca.9-9 level/pre-NAT serum ca.9-9 level as the ca.9-9 ratio(CR).The patients were divided into three groups:CR0.5 and*** regard to tumor size measured by both computed tomography and magnetic resonance imaging,we defined the post-NAT tumor size/pre-NAT tumor size as the tumor size ratio(TR).The patients were then divided into three groups:TR0.5 and*** on these groups divided according to CR and TR,we performed both overall survival(OS)and disease-free survival(DFS)***-rank tests showed that both OS and DFS were significa.tly different among the groups according to CR and TR(Ptio:1.721,95%CI:1.373-3.762;P=0.006),and TR(hazard ratio:1.435,95%CI:1.275-4.363;P=0.014)were identified as independent factors associated with *** This study demonstrated that post-NAT serum ca.9-9 level/pre-NAT serum ca.9-9 level and post-NAT tumor size/pre-NAT tumor size were independent factors associated with OS in patients with PDAC who received NAT and subsequent surgica. resection.

关键词： Pancreatic ductal adenoca.cinoma ca.bohydrate antigen 19-9 Tumor size Pathologic response Biomarkers

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Cretaceous crown male ant reveals the rise of modern lineages

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Zoologica. Research 2024年第5期45卷 983-989页

作者： Qiong Wu Alexander G.Radchenko Michael S.Engel Xiao-Qin Li Hong-Ru Yang Xing-Ru Li Chung-Kun Shih dong Ren Tai-Ping Gao College of Life Sciences Capital Normal UniversityBeijing 100048China I.I.Schmalhausen Institute of Zoology NAS of UkraineKiev 01054Ukraine Division of Invertebrate Zoology American Museum of Natural HistoryNew York 10024-5192USA Facultad de Ciencias Biológica. Universidad Nacional Mayor de San MarcosLima 11-0058Perú Departamento de Entomología Museo de Historia NaturalUniversidad Nacional Mayor de San MarcosLima 15072Perú Department of Chemistry Analytical and Testing CenterCapital Normal UniversityBeijing 100048China Department of Paleobiology National Museum of Natural HistorySmithsonian InstitutionWashington DC 20013-7012USA

Most described Mesozoic ants belong to stem groups that existed only during the Cretaceous ***,the earliest known crown ants were dated to the Turonian(Late Cretaceous,ca.94-90 million years ago(Ma))deposits found in the USA,Kazakhstan,and ***,the recent discovery of an alate male ant in Kachin amber from the earliest Cenomanian(ca.99 Ma),representing a new genus and species,Antiquiformica.alata,revises the narrative on ant *** ca. be distinctly differentiated from all known male stem ants by its geniculate antennae with elongated sca.e,extending far beyond the occipital margin of the head and half the length of the funiculus,as well as its partly reduced forewing ***,the combination of a one-segmented waist with a well-developed node,elongated sca.e extending beyond the occipital margin,and reduced forewing venation,particularly the completely reduced m-cu and rs-m crossveins and absence of rm and mcu closed cells,firmly places the fossil within the extant subfamily *** transform infrared spectroscopy(FtiR)confirmed that the amber containing Antiquiformica.alata originated from the Kachin mines in *** discovery significa.tly revises our understanding of the early evolution of *** presence of Antiquiformica.in Cenomanian amber indica.es that the subfamily Formicinae emerged at least by the start of the Late Cretaceous,with crown ants likely originating earlier during the earliest Cretaceous or possibly the Late Jurassic,although paleontologica. evidence is lacking to support the latter hypothesis.

关键词： Formicidae Formicinae Morphology Taxonomy Antiquiformica.alata Paleontology Kachin amber

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呼和浩特热隆伸展构造:华北“变质核杂岩”再认识

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科学通报 2024年第7期69卷 939-949页

作者：张宇董树文施炜中国地质科学院自然资源部深地科学与探测技术实验室北京100037 南京大学地球科学与工程学院南京210023

对于华北克拉通岩石圈破坏,除了岩石圈厚度减薄和地幔性质改变外,最直接的标志是广泛出露的弥散状穹隆构造及伴随的韧性剪切带、低角度正断层和断陷盆地.这些伸展穹隆构造通常被解释为“变质核杂岩”(metamorphic core complex,MCC),但... 详细信息

对于华北克拉通岩石圈破坏,除了岩石圈厚度减薄和地幔性质改变外,最直接的标志是广泛出露的弥散状穹隆构造及伴随的韧性剪切带、低角度正断层和断陷盆地.这些伸展穹隆构造通常被解释为“变质核杂岩”(metamorphic core complex,MCC),但其组成结构、变形机制和深部过程等方面与北美西部盆岭省经典的变质核杂岩存在明显的区别.本文选择华北克拉通北缘的呼和浩特“变质核杂岩”进行剖析和再研究,在前人研究的基础上,聚焦穹隆核、韧性剪切带和低角度滑覆系统之间的时空关系,通过详细的地质填图、构造解析和年代学研究,将一个以简单剪切应变为主的穹型韧性剪切带(变形时间为152~141 Ma)从原伸展系统中剥离,从而揭示出一个以花岗岩为核的热隆-伸展构造.呼和浩特热隆-伸展构造分为3个结构单元.(1)花岗岩核:由早白垩世A型花岗岩(136~127 Ma)组成;(2)纯剪切应变带:分布在核部花岗岩周缘以纯剪切应变为主的高温(>500℃)变形带,面理发育(无线理),可能由核部岩体侵位时体积膨胀导致;(3)低角度滑覆系统:由韧性剪切带、微角砾岩带、低角度正断层和上叠断陷盆地组成,其变形时代为早白垩世(约134~130 Ma),运动学标志指示上部向南东的剪切特征,其演化过程和变形行为受控核部岩体侵位.通过对热隆-伸展构造的厘定,本研究提出热岩石圈背景下由岩浆上侵主导并伴生热变质变形的伸展机制,为进一步理解华北克拉通伸展动力学提供一个新思路.

关键词：华北克拉通早白垩世热隆-伸展构造岩浆底劈低角度滑覆系统

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Efficient and reversible separation of NH_(3) by deep eutectic solvents with multiple active sites and low viscosities

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Chinese Journal of Chemica. Engineering 2024年第3期67卷 97-105页

作者： Jiayin Zhang Lu Zheng Siqi Fang Hongwei Zhang Zhenping ca. Kuan Huang Lilong Jiang National Engineering Research Center of Chemica. Fertilizer ca.alyst(NERC-CFC) College of Chemical EngineeringFuzhou UniversityFuzhou 350002China Qingyuan Innovation Laboratory Quanzhou 362801China

The efficient separation and collection of ammonia(NH_(3))during NH_(3) synthesis process is essential to improve the economic efficiency and protect the *** this work,ethanolammonium hydrochloride(EtOHACl)and phenol(PhOH)were used to prepare a novel class of deep eutectic solvents(DESs)with multiple active sites and low *** NH_(3) separation performance of EtOHACl+PhOH DESs was analyzed *** is figured out that the NH_(3) absorption rates in EtOHACl+PhOH DESs are very *** NH_(3) absorption ca.acities are very high and reach up to 5.52 and 10.74 mol·kg1 at 11.2 and 100.4 kPa under 298.2 K,*** addition,the EtOHACl+PhOH DESs present highly selective absorption of NH_(3) over N_(2) and H_(2) and good regenerative properties after seven cycles of absorption/*** intrinsic separation mechanism of NH_(3) by EtOHACl+PhOH DESs was further revealed by spectroscopic analysis and quantum chemistry ca.culations.

关键词： Separation Absorption Ionic liquid Deep eutectic solvent Multiple active site Low viscosity

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Preface:Heavy metal(loid)s at mining&metallurgica. sites:Fate,risk and remediation

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Journal of Central South University 2024年第4期31卷 1033-1035页

作者：薛生国李楚璇赵东叶吴川 School of Metallurgy and Environment Central South UniversityChangsha 410083China Department of Civil Constructionand Environmental EngineeringSan Diego State UniversitySan DiegoCA 92182USA

The contamination of heavy metal(loid)s at mining&metallurgica. sites has been a major environmental challenge worldwide[1].Typica.ly,large amounts of metal(loid)s-bearing wastes are generated at these sites,such as smelting slag,combustion residues,mine tailings,wastewater,and exhaust gas[2].Due to their high mobility in the environment,the released heavy metal(loid)s ca. easily enter the soil and water environment,posing long-term and widespread threats to ecologica. and human health[3].

关键词： mining wastewater smelting

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Combined Effect of Outdoor time and Other Modifiable Factors on Myopia Incidence Among Children and Adolescents—9 PLADs,China,2020

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China CDC weekly 2024年第9期6卷 151-156,I0001,I0002页

作者： Panliang Zhong Yunfei Liu Ning Ma Jiajia Dang Di Shi Shan ca. Ziyue Chen Yanhui dong Peijin Hu Jun Ma Patrick W.C Lau Randall S.Stafford Yi Song Institute of Child and Adolescent Health School of Public HealthPeking UniversityNational Health Commission Key Laboratory of Reproductive HealthBeijingChina Department of Sport Physical Education&HealthHong Kong Baptist UniversityKowloon TongHong Kong Special Administrative RegionChina Department of Medicine Stanford Prevention Research CenterStanford University School of MedicineStanfordCAUnited States

Summary What is already known about this topic?Myopia has been identified as a significa.t emerging challenge and policy priority among children and adolescents in China by the Ministry of Educa.ion and seven other *** research has been conducted to investigate the collective impact of outdoor time and other modifiable factors on the incidence of myopia.

关键词： Incidence collective policy

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The biosynthetic pathway of the hallucinogen mesca.ine and its heterologous reconstruction

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Molecular Plant 2024年第7期17卷 1129-1150页

作者： Paula Berman Luis Alejandro de Haro Ana-Rita ca.aco Sayantan Panda Younghui dong Nikolay Kuzmich Gabriel Lichtenstein Yoav Peleg Hila Harat Adam Jozwiaki Jianghua ca. Uwe Heinig Sagit Meir Ilana Rogachev Asaph Aharoni Department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovot 7610001Israel Life Sciences Core Facilities Weizmann Institute of ScienceRehovot 7610001Israel The Maurice and Vivienne Wohl Institute for Drug Discovery Weizmann Institute of ScienceRehovot 7610001Israel Present address:Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Department of Molecular&Cellular Pharmacology University of Miami Miler School of MedicineMiamiFL 33136USA Department of Botany and Plant Sciences University of California RiversideRiversideCA 92521USA Laboratory of Plant Hormones and Development Regulation of Chongqing School of Life SciencesChongqing UniversityChongqing 401331China

Mesca.ine,among the earliest identified natural hallucinogens,holds great potential in psychotherapy ***,despite the existence of a postulated biosynthetic pathway for more than half a century,the specific enzymes involved in this process are yet to be *** this study,we investigated the ca.tus Lophophora williamsii(Peyote),the largest known natural producer of the phenethylamine *** employed a multi-faceted approach,combining de novo whole-genome and transcriptome sequencing with comprehensive chemica. profiling,enzymatic assays,molecular modeling,and pathway engineering for pathway *** identified four groups of enzymes responsible for the six ca.alytic steps in the mesca.ine biosynthetic pathway,and an N-methyltransferase enzyme that N-methylates all phenethylamine intermediates,likely modulating mesca.ine levels in ***,we reconstructed the mesca.ine biosynthetic pathway in both Nicotiana benthamiana plants and yeast cells,providing novel insights into several challenges hindering complete heterologous mesca.ine *** together,our study opens up avenues for exploration of sustainable production approaches and responsible utilization of mesca.ine,safeguarding this valuable natural resource for future generations.

关键词： mesca.ine Lophophora williamsi Peyote biosynthetic pathway de novo genome sequencing mo-lecular modeling

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基于多注意力机制与跨特征融合的语义分割算法

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计算机工程 2024年第8期50卷 282-289页

作者：闵莉董冰洁安冬沈阳建筑大学机械工程学院辽宁沈阳110168

图像语义分割技术在缺陷检测、医疗诊断、无人驾驶等领域广泛应用。针对现有语义分割模型普遍存在训练成本过高、目标轮廓分割效果不佳以及对小目标误分割、漏分割等问题,基于DeepLabv3+网络框架,提出多注意力机制与跨特征融合相结合的... 详细信息

图像语义分割技术在缺陷检测、医疗诊断、无人驾驶等领域广泛应用。针对现有语义分割模型普遍存在训练成本过高、目标轮廓分割效果不佳以及对小目标误分割、漏分割等问题,基于DeepLabv3+网络框架,提出多注意力机制与跨特征融合相结合的图像语义分割算法。该算法选取轻量级网络MobileNetv2作为主干,以缩短训练时间;通过优化空洞空间金字塔池化模块中空洞卷积的膨胀率,改善多尺度语义特征的提取效果,提高模型对小目标的分割能力,并将兼具通道与空间的卷积块注意力机制引入其中,更加关注对分割起决定作用的区域,从而加强对目标边界的提取;在编码器中设计跨特征融合模块,以聚合不同层次特征图的空间信息和语义信息,提高网络学习特征的能力;在编码和解码部分均引入坐标注意力机制,以分解全局平均池化的方式将位置信息嵌入到通道中,从而得到分割目标的准确位置。实验结果表明,所提算法F3crc-DeepLabv3+在PASca. VOC 2012增强数据集和Cityspaces数据集上的平均交并比分别达到了75.06%和73.06%,平均精度分别达到了84.16%和82.05%,精确率分别达到了86.18%和85.43%,训练时间分别为10 h和13.8 h,具有较优的网络性能。

关键词：语义分割 DeepLabv3+网络 MobileNetv2网络坐标注意力卷积块注意力模块跨特征融合

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血清IL-22及ca.9-9水平与结肠癌患者术后淋巴结转移的关系研究

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检验医学与临床 2024年第1期21卷 123-125,130页

作者：季国国杨建军提海梅上海市金山区亭林医院外科上海201505 上海市第五人民医院精神科上海200240 上海市金山区亭林医院门诊护理部上海201505

目的探讨血清白细胞介素(IL)-22及外周血糖链抗原19-9(ca.9-9)水平与结肠癌患者术后淋巴结转移的关系。方法选取上海市金山区亭林医院2021年1月至2023年1月收治的112例结肠癌患者纳入研究,其中26例淋巴结转移的结肠癌患者归为转移组,8... 详细信息

目的探讨血清白细胞介素(IL)-22及外周血糖链抗原19-9(ca.9-9)水平与结肠癌患者术后淋巴结转移的关系。方法选取上海市金山区亭林医院2021年1月至2023年1月收治的112例结肠癌患者纳入研究,其中26例淋巴结转移的结肠癌患者归为转移组,86例未发生淋巴结转移的结肠癌患者归为无转移组。比较两组结肠癌患者相关基线资料,检测并对比两组患者血清IL-22、ca.9-9水平。通过受试者工作特征(ROC)曲线评估血清IL-22、外周血ca.9-9预测结肠癌患者淋巴结转移的价值,采用多因素Logistic回归分析结肠癌患者发生淋巴结转移的影响因素。结果转移组与无转移组患者TNM分期、肿瘤分化程度比较,差异无统计学意义(P>0.05),转移组患者血清IL-22、ca.9-9水平高于无转移组,差异有统计学意义(Pca.9-9预测结肠癌患者淋巴结转移的曲线下面积分别为0.840、0.852。多因素Logistic回归分析结果显示,血清IL-22>30.834 pg/mL、ca.9-9>45.115 U/mL是结肠癌患者发生淋巴结转移的危险因素(Pca.9-9水平升高是结肠癌患者术后淋巴结转移的危险因素,临床可将血清IL-22、ca.9-9作为辅助评估结肠癌患者淋巴结转移风险的标志物。

关键词：白细胞介素-22 糖链抗原19-9 淋巴结转移结肠癌关系

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SlBEL11 regulates flavonoid biosynthesis,thus fine-tuning auxin efflux to prevent premature fruit drop in tomato

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Journal of Integrative Plant Biology 2024年第4期66卷 749-770页

作者： Xiufen dong Xianfeng Liu Lina Cheng Ruizhen Li Siqi Ge Sai Wang Yue ca. Yang Liu Sida Meng ca.-Zhong Jiang Chun-Lin Shi tianlai Li Daqi Fu Mingfang Qi Tao Xu College of Horticulture Shenyang Agricultural UniversityShenyang 110866China Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang Province College of Horticulture ScienceZhejiang A&F UniversityHangzhou 311300China Key Laboratory for Quality and Safety Control of Subtropica. Fruits and Vegetables Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang ProvinceMinistry of Agriculture and Rural AffairsCollege of Horticulture ScienceZhejiang A&F UniversityHangzhou 311300China Key Laboratory of Protected Horticulture of Ministry of Educa.ion Shenyang 110866China Crops Pathology and Genetic Research Unit United States Department of Agriculture Agricultural Research ServiceWashingtonDC 20250USA Department of Plant Sciences University of CaliforniaDavisCA 95616USA ANGENOVO Oslo 0753Norway Laboratory of Fruit Biology College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Auxin regulates flower and fruit abscission,but how developmental signals mediate auxin transport in abscission remains ***,we reveal the role of the transcription factor BEL1-LIKE HOMEODOMAIN11(SlBEL11)in regulating auxin transport during abscission in tomato(Solanum lycopersicum).SlBEL11 is highly expressed in the fruit abscission zone,and its expression increases during fruit *** of SlBEL11 expression by RNA interference(RNAi)ca.sed premature fruit drop at the breaker(Br)and 3d post-breaker(Br+3)stages of fruit *** and metabolome analysis of SlBEL11-RNAi lines revealed impaired flavonoid biosynthesis and decreased levels of most flavonoids,especially quercetin,which functions as an auxin transport *** suggested that SlBEL11 prevents premature fruit abscission by modulating auxin efflux from fruits,which is crucial for the formation of an auxin response ***,quercetin treatment suppressed premature fruit drop in SlBEL11-RNAi *** affinity purifica.ion sequencing(DAP-seq)analysis indica.ed that SlBEL11 induced expression of the transcription factor gene SlMYB111 by directly binding to its *** immunoprecipitation-quantitative polymerase chain reaction and electrophoretic mobility shift assay showed that *** MYELOBLASTOSIS VIRAL ONCOGENE HOMOLOG111(SlMYB111)induces the expression of the core flavonoid biosynthesis genes SlCHS1,SlCHI,SlF3H,and SlFLS by directly binding to their *** findings suggest that the SlBEL11-SlMYB111 module modulates flavonoid biosynthesis to fine-tune auxin efflux from fruits and thus maintain an auxin response gradient in the pedicel,thereby preventing premature fruit drop.

关键词： abscission auxin flavonoid SlBEL11 tomato

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