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Role of Mitophagy in Myocardial Ischemia/Reperfusion Injury and Chinese Medicine Treatment

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Chinese Journal of Integrative Medicine 2023年第1期29卷 81-88页

作者： XIA Jun-yan CHEN Cong LIN Qian CUI jie WAN jie LI Yan LI Dong Department of Cardiology Dongfang Hospitalthe Second Affiliated Hospital of Beijing University of Chinese MedicineBeijing100078China Department of Cardiology Dongzhimen Hospitalthe First Affiliated Hospital of Beijing University of Chinese MedicineBeijing100007China

Mitophagy is one of the important targets for the prevention and treatment of myocardial ischemia/reperfusion injury(MIRI).Moderate mitophagy can remove damaged mitochondria,inhibit excessive reactive oxygen species accumulation,and protect mitochondria from damage.However,excessive enhancement of mitophagy greatly reduces adenosine triphosphate production and energy supply for cell survival,and aggravates cell death.How dysfunctional mitochondria are selectively recognized and engulfed is related to the interaction of adaptors on the mitochondrial membrane,which mainly include phosphatase and tensin homolog deleted on chromosome ten(PTEN)-induced kinase 1/Parkin,hypoxia-inducible factor-1α/Bcl-2 and adenovirus e1b19k Da interacting protein 3,FUN-14 domain containing protein 1 receptor-mediated mitophagy pathway and so on.In this review,the authors briefly summarize the main pathways currently studied on mitophagy and the relationship between mitophagy and MIRI,and incorporate and analyze research data on prevention and treatment of MIRI with Chinese medicine,thereby provide relevant theoretical basis and treatment ideas for clinical prevention of MIRI.

关键词： mitophagy myocardial ischemia/reperfusion injury PTEN-induced kinase 1/Parkin hypoxia-inducible factor-1α/Bcl-2 and adenovirus e1b19k Da interacting protein 3 FUN-14 domain containing protein 1 Chinese medicine

High linearity U-band power amplifier design:a novel intermodulation point analysis method

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Frontiers of Information Technology & Electronic Engineering 2023年第1期24卷 176-186页

作者： jie cui Peipei LI Weixing SHENG School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China

A power amplifier’s linearity determines the emission signal’s quality and the efficiency of the system.Nonlinear distortion can result in system bit error,out-of-band radiation,and interference with other channels,which severely influence communication system’s quality and reliability.Starting from the third-order intermodulation point of the milimeter wave(mm-Wave)power amplifiers,the circuit’s nonlinearity is compensated for.The analysis,design,and implementation of linear class AB mm-Wave power amplifiers based on GlobalFoundries 45 nm CMOS silicon-on-insulator(SOI)technology are presented.Three single-ended and differential stacked power amplifiers have been implemented based on cascode cells and triple cascode cells operating in U-band frequencies.According to nonlinear analysis and on-wafer measurements,designs based on triple cascode cells outperform those based on cascode cells.Using single-ended measurements,the differential power amplifier achieves a measured peak power-added efficiency(PAE)of 47.2%and a saturated output power(P_(sat))of 25.2 dBm at 44 GHz.The amplifier achieves a P_(sat)higher than 23 dBm and a maximum PAE higher than 25%in the measured bandwidth from 44 GHz to 50 GHz.

关键词： CMOS silicon-on-insulator(SOI) Linearity analysis Milimeter wave(mm-Wave) Power amplifier

Forces of fully nonlinear interfacial periodic waves on a cylindrical pile in a two-layer fluid with free-surface boundary conditions

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Journal of Ocean Engineering and Science 2023年第6期8卷 662-674页

作者： Jiyang Li Zeng Liu jie cui School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu 212000PR China School of Naval Architecture and Ocean Engineering Huazhong University of Science and TechnologyWuhan 430074PR China Hubei Key Laboratory of Naval Architecture and Ocean Engineering Hydrodynamics(HUST) Wuhan 430074China Hubei Provincial Engineering Research Center of Data Techniques and Supporting Software for Ships Wuhan 430074PR China

In the frame of fully nonlinear potential flow theory,series solutions of interfacial periodic gravity waves in a two-layer fluid with free surface are obtained by the homotopy analysis method(HAM),and the related wave forces on a vertical cylinder are analyzed.The solution procedure of the HAM for the interfacial wave model with rigid upper surface is further developed to consider the free surface boundary.And forces of nonlinear interfacial periodic waves are estimated by both the classical and modified Mori-son equations.It is found that the estimated wave forces by the classical Morison equation are more conservative than those by the modified Morison’s formula,and the relative error between the total inertial forces calculated by these two kinds of Morison’s formulae remains over 25%for most cases unless the upper and lower layer depths are both large enough.It demonstrates that the convective acceleration neglected in the classical Morison equation is rather important for inertial force exerted by not only internal solitary waves but also interfacial periodic waves.All of these should further deepen our understanding of internal periodic wave forces on a vertical marine riser.

关键词： Interfacial periodic waves Wave force Cylindrical pile Homotopy analysis method Morison equation

Reducing voltage hysteresis of metal oxide anodes to achieve high energy efficiency for Li-ion batteries

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能源化学:英文版 2023年第8期83卷 433-444,I0011页

作者： Xuexia Lan Xingyu Xiong jie cui Renzong Hu School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510640GuangdongChina Analytical and Testing Center South China University of TechnologyGuangzhou 510640GuangdongChina

In the past two decades,a lot of high-capacity conversion-type metal oxides have been intensively studied as alternative anode materials for Li-ion batteries with higher energy density.Unfortunately,their large voltage hysteresis(0.8-1.2 V) within reversed conversion reactions results in huge round-trip inefficiencies and thus lower energy efficiency(50%-75%) in full cells than those with graphite anodes.This remains a long-term open question and has been the most serious drawback toward application of metal oxide anodes.Here we clarify the origins of voltage hysteresis in the typical SnO2anode and propose a universal strategy to minimize it.With the established in situ phosphating to generate metal phosphates during reversed conversion reactions in synergy with boosted reaction kinetics by the added P and Mo,the huge voltage hysteresis of 0.9 V in SnO_(2),SnO_(2)-Mo,and 0.6 V in SnO2-P anodes is minimized to 0.3 V in a ternary SnO_(2)-Mo-P(SOMP) composite,along with stable high capacity of 936 mA h g^(-1)after 800 cycles.The small voltage hysteresis can remain stable even the SOMP anode operated at high current rate of10 A g^(-1)and wide-range temperatures from 60 to 30℃,resulting in a high energy efficiency of88.5% in full cells.This effective strategy to minimize voltage hysteresis has also been demonstrated in Fe2O3,Co3O4-basded conversion-type anodes.This work provides important guidance to advance the high-capacity metal oxide anodes from laboratory to industrialization.

关键词： Conversion reaction Voltage hysteresis Energy efficiency Phosphating

Evolutionary perspectives on novel coronaviruses identified in pneumonia cases in China

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National Science Review 2020年第2期7卷 239-242页

作者： Xiaoman Wei Xiang Li jie cui CAS Key Laboratory of Molecular Virology &Immunology Institut Pasteur of ShanghaiChinese Academy of Sciences Wuhan Institute of Virology Center for Biosafety Mega-Science Chinese Academy of Sciences University of Chinese Academy of Sciences

Coronaviruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), are highly transmissible pathogens, and they can be lethal in humans. Bats are believed to be the original sources of these lethal pathogens. In December 2019, a cluster of pneumonia cases was reported in Wuhan and a novel coronavirus (2019-nCoV, now officially named as SARS-

关键词： origin Evolutionary perspectives on novel coronaviruses identified in pneumonia cases in China

Thermophoresis of nanoparticles hotter/colder than the surrounding dilute gases

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Particuology 2022年第4期20卷 95-102页

作者： Junjie Su jie cui Jun Wang Guodong Xia MOE Key Laboratory of Enhanced Heat Transfer and Energy Conservation Beijing Key Laboratory of Heat Transfer and Energy ConversionBeijing University of TechnologyBeijing 100124China

Aerosol particles suspended in a diluted gas with non-uniform temperature distribution are expected to experience a thermophoretic force.In theoretical treatment of thermophoresis,it is usually assumed that the particle temperature is equal to the surrounding gas temperature.However,this might not always be the case.In some particular applications,the particle temperature can significantly differ from the gas temperature.In the present paper,we theoretically investigate the effect of the particle tempera-ture on the thermophoresis of nanoparticles in the free molecule regime.Theoretical formulas for the thermophoretic force and thermophoretic velocity are obtained based on the gas kinetic theory.As exam-ples,a spherical Ag nanoparticle suspended in a dilute He gas is considered,and the Rudyak-Krasnolutski potential is employed to model the gas-particle interaction.It is found that the influence of the particle temperature on the thermophoresis of nanoparticles can be significant.With increasing particle size,the error due to the equal gas-particle temperature assumption can be neglected.

关键词： Thermophoresis Particle temperature Nanoparticles Free molecule regime

Viromes in marine ecosystems reveal remarkable invertebrate RNA virus diversity

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Science China(Life Sciences) 2022年第2期65卷 426-437页

作者： Yu-Yi Zhang Yicong Chen Xiaoman Wei jie cui CAS Key Laboratory of Molecular Virology&Immunology Institut Pasteur of ShanghaiCenter for Biosafety Mega-ScienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Laboatory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

Little is known about ocean viromes and the ecological drivers of the evolution of aquatic RNA viruses.This study employed a meta-transcriptomic approach to characterize the viromes of 58 marine invertebrate species across three seas.This revealed the presence of 315 newly identified RNA viruses in nine viral families or orders(Durnavirales,Totiviridae,Bunyavirales,Han-taviridae,Picornavirales,Flaviviridae,Hepelivirales,Solemoviridae,and Tombusviridae),with most of them being sufficiently divergent to the already documented viruses.Notably,this study revealed three marine invertebrate hantaviruses that are rooted to vertebrate hantaviruses,further supporting that hantaviruses may have a marine origin.We have also found evidence for possible host sharing and switch events during virus evolution.Overall,we have revealed the hidden diversity of marine invertebrate RNA viruses.

关键词： ocean aquatic invertebrate RNA virome evolution host sharing

Rhodium-catalyzed dearomative rearrangement of 2-oxypyridines with cyclopropenes: access to N-alkylated 2-pyridones

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Organic Chemistry Frontiers 2022年第5期9卷 1295-1299页

作者： Honglian cui Guangyang Xu jie Zhu Jiangtao Sun Jiangsu Key Laboratory of Advanced Catalytic Materials&Technology School of Petrochemical EngineeringChangzhou UniversityChangzhou 213164China

A rhodium-catalyzed dearomative rearrangement reaction of 2-oxypyridines has been developed by using cyclopropenes as carbene precursors.This protocol features broad substrate scope and mild reac-tion conditions,providing a reliable and practical approach for the highly efficient synthesis of 2-alkylated 2-pyridone derivatives from readily available O-substituted pyridine compounds.

关键词： compounds rearrangement pyridine

Pore Connectivity of Deep Lacustrine Shale and its Effect on Gas-bearing Characteristics in the Songliao Basin:Implications from Continental Scientific Drilling

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Acta Geologica Sinica(English Edition) 2023年第5期97卷 1503-1522页

作者： HAN Shuangbiao HUANG jie WANG Chengshan cui Jiayi College of Geoscience and Surveying Engineering China University of Mining and TechnologyBeijing 100083China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China

The lacustrine shale of deep Shahezi Formation in the Songliao basin has great gas potential,but its pore evolution,heterogeneity,and connectivity characteristics remain unclear.In this work,total organic carbon analysis,rock pyrolysis,X-ray diffraction field emission scanning electron microscopy,the particle and crack analysis system software,low-temperature nitrogen adsorption experiment,fractal theory,high-pressure mercury injection experiment and nuclear magnetic resonance experiment were used to study the Shahezi shale from Well SK-2.The result indicated that the organic pores in Shahezi shale are not developed,and the intergranular and intragranular pores are mainly formed by illitedominated clay.As the burial depth increases,the pore size and slit-shaped pores formed by clay decrease,and dissolved pores in the feldspar and carbonate minerals and dissolved fractures in the quartz increase.The pore evolution is affected by clay,compaction,and high-temperature corrosion.Based on the pore structure characteristics reflected by the pore size distribution and pore structure parameters obtained by multiple experimental methods,the pore development and evolution are divided into three stages.During stageⅠandⅡ,the pore heterogeneity of the shale reservoirs increases with the depth,the physical properties and pore connectivity deteriorate,but the gas-bearing property is good.In stageⅢ,the pore heterogeneity is the highest,its gas generation and storage capacity are low,but the increase of micro-fractures makes pore connectivity and gas-bearing better.

关键词： pore evolution pore connectivity gas-bearing deep shale Songliao basin