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Surface analysis of tablets with and without coating film for common cold based on laser-induced breakdown spectroscopy

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Optoelectronics Letters 2025年

作者： YAO Lixing LI Jingwen LIU Yu SHEN Li wang cong Tianjin Key Laboratory of Quantum Optics and Intelligent Photonics， School of Science， Tianjin University of Technology

Medications for common cold are used routinely in daily life， and most of these are compounded to be more effective for people suffering from common cold. The composition and quality of the coating， a common component of tablets， have been of great concern. In this paper， laser-induced breakdown spectroscopy (LIBS)， with advantages of rapid， real-time， and in-situ analysis， was used for surface analysis of tablets with and without coating film for common cold. Firstly， the spectra of compound paracetamol and amantadine hydrochloride tablets (CPAHT) and compound diclofenac sodium and chlorphenamine maleate tablets (CDSCMT)， without and with coating film， respectively， were analyzed. Secondly， two kinds of tablets were investigated in-situ at depth to analyze the changes of atomic and molecular spectral line intensities under different number of laser pulses and verified using LIBS imaging method. Finally， the Ca and Ti elements in CDSCMT were analyzed by calibration free LIBS (CF-LIBS) to further verify the elemental content differences at different depth in the tablets with coating film. These results indicate that the LIBS technology can be used in fast， in-situ， depth， and multi-element detection for cold medication tablets.

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PVIIAD: industrial visual anomaly detection method based on partially visible image inpainting

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Optoelectronics Letters 2025年

作者： WU Qiliang FEI Dongce YAO Minghui NIU Yan wang cong School of Aeronautics and Astronautics， Tiangong University School of Artificial Intelligence， Tiangong University

Industrial anomaly detection is dedicated to identifying and locating regions that deviate from the standard appearance. The prevailing approach achieves unsupervised anomaly detection through the reconstruction of images using autoencoders. Due to the simplistic structure of some abnormal regions， the autoencoder can effectively reconstruct these areas， consequently diminishing the model's anomaly detection capabilities. To address this issue， this paper transforms the reconstruction task into the inpainting-filling-reconstruction task to increase the reconstruction error between abnormal samples and normal samples. In PVIIAD， the masked regions inpainted by the filling network are used to fill in the input image， thereby achieving an effect similar to masking. Unlike typical masking processes， this approach retains partial authentic information in the input image， rendering it partially visible. This is beneficial for the reconstruction network to repair the masked areas. Due to the consistent structure between the masked region inpainted by the filling network and the normal region， the filled abnormal regions display a complex structure that has not been learned， making it difficult for the reconstruction network to reconstruct the abnormal regions. Experimental results indicate that PVIIAD performs better than other methods on both the MVTec AD dataset and the MVTec LOCO AD dataset.

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健康中国视域下本科医学教育阶段的全科医学教育探讨

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中国全科医学 2025年第4期28卷 427-431页

作者：杨珊王璁王留义河南省人民医院(郑州大学人民医院)全科医学科河南省郑州市450003

《“健康中国2030”规划纲要》提出“共享共建、全民健康”。作为居民健康的“守门人”,全科医生的教育与培养至关重要。本科教育是医学院校临床教育的根本,也是后续医学人才储备的核心,其教学质量和效果对我国临床医学事业的发展和规... 详细信息

《“健康中国2030”规划纲要》提出“共享共建、全民健康”。作为居民健康的“守门人”,全科医生的教育与培养至关重要。本科教育是医学院校临床教育的根本,也是后续医学人才储备的核心,其教学质量和效果对我国临床医学事业的发展和规模颇有影响。本文通过对比国内外本科医学教育阶段的全科医学教育情况,发现目前我国高校虽设置有全科医学课程,但课程设置与内容体系仍不健全。构建全科医学课程群,加强医学人文与课程思政教育,创新教学方式,完善教学评价对推动我国全科医学教育可能有益,有助于推动我国的全民健康事业。

关键词：全科医学教育医学本科健康中国

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miR-212-3p靶向MAPK3调控骨髓间充质干细胞的衰老

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中国组织工程研究 2025年第13期29卷 2690-2697页

作者：钟丽颖李顺东王聪长沙市第三医院老年病科湖南省长沙市410015

背景:骨质疏松症患者的骨髓间充质干细胞表现出明显衰老状态,并且细胞活性及成骨分化水平显著降低。miR-212-3p能够抑制人骨髓间充质干细胞的成骨分化,但其对骨髓间充质干细胞衰老调控的作用及机制尚不明确。目的:研究miR-212-3p通过靶... 详细信息

背景:骨质疏松症患者的骨髓间充质干细胞表现出明显衰老状态,并且细胞活性及成骨分化水平显著降低。miR-212-3p能够抑制人骨髓间充质干细胞的成骨分化,但其对骨髓间充质干细胞衰老调控的作用及机制尚不明确。目的:研究miR-212-3p通过靶向丝裂原活化蛋白激酶3(mitogen-activated protein kinase 3,MAPK3)对骨髓间充质干细胞衰老的影响及其机制。方法:体外分离培养大鼠骨髓间充质干细胞,收集第3代进行以下实验:①分2组培养:对照组加入完全培养基,造模组加入含H_(2)O_(2)的完全培养基培养,培养72 h后,检测细胞中β-半乳糖苷酶活性、miR-212-3p和MAPK3 mRNA表达,以及MAPK3、p16和p21蛋白表达。②分3组培养:对照组、抑制物对照组、miR-212-3p抑制物组,转染24 h后,检测细胞中miR-212-3p、MAPK3 mRNA表达及MAPK3蛋白表达。③采用双荧光素酶报告基因联合qRT-PCR和Western blot验证miR-212-3p与MAPK3靶向调控作用。④分组培养:分为对照抑制物组、miR-212-3p抑制物组、miR-212-3p抑制物+干扰对照组、miR-212-3p抑制物+MAPK3干扰组,转染24 h后,检测细胞中MAPK蛋白与mRNA表达。分为对照组、H_(2)O_(2)组、H_(2)O_(2)+对照抑制物组、H_(2)O_(2)+miR-212-3p抑制物组、H_(2)O_(2)+miR-212-3p抑制物+干扰对照组、H_(2)O_(2)+miR-212-3p抑制物+MAPK3干扰组,细胞转染24 h后再加入H_(2)O_(2)培养72 h,检测细胞中衰老相关β-半乳糖苷酶活性、p16和p21蛋白表达。结果与结论:①与对照组比较,造模组β-半乳糖苷酶活性、miR-212-3p mRNA表达及p16、p21蛋白表达升高(P<0.05),MAPK3 mRNA和蛋白表达降低(P<0.05)。②与对照组比较,miR-212-3p抑制物组细胞中miR-212-3p mRNA表达降低(P<0.05),MAPK3 mRNA与蛋白表达升高(P<0.05)。③双荧光素酶报告基因实验证实,MAPK3是miR-212-3p下游靶基因。④与对照抑制物组比较,miR-212-3p抑制物组细胞中MAPK3 mRNA和蛋白表达升高(P<0.05);与miR-212-3p抑制物组比较,miR-212-3p抑制物+MAPK3干扰组细胞中MAPK3 mRNA和蛋白表达降低(P<0.05)。与H_(2)O_(2)+对照抑制物组比较,H_(2)O_(2)+miR-212-3p抑制物组β-半乳糖苷酶活性降低(P<0.05);与H_(2)O_(2)+miR-212-3p抑制物组比较,H_(2)O_(2)+miR-212-3p抑制物+MAPK3干扰组β-半乳糖苷酶活性升高(P<0.05)。与H_(2)O_(2)+对照抑制物组比较,H_(2)O_(2)+miR-212-3p抑制物组细胞中p16和p21蛋白表达降低(P<0.05);与H_(2)O_(2)+miR-212-3p抑制物组比较,H_(2)O_(2)+miR-212-3p抑制物+MAPK3干扰组细胞中p16和p21蛋白表达升高(P<0.05)。⑤结果表明,下调miR-212-3p可抑制大鼠骨髓间充质干细胞衰老,其作用机制可能是通过靶向上调MAPK3表达实现的。

关键词：骨髓间充质干细胞细胞衰老 miR-212-3p 丝裂原活化蛋白激酶3 β-半乳糖苷酶

Growth kinetics of interfacial reaction layer products between cubic boron nitride and Cu-Sn-Ti active filler metal

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Journal of Materials Science & Technology 2021年第33期92卷 69-74页

作者： Yonggang Fan cong wang School of Metallurgy Northeastern UniversityShenyang110819China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China

In the present investigation,the growth kinetics of interfacial reaction layer products between cubic boron nitride(CBN) and Cu-Sn-Ti filler metal has been thoroughly *** morphological and compositional features of respective compounds have been demonstrated for a wide brazing temperature ranging from 1153 K to 1223 *** is found that within 30 minutes brazing holding time,the reaction layer growth is largely determined by the population of Ti N via effective Ti diffusion with an activation energy of 223.51 k J/mol,leading to parabolic growth *** is further revealed that TiN grows both in axial and length dimensions,which eventually extends to the forefront and covers the reaction layer.

关键词： Cubic boron nitride Cu-Sn-Ti Interfacial reaction layer Activation energy

Distributed Cooperative Learning for Discrete-Time Strict-Feedback Multi Agent Systems Over Directed Graphs

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IEEE/CAA Journal of Automatica Sinica 2022年第10期9卷 1831-1844页

作者： Min wang Haotian Shi cong wang IEEE the School of Automation Science and Engineering South China University of TechnologyGuangzhou 510641 Peng Cheng Laboratory Shenzhen 518055China the School of Control Science and Engineering Shandong UniversityJinan 250061China the Center for Intelligent Medical Engineering Shandong UniversityJinan 250061China

This paper focuses on the distributed cooperative learning(DCL)problem for a class of discrete-time strict-feedback multi-agent systems under directed *** with the previous DCL works based on undirected graphs,two main challenges lie in that the Laplacian matrix of directed graphs is nonsymmetric,and the derived weight error systems exist n-step *** novel lemmas are developed in this paper to show the exponential convergence for two kinds of linear time-varying(LTV)systems with different phenomena including the nonsymmetric Laplacian matrix and time ***,an adaptive neural network(NN)control scheme is proposed by establishing a directed communication graph along with n-step delays weight updating ***,by using two novel lemmas on the extended exponential convergence of LTV systems,estimated NN weights of all agents are verified to exponentially converge to small neighbourhoods of their common optimal values if directed communication graphs are strongly connected and *** stored NN weights are reused to structure learning controllers for the improved control performance of similar control tasks by the“mod”function and proper time series.A simulation comparison is shown to demonstrate the validity of the proposed DCL method.

关键词： Cooperative learning control directed graphs discrete-time nonlinear system neural networks(NNs) strict-feedback systems

Recent advances on dynamic learning from adaptive NN control

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Control Theory and Technology 2020年第1期18卷 107-109页

作者： Min wang cong wang School of Automation Science and Engineering South China University of TechnologyGuangzhou Guangdong 510641China

Notice that intelligent control is developed based on the learning and control abilities of human *** such,an ideal intelligent control system should not only have the ability to adapt to complex dynamic environments,but also the ability to imitate human *** learning ability means to acquire the knowledge of uncertain closed-loop dynamics from dynamic environments,and use the stored experience knowledge to improve control performance[1,2].Such an autonomous learning has been viewed as one of the most important and indispensable capabilities to achieve a high degree of system autonomy.

关键词： knowledge dynamic environments

A high-order model of rotating stall in axial compressors with inlet distortion

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Chinese Journal of Aeronautics 2017年第3期30卷 898-906页

作者： Peng LIN cong wang Yong wang School of Automation Science and Engineering South China University of Technology Department of Mechanics and Engineering Science Peking University

In this paper,a high-order distortion model is proposed for analyzing the rotating stall inception process induced by inlet distortion in axial compressors.A distortion-generating screen in the compressor inlet is *** assuming a quadratic function for the local flow total pressure-drop,the existing Mansoux model is extended to include the effects of static inlet distortion,and a new high-order distortion model is *** illustrate the effectiveness of the distortion model,numerical simulations are performed on an eighteenth-order *** is demonstrated that long length-scale disturbances emerge out of the distorted background flow,and further induce the onset of rotating stall in *** addition,the circumferential non-uniform distribution and time evolution of the axial flow are also shown to be consistent with the existing *** is thus shown that the high-order distortion model is capable of describing the transient behavior of stall inception and will contribute further to stall detection under inlet distortion.

关键词： Axial compressors Dynamic modeling Flow instability Inlet distortion Rotating stall Stall inception

中国数字乡村政策关注度识别——基于“工具-场景”二维框架的文本分析

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河北学刊 2025年第1期45卷 183-192页

作者：王俊芹王聪聪河北农业大学经济管理学院河北农业大学乡村振兴研究中心

数字乡村是促进乡村振兴和农业农村现代化的关键战略方向。中国数字乡村政策注意力分配存在差异。政府偏好使用供给型工具,环境型工具次之,需求型工具应用最少。政策工具内部结构也存在“冷热不均”,对不同场景数字化建设均有所关注,较... 详细信息

数字乡村是促进乡村振兴和农业农村现代化的关键战略方向。中国数字乡村政策注意力分配存在差异。政府偏好使用供给型工具,环境型工具次之,需求型工具应用最少。政策工具内部结构也存在“冷热不均”,对不同场景数字化建设均有所关注,较多政策指向乡村数字经济,对乡村网络文化和智慧绿色乡村关注度较低。在“工具—场景”交叉维度视角下,政府在使用较多供给型工具的前提下,更侧重运用需求型工具推进乡村数字经济和信息惠民服务建设,通过环境型工具推动乡村数字治理、乡村网络文化及智慧绿色乡村建设,但整体均呈供给型工具过多、环境型和需求型工具不足现象。未来应优化政策工具使用结构,平衡数字应用场景政策关注,提升“工具—场景”适配度。

关键词：数字乡村政策关注度政策工具理论数字应用场景内容分析法

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