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ATIS环境下通勤者逐日出行路径更换行为仿真

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吉林大学学报（工学版） 2009年第3期39卷 587-592页

作者：安实李静崔娜哈尔滨工业大学交通科学与工程学院哈尔滨150090 广东省交通集团有限公司广州510101 哈尔滨工业大学管理学院哈尔滨150001

基于'有限理性'行为理论,提出了通勤者逐日出行路径动态更换行为的模型框架,'有限理性'规则的应用主要体现在'无差别阈值'上。为捕捉通勤者逐日出行中的经验积累过程以及路径选择中存在的序列相关性及同期相关性,分别针对出行前和出行... 详细信息

基于'有限理性'行为理论,提出了通勤者逐日出行路径动态更换行为的模型框架,'有限理性'规则的应用主要体现在'无差别阈值'上。为捕捉通勤者逐日出行中的经验积累过程以及路径选择中存在的序列相关性及同期相关性,分别针对出行前和出行中的路径更换行为建立了MNP形式的无差别阈值模型。在此基础上,采用驾驶员训练模拟器对驾驶员在不同ATIS信息下的逐日动态更换行为进行了仿真实验,并采集实验数据对通勤者出行前和出行中的路径更换无差别阈值模型进行参数标定。参数估计结果显示了ATIS信息、驾驶员个人属性、信息质量以及行程延误等各方面因素对通勤者逐日动态更换行为的影响,为驾驶员行为分析的深入研究提供了有益的参考。

关键词：交通运输系统工程路径更换行为逐日出行有限理性 MNP 无差别阈值驾驶员训练模拟器

共享发展理念下矿产资源开发收益分配机制研究

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中国矿业 2020年第2期29卷 46-51页

作者：崔娜中南林业科技大学

以共享发展理念指导矿产资源开发收益分配是实现矿产资源开发收益公平合理分配、规避“资源诅咒”的有效途径。本文在分析矿产资源开发收益构成的基础上,明确共享发展理念下矿产资源开发收益分配内涵,并针对我国矿产资源开发收益分配中... 详细信息

以共享发展理念指导矿产资源开发收益分配是实现矿产资源开发收益公平合理分配、规避“资源诅咒”的有效途径。本文在分析矿产资源开发收益构成的基础上,明确共享发展理念下矿产资源开发收益分配内涵,并针对我国矿产资源开发收益分配中分配主体不完整、主体与客体错位、分配标准不公平、分配目标难以实现等问题,提出完善矿产资源完全成本、健全矿产资源开发补偿机制、建立财富合理转化机制、规范资源税费的支出与使用等建议。

关键词：共享发展矿产资源收益分配

Accelerated Autophagy of Cecal Ligation and Puncture-Induced Myocardial Dysfunction and Its Correlation with Mammalian Target of Rapamycin Pathway in Rats

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Chinese Medical Journal 2018年第10期131卷 1185-1190页

作者： Hao Wang na cui Wen Han Long-Xiang Su Yun Long Da-Wei Liu Department of Critical Care Medicine Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Science Beijing 100730 China

Background：Recent studies have indicated that autophagy is involved in sepsis-induced myocardial *** study aimed to investigate the change of autophagy in cecal ligation and puncture （CLP）-induced myocardium dysfunction and its relationship with mammalian target of rapamycin （mTOR） ***：Totally,12 rats were randomly divided into CLP group or sham-operated （SHAM） *** tissues were harvested 18 h after CLP or sham *** was detected by hematoxylin and eosin staining,cardiac functions by echocardiography,distribution ofmicrotubule-associated protein light chain 3 type Ⅱ （LC3II） by immunohistochemical staining,and autophagic vacuoles by transmission electron ***,phosphorylation of mTOR （p-mTOR）,phosphorylation of S6 kinase-1 （PS6K1）,and LC3II and p62 expression were measured by western ***＇s correlation coefficient was used to analyze the correlation of two ***：The results by pathology and echocardiography revealed that there was obvious myocardial injury in CLP rats （left ventricle ejection fraction：SHAM 0.76 ± 0.06 *** 0.59 ± 0.l l,P 〈 0.01;fractional shortening：SHAM 0.51 ± 0.09 *** 0.37 ± 0.06,P 〈 0.05）.We also found that the autophagy process was elevated by CLE the ratio of LC3II/LC3I was increased （P 〈 0.05） while the expression of p62 was decreased （P 〈 0.05） in the CLP rats,and there were also more autophagosomes and autolysosomes in the CLP ***,the mTOR pathway in CLP myocardium was inhibited when compared with the sham-operated rats;p-mTOR （P 〈 0.01） and PS6K 1 （P 〈 0.05） were both significantly suppressed following CLP ***,we found that the mTOR pathway was closely correlated with the autophagy *** our study,while p-mTOR in the myocardium was significantly correlated with p62 （r=0.66,P =0.02）,PS6K1 was significantly positively correlated with p62 （r =0.70,P =0.01） and negatively correlated with LC31I （r =-0.71,P =0.01）.Con

关键词： Autophagy Cecal Ligation and Puncture Mammalian Target of Rapamycin: Myocardial Dysfunction Sepsis

Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8＋ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis

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Chinese Medical Journal 2017年第10期130卷 1211-1217页

作者： na cui Hao Wang Long-Xiang Su Jia-Hui Zhang Yun Long Da-Wei Liu Department of Critical Care Medicine Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China

Background： Triggering receptor expressed on myeloid cell- 1 （TREM- 1） may play a vital role in mammalian target ofrapamycin （mTOR） modulation ofCD8＋ T-cell differentiation through the transcription factors T-box expressed in T-cells and eomesodermin during the immune response to invasive pulmonary aspergillosis （IPA）. This study aimed to investigate whether the roTOR signaling pathway modulates the proliferation and differentiation of CD8＋ T-cells during the immune response to I PA and the role TREM-1 plays in this process. Methods： Cyclophosphamide （CTX） was injected intraperitoneally, and Asl？e;gillus.[mnigams spore suspension was inoculated intranasally to establish the immunosuppressed IPA mouse model. After inoculation, rapamycin （2 mg-kg ·d -1） or interleukin （IL）-12 （5 μg/kg every other day） was given for 7 days. The number of CD8＋ effector memory T-cells （Tern）, expression of interferon （IFN）-y, roTOR, and ribosomal protein $6 kinase （S6K）, and the levels of IL-6, IL- 10, galactomannan （GM）, and soluble TREM- 1 （sTREM-I） were measured. Results： Viable A. fumigatus was cultured from the lung tissue of the inoculated mice. Histological examination indicated greater inflammation, hemorrhage, and lung tissue injury in both IPA and CTX ＋ IPA mice groups. The expression of mTOR and S6K was significantly increased in the CTX ＋ IPA ＋ I L- 12 group compared with the control, I PA （P = 0.01 ; P - 0.001 ）, and CTX ＋ 1PA （P = 0.034; P = 0.032） groups, but significantly decreased in the CTX ＋ IPA ＋ RAPA group （P 〈 0.001 ）. Compared with the CTX ＋ IPA group, the proportion of Tern, expression of IFN-y, and the level ofsTREM-I were significantly higher after IL-12 treatment （P = 0.024, P = 0.032, and P = 0.017, respectively）, and the opposite results were observed when the roTOR pathway was blocked by rapamycin （P 〈 0.001）. Compared with the CTX ＋ I PA and CTX ＋ I PA ＋ RAPA groups, IL-12 treatment increased IL-6 and downregulated IL- 10 as well as G M, which strengthened

关键词： CD8+ T Effector Memory Cells lmmunosuppression Invasive Pulmonary Aspergillosis Mammalian Target ofRapamycin Triggering Receptor Expressed on Myeloid Cell-1

Incomplete fluid-air exchange technique for idiopathic macular hole surgery

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1582-1588页

作者： Bo-Jie Hu Xue-Li Du Wen-Bo Li Yu-Wen Chang Xing-Dong Shi Teng Ma Yong Wang Yan-HuaHe Rui Niu Wei-na cui Department of Retina Tianjin Medical University EyeHospital251Fukang RoadTianjin300384China People’s Hospital of Hetian District Hetian848000XinjiangUygur Autonomous RegionChina Department of Ophthalmology Tianjin First Central HospitalTianjin300192China

AIM: To explore an improved procedure involving incomplete fluid-air exchange for idiopathic macular hole(IMH), and the closure rate, visual function, and the visual field of macular holes(MHs) were ***: This prospective randomized controlled study, included 40 eyes of 40 patients with IMH who were treated with pars plana vitrectomy and peeling of the internal limiting membrane. They were grouped by random digital table. Twenty-one eyes underwent incomplete fluidair exchange(IFA) and 19 eyes underwent traditional complete fluid-air exchange(CFA) as the control group. Outcomes included best-corrected visual acuity(BCVA), intraocular pressure, and optical coherence tomography, light adaptive electroretinography, and visual field ***: All MHs nalysis of patients in IFA group revealed increases in b-wave amplitudes at 1, 3, and 6 mo after surgery. Additionally, patients in IFA group showed an amplitude increase of 28.6% from baseline at 6 mo(P0.05).CONCLUSION: IFA is a reliable method that offers comparable closure rate to CFA and facilitates improvements in visual function.

关键词： best-corrected visual acuity electroretinography internal limiting membrane macular hole fluid-air exchange visual field defect

基于宏基因组学探讨东平湖水库的菌群结构、耐药基因谱及其公共健康风险

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环境科学 2021年第1期42卷 211-220页

作者：张红娜崔娜申红妙河北经贸大学生物科学与工程学院石家庄050061

水库中长时间滞留的水体会成为耐药基因的存储库,因此研究其菌群结构、耐药基因谱及其潜在的健康风险具有重要的公共卫生学意义.本研究以东平湖水库的水体和沉积物为研究对象,采用宏基因组测序技术,系统分析其在旱季和雨季中的菌群结构... 详细信息

水库中长时间滞留的水体会成为耐药基因的存储库,因此研究其菌群结构、耐药基因谱及其潜在的健康风险具有重要的公共卫生学意义.本研究以东平湖水库的水体和沉积物为研究对象,采用宏基因组测序技术,系统分析其在旱季和雨季中的菌群结构、耐药基因谱、耐药基因水平转移以及携带耐药基因的致病菌类型.结果表明,与水库沉积物相比,水体中的菌群结构和耐药基因谱受季节影响较大,且旱季的总耐药基因丰度明显高于雨季;水库沉积物中总耐药基因丰度高于水体,但水体中耐药基因的水平转移高于沉积物.本研究共检测到20个耐药基因型,377个耐药基因亚型;杆菌素和万古霉素耐药基因分别是水和沉积物中主要的耐药基因型,变形杆菌和放线菌分别是水体和沉积物中主要携带耐药基因的菌群.此外,本研究还鉴定出30株携带耐药基因的致病菌,包括大肠杆菌、肺炎克雷伯菌、铜绿假单胞菌、肠炎沙门氏菌以及鲍曼不动杆菌,其中有2株大肠杆菌携带毒力因子.综上所述,东平湖水库中的耐药基因不仅种类繁多,而且还存在潜在的公共健康风险;因此定期检测水体环境的菌群结构及其耐药基因谱具有重要的科学价值和现实意义.

关键词：东平湖水库宏基因测序菌群结构耐药基因水平转移致病菌

中国主观社会流动性研究——基于CGSS数据的实证分析

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首都师范大学学报（社会科学版） 2018年第4期 65-73页

作者：李虹宋煜北京大学经济学院

利用中国综合社会调查数据(CGSS2013),从主观角度探讨了当前中国社会地位的结构特征、流动特征及影响因素。研究发现:(1)中国主观社会地位结构由"金字塔型"向"橄榄型"转变,但主观社会地区总体评价偏低;"比较群体"的异质性使得农村居民... 详细信息

利用中国综合社会调查数据(CGSS2013),从主观角度探讨了当前中国社会地位的结构特征、流动特征及影响因素。研究发现:(1)中国主观社会地位结构由"金字塔型"向"橄榄型"转变,但主观社会地区总体评价偏低;"比较群体"的异质性使得农村居民的主观阶层认知评价比城镇居民高。(2)主观社会地位代际流动呈"趋中流动",即趋中间阶层流动,社会中层的不流动率最高,无明显的城乡差异。(3)收入、教育、在体制内工作会显著提升中国居民的主观社会地位。建议缩小地区发展差距和阶层收入差距,调整利益分配机制,促进教育机会和教育资源更加公平地向各个阶层开放。

关键词：社会流动主观社会地位

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柳州市不同产区麻竹笋品质分析

广西林业科学 2024年第1期53卷 87-93页

作者：贾冬冬梁绍煜熊建文潘慧玲朱秀芬崔娜徐振国广西壮族自治区林业科学研究院广西优良用材林资源培育重点实验室广西南宁530002 广西大学林学院广西南宁530004 柳州市林业技术推广站广西柳州545000 柳州工学院食品与化学工程学院广西柳州545616 柳州市螺蛳粉植物源性配料研究重点实验室广西柳州545616

为揭示柳州市不同产区麻竹(Dendrocalamuslatiflorus)笋品质差异,以柳州螺蛳粉酸笋原材料认定基地的麻竹笋为研究对象,测定麻竹笋外观品质、营养品质和食味品质,比较分析各产区麻竹笋品质差异。结果表明,不同产区竹笋外观品质差异显著;... 详细信息

为揭示柳州市不同产区麻竹(Dendrocalamuslatiflorus)笋品质差异,以柳州螺蛳粉酸笋原材料认定基地的麻竹笋为研究对象,测定麻竹笋外观品质、营养品质和食味品质,比较分析各产区麻竹笋品质差异。结果表明,不同产区竹笋外观品质差异显著;柳北、柳城县-1产区竹笋基径、长度和质量均显著高于其他产区,可食率均较高;柳北产区竹笋外观品质最好。不同产区竹笋营养品质差异显著;柳城县-2产区竹笋蛋白质、淀粉、总糖、维生素C和氨基酸含量均较高,营养品质最好。不同产区竹笋食味品质差异显著;柳城县-1产区竹笋纤维素和单宁含量均最低,草酸含量较低,食味品质最好。不同产区竹笋品质综合得分指数表现为柳城县-1>柳北>柳城县-2>柳南>鱼峰。

关键词：外观品质营养品质食味品质麻竹

Anisotropy of the thermal and laser output properties in Yb,Nd:Sc_(2)SiO_(5) crystal

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Chinese Optics Letters 2021年第4期19卷 62-66页

作者： Yuqing Zhao Qiangguo Wang Lihua Meng Yongping Yao Shande Liu na cui Liangbi Su Lihe Zheng Huiyun Zhang Yuping Zhang College of Electronic and Information Engineering Shandong University of Science and TechnologyQingdao 266590China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China Key Laboratory of Transparent and Opto-functional Inorganic Materials Artificial Crystal Research CenterShanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China School of Physics and Astronomy Yunnan UniversityKunming 650091China

The anisotropy of thermal property in an Yb,Nd∶Sc_(2)SiO_(5) crystal is investigated from the temperature of 293 to 573 K. Based on the systematical study of thermal expansion, thermal diffusivity, and specific heat, the thermal conductivity in Yb,Nd∶Sc_(2)SiO_(5) crystals orientated at(100),(010),(001), and(406) is calculated to be 3.46, 2.60, 3.35, and 3.68 W=/(m·K),respectively. The laser output anisotropy of a continuous-wave(CW) and tunable laser is characterized, accordingly. A maximum output power of 6.09 W is achieved in the Yb,Nd∶Sc_(2)SiO_(5) crystal with(010) direction, corresponding to a slope efficiency of 48.56%. The tuning wavelength range in the Yb,Nd∶Sc_(2)SiO_(5) crystal orientated at(100),(010), and(001) is 68, 67,and 65 nm, separately. The effects of thermal properties on CW laser performance are discussed.

关键词： anisotropy thermal property tunable laser Yb Nd:Sc_(2)SiO_5 crystal