检索结果-南通市图书馆

molecular profiling of indolent human prostate cancer： tackling technical challenges to achieve high-fidelity genome-wide data

引用

Asian Journal of Andrology 2012年第3期14卷 385-392,I0005页

作者： Thomas A. Dunn helen L. Fedor Angelo m. De marzo Jun Luo Department of Urology Johns Hopkins University Baltimore MD 21287 USA Department of Pathology Johns Hopkins University Baltimore MD 21287 USA

The contemporary problem of prostate cancer overtreatment can be partially attributed to the diagnosis of potentially indolent prostate cancers that pose low risk to aged men, and lack of sufficiently accurate risk stratification methods to reliably seek out men with indolent diseases. Since progressive acquisition and accumulation of genomic alterations, both genetic and epigenetic, is a defining feature of all human cancers at different stages of disease progression, it is hypothesized that RNA and DNA alterations characteristic of indolent prostate tumors may be different from those previously characterized in the setting of clinically significant prostate cancer. Approaches capable of detecting such alterations on a genome-wide level are the most promising. Such analysis may uncover molecular events defining early initiating stages along the natural history of prostate cancer progression, and ultimately lead to rational development of risk stratification methods for identification of men who can safely forego treatment. However, defining and characterizing indolent prostate cancer in a clinically relevant context remains a challenge, particularly when genome-wide approaches are employed to profile formalin-fixed paraffin-embedded （FFPE） tissue specimens. Here, we provide the conceptual basis underlying the importance of understanding indolent prostate cancer from molecular profiling studies, identify the key hurdles in sample acquisition and variables that affect molecular data derived from FFPE tissues, and highlight recent progresses in efforts to address these technical challenges.

关键词： active surveillance formalin-fixed paraffin-embedded indolent prostate cancer microarray molecular profiling prostatecancer prostate cancer progression risk stratification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Brains for Dementia Research: The Importance of Cohorts in Brain Banking

引用

Neuroscience Bulletin 2019年第2期35卷 289-294页

作者： Paul T.Francis Gillian m.Hayes helen Costello David R.Whitfield Wolfson Centre for Age-Related Diseases King's College London

Background:The Historical Importance of Studies of Human Brain in Dementia Research The collection of brain and related tissue has a long history(1)In terms of dementia,a more systematic examination of the relationship between brain pathology and clinical symptoms can be traced to Alois Alzheimer’s group in munich in the early 1900s(2)The use of human brain tissue is essential to increase our understanding of dementia as it gives us the gold standard of disease pathogenesis and clues as to the molecular mechanisms that underpin the various diseases and conditions.

关键词： Importance of Cohorts Dementia Research mechanisms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatocellular carcinoma in non-alcoholic fatty liver disease-a review of an emerging challenge facing clinicians

引用

Hepatobiliary Surgery and Nutrition 2021年第1期10卷 59-75页

作者： Daniel Geh Derek m.manas helen L.Reeves Northern Institute for Cancer Research Institute of Cellular medicine Newcastle UniversityNewcastle upon TyneUK Hepatopancreatobiliary multidisciplinary Team Newcastle upon Tyne Hospitals NHS Foundation TrustNewcastle upon TyneUK

Importance:Non-alcoholic fatty liver disease(NAFLD)is a rapidly growing cause of chronic liver disease and is becoming a leading cause of hepatocellular carcinoma(HCC)in many developed *** presents major challenges for the surveillance,diagnosis and treatment of ***:To discuss the clinical challenges faced by clinicians in managing the rising number of NAFLD-HCC *** Review:mEDLINE,Pubmed and Embase databases were searched using the keywords;NAFLD,HCC,surveillance,hepatectomy,liver transplantation,percutaneous ablation,transarterial chemoembolization(TACE),selective internal radiotherapy treatment(SIRT)and *** clinical studies were ***:Current HCC surveillance programmes are inadequate because they only screen for HCC in patients with cirrhosis,whereas in NAFLD a significant proportion of HCC develops in the absence of *** NAFLD patients often present with a more advanced stage of HCC,with a poorer ***-HCC patients also tend to be older and to have more co-morbidities compared to HCC of other *** limits the use of curative treatments such as liver resection and orthotopic liver transplantation(OLT).Evidence suggests that although NAFLD-HCC patients who undergo liver resection or OLT have worse perioperative and short-term outcomes,overall long-term survival is comparable to HCC of other *** highlights the importance of careful patient selection,pre-habilitation and perioperative planning for NAFLD-HCC patients being considered for surgical *** consideration is also important for non-surgical treatments,although the evidence supporting treatment selection is frequently lacking,as these patients tend to be poorly represented in clinical *** therapies such as percutaneous ablation and TACE may be less well tolerated and less effective in NAFLD patients with obesity or *** tyrosine kinase inhibitor sorafenib may also b

关键词： Non-alcoholic fatty liver disease(NAFLD) hepatocellular carcinoma(HCC) liver transplantation hepatectomy catheter ablation sorafenib population surveillance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Kidney disease in patients with chronic liver disease:Does sex matter?

引用

World Journal of Clinical Cases 2023年第17期11卷 3980-3992页

作者： Katherine m cooper Alessandro Colletta Kristen moulton Kenneth m Ralto Deepika Devuni Department of medicine UMass Chan Medical SchoolWorcesterMA 01665United States Department of medicine Division of GastroenterologyUMass Chan Medical SchoolWorcesterMA 01665United States Department of medicine Division of Renal MedicineUMass Chan Medical SchoolWorcesterMA 01665United States

Kidney disease in patients with liver disease is serious and increases *** to 50%of patients hospitalized experience an episode of acute kidney *** general,men with liver disease are thought to be at increased risk of kidney ***,this association should be considered with caution because most studies use creatinine-based inclusion criteria,which is negatively biased against *** this review,we synthesize data on sex differences in kidney disease in patients with chronic liver disease in the clinical setting and discuss potential physiologic underpinnings.

关键词： Sex differences Renal disease Gender disparity Hepatorenal syndrome Renal replacement therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Environmental and landscape influences on the spatial and temporal distribution of a cattle herd in a South Texas rangeland

引用

Ecological Processes 2020年第1期9卷 443-460页

作者： Christopher Cheleuitte-Nieves Humberto L.Perotto-Baldivieso XBen Wu Susan m.cooper Department of Ecosystem Science and management Texas A&M University2120 TAMU320 WFES BuildingCollege StationTX 77843-2138USA Present address:Center of Comparative medicine and Pathology Memorial Sloan Kettering Cancer CenterWeill Cornell Medicineand Hospital for Special Surgery408 East 69th StreetZ-913New YorkNY 10021USA Caesar Kleberg Wildlife Research Institute Texas A&M University-Kingsville700 University Blvd.MSC 218KingsvilleTX 78363USA Texas A&m AgriLife Research 1619 Garner Field RoadUvaldeTX 78801USA

The multiple spatial and temporal parameters affecting cattle herd distribution and activity dynamics can significantly affect resource utilization but are not fully *** aim of this study was to determine whether current animal tracking technology and spatio-temporal analysis tools can be used to integrate multi-scale information on herd distribution patterns as a function of seasonal forage production,periods of the day,animal activity,and landscape *** and activity information of 11 free-ranging cows within a 31-member herd was obtained at 5-min intervals by using GPS collars for 1 year within a 457-ha ranch in the semi-arid rangelands of South *** biomass was calculated with satellite *** analysis of cattle distribution and landscape features was conducted with *** spread was greatest during the growing *** the year,during midday,the herd showed smaller spread and greater use of shade patches than any other time of *** also aggregated under trees in winter,particularly during the *** was no statistically significant overall pattern of seasonal changes in the use of water and supplemental feeding areas,but a trend toward highest use during the ***,significantly different diurnal patterns in the use of supplemental feed and water were observed within each *** study found a strong influence of shade patches relative to the influence of water and supplemental feeding areas on the diurnal and seasonal movement patterns of cattle in shrub-dominated *** this study used only 11 tracked cows in a 31-member herd,the results indicated that techniques such as seasonal and diurnal GPS tracking,GIS,and remote sensing data enable evaluation of multiple spatial and temporal dynamics of cattle distribution and activity *** smaller spread during the dry winter season associated with the observed aggregation of individuals in water and supplemental feeding ar

关键词： Cattle behavior Cross-scale interactions GPS collars Group dispersion Normalized difference vegetation index(NDVI) Thermoregulation Ungulate grazing patterns

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Branched hybridization chain reaction-using highly dimensional DNA nanostructures for label-free,reagent-less,multiplexed molecular diagnostics

引用

microsystems & Nanoengineering 2019年第1期5卷 316-322页

作者： Gaolian Xu mingliang Lai Rab Wilson Andrew Glidle Julien Reboud Jonathan m.cooper Division of Biomedical Engineering James Watt School of EngineeringUniversity of GlasgowOakfield AvenueGlasgow G128LTUK

The specific and multiplexed detection of DNA underpins many analytical methods,including the detection of microorganisms that are important in the medical,veterinary,and environmental *** achieve such measurements generally requires enzyme-mediated amplification of the low concentrations of the target nucleic acid sequences present,together with the precise control of temperature,as well as the use of enzyme-compatible *** inevitably leads to compromises between analytical performance and the complexity of the *** hybridization chain reaction(HCR)provides an attractive alternative,as a route to enzyme-free DNA *** date,the linear nucleic acid products,produced during amplification,have not enabled the development of efficient multiplexing strategies,nor the use of label-free ***,we show that by designing new DNA nanoconstructs,we are able,for the first time,to increase the molecular dimensionality of HCR products,creating highly branched amplification products,which can be readily detected on label-free *** show that this new,branching HCR system offers a route for enzyme-free,label-free DNA detection,we demonstrate the multiplexed detection of a target sequence(as the initiator)in whole *** the future,this technology will enable rapid point-of-care multiplexed clinical analysis or in-the-field environmental monitoring.

关键词： reagent attractive branching

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rapunzel syndrome is not just a mere surgical problem: A case report and review of current management

引用

World Journal of Clinical Cases 2017年第2期5卷 50-55页

作者： Obinna Obinwa David cooper Faraz Khan James m O'Riordan Department of Surgery the Adelaide and Meath Hospital Dublin Incorporating the National Children’s Hospital

Recurrent Rapunzel syndrome(RRS) is a rare clinical presentation with fewer than six cases reported in the Pub med literature. A report of RRS and literature review is presented. A 25-year-old female was admitted to hospital with a 4-wk history of epigastric pain and swelling. She had a known history of trichophagia with a previous admission for Rapunzel syndrome requiring a laparotomy nine years earlier, aged 16. Psychological treatment had been successfully achieved for nine years with outpatient hypnotherapy sessions only, but she defaulted on her last session due to stressors at home. The abdominal examination demonstrated an epigastric mass. Computer tomography scan revealed a large gastric bezoar and features of aspiration pneumonia. The patient underwent emergency open surgical laparotomy for removal as the bezoar could not be removed endoscopically. The bezoar was cast in a shape that mimicked the contours of the stomach and proximal small bowel, hence the diagnosis of RRS. The patient was seen by a psychiatrist and was commenced on Quetiapine before discharge. She continues to attend follow-up.

关键词： Trichobezoars Rapunzel syndrome Recurrence Obsessive compulsive disorders Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of wood species and retention levels on removal of copper,chromium,and arsenic from CCA-treated wood using sodium hypochlorite

引用

Journal of Forestry Research 2016年第2期27卷 433-442页

作者： Engin Derya Gezer Paul A.cooper Department of Forest Industry Engineering Karadeniz Technical University61080 TrabzonTurkey Faculty of Forestry University of Toronto33 Willcocks St.TorontoON M5S 3B3Canada

Chemical extraction, bioremediation, and electrodialytic processes have been extensively studied for removal of copper, chromium, and arsenic from wood treated with chromated copper arsenate （CCA）. However, one problem has not been addressed： the effects of wood species and retention levels on remediation efficiency. The objectives of this study were to investigate the effects of wood species and retention levels on removal of copper, chromium, and arsenic from CCA-treated wood samples using sodium hypochlorite. Our results showed that sodium hypochlorite （NaOC1） was very effective for removal of copper, chromium, and arsenic from CCA-C treated milled wood samples for all three species used in this study. The Cu, Cr, and As extraction efficiencies for red pine were 95 % Cu, 97 % Cr and 94 % As, for maple were 95 % Cu, 97 % Cr, and 98 % As at 4.0 kg m-3 retention levels, and for aspen were 95 % Cu, 92% Cr, and 91% As at 9.6 kg m-3 retention level, respectively. However, the results showed that wood species and initial retention levels of CCA-treated wood products played very impor- tant roles in terms of removal of Cu, Cr, and As.

关键词： Chromated copper arsenate (CCA) Remediation Remediation efficiency Wood species Retention level

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biodegradable stent or balloon dilatation for benign oesophageal stricture: Pilot randomised controlled trial

引用

World Journal of Gastroenterology 2014年第48期20卷 18199-18206页

作者： Anjan Dhar helen Close Yirupaiahgari K Viswanath Colin J Rees helen C Hancock A Deepak Dwarakanath Rebecca H maier Douglas Wilson James m mason Department of Gastroenterology County Durhamand Darlington NHS Foundation Trust Co. Durham DL14 6ADUnited Kingdom Durham Clinical Trials Unit School of Medicine Pharmacy and Health Durham University Queen’s Campus Wolfson Research Institute University Boulevard Stockton-on-Tees TS17 6BH United Kingdom Department of Surgery James Cook University Hospital Marton Road Middlesbrough TS4 3BW United Kingdom Department of Gastroenterology South Tyneside Hospitals NHS Foundation Trust Harton Lane South Shields NE34 0PL United Kingdom Department of Gastroenterology University Hospitals of North Tees Hardwick Stockton on Tees TS19 8PE United Kingdom

AIm: To undertake a randomised pilot study comparing biodegradable stents and endoscopic dilatation in patients with strictures.

关键词： Benign oesophageal stricture Biodegradable stent Endoscopic balloon dilatation Pilot study Randomised controlled trial Dysphagia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adiponectin signalling in bone homeostasis,with age and in disease

引用

Bone Research 2021年第1期9卷 15-25页

作者： Jonathan W.Lewis James R.Edwards Amy J.Naylor helen m.mcGettrick Rheumatology Research Group Institute of Inflammation and AgeingUniversity of BirminghamBirmingham B152TTUK Ageing&Regeneration Research Group Botnar Research CentreUniversity of OxfordOxford OX37LDUK

Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin *** the bone,osteoblasts and osteoclasts express the adiponectin receptors,however,there are conflicting reports on the effects of adiponectin on bone formation and *** studies have shown a pro-osteogenic role for adiponectin in in vivo murine models and in vitro:with increased osteoblast differentiation and activity,alongside lower levels of ***,human studies often demonstrate an inverse relationship between adiponectin concentration and bone ***,the presence of multiple isoforms of adiponectin and multiple receptor subtypes has the potential to lead to more complex signalling and functional *** such,we still do not fully understand the importance of the adiponectin signalling pathway in regulating bone homeostasis and repair in health,with age and in *** this review,we explore our current understanding of adiponectin bioactivity in the bone;the significance of its different isoforms;and how adiponectin biology is altered in ***,furthering our understanding of adiponectin regulation of bone biology is key to developing pharmacological and non-pharmacological(lifestyle)interventions that target adiponectin signalling to boost bone growth and repair in healthy ageing,following injury or in disease.

关键词： homeostasis metabolism consequences

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：