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Molecular Profiling of Colon and Breast ca.cer:Novel Clinica. Diagnostics

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Molecular Profiling of Colon and Breast Cancer:Novel Clinica...

1,3-Dica.bonyl compounds as phosphine-free ligands for Pd-ca.alyzed Heck and Suzuki reactions

第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Wang Yi - xin Veridex LLC Johnson & Johnson 3210 Menyfield Row San Diego ca.92121 USA

＜正＞The development of the traditional ca.cer diagnostic markers has been largely disappointing and is clearly not able to meet the needs in ca.cer patient ca.e. One reason is that highly heterogeneous specimens from ca.cer patients require multiple markers to produce a clinica.ly useful assay. DNA microarray technology is widely used to classify tu-

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Chinese Chemica. Letters 2007年第6期18卷 625-628页

作者： xin Cui Juan Li Lei Liu Qing Xiang Guo Department of Chemistry University of Science and Technology of China Hefei 230026 China

Some 1,3-dica.bonyl compounds (such as pentane-2,4-dione and 3-oxo-N-phenylbutanamide) were found to constitute highly efficient, yet low-priced and phosphine-free ligands for the Pd-ca.alyzed Heck and Suzuki reaction... 详细信息

关键词： Palladium ca.alyst Suzuki reaction Heck reaction Phosphine-free ligand

A new combined criterion to better predict malignant lesions in patients with pancreatic cystic neoplasms

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ca.cer Biology & Medicine 2018年第1期15卷 70-78页

作者： Chungen Lan xin Li Xiuchao Wang Jihui Hao He Ren Department of Pancreatic ca.cer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Centerfor Cancer Key Laboratory of ca.cer Prevention and Therapy TianjinTianjin's Clinical Research Center for CancerTianjin 300060China

Objective:Cystic lesions of the pancreas have been increasingly *** lesions exhibit benign behavior,while others have unequivoca. malignant ***,accurate identifica.ion of malignancy in patients diagnosed with pancreatic cystic neoplasms(PCNs)remains a major *** aim of this study was to define a combined criterion to better predict malignant lesions in patients with ***:We retrospectively analyzed 165 patients who underwent resection of PCNs from October 2011 to May *** relationship among malignancy and serum ca.bohydrate antigen 19-9(ca.9-9),preoperative neutrophil-to-lymphocyte ratio(NLR),and the presence of enhanced solid component on imaging was ***:NLR before surgery in patients with malignant PCNs(2.81±2.14)was significa.tly higher than that in patients diagnosed with pancreatic neuroendocrine tumor(1.90±0.69,P=0.013)or healthy volunteers(1.40±0.48;Pca.9-9≥39U/m L,NLR>1.976 and presence of enhanced solid component were independent predictors of PCN malignancy.A combined criterion meeting any two or more of the three elements including ca.9-9≥39 U/m L,NLR>1.976,and presence of enhanced solid component on computed tomography imaging is an indica.or with a high positive predictive value of 80.5%and a high negative predictive value of 87.9%,and thus,represents a highly accurate test(86.1%).Conclusions:The new combined criterion is an effective predictor of tumor malignancy in patients with PCNs.

关键词： Malignant pancreatic cystic neoplasm neutrophil-lymphocyte ratio enhanced solid component combined criterion diagnosis

The Influence of Seafloor Hydrothermal Activity on Major and Trace Elements of the Sediments From the South Mid-Atlantic Ridge

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Journal of Ocean University of China 2017年第5期16卷 775-780页

作者： HUANG xin CHEN Shuai ZENG Zhigang PU Xiaoqiang HOU Qinghua Guangdong Province Key Laboratory for Coastal Ocean Variation and Disaster Prediction Technologies Guangdong Ocean University Key Laboratory of Marine Geology and Environment Institute of Oceanology Chinese Academy of Sciences Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and Technology

Sediment samples obtained from the South Mid-Atlantic Ridge were analyzed for the major and trace elements by inductively coupled plasma atomic emission spectroscopy and inductively coupled plasma mass spectrometry. Results revealed that the contents of elements(e.g., Fe, Mn, Cu, Zn, V, Co) were high in samples 22V-TVG10 and 26V-TVG05 from the sites near the hydrothermal areas, and low in sample 22V-TVG14, which was collected far from the hydrothermal areas. The contents of ca. Sr and Ba in the samples showed opposite trends. A positive correlation between the concentrations of metallic elements(Cu, Zn, Co, Ni, Pb, V) and Fe in the samples were observed. These results are consistent with chemica. evolution of the dispersing hydrothermal plume.

关键词： Atlantic hydrothermal inductively metallic Sediment viscosity ocean agate Major opposite

Preparation and characterization of gadolinium hydroxide single-crystalline nanorods by a hydrothermal process

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Chinese Chemica. Letters 2007年第4期18卷 491-494页

作者： Yi Dong Yin Guang Yan Hong Bai Fu xin School of Chemistry ＆ Materials Science Heilongjiang University Harbin 150080 China Key Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

The Gd（OH）3 nanorods with diameters of ca. 40--60 nm and lengths of more than 400-550 nm have been prepared by a novel hydrothermal technique. The structural features and chemica. composition of the nanorods were investigated by X-ray diffraction （XILD）, transmission electron microscopy （TEM）, and field emission sca.ning electron microscope （FESEM）, selected area electron diffraction （SAED）, and high resolution transmission electron microscopy （HRTEM）. The possible mechanism for the formation of Gd（OH）3 nanorods was proposed.

关键词： Gd(OH)3 Nanorods Hydrothermal method Lanthanide

Synthesis, bioactivity and functional evaluation of linker-modified allatostatin analogs as potential insect growth regulators

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Chinese Chemica. Letters 2016年第4期27卷 559-562页

作者： Xiao-Qing Wu Juan Huang Mei-Zi Wang Zhe Zhang xin-Lu Li xin-Ling Yang Stephen S.Tobe Department of Applied Chemistry College of Science China Agricultural University Department of Cell and Systems Biology University of Toronto

Insect growth regulators play an important role in integrated pest management *** FGLa–allatostatins（ASTs）are a family of neuropeptides that ca. inhibit juvenile hormone（JH）biosynthesis by the corpora allata（ca.of Diploptera punctata in vitro,are regarded as insect growth regulator *** the search for new potential mimics and to explore the effect of linker length on inhibiting JH biosynthesis,a series of AST analogs were synthesized by modifying the linker of K24,which was found to have a significa.t effect on JH biosynthesis in vitro in our previous *** evaluation demonstrated that all the target compounds ca. activate the Dippu-Ast R,albeit with different *** L6 with the longest linker（n=5）,exhibited not only a promising effect on inhibition of JH biosynthesis both in vitro and in vivo,but also good activity in inhibiting basal oocyte ***–activity relationships（SAR）studies showed that longer linkers provided greater contribution to activity.

关键词： Allatostatin Insect growth regulators Juvenile hormone Analogs Dippu-Ast receptor

Alternative splicing of inner-ear-expressed genes

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Frontiers of Medicine 2016年第3期10卷 250-257页

作者： Yanfei Wang Yueyue Liu Hongyun Nie xin Ma Zhigang Xu Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology School of Life Sciences Shandong University Jinan 250100 China School of Control Science and Engineering Shandong University Jinan 250061 China

Alternative splicing plays a fundamental role in the development and physiologica. function of the inner ear. Inner-ear-specific gene splicing is necessary to establish the identity and maintain the function of the inner ear. For example, exon 68 of ca.herin 23 （Cdh23） gene is subject to inner-ear-specific alternative splicing, and as a result, Cdh23（＋ 68） is only expressed in inner ear hair cells. Alternative splicing along the tonotopic axis of the cochlea contributes to frequency tuning, particularly in lower vertebrates, such as chickens and turtles. Differential splicing of Kcnmal, which encodes for the a subunit of the ca.＋-activated K~ channel （BK channel）, has been suggested to affect the channel gating properties and is important for frequency tuning. Consequently, deficits in alternative splicing have been shown to ca.se hearing loss, as we ca. observe in Bronx Waltzer Cov） mice and Sfswap mutant mice. Despite the advances in this field, the regulation of alternative splicing in the inner ear remains elusive. Further investigation is also needed to clarify the mechanism of hearing loss ca.sed by alternative splicing deficits.

关键词： alternative splicing inner ear hearing loss hair cells

Evaluation, prediction, and protection of water quality in Danjiangkou Reservoir, China

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Water Science and Engineering 2015年第1期8卷 30-39页

作者： Xiao-kang xin Ke-feng Li Brian Finlayson Wei Yin State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Changjiang Water Resources Protection Institute Changjiang Water Resources Commission Department of Resource Management and Geography the University of Melbourne

The water quality in the Danjiangkou Reservoir has attracted considerable attention from the Chinese public and government since the announcement of the Middle Route of the South to North Water Diversion Project （SNWDP）, which commenced transferring water in 2014. Integrated research on the evaluation, prediction, and protection of water quality in the Danjiangkou Reservoir was ca.ried out in this study in order to improve environmental management. Based on 120 water samples, wherein 17 water quality indices were measured at 20 monitoring sites, a single factor evaluation method was used to evaluate the current status of water quality. The results show that the main indices influencing the water quality in the Danjiangkou Reservoir are total phosphorus （TP）, permanganate index （CODM,）, dissolved oxygen （DO）, and five-day biochemica. oxygen demand （BODs）, and the concentrations of TP, BODs, ammonia nitrogen （NH3--N）, CODM,, DO, and anionic surfactant （Surfa） do not reach the specified standard levels in the tributaries. Seasonal Mann--Kendall tests indica.ed that the CODMn concentration shows a highly significa.t increasing trend, and the TP concentration shows a significa.t increasing trend in the Danjiangkou Reservoir. The distribution of the main water quality indices in the Danjiangkou Reservoir was predicted using a two-dimensional water quality numerica. model, and showed that the sphere of influence from the tributaries ca. spread across half of the Han Reservoir if the pollutants are not controlled. Cluster analysis （ca. results suggest that the Shending River is heavily polluted, that the Jianghe, Sihe, and Jianhe rivers are moderately polluted, and that they should be the focus of environmental remediation.

关键词： Water quality Single factor evaluation method Mann--Kendall test Numerica. modeling Cluster analysis Dangjiangkou Reservoir

In vivo electrochemica. recording of continuous change of magnesium in medial vestibular nucleus following vertigo induced by ice water vestibular stimulation

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Science China Chemistry 2013年第2期56卷 256-261页

作者： xin Ying ZHANG ZiPin YU Ping MA FuRong MAO LanQun Department of Otorhinolaryngology Peking University Third Hospital Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytica. Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences

Vertigo is one of the most common clinica. symptoms. However, the chemica. processes involved in the pathologica. mechanism of vertigo remain to be fully understood. In this study, we investigate the dynamic changes in the magnesium (Mg 2+ ) concentration in medial vestibular nucleus (MVN) of guinea pigs following vertigo induced by vestibular ice water stimulation with an electrochemica. detection method consisting of in vivo microdialysis and on-line selective electrochemica. detection. Electrochemica. detection of Mg 2+ was accomplished based on the current enhancement of Mg 2+ towards the electroca.alytic oxidation of NADH at the electrodes modified with the polymerized film of toluidine blue O (TBO). Selectivity for the on-line electrochemica. detection against ca.2+ was achieved by using ethyleneglcol-bis(2-aminoethylether) tetraacetic acid (EGTA) as the selective masking agent for ca.2+ . The basal level of the extracellular Mg 2+ in the MVN of guinea pigs was determined to be 759.7 ± 176.2 M(n = 16). Upon ice water irrigation of the left external ear ca.al, the concentration of Mg 2+ in the MVN decreases significa.tly, reaches 72 ± 6% (n = 8) of the basal level, and maintains for at least 1000 s. Control experiments reveal that neither warm water irrigation of the external ear ca.al nor ice water irrigation of the auricle induces the decrease in the concentration of Mg 2+ in the MVN. These results demonstrate that the extracellular Mg 2+ in the MVN decreases significa.tly following vertigo induced by vestibular ice water stimulation. This demonstration suggests that Mg 2+ might play an important role in the pathologica. mechanism of vertigo.

关键词： on-line electrochemica. detection in vivo microdialysis magnesium vertigo