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Treatment Efficacy and Safety of Bortezomib Combined with Dexamethasone and Lenalidomide Chemotherapy Regimen for Multiple Myeloma

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Journal of Clinical and Nursing Research 2024年第5期8卷 7-12页

作者： Changyong Yuan na cui Shumei Liu Department of Hematology Dezhou HospitalQilu HospitalShandong UniversityDezhou 253000Shandong ProvinceChina School of Clinical Medicine Shandong Second Medical UniversityWeifang 261000Shandong ProvinceChina

Objective:To analyze the effect of bortezomib combined with dexamethasone and lenalidomide in the treatment of multiple ***:60 cases of multiple myeloma patients admitted to our hospital from January 2022 to December 2023 were selected randomly,with 30 cases in each *** combined with dexamethasone was administered in the control group,and bortezomib combined with dexamethasone and lenalidomide was given to the observation group,and the treatment effect was ***:After treatment,CD^(3+)and CD^(4+)of the observation group were higher than that of the control group,CD^(8+)was lower than that of the control group,and the total treatment efficiency was higher,which was statistically significant(P0.05).Conclusion:Bortezomib combined with dexamethasone and lenalidomide is effective in the treatment of multiple myeloma as it regulates the immune function and is safe,thus it can be promoted in clinical practice.

关键词： Multiple myeloma Bortezomib Dexamethasone Lenalidomide Efficacy Safety

Laryngopharyngeal reflux disease:Updated examination of mechanisms,pathophysiology,treatment,and association with gastroesophageal reflux disease

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World Journal of Gastroenterology 2024年第16期30卷 2209-2219页

作者： na cui Ting Dai Yang Liu Ya-Yu Wang Jia-Yu Lin Qing-Fan Zheng Dong-Dong Zhu Xue-Wei Zhu Department of Otorhinolaryngology Head and Neck Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Ultrasound China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Gastroenterology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

Laryngopharyngeal reflux disease(LPRD)is an inflammatory condition in the laryngopharynx and upper aerodigestive tract mucosa caused by reflux of stomach contents beyond the *** commonly presents with symptoms such as hoarseness,cough,sore throat,a feeling of throat obstruction,excessive throat *** complex condition is thought to involve both reflux and reflex mechanisms,but a clear understanding of its molecular mechanisms is still ***,there is no standardized diagnosis or treatment *** strategies for LPRD mainly include lifestyle modifications,proton pump inhibitors and endoscopic *** paper seeks to provide a comprehensive overview of the existing literature regarding the mechanisms,pathophysiology and treatment of *** also provide an in-depth exploration of the association between LPRD and gastroesophageal reflux disease.

关键词： Laryngopharyngeal reflux Gastroesophageal reflux Head neck surgery Laryngitis Otolaryngology

Effects of traditional Chinese medicine on symptoms of patients with spleen and stomach deficiency-related tinnitus

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World Journal of Clinical Cases 2024年第28期12卷 6165-6172页

作者： na cui Chen Zhao Jun-Lai Xue Xue-Wei Zhu Department of Otorhinolaryngology Head and Neck Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Traditional Chinese Medicine China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

BACKGROUND Tinnitus affects 10%-30%of the *** evidence suggests that tinnitus is associated with spleen ***,compared with kidney deficiency-related tinnitus,less research has been conducted on the impact of spleen defi-ciency-related *** To investigate the clinical efficacy of using Guipi Wan and dietary and lifestyle modification based on traditional Chinese medicine for treatment of patients with spleen and stomach deficiency-related *** We enrolled 110 patients with spleen and stomach deficiency-related tinnitus who were distributed into treatment(58 cases)and control(52 cases)*** severity,sleep quality and emotional state were assessed by questionnaires[Tinnitus Evaluation Questionnaire(TEQ);Pittsburgh Sleep Quality Index(PSQI);Depression-Anxiety-Stress Scale-21(DASS-21)]that were used for analysis in the two groups during the initial and intervention and *** the treatment group,patients were treated with oral administration of Guipi Wan and consulted for healthy dietary and lifestyle *** the control group,patients were only assessed and not *** At the end of the 6-months,TEQ scores decreased significantly in the treatment group(P=0.021)but not in the Control *** effects in the treatment group were noted for PSQI total score(P=0.043)and several PSQI component scores in the treatment group(P<0.05).After treatment,the DASS-21 scores were significantly reduced in the treatment group(P<0.05).CONCLUSION Guipi Wan combined with dietary and lifestyle modification based on regulating the spleen and stomach can be considered core to the treatment of tinnitus related to spleen and stomach deficiency.

关键词： Spleen and stomach deficiency-related tinnitus Traditional Chinese medicine Guipi Wan Dietary modification Lifestyle modification

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灾前应急疏散与物资调配的协同优化研究

重庆交通大学学报（自然科学版） 2024年第10期43卷 79-89页

作者：崔娜张艳萍济南大学土木建筑学院山东济南250022 阿斯顿大学工程与技术学院英国伯明翰B47ET

在可预测灾害背景下,高效组织灾害影响区域内的群众安全疏散以及合理调配物资是应急疏散活动中的核心环节;基于此,对多级应急服务网络中应急疏散与物资调配的协同运行整体优化策略进行了研究。受灾群众步行到临时安置点、又由应急车辆... 详细信息

在可预测灾害背景下,高效组织灾害影响区域内的群众安全疏散以及合理调配物资是应急疏散活动中的核心环节;基于此,对多级应急服务网络中应急疏散与物资调配的协同运行整体优化策略进行了研究。受灾群众步行到临时安置点、又由应急车辆疏散至避难所,应急物资调配中心将物资运送至避难所,对上述过程中所涉及到的各类经济成本及利益成本进行分析;着重考虑了连续多周期动态应急活动中的疏散活动和物资调配协同配合,建立了以系统总成本最小为目标的动态整数规划模型;通过GAMS平台编程,调用CPLEX求解器,以不同规模的实验路网验证了模型的有效性,并对关键参数进行了灵敏性分析。研究结果表明:动态疏散方案与应急物资调配数量之间相互影响,足够多的物资能避免哄抢等现象,但需要考虑在避难所这种有限空间下的避难者与应急物资数量之间的均衡;提高受灾群众疏散响应率并增大避难所容量有助于实现更理想的“零滞留”疏散状态;确定合理的未疏散群众单位惩罚成本能有效地保证较高疏散清空率,同时可控制系统惩罚成本无意义的过高。

关键词：交通运输工程应急优化安全疏散物资调配灾前预防 GAMS

Prediction of mechanical ventilation outcome by early abdominal-visceral-blood-flow-and-function score in critically ill patients after cardiopulmonary bypass in the ICU: A prospective observational study

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Journal of Intensive Medicine 2024年第1期4卷 101-107页

作者： Chaofu Yue Longxiang Su Jun Wang na cui Yuankai Zhou Wei Cheng Bo Tang Xi Rui Huaiwu He Yun Long Department of Intensive Care Unit Peking Union Medical College HospitalBeijingChina Department of Intensive Care Unit Qujing First People’s HospitalQujingYunnanChina Department of Intensive Care Unit Shiyan People’s Hospital of Bao’an DistrictShenzhenGuangdongChina

Background:Abdominal organs are important organs that sense and respond to ischemia and hypoxia,but there are few evaluation *** use ultrasonography to evaluate abdominal organ function and blood flow in patients with mechanical ventilation(MV)after cardiopulmonary bypass and to obtain a semiquantitative score for abdominal organ function and blood ***:Patients with cardiopulmonary bypass in the Critical Care Department of Peking Union Medical College Hospital in China from March to July 2021 were enrolled in this prospective observational *** correlation of the abdominal-visceral-blood-flow-and-function score(AVBFS)with the duration of MV,number of days spent in the intensive care unit(ICU),acute physiology and chronic health evaluation II(APACHE-II),sequential organ failure assessment(SOFA),lactate,epinephrine,and norepinephrine use was analyzed,and the results were used to assess the predictive value of the receiver operating characteristic curve(ROC)regression analysis score for the duration of ***:Of the 92 patients who underwent cardiopulmonary bypass,41 were finally *** AVBFS were significantly correlated with the duration of MV,number of days spent in the ICU,APACHE-II score,SOFA score,and norepinephrine use *** AVBFS in a group of patients using ventilators≥36 h were significantly higher than those obtained for a group of patients using ventilatorsnal visceral organ function and blood perfusion can be used to evaluate gastrointestinal *** is related to early and late extubation after cardiac surgery.

关键词： Ultrasonic evaluation Abdominal-visceral-blood-flow-and-function score(AVBFS) Gastrointestinal dysfunction Mechanical ventilation Cardiopulmonary bypass

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基于活性和亲和性的泛素探针的发展与合成

生物化学与生物物理进展 2024年第3期51卷 598-623页

作者：许玲魏翠娜鲁显福李宜明安徽医科大学第一附属医院合肥230022 合肥工业大学食品与生物工程学院农产品生物化工教育部工程中心合肥230009

泛素(ubiquitin,Ub)作为一种重要的翻译后修饰,参与调控细胞内几乎所有的生命活动。泛素化通常由E1s、E2s、E3s以及去泛素化酶(deubiquitinating enzyme,DUBs)相互协调完成,并在底物蛋白上形成不同链长、不同连接类型的泛素链。这些泛... 详细信息

泛素(ubiquitin,Ub)作为一种重要的翻译后修饰,参与调控细胞内几乎所有的生命活动。泛素化通常由E1s、E2s、E3s以及去泛素化酶(deubiquitinating enzyme,DUBs)相互协调完成,并在底物蛋白上形成不同链长、不同连接类型的泛素链。这些泛素链可以产生多样的拓扑结构,被含有泛素结合域(Ub binding domain,UBD)的不同识别蛋白结合,进而传递不同的信号。泛素化过程或者识别蛋白的读取一旦发生错误,对细胞来说都可能是灾难性的。为深入了解泛素相关的生理机制,多种泛素探针被设计与合成,用于对目标蛋白酶或识别蛋白进行标记和监测。本综述总结了当前的泛素探针(包括基于活性和基于亲和性的探针)的最新发展,并详细阐述了它们的合成策略。进一步介绍了细胞穿梭型泛素探针在活细胞内的最新应用。

关键词：泛素活性亲和性探针化学合成

层次分析法和熵权法模糊综合评价水泥混凝土路面结构性能

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济南大学学报（自然科学版） 2024年第4期38卷 503-509,516页

作者：吴晟乔明史斌侯睿崔娜江西赣北公路勘察设计院江西九江332099 九江市公路发展中心九江市公路应急抢险大队江西九江332000 同济大学交通运输工程学院上海201804 上海道淳工程技术研究有限公司上海201804 济南大学土木建筑学院山东济南250022

为了解决因旧水泥混凝土路面的结构性能评估结果经验性较强而无法为旧水泥混凝土路面改造成沥青路面决策方案提供有效理论依据的问题,基于结构性能评价指标和统计学方法构建水泥混凝土路面结构性能模糊综合评价模型,从表面、内部和整体... 详细信息

为了解决因旧水泥混凝土路面的结构性能评估结果经验性较强而无法为旧水泥混凝土路面改造成沥青路面决策方案提供有效理论依据的问题,基于结构性能评价指标和统计学方法构建水泥混凝土路面结构性能模糊综合评价模型,从表面、内部和整体结构状况3个方面分别对旧水泥混凝土路面进行结构性能评价;基于模糊评价法建立模糊关系矩阵,采用层次分析法和熵权法确定综合权重向量,得到综合评价向量和综合评价等级,并利用所构建模型和我国相关行业标准中的路面结构强度指数模型,对上海市奉贤区和浙江省嘉兴市的4段水泥混凝土路面FX-A、 FX-B、 JX-A、 JX-B进行实例分析。结果表明:通过所构建模型得到各路段按结构性能从优到差的顺序为JX-A、 JX-B、 FX-B、 FX-A;与我国相关行业标准中的路面结构强度指数模型相比,所构建模型的评价结果更符合实际路面结构性能。

关键词：道路工程结构性能评价模糊综合评价水泥混凝土路面层次分析法熵权法

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脑靶向肽偶联药物研究进展

中国药学杂志 2024年第9期59卷 768-775页

作者：崔娜史亚军白敏王胜正丁一陕西中医药大学药学院陕西咸阳712046 空军军医大学第一附属医院药剂科西安710032 空军军医大学药学系药物化学与药物分析学教研室西安710032

中枢神经系统(central nervous system,CNS)疾病严重危害人类的生命健康。但由于血脑屏障(blood-brain barrier,BBB)的存在,缺乏将药物输送到大脑的有效技术,这严重影响CNS疾病相关药物的开发成功率,致使治疗效果往往不尽如人意。因此,... 详细信息

中枢神经系统(central nervous system,CNS)疾病严重危害人类的生命健康。但由于血脑屏障(blood-brain barrier,BBB)的存在,缺乏将药物输送到大脑的有效技术,这严重影响CNS疾病相关药物的开发成功率,致使治疗效果往往不尽如人意。因此,迫切需要一种新技术解决上述问题。脑靶向肽偶联药物由脑靶向肽、连接基团和有效载荷3部分组成,其利用生物相关的内源性转运机制使生物活性分子透过BBB,并到达脑实质,已成为一种有前景的CNS药物。本文简要介绍了脑靶向肽偶联药物中脑靶向肽、连接基团和有效载荷的种类及特征等,并列举了一些常见的脑靶向肽偶联药物,以及此类药物面临的挑战和改进的方法,以期为后续CNS药物的设计和开发提供新思路。

关键词：多肽偶联药物脑靶向肽连接基团有效载荷中枢神经系统血脑屏障

基于点云数据的大型复杂钢结构智能化施工方法

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土木工程学报 2024年第1期57卷 65-75页

作者：齐宏拓刘界鹏程国忠崔娜刘雨鑫刘虎梁俊海重庆大学溧阳智慧城市研究院江苏溧阳213332 重庆大学山地城镇建设与新技术教育部重点实验室重庆400045 重庆大学土木工程学院重庆400045 中建科工集团有限公司重庆400000

大型复杂钢结构施工过程中,常面临施工尺寸质量难以把控、构件提升变形监测困难和合拢段现场配切效率低等问题。三维激光扫描技术可全覆盖地、快速精准地获取复杂构部件在施工过程中的点云数据,这为解决上述问题提供了新方法。为此,该... 详细信息

大型复杂钢结构施工过程中,常面临施工尺寸质量难以把控、构件提升变形监测困难和合拢段现场配切效率低等问题。三维激光扫描技术可全覆盖地、快速精准地获取复杂构部件在施工过程中的点云数据,这为解决上述问题提供了新方法。为此,该文以重庆两江新区寨子路钢拱桥为工程背景,开展基于点云数据的大型复杂钢拱桥智能化施工方法的全流程研究。基于标靶球检测算法、快速四点一致集算法、迭代最近邻算法等实现标靶球点云数据的自动检测及多站点云数据之间的自动配准;通过BIM点云化技术、kNN算法等完成目标点云数据的半自动化提取,实现拱肋尺寸的智能化检测;基于八叉树算法、区域增长算法等实现拱肋提升变形的智能检测;为缩短拱肋的合拢工期,基于BIM模型焊缝信息提取技术、主成分分析算法、Canny边界检测算法、霍夫变换算法等提出数字化预拼装算法,得到合拢段的配切量。工程应用表明,该文所提出的智能施工方法效率高、自动化程度好,研究成果可为大型复杂钢结构的施工质量和安装效率的提升提供理论和算法支撑。

关键词：大型复杂钢结构智能化施工施工尺寸质量检测提升变形检测合拢段配切点云数据