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Targeting TrkB–PSD-95 coupling to mitigate neurologica. disorders

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang Yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-ca.(2+)/ca.modulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurologica. disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the trunca.ed TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they ca.not distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifica.ly boost TrkB signaling at loca.ized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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ca.and Mg-rich waste as high active ca.rier for chemica. looping gasifica.ion of biomass

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Chinese Journal of Chemica. Engineering 2021年第10期34卷 145-154页

作者： xin Niu Laihong Shen School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Educa.ion School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Chemica. looping gasifica.ion(CLG)is a promising technology for high-quality syngas *** key issue to successful CLG is the selection of high-performance oxygen *** this study,several ca.and Mg-rich steelmaking wastes from steel industry,such as blast furnace slag(BF slag),blast furnace dust(BF dust)and Linz-Donawitz converter slag(LD slag),were used as oxygen ca.riers in chemica. looping gasifica.ion of *** results showed that the reducibility of ca.and Mg-rich waste,especially LD slag and BF dust,was superior to that of *** long-term operation,the cyclic stability of steelmaking waste was *** dust showed a poor stability,while the other ca.rier(hematite,BF slag or LD slag)presented an excellent stability during multiple redox cycles in spite of partial sintering and ***,the effects of supply oxygen coefficient(O/B ratio)and reaction temperature on CLG of biomass were *** results revealed that ca.and Mg-rich waste exhibited a higher syngas production compared to *** higher performance could be attributed to the improved reduction rate of Fe2O3 and gasifica.ion rate of biomass by ca.or Mg in steelmaking *** addition,LD slag exhibited the higher gas value at the O/B ratio of 1 at 900℃.As a consequence,LD slag was an appropriate oxygen ca.rier for CLG of biomass in terms of perfect reducibility,superior cyclic stability and high reactivity.

关键词： Biomass Syngas Gasifica.ion ca.and Mg-rich waste Chemica. looping

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Histologica. origin of pseudomyxoma peritonei in Chinese women:Clinicopathology and

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World Journal of Gastroenterology 2011年第30期17卷 3531-3537页

作者： Ai-Tao Guo xin Song Li-xin Wei Po Zhao Department of Pathology The General Hospital of PLA 100853 Beijing China

AIM： To investigate the myxoma peritonei （PMP） histologica. origin of pseudo- n Chinese women. METHODS： The clinica. and pathologica. data were reviewed for 35 women with PMP, and specimens of the peritoneal, appendiceal and ovarian lesions of each patient were examined using the PV-6000 immunohistochemistry method. Antibodies included cytokeratin （CK）7, CK20, mucin （MUC）-1, MUC-2, ca.bohydrate antigen （ca.-125, estrogen receptor （ER）, and progesterone receptor （PR）. RESULTS： Abundant colloidal mucinous tumors were observed in the peritoneum in all 35 ca.es. Thirty-one patients had a history of appendectomy, 28 of whom had mucinous lesions. There was one patient with appendicitis, one whose appendix showed no apparent pathologica. changes, and one with unknown surgica. pathology. Ovarian mucinous tumors were found in 24 patients. The tumors were bilateral in 13 patients, on the right-side in nine, and on the left side in two. Twenty patients had combined appendiceal and ovarian lesions; 16 of whom had undergone initial surgery for appendiceal lesions. Four patients had undergone initial surgery for ovarian lesions, and relapse occurred in these patients at 1, 11, 32 and 85 mo after initial surgery. Appendi-ceal mucinous tumors were found in each of these four patients. Thirty-three of the 35 patients showed peritoneal lesions that were positive for CK20 and MUC-2, but negative for CK7, MUC-1, ca.25, ER and PR. The expression patterns in the appendix and the ovary were similar to those of the peritoneal lesions. In one of the remaining two ca.es, CK20, CK7 and MUC-2 were positive, and MUC-1, ca.25, ER and PR were negative. The ovaries were not resected. The appendix of one patient was removed at another hospital, and no specimen was evaluated. In the other ca.e, the appendix appeared to be normal during surgery, and was not resected. Peritoneal and ovarian lesions were negative for CK20, MUC-2, CK7, MUC-1, ca.25, ER and PR. CONCLUSION： Most PMP originated from the ap

关键词： Pseudomyxoma peritonei Peritoneum Tumor origin Ovary Appendix Immunohistochemistry

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A developmental stage-dependent switch of the mechanisms for prostate epithelial maintenance

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Asian Journal of Andrology 2013年第1期15卷 85-86页

作者： Li xin Department of Molecular and Cellular Biology Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA Department of Pathology and Immunology Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA Dan L. Dunca. ca.cer Center Baylor College of Medicine One Baylor Plaza. Houston TX 77030 USA

Previous studies demonstrated that adult murine prostate basal and luminal cells are independently self-sustained, but prostate basal cells possess the potential to differentiate into multiple lineages upon induction by embryonic urogenital sinus mesenchyme. Nevertheless, it is unknown how prostate epithelia mature during the postnatal stage. Recently, Ousset et al.

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Seismic response control with density-variable tuned liquid dampers

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Earthquake Engineering and Engineering Vibration 2009年第4期8卷 537-546页

作者： Yuxiang xin Genda Chen Lou Menglin HNTB Corporation. 1330 Broadway. Oakland CA 94612 USA Centerfir Infrastructure Engineering Studies Misxouri University of Science and Technology Rolla M.O 65409 USA State Key Laboratory for Disaster Reduction in Civil Engineering Tongji University Shanghai China

In this paper, the seismic effectiveness of a density-variable tuned liquid damper （DVTLD） with a sloping bottom is experimentally investigated through a series of shake table tests on a 1/4-sca.e, 3-story frame structure and numerica.ly simulated by a new semi-analytica. model. Special attention was given to reducing the first peak and maximum response under near- and far-field ground motions, and the robustness of a density-variable control system consisting of multiple DVTLDs with closely-spaced frequencies. Adaptable to earthquake excitations, the density-variable control system has been demonstrated to be more effective and more robust than its corresponding traditional tuned liquid damper in suppressing story drift and floor acceleration of the structure. Numerica. simulations of the DVTLD-controlled structure agreed very well in phase with experimental results but somewhat overestimated the amplitude of the structural response.

关键词： tuned liquid damper density-variable tuned liquid damper seismic response seismic effectivenessrobustness

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Bayesian analysis of nuclear equation of state at high baryon density

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Nuclear Science and Techniques 2023年第12期34卷 156-158页

作者： Long‑Gang Pang xin‑Nian Wang Key Laboratory of Quark and Lepton Physics(MOE) Institute of Particle PhysicsCentral China Normal UniversityWuhan 430079China Nuclear Science Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Bayesian analysis was employed to constrain the equation of state(EoS)of nuclear matter with a baryon density of up to six times the nuclear saturation density,using data from heavy-ion collisions at beam energies√S_... 详细信息

关键词： observations equation state

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Necessary and Sufficient Conditions of Separability for Multipartite Pure States

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Communica.ions in Theoretica. Physics 2008年第5期49卷 1211-1216页

作者： LI Da-Fa LI Xiang-Rong HUANG Hong-Tao LI xin-xin Department of Mathematica. Sciences Tsinghua University Beijing 100084 China Department of Mathematics University of California Irvine CA 92697-3875 USA Electrica. Engineering and Computer Science Department University of Michigan Ann Arbor MI 48109 USA Department of Computer Science Wayne State University Detroit MI 48202 USA

In this paper we present a necessary and sufficient condition of separability for multipartite pure states and variants of it. These conditions are very simple and ca.culable, and they do not require Schmidt decomposition （for two subsystems） or tracing out operations. We also give a necessary condition for a loca. unitary equivalence class for a bipartite system in terms of the determinant of the matrix of amplitudes.

关键词： entanglement quantum computing separability

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A Fast Tongue Detection and Loca.ion Algorithm in Natural Environment

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Computers, Materials & Continua 2022年第12期73卷 4727-4742页

作者： Lei Zhu Guojiang xin xin Wang Changsong Ding Hao Liang Qilei Chen School of Informatics Hunan University of Chinese MedicineChangsha410208China TCM Big Data Analysis Laboratory of Hunan Changsha410208China Department of Computer Science University of Massachusetts LowellLowell01854USA

The collection and extraction of tongue images has always been an important part of intelligent tongue *** present,the collection of tongue images generally needs to be completed in a sealed,stable light environment,which is not conducive to the promotion of extensive tongue image and intelligent tongue *** response to the problem,a newalgorithm named GCYTD(GELU-ca.YOLO Tongue Detection)is proposed to quickly detect and loca.e the tongue in a natural environment,which ca. greatly reduce the restriction of the tongue image collection *** algorithm is based on the YOLO(You Only Look Once)V4-tiny network model to detect the ***,the GELU(Gaussian Error Liner Units)activation function is integrated into the model to improve the training speed and reduce the number of model parameters;then,the ca.Coordinate Attention)mechanism is integrated into the model to enhance the detection precision and improve the failure tolerance of the *** with the other classica. algorithms,Experimental results show thatGCYTD algorithm has a better performance on the tongue images of all types in terms of training speed,tongue detection speed and detection precision,*** lighter model ca. contribute on deploying the tongue detection model on small mobile terminals.

关键词： Tongue detection YOLO V4-tiny ca.mechanism GELU

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Subcritica.,Critica. and Supercritica. Size Distributions in Random Coagulation-Fragmentation Processes

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Acta Mathematica.Sinica.English Series 2008年第1期24卷 121-138页

作者： xin Sheng ZHANG Wei An ZHENG Department of Statistics Fudan University 200433 P R. China Department of Mathematics University of California Irvine CA USA

We consider the asymptotic probability distribution coagula-tion-fragmentation process in the thermodynamic limit of the size of a reversible random We prove that the distributions of small, medium and the largest clusters converge to Gaussian, Poisson and 0-1 distributions in the supercritica. stage （post-gelation）, respectively. We show also that the mutually dependent distributions of clusters will become independent after the occurrence of a gelation transition. Furthermore, it is proved that all the number distributions of clusters are mutually independent at the critica. stage （gelation）, but the distributions of medium and the largest clusters are mutually dependent with positive correlation coefficient in the supercritica. stage. When the fragmentation strength goes to zero, there will exist only two types of clusters in the process, one type consists of the smallest clusters, the other is the largest one which has a size nearly equal to the volume （total number of units）.

关键词： asymptotic distribution coagulation-fragmentation process gelation transition

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Phylogeny,character evolution,and classifica.ion of Selaginellaceae(lycophytes)

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Plant Diversity 2023年第6期45卷 630-684页

作者： xin-Mao Zhou Li-Bing Zhang School of Ecology and Environmental Science Yunnan UniversityKunming 650504YunnanChina Missouri Botanica. Garden 4344 Shaw BlvdSt.LouisMissouri 63110USA Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041SichuanChina

Selaginella is the largest and most taxonomica.ly complex genus in *** fact that over 750 species are currently treated in a single genus makes Selaginellales/Selaginellaceae unique in *** we assembled a dataset of six existing and newly sampled plastid and nuclear loci with a total of 684 accessions(74%increase of the earlier largest sampling)representing ca.300 species to infer a new *** evolution of 10 morphologica. characters is studied in the new phylogenetic *** major results include:(1)the nuclear and plastid phylogenies are congruent with each other and combined analysis well resolved and strongly supported the relationships of all but two major clades;(2)the Sinensis group is resolved as sister to *** with strong support in two of the three analyses;(3)most morphologica. characters are highly homoplasious but some characters alone or combinations of characters well define the major clades in the family;and(4)an infrafamilial classifica.ion of Selaginellaceae is proposed and the currently defined Selaginella *** split into seven subfamilies(corresponding to the current six subgenera t the Sinensis group)and 19 genera(the major diagnosable clades)with nine new species-poor *** support the conservation of Selaginella with a new type,***,to minimize nomenclatural *** provide a key to subfamilies and genera,images illustrating their morphology,their morphologica. and geographica. synopses,a list of constituent species,and necessary new *** new classifica.ion will hopefully facilitate communica.ion,promote further studies,and help conservation.

关键词： Generic classifica.ion Homoplasy Lycophyte phylogeny Megaspore types Microspores Nuclear 18S and 26S genes

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