检索结果-南通市图书馆

大光包滑坡层间错动带液化特性及滑坡启动成因探讨

在线全文

学校读者我要写书评

暂无评论

岩土力学 2019年第3期40卷 1085-1096页

作者：裴向军朱凌崔圣华张晓超梁玉飞高会会张子东成都理工大学地质灾害防治与地质环境保护国家重点实验室四川成都610059

大光包滑坡是2008年汶川地震触发的最大规模滑坡,其剪滑破坏发生在斜坡先期构造层间错动带内,该带主要由糜棱化、角砾化的构造碎裂物质组成,且具有显著地下水赋存与运移特征。为探讨强震过程地下水参与下该错动带动力学行为及对大光包... 详细信息

大光包滑坡是2008年汶川地震触发的最大规模滑坡,其剪滑破坏发生在斜坡先期构造层间错动带内,该带主要由糜棱化、角砾化的构造碎裂物质组成,且具有显著地下水赋存与运移特征。为探讨强震过程地下水参与下该错动带动力学行为及对大光包滑坡启动的可能影响,取错动带材料,室内开展系列饱水静三轴、单向和双向动三轴试验,分析该材料液化特性。试验结果表明:材料具有较强的潜在液化能力;单向和双向动载作用下材料均能液化,但双向振动液化速率更快,且动强度比单向降低约20%;双向振动下材料液化速率随循环偏应力和径向循环应力增大而加快,相位差180o比0o液化速率更快。研究表明,对于产状倾斜(N2°W/NE/30°)的大光包滑坡层间错动带,双向动三轴试验动力条件可能更接近实际应力状态;强震过程,该错动带液化可能是大光包滑坡突然启动原因。

关键词：大光包滑坡动三轴试验滑带液化滑坡启动层间错动带

GFRP筋混杂纤维混凝土隧道管片力学性能研究

在线全文

学校读者我要写书评

暂无评论

工程力学 2024年第S01期41卷 238-244,252页

作者：陈晟晟周春恒章子华宁波大学土木工程与地理环境学院宁波315211

为研究GFRP筋混杂纤维混凝土隧道管片的力学性能,进行了三个不同GFRP筋配筋率的钢-聚丙烯纤维混凝土管片静力受弯试验,获得了试件的破坏形态、承载力及裂缝扩展模式。考虑GFRP筋与混杂纤维混凝土的界面黏结,采用ABAQUS建立了GFRP筋混杂... 详细信息

为研究GFRP筋混杂纤维混凝土隧道管片的力学性能,进行了三个不同GFRP筋配筋率的钢-聚丙烯纤维混凝土管片静力受弯试验,获得了试件的破坏形态、承载力及裂缝扩展模式。考虑GFRP筋与混杂纤维混凝土的界面黏结,采用ABAQUS建立了GFRP筋混杂纤维混凝土管片的有限元模型,分析了不同混杂纤维掺量和配筋率对管片受弯承载力的影响。研究结果表明:GFRP筋混杂纤维混凝土管片的破坏主要是由跨中主裂缝贯穿和GFRP筋材断裂导致;在纤维体积掺量不变的情况下,提高纵向受拉GFRP筋的配筋率,可以有效提高管片的受弯承载力;在数值计算中,考虑GFRP筋与混杂纤维混凝土的界面黏结滑移的有限元模型能更准确地模拟试件的开裂荷载、极限荷载和弯曲刚度;在承载力不变的情况下,增加混杂纤维的体积分数能有效减少管片的配筋率,并且提高管片的抗变形能力;通过回归分析,提出了纤维掺量与配筋率关系的计算式,理论计算结果与数值结果符合较好。

关键词： GFRP筋混杂纤维混凝土配筋率静力受弯试验界面黏结有限元模型

Serum inflammatory markers in children with Mycoplasma pneumoniae pneumonia and their predictive value for mycoplasma severity

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第22期12卷 4940-4946页

作者： Li-Ping Wang Zhong-hua Hu Jun-sheng Jiang Jie Jin Department of Pediatrics The First People's Hospital of Linping DistrictHangzhou 310000Zhejiang ProvinceChina Department of Pediatrics Changzhou Children HospitalChangzhou 213100Jiangsu ProvinceChina

BACKGROUND Mycoplasma pneumoniae pneumonia(MPP)significantly impacts pediatric health,necessitating markers for early severe disease *** To investigate the correlation between serum inflammatory marker and the severity of MPP in *** A prospective study was carried out from January 2023 to November 2023.A total of 160 children with MPP who underwent treatment were selected:80 had severe MPP and 80 had mild *** and laboratory data were collected at the time of hospital admission and during *** operating characteristic curves were utilized to assess the diagnostic and prognostic for severe *** Fever duration and length of hospitalization in pediatric patients with severe MPP exceeded those with mild *** incidence of pleural effusion,lung consolidation,and bronchopneumonia on imaging was markedly elevated in the severe MPP cohort compared to the mild MPP *** contrast to the mild cohort,there was a notable increase in C-reactive protein(CRP),procalcitonin(PCT),erythrocyte sedimentation rate,lactic dehydrogenase,D-dimer,and inflammatory cytokines[interleukin(IL)-6,IL-8,IL-10 and tumor necrosis factor(TNF)-α]in the severe MPP group were significantly *** Serum inflammatory markers(CRP,PCT,IL-6,D-dimer,IL-10 and TNF-α)were considered as predictors in children with severe MPP.

关键词： Cytokine Mycoplasma pneumoniae pneumonia Children,Community-acquired pneumonia levels Interleukin-6 D-dimer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

一株野生桑黄菌的分离鉴定及活性成分分析

北方园艺 2024年第12期 108-114页

作者：王华朱荣才崔胜潘茂华崔自学张芊河南省蚕业科学研究院河南郑州454000

以采自河南省南阳市西峡县的野生桑黄为试材,采用形态学鉴定、系统发育分析及单因素试验法,研究了该菌的分类地位和生物学特性。同时,对比了桑树桑黄、杨树桑黄及粗毛纤孔菌3种子实体中多糖、黄酮、多酚及皂苷4种活性成分含量,以期丰富... 详细信息

以采自河南省南阳市西峡县的野生桑黄为试材,采用形态学鉴定、系统发育分析及单因素试验法,研究了该菌的分类地位和生物学特性。同时,对比了桑树桑黄、杨树桑黄及粗毛纤孔菌3种子实体中多糖、黄酮、多酚及皂苷4种活性成分含量,以期丰富桑树桑黄种质资源。结果表明:该菌为桑黄孔菌属的桑树桑黄(Sanghuangporus sanghuang)。在纯培养条件下,该菌的最适温度为26~28℃,最适生长pH为6,最适碳源为麦芽糖和葡萄糖,最适氮源为酵母浸粉和胰蛋白胨。桑树桑黄、杨树桑黄及粗毛纤孔菌3种桑黄的活性成分含量差异显著,其中,桑树桑黄中黄酮和总酚含量最高,粗毛纤孔菌中多糖和皂苷含量最高。综上所述,采自河南省的野生桑黄为桑树桑黄,且该菌在桑黄类真菌中具备较高的药用价值。

关键词：桑树桑黄分子鉴定活性成分

新能源汽车浸没式锂离子电池冷却技术研究进展

在线全文

学校读者我要写书评

暂无评论

制冷学报 2024年第3期45卷 38-49页

作者：李哲张华盛雷上海理工大学能源与动力工程学院上海200093 上海理工大学机械工程学院上海200093

浸没式电池冷却是将电池直接浸泡于冷却液中,相比常规间接式液冷、风冷和相变冷却,具有结构简单、降温迅速、均温性能好等优势。对目前浸没式电池冷却的相关技术进行了统计、归纳和总结,包括浸没液采选、冷却系统结构设计、热安全等,并... 详细信息

浸没式电池冷却是将电池直接浸泡于冷却液中,相比常规间接式液冷、风冷和相变冷却,具有结构简单、降温迅速、均温性能好等优势。对目前浸没式电池冷却的相关技术进行了统计、归纳和总结,包括浸没液采选、冷却系统结构设计、热安全等,并结合上述工作对浸没式电池冷却系统的技术应用进行分析。结果表明:浸没式冷却可快速降低电池温度,能够有效提升电池组的温度均一性;但该技术对电池模组的密封性要求较高,漏液以及腐蚀等难题有待解决。

关键词：新能源汽车浸没式电池冷却电池热管理浸没液

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第3期14卷 401-415页

作者： Ke-Gang Linghu Tian Zhang Guang-Tao Zhang Peng Lv Wen-Jun Zhang Guan-Ding Zhao Shi-Hang Xiong Qiu-Shuo Ma Ming-Ming Zhao Meiwan Chen Yuan-Jia Hu Chang-sheng Zhang hua Yu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Key Laboratory of Tropical Marine Bio-resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaRNAM Center for Marine MicrobiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301China State Key Laboratory of Functions and Applications of Medicinal Plants&School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang550025China

Activation of nuclear factor erythroid 2-related factor 2(Nrf2)by Kelch-like ECH-associated protein 1(Keap1)alkylation plays a central role in anti-inflammatory ***,activators of Nrf2 through alkylation of Keap1-Kelch domain have not been ***(DNQ)is a natural small molecule discovered from marine *** current study was designed to investigate the anti-inflammatory effects and molecular mechanisms of DNQ via alkylation of *** exhibited significant anti-inflammatory properties both in vitro and in *** pharmacophore responsible for the anti-inflammatory properties of DNQ was determined to be theα,β-unsaturated amides moieties by a chemical reaction between DNQ and *** exerted anti-inflammatory effects through activation of Nrf2/ARE ***1 was demonstrated to be the direct target of DNQ and bound with DNQ through conjugate addition reaction involving *** specific alkylation site of DNQ on Keap1 for Nrf2 activation was elucidated with a synthesized probe in conjunction with liquid chromatography-tandem mass *** triggered the ubiquitination and subsequent degradation of Keap1 by alkylation of the cysteine residue 489(Cys489)on Keap1-Kelch domain,ultimately enabling the activation of *** findings revealed that DNQ exhibited potent anti-inflammatory capacity throughα,β-unsaturated amides moieties active group which specifically activated Nrf2 signal pathway via alkylation/ubiquitination of Keap1-Kelch domain,suggesting the potential values of targeting Cys489 on Keap1-Kelch domain by DNQ-like small molecules in inflammatory therapies.

关键词： Deoxynyboquinone Anti-inflammation Target Keap1/Nrf2 Alkylation Ubiquitination

Link between mutations in ACVRL1 and PLA2G4A genes and chronic intestinal ulcers:A case report and review of literature

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第3期16卷 932-943页

作者： Yong-Jing Tang Jian Zhang Jie Wang Ren-Dong Tian Wei-Wei Zhong Ben-sheng Yao Bing-Yu Hou Ying-hua Chen Wei He Yi-huai He Department of Infectious Diseases The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Gastroenterology Dafang County People's HospitalBijie 551600Guizhou ProvinceChina Department of Internal Medicine Puchang BranchMedical CommunitySuiyang County People's HospitalZunyi 563300Guizhou ProvinceChina Department of Infectious Diseases Jingmen Central HospitalJingmen 448000Hubei ProvinceChina Department of Infectious Diseases Dafang County People's HospitalBijie 551600Guizhou ProvinceChina

BACKGROUND Genetic factors of chronic intestinal ulcers are increasingly garnering *** present a case of chronic intestinal ulcers and bleeding associated with mu-tations of the activin A receptor type II-like 1(ACVRL1)and phospholipase A2 group IVA(PLA2G4A)genes and review the available relevant *** SUMMARY A 20-year-old man was admitted to our center with a 6-year history of recurrent abdominal pain,diarrhea,and dark *** the onset 6 years ago,the patient had received treatment at a local hospital for abdominal pain persisting for 7 d,under the diagnosis of diffuse peritonitis,acute gangrenous appendicitis with perforation,adhesive intestinal obstruction,and pelvic *** surgical treat-ment included exploratory laparotomy,appendectomy,intestinal adhesiolysis,and pelvic abscess *** patient’s condition improved and he was ***,the recurrent episodes of abdominal pain and passage of black stools started again one year after *** the basis of these features and results of subsequent colonoscopy,the clinical diagnosis was established as in-flammatory bowel disease(IBD).Accordingly,aminosalicylic acid,immunotherapy,and related symptomatic treatment were administered,but the symptoms of the patient did not improve *** investigations revealed mutations in the ACVRL1 and PLA2G4A ***1 and PLA2G4A are involved in angiogenesis and coagulation,*** suggests that the chronic intestinal ulcers and bleeding in this case may be linked to mutations in the ACVRL1 and PLA2G4A *** Kangfuxin liquid was administered to promote healing of the intestinal mucosa and effectively manage clinical *** Mutations in the ACVRL1 and PLA2G4A genes may be one of the causes of chronic intestinal ulcers and bleeding in *** administered Kangfuxin liquid may have therapeutic potential.

关键词： Intestinal ulcers Crohn’s disease Ulcerative colitis Activin A receptor type II-like 1 Phospholipase A2 group 4A Case report

LncRNA CCRR maintains Ca^(2+)homeostasis against myocardial infarction through the FTO-SERCA2a pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第8期67卷 1601-1619页

作者： hua Yang Lina Xuan shengjie Wang Huishan Luo Xiaomeng Duan Jianjun Guo Shijia cui Jieru Xin Junwei Hao Xiufang Li Jun Chen Feihan Sun Xiaolin Hu Siyun Li Ying Zhang Lei Jiao Baofeng Yang Lihua Sun Department of Pharmacology Harbin Medical University(State Key Laboratory of Frigid Zone Cardiovascular Diseasethe State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of EducationJoint International Research Laboratory of Cardiovascular Medicine ResearchMinistry of EducationChina)College of PharmacyHarbin Medical UniversityHarbin 150081China

Cardiac conduction regulatory RNA(CCRR)has been documented as an antiarrhythmic lncRNA in our earlier *** study aimed to evaluate the effects of CCRR on SERCA2a and the associated Ca^(2+)homeostasis in myocardial infarction(MI).Overexpression of CCRR via AAV9-mediated delivery not only partially reversed ischemia-induced contractile dysfunction but also alleviated abnormal Ca^(2+)homeostasis and reduced the heightened methylation level of SERCA2a following *** effects were also observed in CCRR overexpressing transgenic mice.A conserved sequence domain of CCRR mimicked the protective function observed with the full ***,silencing CCRR in healthy mice led to intracellular Ca^(2+)overloading of *** increased SERCA2a protein stability by upregulating FTO *** direct interaction between CCRR and FTO protein was characterized by RNA-binding protein immunoprecipitation(RIP)analysis and RNA pulldown *** of NFATc3 was identified as an upstream mechanism responsible for CCRR downregulation in *** study demonstrates that CCRR is a protective lncRNA that acts by maintaining the function of FTO,thereby reducing the m^(6)A RNA methylation level of SERCA2a,ultimately preserving calcium homeostasis for myocardial contractile function in ***,CCRR may be considered a promising therapeutic strategy with a beneficial role in cardiac pathology.

关键词： CCRR calcium homeostasis FTO myocardial infarction SERCA2a

Behavior of exciton in direct−indirect band gap Al_(x)Ga_(1−x)As crystal lattice quantum wells

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2024年第3期45卷 64-70页

作者： Yong Sun Wei Zhang Shuang Han Ran An Xin-sheng Tang Xin-Lei Yu Xiu-Juan Miao Xin-Jun Ma Xianglian Pei-Fang Li cui-Lan Zhao Zhao-hua Ding Jing-Lin Xiao Institute of Condensed Matter Physics Inner Mongolia Minzu UniversityTongliao 028043China College of Physics and Electronic Information Inner Mongolia Minzu UniversityTongliao 028043China

Excitons have significant impacts on the properties of *** exhibit significantly different properties when a direct semiconductor turns in to an indirect one by *** variational method is also found to influence the study of exciton ground state energy and ground state binding energy in Al_(x)Ga_(1−x)As semiconductor spherical quantum *** Al_(x)Ga_(1−x)As is considered to be a direct semiconductor at AI concentration below 0.45,and an indirect one at the concentration above *** regards to the former,the ground state binding energy increases and decreases with AI concentration and eigenfrequency,respectively;however,while the ground state energy increases with AI concentration,it is marginally influenced by *** the other hand,considering the latter,while the ground state binding energy increases with AI concentration,it decreases with eigenfrequency;nevertheless,the ground state energy increases both with AI concentration and ***,for the better practical performance of the semiconductors,the properties of the excitons are suggested to vary by adjusting AI concentration and eigenfrequency.

关键词： exciton effects aluminum gallium arsenide crystal direct band gap semiconductor indirect band gap semiconductor