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Histopathological diagnosis of microvascular invasion in hepatocellular carcinoma:Is it reliable?

World Journal of Gastroenterology 2025年第5期31卷 105-116页

作者： liu-Jun li Chao-Qun Wu Fei-Le Ye Zhou Xuan Xiao-li Zhang jian-Ping li Jia Zhou Zhong-Zhen Su Department of Ultrasound The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina Department of Ultrasound The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Pathology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Pathology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Microvascular invasion(MVI)is a critical prognostic factor for postoperative hepatocellular carcinoma recurrence,but the reliability of its current pathological diagnosis remains *** To evaluate the accuracy of current 7-point sampling methods and propose an optimal pathological protocol using whole-mount slide imaging(WSI)for better MVI *** We utilized 40 New Zealand white rabbits to establish VX2 liver tumor *** entire tumor-containing liver lobe was subsequently obtained,following which five different sampling protocols(A-E)were employed to evaluate the detection rate,accuracy,quantity,and distribution of MVI,with the aim of identifying the optimal sampling *** VX2 liver tumor models were successfully established in 37 rabbits,with an incidence of MVI of 81.1%(30/37).The detection rates[27%(10/37),43%(16/37),62%(23/37),68%(25/37),and 93%(14/15)]and quantity(15,36,107,125,and 395)of MVI increased significantly from protocols A to *** distribution of MVI showed fewer MVIs farther away from the tumor,but the percentage of MVI detected quantity gradually increased from 6.7%to 48.3%in the distant nonneoplastic liver tissue from protocols A to *** C was identified as the optimal sampling method by comparing them in *** sampling protocol of three consecutive interval WSIs at the tumor center(WSI3)was further screened to determine the optimal number of *** A(7-point sampling method)exhibited only 46%accuracy and a high false-negative rate of 67%.Notably,the WSI3 protocol improved the accuracy to 78%and decreased the false-negative rate to 27%.CONCLUSION The current 7-point sampling method has a high false-negative rate in MVI *** contrast,the WSI3 protocol provides a practical and effective approach to improve MVI diagnostic accuracy,which is crucial for hepatocellular carcinoma diagnosis and treatment planning.

关键词： Hepatocellular carcinoma Microvascular invasion Histopathological diagnosis Whole-mount slide imaging Sampling protocol

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Resistance of Cement-based Grouting Materials with Nano- SiO_(2) Emulsion to Chloride Ion Penetration

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 114-119页

作者： li Shuiping CHENG jian WEI Chao YUAN Bin YU Chengxiao College of Architectural Science and Engineering Yangzhou UniversityYangzhou 225127China

The chloride penetration resistance of cement-based grout materials was improved by nano-silica *** of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test *** properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and *** results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion *** improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.

关键词： grouting materials nano-SiO_(2)emulsion chloride ion penetration,weight loss strength loss

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Web GIS技术现状与发展趋势

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农业网络信息 2006年第5期 12-15页

作者：崔立剑吴平中国农业大学信息与电气工程学院北京100083

对WebGIS技术进行扼要综述,总结WebGIS特点以及技术研究状况。在GIS技术和信息技术发展的推动下,探讨WebGIS技术的发展趋势。

关键词： Web GIS 分布式互操作地理信息系统

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Java多线程设计模式研究

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计算机与现代化 2006年第11期 92-94,98页

作者：崔立剑吴平中国农业大学信息与电气工程学院北京100083

针对Java多线程并发程序设计,归类和总结了不同功能的Java多线程设计模式,结合实例分析比较了这些设计模式,这有助于解决实际编程中的并发问题,开发出高质量的Java多线程程序。

关键词：多线程 synchronized 读-写锁生产者-消费者

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MEMS射频同轴线的仿真与工艺研究

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中北大学学报（自然科学版） 2015年第6期36卷 713-718页

作者：高荣惠赵龙崔建利张斌珍中北大学电子测试技术重点实验室山西太原030051

以SU-8方形柱作为支撑衬底,初步设计中心频率为38GHz空气填充的微型矩形同轴线,通过HFSS电磁仿真软件对设计的结构进行模拟仿真与优化,并结合实际加工工艺和测试条件,最终确定中心同轴的横截面为200μm×200μm,外壁内表面的横截面为500... 详细信息

以SU-8方形柱作为支撑衬底,初步设计中心频率为38GHz空气填充的微型矩形同轴线,通过HFSS电磁仿真软件对设计的结构进行模拟仿真与优化,并结合实际加工工艺和测试条件,最终确定中心同轴的横截面为200μm×200μm,外壁内表面的横截面为500μm×500μm,对支撑衬底尺寸进行最优化模拟仿真,确定SU-8矩形支撑衬底宽度为200μm.采用SU-8紫外光刻工艺并结合铜的电镀工艺进行微型同轴线结构的加工.利用微波探针测试台对其传输性能进行测试,测试结果显示该微型同轴线在中心频率处回波损耗S11在-30dB以下,插入损耗S12参数为-0.3dB.该工艺方法加工的同轴传输线具有带宽大、介质损耗小、辐射损耗小和抗干扰强等优点,可用于高性能射频和微波电路.另外,它的制作工艺可与其他射频和微波器件及集成电路工艺兼容,便于与射频和微波电路集成.

关键词：同轴传输线光刻电镀 SU-8 RF MEMS

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Structural design and controllable preparation of SiC NWs@Fe_(3)O_(4)@NC nanocomposites for electromagnetic wave absorption

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International Journal of Minerals,Metallurgy and Materials 2025年第3期32卷 520-533页

作者： Wenxin Zhao Meng Zhang Yukun Miao Chang Wang Anguo cui liying Yuan Zeqing Miao Xiaoqing Wang Zhibo Wang Haoyu Pang Alan Meng Zhenjiang li Ting Wang College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China Shandong Engineering Laboratory for Preparation and Application of High-Performance Carbon-Materials College of Electromechanical EngineeringQingdao University of Science and TechnologyQingdao 266061China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for life Science MOEShandong Key Laboratory of Biochemical AnalysisCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China

Using SiC nanowires(SiCNWs)as the substrate,reflux-annealing and electrodeposition-carbonization were sequentially applied to integrate SiC nanowires with magnetic Fe_(3)O_(4) nanoparticles and amorphous nitrogen-doped carbon(NC)for the fabrication of SiCNWs@Fe_(3)O_(4)@NC *** testing and characterization of this product provided valuable insights into the im-pact of structural and composition changes on its electromagnetic wave absorption *** optimized SiCNWs@Fe_(3)O_(4)@NC nanocomposite,which has 30wt%filler content and a corresponding thickness of 2.03 mm,demonstrates exceptional performance with the minimum reflection loss(RL_(min))of-53.69 dB at 11.04 GHz and effective absorption bandwidth(EAB)of 4.4 *** synergistic effects of the enhanced nanocomposite on electromagnetic wave absorption were thoroughly elucidated using the theories of multiple scattering,polarization relaxation,hysteresis loss,and eddy current ***,a multicomponent electromagnetic wave attenu-ation model was established,providing valuable insight into the design of novel absorbing materials and the enhancement of their absorp-tion *** research demonstrated the significant potential of the SiCNWs@Fe_(3)O_(4)@NC nanocomposite as a highly efficient electromagnetic wave-absorbing material with potential applications in various fields,such as stealth technology and microwave absorption.

关键词： electromagnetic attenuation mechanism multicomponent nanocomposite SiC nanowires structural design

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Gold-catalyzed intermolecular amination of allyl azides with ynamides: Efficient construction of 3-azabicyclo[3.1.0] scaffold

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Chinese Chemical Letters 2025年第2期36卷 384-388页

作者： Chong-Yang Shi jian-Xing Gong Zhen li Chao Shu Long-Wu Ye Qing Sun Bo Zhou Xin-Qi Zhu College of Chemistry and Chemical Engineering Yunnan Normal University Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfacesand College of Chemistry and Chemical EngineeringXiamen University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences Key Laboratory of jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong University

Gold-catalyzed amination reactions based on azides via α-imino gold carbene intermediates have attracted extensive attention in the past decades because this methodology leads to the facile and efficient construction of synthetically useful N-containing molecules, especially valuable N-heterocycles. However,successful examples of intermolecular generation of α-imino gold carbenes by using azides as amination reagents are rarely explored probably due to the weak nucleophilicity of azides. Herein, we disclose an efficient gold-catalyzed intermolecular aminative cyclopropanation of ynamides with the allyl azides, enabling flexible synthesis of a wide range of valuable 3-azabicyclo[3.1.0]hex–2-ene derivatives in good to excellent yields with excellent diastereoselectivities. Importantly, this protocol represents the first use of allyl azide as an efficient amination reagent in gold-catalyzed alkyne amination reactions.

关键词： Alkynes Amination Azides Gold Heterocycles

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Efficient generation of all ESC-derived mice carrying a homozygous lethal mutation through eight-cell embryo injection

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Science China life Sciences 2025年

作者： Xidi Yin Meng Yan Yanbo Cheng Zhoujie li Chong cui Yingyi Wang Nan liu Yilai Shu Jinsong li Qing li Key Laboratory of Multi-Cell Systems Shanghai Key Laboratory of Molecular Andrology Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences School of life Science and Technology ShanghaiTech University Animal Core Facility Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences ENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan University Key Laboratory of Systems and Health Science of Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences

Dear Editor,Large-scale phenotyping efforts have shown that placental defects correlate strongly with embryonic lethal mouse mutants(Perez-Garcia et al., 2018). To rescue normal development of these mutant embryos, tetraploid complementation can be a reliable strategy, in which,tetraploid cells form extraembryonic lineages thus providing the embryo with a wild-type placenta(Nagy et al., 1990).

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Terahertz Frequency Domain Response for Insulation State Assessment of Vehicle Cable Terminal Under Electro-Thermal Aging

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CSEE Journal of Power and Energy Systems 2025年第1期11卷 458-467页

作者： Binglei Cao Shuaibing li Yi cui Dong Yang Yongqiang Kang Baopeng Lu Guangning Wu School of New Energy and Power Engineering Lanzhou Jiaotong UniversityLanzhouChina School of Engineering University of Southern QueenslandSpringfieldAustralia School of Automation and Electrical Engineering Lanzhou Jiaotong UniversityLanzhouChina School of Electrical Engineering Southwest Jiaotong UniversityChengduChina

To accurately diagnose the aging condition of the vehicle-mounted high-voltage cable terminals under the combined electro-thermal stress,this paper proposes a terahertz frequency spectrum technology-based ***,an electro-thermal aging platform is established in the laboratory to obtain the test samples of ethylene-propylene rubber(EPR)cable terminals with different aging ***,the degree of electro-thermal aging is characterized by frequency spectrum,absorption coefficient spectrum,absorption spectrum,refractive index and dielectric constant in the terahertz ***,the micro-morphology and micro-area structure of the test samples under different aging gradients are also observed by scanning electron microscopy,and both the material and chemical properties are *** findings demonstrate that terahertz frequency spectra offer significant benefits in non-destructively detecting and identifying the insulation condition of vehicle cable terminals during electro-thermal *** tests confirm the feasibility of utilizing the terahertz frequency spectrum to assess the insulation aging state of EPR cable terminals,making it potentially applicable for on-site purposes.

关键词： Cable terminal degradation electro-thermal aging nondestructive inspection terahertz(THz)technology.

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Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong Hu Wenyi lian Kang Hu Qiuju li Xueliang cui Tengyu Yao Laifa Shen jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)

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