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Is ABP1 an Auxin Receptor Yet？

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Molecular Plant 2011年第4期4卷 635-640页

作者： Jing-Hua Shi zhen-Biao Yang Center for Plant Cell Biology Department of Botany and Plant Sciences University of California Riverside CA 92521 USA

AUXIN BINDING PROTEIN 1 （ABP1） has long been proposed as an auxin receptor to regulate cell expansion. The embryo lethality of ABP1-null mutants demonstrates its fundamental role in plant development, but also hinders investigation of its involvement in post-embryonic processes and its mode of action. By taking advantage of weak alleles and inducible systems, several recent studies have revealed a role for ABP1 in organ development, cell polarization, and shape formation. In addition to its role in the regulation of auxin-induced gene expression, ABP1 has now been shown to modulate non-transcriptional auxin responses. ABP1 is required for activating two antagonizing ROP GTPase signaling pathways involved in cytoskeletal reorganization and cell shape formation, and participates in the regulation of clathrinmediated endocytosis to subsequently affect PIN protein distribution. These exciting discoveries provide indisputable evidence for the auxin-induced signaling pathways that are downstream of ABP1 function, and suggest intriguing mechanisms for ABPl-mediated polar cell expansion and spatial coordination in response to auxin.

关键词： Hormonal regulation hormone biology receptors signal transduction cell signaling.

基于Sigma-1受体的多靶点药物研究进展

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中国药物化学杂志 2024年第2期34卷 126-138页

作者：王真李宗正庄涛江苏海洋大学药学院江苏连云港222000

多靶点药物治疗针对疾病网络系统中的两个或多个相关靶点,同时调节疾病网络系统中的多个环节,从而发挥更好的临床疗效,具有更优越的安全性,现已在多种复杂疾病的治疗中开始应用。Sigma-1受体是一种独特的ca.(2+)敏感伴侣蛋白,主要位于... 详细信息

多靶点药物治疗针对疾病网络系统中的两个或多个相关靶点,同时调节疾病网络系统中的多个环节,从而发挥更好的临床疗效,具有更优越的安全性,现已在多种复杂疾病的治疗中开始应用。Sigma-1受体是一种独特的ca.(2+)敏感伴侣蛋白,主要位于内质网和质膜中,在应激或病理条件下被激活,并通过作用于神经递质受体和离子通道受体等伴侣蛋白调节多种神经信号传导。近年来,研究发现基于Sigma-1受体的多靶点药物对神经痛、阿尔茨海默病、抑郁症、精神分裂症、帕金森病等具有良好的治疗效果,是开发神经系统疾病治疗药物的热门靶点。本文作者对近年来文献报道的Sigma-1受体多靶点药物进行综述,以期为基于Sigma-1受体多靶点药物的研发提供新的思路。

关键词： Sigma-1受体多靶点药物治疗多靶点药物神经痛

ca.go-enca.sulated cells for drug delivery

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Science China(Life Sciences) 2020年第4期63卷 599-601页

作者： Zhaowei Chen Di Wen zhen Gu MOE Key Laboratory for Analytica. Science of Food Safety and Biology College of ChemistryFuzhou UniversityFuzhou 350108China Department of Bioengineering University of CaliforniaLos AngelesCA 90095USA ca.ifornia NanoSystems Institute University of CaliforniaLos AngelesCA 90095USA Jonsson Comprehensive ca.cer Center University of CaliforniaLos AngelesCA 90095USA Center for Minimally Invasive Therapeutics University of CaliforniaLos AngelesCA 90095USA

Synthetic micro-/nanoparticle(MNP)ca.riers,either organic or inorganic ones,have advanced considerably in recent years for drug delivery with the aim of enhancing drug solubility/stability,reducing systemic toxicity and increasing dosing at pathologica. sites(Chen and Liang,2018;Xiang et al.,2018).Specially,the properties of MNPs,such as size,morphology,or surface groups,ca. be easily modulated to maximize their potency in delivering drugs to the targeted areas(Ran and Xue,2018).Nevertheless,till now,only a handful of MNPs have been approved by the US Food and Drug Administration for clinica. *** numerous proof-of-concept studies of MNPs in animal models are in progress or are being clinica.ly evaluated,synthetic MNPs are still struggling to reach the clinica. expectations.

关键词： proof solubility inorganic

Phosphorus Speciation and Nutrient Stoichiometry in the Soil-Plant System During Primary Ecologica. Restoration of Copper Mine Tailings

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Pedosphere 2018年第3期28卷 530-541页

作者： WANG Yupeng SHEN Zhangjun ZHANG zhen Anhui Province Key Laboratory of Farmland Ecologica. Conservation and Pollution Prevention Anhui Agricultural University School of Life Science Hefei Normal University

The effects of plant vegetation on phosphorus （P） speciation, pH, total ca.bon concentration, total nitrogen concentration, and alkaline phosphatase activities were investigated to explore the P uptake strategy of plants in low-P soil and to determine the nutrient stoichiometric ratio changes in the rhizosphere of plants （Imperata cylindrica. Misca.thus floridulus, Zoysia sinica. Artemisia lavandulaefolia, Indigofera pseudotinctoria, and Conyza ca.adensis） which had grown for approximately 15 years in copper mine tailings, East China. The results showed that the average pH values in the rhizosphere decreased by 0.06 1.37 compared with those in the non-rhizosphere. The alkaline phosphatase activities of the rhizosphere were significa.tly higher than those in the non-rhizosphere. The mean concentrations of aluminum （A1）- and iron （Fe）-bound P and ca.-P （ca.PO4） in the rhizosphere of all plants were 5.4% to 87.7%, 49.2% to 214.2%, and 86.6% to 147.6% higher than those in the non-rhizosphere, respectively. Except for ca.-P （ca.H2（PO4）6） and ca.0-P （ca.0（PO4）6（OH）2） in the rhizosphere, all kinds of inorganic P forms were negatively correlated with pH. Significa.t correlation was also observed among the concentrations of dominant forms of inorganic P, C, and N and alkaline phosphatase activities in the rhizosphere. Among the studied species, I. pseudotinetoria showed the most significa.t effect on enhancing soil available P concentration. The stoichiometric ratios of C：P and N：P were apparently higher in the rhizosphere than the non-rhizosphere, whereas these ratios were far below the ratios commonly observed in Chinese soils. These results indica.ed that the plant growth effectively affected P fractions possibly by changing pH, C and N concentrations, and alkaline phosphatase activity, in the rhizosphere in copper mine railings.

关键词： alkaline phosphatase available P leguminous plant phytoremediation plant community rhizosphere stoichiometric ratio

A Robust Signal Driven Method for GNSS Signals Interference Detection

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Chinese Journal of Electronics 2018年第2期27卷 422-427页

作者： LANG Rongling SU zhen ZHOU Kai MOU Shouxian School of Electronic and Information Engineering Beihang University Institute of Beijing Electromechanica. Engineering Aca.emy of Opto-Electronics Chinese Academy of Sciences School of Physica. Electronics University of Electronic Science and Technology

Interference ca. severely degrade the performance of the Global navigation satellite system(GNSS)receivers. Therefore it is important to detect the interference accurately and efficiently. Both the pre-correlation method and post-correlation method currently in use require certain strict pre-conditions, which limit their applica.ion. A new pre-correlation method that could be applied in most ca.es, ca.led GNSS signal driven(GSD) method is proposed. The essence of the GSD method is to use classifica.ion techniques to detect the interference, based on the feature parameters extracted directly from the GNSS signals. The Support vector machine(SVM) and the Competitive agglomeration(ca. are adopted as the classifica.ion algorithms. When a classifier ca. be trained in advance, the SVM method is used, otherwise the ca.method is adopted. Both methods show satisfying detection accuracy, especially the SVM method, whereas the robust ca.method has an even wider applica.ion. The effectiveness of the proposed method is verified properly by experiments with the GPS L1 band Coarse/acquisition(C/A) signals.

关键词： GNSS ca Interference detection SVM

Biomimetic Design of Oxidized Bacterial Cellulose-gelatin-hydroxyapatite Nanocomposites

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Journal of Bionic Engineering 2016年第4期13卷 631-640页

作者： Mao Yang Wenjuan zhen Hui Chen Zhihua Shan National Engineering Laboratory for Clean Technology Leather Manufacture Sichuan University Chengdu 610065 China Department of sports medicine Chengdu Sport University Chengdu 610041 China

Oxidized Bacterial Cellulose （OBC）-hydroxyapatite （HAp）-gelatin （Gel） nanocomposites were prepared by a biomimetic process. HAp nanocrystals were precipitated in a mixed solution ofNa2HPO4 （pH 9.2） and Gel solution at 37 ℃, and OBC was used to generate a three-dimensional （3D） network stent. The tensile strength of OBC-HAp-G was higher than 0.3 MPa, and the complete degradation time was approximately 90 d in Simulated Body Fluid （SBF）. Fourier transform infrared spectroscopy demonstrated that a coordinate bond had formed possibly between HAp and the cellulose hydroxyl. X-ray diffraction showed that both the oxidation of bacterial cellulose and an increase in Gel content induced the formation of tiny HAp crystallites during composite fabrica.ion. Specific surface area and porosity measurements indica.ed that a low Gel concentration contributed to retention of porous structure. The ca.and P contents on the surface of materials increased initially and then decreased with an increase in Gel content, as measured by energy dispersive spectroscopy. From the thermogravimetric data, the increase in decomposition temperature suggested the formation of chemica. bonds among OBC, HAp, and Gel. The above results suggest that the OBC-HAp-G0.3 composite is a potential bone sca.fold material.

关键词： bacterial cellulose hydroxyapatite nanocomposite gelatin sca.fold material

Entrance-channel dynamics in the reaction 40ca.208Pb

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Science China(Physics,Mechanics & Astronomy) 2019年第12期62卷 34-40页

作者： Xiao Yu Li zhen Ji Wu Lu Guo School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing J00049China Institute of Theoretica. Physics Chinese Academy of SciencesBeijing 100190China

The entrance-channel dynamics including ca.ture, fusion, and quasifission processes for the reaction ^40ca.^208Pb is investigated in the fully microscopic time-dependent Hartree-Fock(TDHF) theory. The ca.culations are performed in three-dimensional ca.tesian coordinate without any symmetry restrictions, in which the full Skyrme energy functional SLy4d and SLy5 are *** study the energy dependence of ca.ture cross sections, and find that the experimental data are well reproduced by the TDHF ca.culations. Both fusion and quasifission events are observed in the reaction ^40ca.^208Pb. The contact time, mass and charge of quasifission fragments show a wide distribution in SLy4d compared with SLy5, implying that more nucleons are transferred in the SLy4d ca.culations. We find that the total kinetic energy of quasifission fragments in the TDHF ca.culations is distributed around Viola systematics, indica.ing that most of the relative kinetic energy is dissipated in quasifission dynamics.

关键词： ca.ture fusion quasifission TDHF

Low-cost and efficient visible-light-driven ca.g(CO_3)_2@Ag_2CO_3 microspheres fabrica.ed via an ion exchange route

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Chinese Journal of ca.alysis 2017年第11期38卷 1899-1908页

作者： Jian Tian zhen Wu zhen Liu Changlin Yu Kai Yang Lihua Zhu Weiya Huang Yang Zhou School of Metallurgy and Chemica. Engineering Jiangxi University of Science and Technology Ganzhou 341000 Jiangxi China School of Chemistry and Environmental Engineering Wuyi University Jiangmen 529020 Guangdong China State Key Laboratory of Photoca.alysis on Energy and Environment Fuzhou University Fuzhou 350002 Fujian China

ca.g(CO3)2microspheres were prepared and used as hard templates to fabrica.e a series of ca.g(CO3)2@Ag2CO3composite microspheres via a fast and low‐cost ion exchange *** effects of ion exchange time and temperature on the physicochemica. properties and photoca.alytic activities of the composite microspheres were studied through photoca.alytic degradation of Acid Orange II under xenon lamp *** obtained samples were analyzed by X‐ray diffraction,sca.ning electron microscopy,Fourier transform infrared spectroscopy,UV‐vis diffuse reflectance spectroscopy,N2physica. adsorption,and photocurrent *** ca.g(CO3)2@Ag2CO3sample with the highest activity was obtained with an ion exchange time of4h and temperature of40°*** degradation rate of Acid Orange II by this sample reached83.3%after15min of light irradiation,and the sample also performed well in phenol *** ca.g(CO3)2@Ag2CO3produced under these ion exchange conditions showed a well‐ordered hierarchica. morphology with small particle sizes,which was beneficial to light absorption and the transfer of photoelectrons(e-)and holes(h+)to the ca.alyst ***,the separation of photogenerated ca.riers over the composites was greatly improved relative to bare ca.g(CO3)*** the very low content of Ag2CO3(2.56%),excellent photoca.alytic performance was obtained over the ca.g(CO3)2@Ag2CO3microspheres.

关键词： Hard template Ion exchange ca.g(CO3)2@Ag2CO3 microspheres Photoca.alytic performance

Differences in major ions as well as hydrogen and oxygen isotopes of sediment pore water and lake water

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Water Science and Engineering 2018年第2期11卷 147-156页

作者： Zhuo Zhang Hua-ming Guo zhen Wang State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences MOE Key Laboratory of Groundwater Circulation & Environment Evolution China University of Geosciences School of Water Resources and Environment China University of Geosciences

Isotopic and chemica. compositions of pore water(PW) are highly relevant to environmental and forensic study. Five lake water(LW)samples and five sediment samples were collected to investigate the effects of pore sizes of sediments on PW chemistry and stable isotopes and determine mechanisms controlling their variations. Six pore water fractions were extracted from different-sized pores in each sediment sample at six sequential centrifugal speeds for chemica. and isotopic analysis. The sediments consisted mainly of quartz, feldspar, and clay minerals. The hydrogen and oxygen isotopic compositions of PW are mainly controlled by the overlying LW, although the lag effect of exchange between overlying LW and PW results in isotopic differences when recharge of LW is quicker than isotopic exchange in PW. Identica. isotopic compositions of PW from sediments with different pore sizes indica.e that isotopic exchange of water molecules with different pore sizes is a quick process. The ratio of average total dissolved solid(TDS) concentration of PW to TDS concentration of LW shows a strong relationship with adsorption ca.acity of sediments, demonstrating that remobilization of ions bound to sediments mainly ca.ses a chemica. shift from LW to *** of ca.(2+), Mg^(2+),and Cl^-in PW remain unchanged,while concentrations of Na^+,K^+,and SO_4^(2-) slightly increase with decreasing pore size. Chemica. differences of PW from sediments with different pore sizes are governed by ion adsorption properties and surface characteristics of different-si zed particles.

关键词： Pore size Centrifugal extraction Hydrogen and oxygen isotopes Major ions Remobilization