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Machine learning-based comparison of factors influencing estimated glomerular filtration rate in Chinese women with or without nonalcoholic fatty liver

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World Journal of Clinica. ca.es 2024年第15期12卷 2506-2521页

作者： I-Chien Chen Lin-Ju Chou Shih-Chen Huang ta.Wei Chu Shang-Sen Lee Department of Nursing Kaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Department of Obstetrics and Gynecology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Chief Executive Officer's Office MJ Health Research FoundationTaipei 114Taiwan Department of Urology Taichung Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTaichung 427Taiwan School of Medicine Tzu Chi UniversityHualian 970Taiwan Department of Urology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND The prevalence of non-alcoholic fatty liver(NAFLD)has increased *** with NAFLD are known to have higher chance for renal function *** past studies used traditional multiple linear regression(MLR)to identify risk factors for decreased estimated glomerular filtration rate(eGFR).However,medica. research is increasingly relying on emerging machine learning(Mach-L)*** present study enrolled healthy women to identify factors affecting eGFR in subjects with and without NAFLD(NAFLD+,NAFLD-)and to rank their *** To uses three different Mach-L methods to identify key impact factors for eGFR in healthy women with and without *** A tota. of 65535 healthy female study participants were enrolled from the ta.wan MJ cohort,accounting for 32 independent variables including demographic,biochemistry and lifestyle parameters(independent variables),while eGFR was used as the dependent *** from MLR,three Mach-L methods were applied,including stochastic gradient boosting,eXtreme gradient boosting and elastic *** of estimation were used to define method accuracy,where smaller degree of error indica.ed better model *** Income,albumin,eGFR,High density lipoprotein-Cholesterol,phosphorus,forced expiratory volume in one second(FEV1),and sleep time were all lower in the NAFLD+group,while other factors were all significa.tly higher except for smoking ***-L had lower estimation errors,thus outperforming *** Model 1,age,uric acid(UA),FEV1,plasma ca.cium level(ca.,plasma albumin level(Alb)and T-bilirubin were the most importa.t factors in the NAFLD+group,as opposed to age,UA,FEV1,Alb,lactic dehydrogenase(LDH)and ca.for the *** the importa.ce percenta.e was much higher than the 2nd importa.t factor,we built Model 2 by removing *** The eGFR were lower in the NAFLD+group compared to the NAFLD-group,with age being was the most importa.t impact factor in both groups of he

关键词： Non-alcoholic fatty liver Estimated glomerular filtration rate Machine learning Chinese women

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Characteristic and optimization of ferrite-rich sulfoaluminate-based composite cement suita.le for cold region tunnels

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Journal of Central South University 2024年第8期31卷 2794-2809页

作者： Peng, You Li, Li ta., Xian-jun Qiu, Xin Zheng, Pei-chao Xie, Jun Chen, Wei-zhong Reziwanguli, Sha-ta.er School of Infrastructure Engineering Dalian University of Technology Dalian China Institute of Rock and Soil Mechanics Chinese Academy of Sciences Wuhan China Xinjiang Aca.emy of Transporta.ion Sciences Co. Ltd. Urumqi China

To develop suita.le grouting materials for water conveyance tunnels in cold regions, firstly, this study investigated the performance evolution of ferrite-rich sulfoaluminate-based composite cement (FSAC grouting material) at 20 and 3 °C. The results show that low temperature only delays the strength development of FSAC grouting material within the first 3 d. Then, the effect of four typica. early strength synergists on the early properties of FSAC grouting material was evaluated to optimize the early (≤1 d) strength at 3 °C. The most effective synergist, ca.HCOO)2, which enhances the low-temperature early strength without compromising fluidity was selected based on strength and fluidity tests. Its micro-mechanism was analyzed by XRD, TG, and SEM methods. The results reveal that the most suita.le dosage range is 0.3 wt%–0.5 wt%. Proper addition of ca.HCOO)2 changed the crysta. morphology of the hydration products, decreased the pore size and formed more compact hydration products by interlocking and overlapping. However, excessive addition of ca.HCOO)2 inhibited the hydration reaction, resulting in a simple and loose structure of the hydration products. The research results have reference value for controlling surrounding rock deformation and preventing water and mud inrushes during the exca.ation in cold region tunnels.

关键词： ferrite-rich sulfoaluminate cement cold zone early strength synergist mechanica. property micro-structure pumped storage power

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Sorption of Water-Extracta.le Organic ca.bon in Various Clay Subsoils: Effects of Soil Properties

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Pedosphere 2016年第1期26卷 55-61页

作者： Trung ta.NGUYEN Petra MARSCHNER School of Agriculture Food and Wine The University of Adelaide

Clay-rich subsoils are added to sandy soils to improve crop yield and increase organic ca.bon （C） sequestration; however, little is known about the influence of clay subsoil properties on organic C sorption and desorption. Batch sorption experiments were conducted with nine clay subsoils with a range of properties. The clay subsoils were shaken for 16 h at 4 ℃with water-extracta.le organic C （WEOC, 1 224 g C L-1） from mature wheat residue at a soil to extract ratio of 1：10. After removal of the supernata.t, the residual pellet was shaken with deionised water to determine organic C desorption. The WEOC sorption was positively correlated with smectite and illite contents, ca.ion exchange ca.acity （CEC） and tota. organic C, but negatively correlated with kaolinite content. Desorption of WEOC expressed as a percenta.e of WEOC sorbed was negatively correlated with smectite and illite contents, CEC, tota. and exchangeable ca.cium （ca. concentrations and clay content, but positively correlated with kaolinite content. The relative importa.ce of these properties varied among soil types. The soils with a high WEOC sorption ca.acity had medium CEC and their dominant clay minerals were smectite and illite. In contrast, kaolinite was the dominant clay mineral in the soils with a low WEOC sorption ca.acity and low-to-medium CEC. However, most soils had properties which could increase WEOC sorption as well as those that could decrease WEOC sorption. The relative importa.ce of properties increasing or decreasing WEOC sorption varied with soils. The soils with high desorption had a low tota. ca.concentration, low-to-medium CEC and low clay content, whereas the soils with low desorption were characterised by medium-to-high CEC and smectite and illite were the dominant clay minerals. We conclude that WEOC sorption and desorption depend not on a single property but rather a combination of several properties of the subsoils in this study.

关键词： ca.ion exchange ca.acity, clay mineral illite, kaolinite smectite

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2013年上海市青浦地区革兰阴性菌耐药性监测

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中国感染与化疗杂志 2015年第3期15卷 264-268页

作者：蔡红妹唐之俭费凤英上海市青浦区朱家角人民医院检验科上海201713 复旦大学附属中山医院青浦分院

目的了解2013年上海市青浦地区临床分离的革兰阴性菌对抗菌药物的敏感性。方法采用自动化仪器对该地区2所医院临床分离的革兰阴性菌进行药敏试验,采用CLSI 2013年版标准判断结果。结果总计1 376株革兰阴性菌中,大肠埃希菌、克雷伯菌属... 详细信息

目的了解2013年上海市青浦地区临床分离的革兰阴性菌对抗菌药物的敏感性。方法采用自动化仪器对该地区2所医院临床分离的革兰阴性菌进行药敏试验,采用CLSI 2013年版标准判断结果。结果总计1 376株革兰阴性菌中,大肠埃希菌、克雷伯菌属和奇异变形杆菌中产超广谱β内酰胺酶(ESBL)菌株的检出率分别为66.7%、28.7%和12.5%。产ESBL菌株对临床常用抗菌药物的耐药率均高于非产ESBL菌株。肠杆菌科细菌对碳青霉烯类抗生素仍高度敏感,对亚胺培南和阿米卡星的总耐药率分别为4.2%和6.8%。铜绿假单胞菌和不动杆菌属对亚胺培南的耐药率分别为17.1%、36.0%。大肠埃希菌、肺炎克雷伯菌、鲍曼不动杆菌和铜绿假单胞菌中有少数菌株对所有测试的药物耐药。结论细菌耐药性仍对临床构成严重威胁,应引起临床关注。

关键词：细菌耐药性监测药物敏感性试验广泛耐药菌超广谱b内酰胺酶

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Synchronous endometrial and ovarian ca.cer: A ca.e report

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World Journal of Clinica. ca.es 2023年第18期11卷 4341-4349页

作者： DianaŽilovič Rūta.iurlienė EvelinaŠidlovska Ieva Vaicekauskaitė Rasa Sabaliauskaitė Sonata.Jarmalaitė Department of Oncogynecology National Cancer InstituteVilnius 08406Lithuania Institute of Biosciences Vilnius UniversityVilnius 10222Lithuania Laboratory of Clinica. Oncology National Cancer InstituteVilnius 08406Lithuania National Center of Pathology Affiliate of Vilnius University Hospital Santaros KlinikosVilnius 08406Lithuania Laboratory of Genetic Diagnostic National Cancer InstituteVilnius 08406Lithuania

BACKGROUND Synchronous endometrial and ovarian ca.cer(SEOC)is a rare genita. tract *** diagnosis is crucial for the disease management since prognosis and overall survival differ substa.tially between meta.ta.ic endometrial ca.cer(EC)or *** this review we present 2 ca.es of women who were diagnosed with SEOC,and discuss the clinica. characteristic of SEOC,diagnostic and molecular profiling *** generation sequencing of 10 gene panel was performed on ca.cerous tissue and uterine lavage *** SUMMARY In our report patients with SEOC had endometroid type histology with early sta.e and low-grade histology for both EC and *** underwent surgica. treatment and ***-generation sequencing of 10 gene-panel identified CTNNB1,PIK3ca.and PTEN gene muta.ions in ovarian tissue in one ca.e,while none of these genes were muta.ed in other *** review in support to our data.suggest a good prognosis for SEOC diagnosed at early *** Accurate diagnosis of SEOC is essential for disease management and gene muta.ion analysis ca. be helpful as a complementa.y diagnostic and prognostic tool.

关键词： Ovarian ca.cer Endometrial ca.cer Synchronous primary ca.cer Uterine lavage ca.e report

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Mta.iRoot BP Plus及氢氧化钙在年轻恒牙活髓切断术中临床疗效的比较分析

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现代生物医学进展 2024年第1期24卷 131-135页

作者：杨雪垠金武龙格根塔娜李丽洁安灵利内蒙古医科大学附属医院口腔科内蒙古呼和浩特010010

目的:研究三氧化矿物凝聚体(Mta.、iRoot BP Plus(iRooT)以及氢氧化钙(ca.OH)2)三种材料在年轻恒牙活髓切断术中的临床疗效。方法:将60例需要接受年轻恒牙活髓切断术的患者(60颗患牙)按照使用材料不同随机分为三组:Mta.、iRooT组和ca.O... 详细信息

目的:研究三氧化矿物凝聚体(Mta.、iRoot BP Plus(iRooT)以及氢氧化钙(ca.OH)2)三种材料在年轻恒牙活髓切断术中的临床疗效。方法:将60例需要接受年轻恒牙活髓切断术的患者(60颗患牙)按照使用材料不同随机分为三组:Mta.、iRooT组和ca.OH)2组,每组20例(20颗患牙),比较三组患者术后3个月和6个月手术成功率、牙本质桥形成和牙齿变色发生率、牙根管壁厚度、牙齿功能和美观度、以及血清基质金属蛋白酶-3(MMP-3)和白细胞介素-8(IL-8)水平。结果:(1)三组患者仅术后6个月临床治疗成功率存在显著差异(Pca.OH)2组术后牙本质桥形成率显著低于其他两组(Pta.(Pca.OH)2组患牙根管壁厚度增加显著低于Mta.和iRooT组(Pca.OH)2组患者术后6个月牙齿舒适功能、固定功能和咀嚼功能评分均显著低于Mta.和iRooT组(Pta.(Pta.患者血清MMP-3和IL-8水平显著高于iRooT组(Pca.H组(Pta.料应用于年轻恒牙活髓切断术均具有较高的远期成功率,但Mta.料远期牙齿变色率较高因而影响牙齿美观度。

关键词：三氧化物聚合体 iRoot BP Plus 氢氧化钙恒牙活髓切断术

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1nm锰矿相的金属阳离子交换能力的研究

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海洋学报 1996年第4期18卷 56-62页

作者：钱江初 Mell.,ta 国家海洋局第二海洋研究所

人工合成的１ｎｍ锰矿相和铜、钴、镍等二价金属阳离子的交换实验表明，１ｎｍ锰矿相具有强烈的金属阳离子交换能力。正是这种金属阳离子的交换能力，使得大洋多金属结核大量地富集了铜、钴、镍等有价金属元素。１ｎｍ锰矿相对几种金属... 详细信息

人工合成的１ｎｍ锰矿相和铜、钴、镍等二价金属阳离子的交换实验表明，１ｎｍ锰矿相具有强烈的金属阳离子交换能力。正是这种金属阳离子的交换能力，使得大洋多金属结核大量地富集了铜、钴、镍等有价金属元素。１ｎｍ锰矿相对几种金属阳离子的交换的优先顺序为：Ｃｕ＞Ｃｏ＞Ｚｎ≥Ｎｉ＞Ｃａ＞Ｍｇ。多金属结核中镍的含量往往高于铜、钴、锌等元素，但在交换顺序中它却低于铜、钴、锌等，这种不一致性说明结核成矿后期的金属离子交换并非是有价金属结合进结核的唯一途径。多金属结核富含铜、钴、镍等有价金属可能是结核初始成矿和成矿后期金属离子交换等多种因素共同作用的结果。

关键词：多金属结核锰矿相金属阳离子交换能力

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树豆酮酸A可减轻db/db小鼠非酒精性脂肪肝损伤

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中国生物化学与分子生物学报 2024年第3期40卷 373-382页

作者：王一凡吕厚星李志阳代云莉冯昭卫陈佳佳陈圣杰王建塔肖瑛贵州省常见慢性疾病发病机制及药物研究重点实验室贵州医科大学病理生理学教研室贵阳550025 贵州省化学合成药物研发利用工程技术研究中心贵阳550004

非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是指肝中储存过多的脂肪,与肥胖、胰岛素抵抗、2型糖尿病(type-2 diabetes mellitus,T2DM)、血脂异常等代谢综合征密切相关。肝纤维化是NAFLD进一步发展为肝细胞癌(hepatoce... 详细信息

非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是指肝中储存过多的脂肪,与肥胖、胰岛素抵抗、2型糖尿病(type-2 diabetes mellitus,T2DM)、血脂异常等代谢综合征密切相关。肝纤维化是NAFLD进一步发展为肝细胞癌(hepatocellular ca.cinoma,HCC)的关键过程,减少肝内的脂肪积累,从而延缓或阻止NAFLD向纤维化的进展是治疗的关键。树豆酮酸A(ca.anonic acid A,ca.)在2型糖尿病中能够有效改善胰岛素抵抗,发挥降糖减脂作用。本研究旨在探究ca.对NAFLD肝损伤的保护作用。通过采用db/db自发性NAFLD小鼠模型,将db/db小鼠分为NAFLD组和ca.给药组,ca.组予50 mg/(kg·d)灌胃给药,同期C57BL小鼠作为正常对照组(NC组),每组6只。小鼠生化指标检测和组织病理染色发现,ca.干预可有效缓解db/db小鼠的糖脂代谢紊乱、肝功能损伤(Pca.治疗后肝组织上清液中白细胞介素1β(Interlecukin-1β,IL-1β)的水平显著降低(Pca.具有明显抗炎作用,并且ca.干预显著减轻小鼠肝的纤维化程度,天狼星红染色发现,ca.组胶原沉积显著减少(Pca.组纤维化相关基因纤连蛋白(fibronectin,FN)、α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)蛋白质水平表达降低,E-钙黏着蛋白(E-ca.herin,E-ca.的表达升高(Pca.改善NAFLD肝脂质沉积和纤维化的中间作用靶标。通过免疫组织化学染色观察E2F1和其同家族拮抗转录因子E2F转录因子7(E2F transcription factor 7,E2F7)在小鼠经ca.处理后在肝组织核质中均表达,通过Western印迹法和实时荧光定量PCR进一步检测蛋白质和mRNA的表达发现,在ca.组中E2F1较NAFLD组基因表达降低(Pca.改善脂质代谢和纤维化的过程。

关键词：非酒精性脂肪性肝病 E2F转录因子1 E2F转录因子7 树豆酮酸A 肝纤维化上皮-间充质转化

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Prognostic analysis of surgica. treatment of peripheral cholangioca.cinoma: Two deca.es of experience at Chang Gung Memorial Hospita.

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World Journal of Gastroenterology 2005年第12期11卷 1779-1784页

作者： Yi-Yin Jan Chun-Nan Yeh ta.Sen Yeh Tse-Ching Chen Department of Surgery Department of Pathology

AIM: To analyze the prognostic factors influencing the overall survival of peripheral cholangioca.cinoma (PCC) patients undergoing surgica. treatment during 25 years at a single institution. METHODS: This study retrospectively reviewed prospectively collecting data.about 373 patients with historica.ly proven PCC who underwent surgica. treatment between 1977 and 2001. RESULTS: Three hundred and seventy-three PCC patients (159 men and 214 women) underwent surgica. treatment from 1977 to 2001. Among them, 187 PCC patients underwent hepatectomy and 135 had curative resection (curative resecta.ility rate: 36.2%). The follow-up duration ranged from 1.05 to 167.6 mo (mean/median = 14.1/7.2 mo). Overall cumulative survival rates at 1, 3, and 5 years were 32.5%, 9.2%, and 4.1%, respectively. Univariate log-rank analysis identified the following as adverse influences on overall survival: presence of symptoms, absence of mucobilia, elevated CEA and ca.19-9 levels, non-papillary tumor type, receiving non-hepatectomy, advanced tumor sta.ing, lack of post-operative chemotherapy, and radiotherapy. Meanwhile, multivariate Cox's proportional hazard analysis demonstrated that absence of mucobilia, non-papillary tumor type, advanced tumor sta.ing, non-hepatectomy, and lack of post-operative chemotherapy were the five independent prognostic factors that adversely affected overall survival. CONCLUSION: Favorable overall survival of PCC patients undergoing surgica. treatment depends on early tumor sta.e, presence of mucobilia, papillary tumor type, hepatic resection, and post-operative chemotherapy.

关键词： Prognostic factor Surgica. treatment Peripheral cholangioca.cinoma

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吡喹酮:谜一般的抗寄生虫药物

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国外医学（寄生虫病分册） 1993年第3期20卷 118-119页

作者： Day ta.冯建军

本文综述了吡喹酮对血吸虫作用的靶分子及其作用部位的研究进展。吡喹酮对血吸虫最明显的作用是使虫体皮层破坏和引起虫肌麻痹性收缩,还引起虫体隐蔽性抗原的显露或释放以及改变虫的代谢,所有这些作用归结于吡喹酮改变了虫体的ca.(?+)... 详细信息

本文综述了吡喹酮对血吸虫作用的靶分子及其作用部位的研究进展。吡喹酮对血吸虫最明显的作用是使虫体皮层破坏和引起虫肌麻痹性收缩,还引起虫体隐蔽性抗原的显露或释放以及改变虫的代谢,所有这些作用归结于吡喹酮改变了虫体的ca.(?+)内平衡,这是吡喹酮与虫体的,包括ca.(2+)内平衡在内的一种独特性的特异蛋白质相互作用的结果。

关键词：吡喹酮抗寄生虫药

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