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Identification and functional characterization of ApisOr23 in pea aphid Acyrthosiphon pisum

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Journal of Integrative Agriculture 2022年第5期21卷 1414-1423页

作者： HUANG Tian-yu ZHANG Rui-bin YANG Lu-lu CAO Song frederic FRANCIS WANG Bing WANG Gui-rong State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China Guangdong Laboratory for Lingnan Modern Agriculture(Shenzhen Branch) Genome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120P.R.China Functional and Evolutionary Entomology Gembloux Agro-Bio TechUniversity of LiegeGembloux 5030Belgium

Pea aphid,Acyrthosiphon pisum,is a serious pest of many different leguminous plants,and it mainly relies on its odorant receptors(Ors)to discriminate among host ***,less is known about the role that Ors play in the host plant *** this study,we identified a novel conserved odorant receptor clade by phylogenetic analysis,and conducted the functional analysis of ApisOr23 in *** results showed that the homologous Ors from ***,Aphis glycines and Aphis gossypii share 94.28% identity in amino acid ***,conserved motifs were analyzed using the annotated homologous Or23 from eight aphid species,providing further proof of the high conservation level of the Or23 *** to the tissue expression pattern analysis,ApisOr23 was mainly expressed in the *** functional study using a heterologous Xenopus expression system revealed that ApisOr23 was tuned to five plant volatiles,namely trans-2-hexen-1-al,cis-2-hexen-1-ol,1-heptanol,4’-ethylacetophenone,and hexyl *** them,trans-2-hexen-1-al,which is one of the main volatile organic compounds released from legume plants,activated the highest response of *** findings suggest that the conserved Or23 clade in most aphid species might play an important role in host plant detection.

关键词： Acyrthosiphon pisum odorant receptor phylogenetic analysis two-electrode voltage clamp trans-2-hexen-1-al

Self-activation of Vγ9Vδ2 T cells by exogenous phosphoantigens involves TCR and butyrophilins

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Cellular & Molecular Immunology 2021年第8期18卷 1861-1870页

作者： ChloéLaplagne Laetitia Ligat Juliet Foote frederic Lopez Jean-Jacques Fournié Camille Laurent Salvatore Valitutti Mary Poupot Inserm UMR1037 Centre de Recherches en Cancérologie de ToulouseToulouseFrance UniversitéToulouse III Paul-Sabatier ToulouseFrance ERL 5294 CNRS ToulouseFrance IUCT-O ToulouseFrance

The high cytotoxic activity of Vγ9Vδ2 T lymphocytes against tumor cells makes them useful candidates in anticancer ***,the molecular mechanism of their activation by phosphoantigens(PAgs)is not completely *** studies have depicted the mechanism of Vγ9Vδ2 T-cell activation by PAg-sensed accessory cells,such as immune presenting cells or tumor *** this study,we demonstrated that pure resting Vγ9Vδ2 T lymphocytes can self-activate through exogenous PAgs,involving their TCR and the butyrophilins BTN3A1 and *** is the first time that these three molecules,concurrently expressed at the plasma membrane of Vγ9Vδ2 T cells,have been shown to be involved together on the same and unique T cell during PAg ***,the use of probucol to stimulate the inhibition of this self-activation prompted us to propose that ABCA-1 could be implicated in the transfer of exogenous PAgs inside Vγ9Vδ2 T cells before activating them through membrane clusters formed byγ9TCR,BTN3A1 and *** self-activation of Vγ9Vδ2 T cells,which leads to self-killing,can therefore participate in the failure ofγδT cell-based therapies with exogenous PAgs and should be taken into account.

关键词： Vγ9Vδ2 T cells Phosphoantigen Butyrophilins T-cell receptor

Will high-entropy carbides and borides be enabling materials for extreme environments?

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International Journal of Extreme Manufacturing 2023年第2期5卷 23-34页

作者： Fei Wang frederic Monteverde Bai Cui Department of Mechanical&Materials Engineering University of Nebraska–LincolnLincolnNE 68588United States of America National Research Council of Italy—Institute of Science Technology and Sustainability for CeramicsI-48018 FaenzaItaly Nebraska Center for Materials and Nanoscience University of Nebraska–LincolnLincolnNE 68588United States of America

The concept of multi-principal component has created promising opportunities for the development of novel high-entropy ceramics for extreme environments encountered in advanced turbine engines, nuclear reactors, and hypersonic vehicles, as it expands the compositional space of ceramic materials with tailored properties within a single-phase solid solution. The unique physical properties of some high-entropy carbides and borides, such as higher hardness, high-temperature strength, lower thermal conductivity, and improved irradiation resistance than the constitute ceramics, have been observed. These promising properties may be attributed to the compositional complexity, atomic-level disorder, lattice distortion, and other fundamental processes related to defect formation and phonon *** manuscript serves as a critical review of the recent progress in high-entropy carbides and borides, focusing on synthesis and evaluations of their performance in extreme high-temperature, irradiation, and gaseous environments.

关键词： high-entropy ceramics high-entropy materials extreme environments ceramics

A Review on Technologies for the Use of CO2 as a Working Fluid in Refrigeration and Power Cycles

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Role of near-infrared fluorescence in colorectal surgery

Energy and Power Engineering（能源与动力工程） 2024年第6期 217页

作者： Orelien T.Boupda Hyacinthe D.Tessemo Isidore B.Nkounda Fongang Francklin G.Nyami frederic Lontsi Thomas Djiako

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World Journal of Gastroenterology 2021年第31期27卷 5189-5200页

作者： Elodie Zocola Jeremy Meyer Niki Christou Emilie Liot Christian Toso Nicolas Christian Buchs frederic Ris Medical School University of GenevaGenève 1205Switzerland Division of Digestive Surgery University Hospitals of GenevaGenève 1205Switzerland Service de Chirurgie Digestive Endocrinienne et GénéraleCHU de LimogesLimoges Cedex 87025France

Near-infrared fluorescence(NIRF)is a technique of augmented reality that,when applied in the operating theatre,allows the colorectal surgeon to visualize and assess bowel vascularization,to identify lymph nodes draini... 详细信息

关键词： Fluorescence Enhanced reality Anastomotic leak Ureter Anastomosis

Formation of Nanotubular Structures with Petal Effect by Soft-Template Electropolymerization of Benzotrithiophene with Hydrophilic Carboxyl Group

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Journal of Bionic Engineering 2022年第4期19卷 1054-1063页

作者： Maroua Khodja Imen Bousrih Mejda El Kateb Mohammed Beji frederic Guittard Thierry Darmanin Laboratory of Structural Organic Chemistry Faculty of Sciences of Tunis University of Tunis El Manar2092 TunisTunisia NICE Lab Universite Cote d’Azur06100 NiceFrance

The bioinspiration is one of the best ways to make a breakthrough in a field,and particularly in the wetting *** by natural species,such as rose petals and gecko foot,and previous researches,nanotubular structures are prepared here by soft-template electropolymerization in organic solvent and using an original benzotrithiophene with a hydrophilic carboxyl group,as the *** best results are obtained by cyclic voltammetry because of a much higher amount of gas bubbles released with this deposition *** nanoparticles and nanotubes are observed while the water content has an influence on the number of *** if the monomer has hydrophilic carboxyl group,the best films have both high hydrophobicity(apparent water contact angle up to 130.7°)and strong water adhesion(petal effect).These surfaces could be used in future in applications such as water harvesting systems.

关键词： Bioinspired Electropolymerization Hydrophobicity Nanostructures Nanotubes Wettability

Impact of switching from ranibizumab to aflibercept on the number of intravitreous injection and follow up visit in wet AMD:results of real life ELU study

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International Journal of Ophthalmology(English edition) 2020年第2期13卷 252-256页

作者： frederic Queguiner Kristina Bezirganyan Jean Christophe Courjaret Laurence Curel Guillaume Penaranda Maud Righini Chossegros Ophthalmology and Clinical Research Departments Hopital Saint JosephMarseille F-13008France Biostatistics Department Alphabio LaboratoryMarseille F-13003France

●AIM:To study if one of the two molecules could lead to a lower number of follow up visits and intra-vitreous injection(IVI)with the same efficacy.●METHODS:ELU(or"elected"in French)study is a retrospective study conducted in real life in patients presenting suboptimal response after ranibizumab IVI(phase 1)and secondary switched to aflibercept(phase 2).The number of follow up visits and IVI were compared in both *** acuity(VA)evolution and"switching"reasons were secondary analyzed.●RESULTS:We retrospectively included data of 33 patients(38 eyes)with age-related macular degeneration(AMD;mean age:77±7.7 y).The number of monthly follow up visits[median(Q1;Q3)]:was significantly lower with aflibercept(phase 2),respectively 1.0(0.81;1.49)visits in phase 1,versus 0.79(0.67;0.86)visits in phase *** median number of monthly IVI also significantly decreased in phase 2,respectively 0.67(0.55;0.90)IVI in phase 1,versus 0.55(0.45;0.67)IVI in phase *** mean VA evolution(VA final-VA initial)was similar in both phases,(P>0.05).Whatever the reason for"switching"(loss of efficacy,tachyphylaxis,tolerance problems),there was no incidence on VA evolution over the time.●CONCLUSION:Our results show that switching from ranibizumab to aflibercept in"suboptimal"patients significantly reduce the number of follow up visits and IVI,with a comparable *** decrease in visit number could improve patients’quality of life and reduce surgical risk by reducing the number of injections.

关键词： wet age-related macular degeneration anti-VEGF aflibercept ranibizumab follow up visit intravitreal injection visual acuity

Supporting and strengthening research on urban health interventions for the prevention and control of vector-borne and other infectious diseases of poverty:scoping reviews and research gap analysis

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Infectious Diseases of Poverty 2018年第1期7卷 967-975页

作者： Mariam Otmani del Barrio frederic Simard Andrea Caprara Vectors Environment and Society UnitSpecial Programme for Research and Training in Tropical Diseases(TDR)World Health Organization(WHO)20avenue AppiaCH-1211 Geneva 27Switzerland Maladies Infectieuses et Vecteurs:Ecologie GenetiqueEvolution et Controle(MIVEGEC)IRD-CNRS University of MontpellierMontpellierFrance Ceara State 639 University FortalezaBrazil.

Background:More than half of the world’s population currently lives in urban settlements that grow both in size and *** 2050,approximately 70%of the global population will be living in urban conglomerations,mainly in low-and middle-income ***,poverty,different layers of inequalities as well as climate variability and change are some of the social and environmental factors that influence the exposure of human populations in urban settings to vector-borne diseases,which pose eminent public health ***,consistent,and evidencebased interventions for prevention and control of vector-borne and other infectious diseases of poverty in urban settings are needed to implement innovative and cost-effective public policy and to promote inclusive and equitable urban health *** body:While there is growing awareness of vector-borne diseases epidemiology at the urban level,there is still a paucity of research and action being undertaken in this area,hindering evidence-based public health policy decisions and practice and strategies for active community *** paper describes the collaboration and partnership of the Special Programme for Research and Training in Tropical Diseases(TDR)hosted by the World Health Organization(WHO)and the“VEctor boRne DiseAses Scoping reviews”(VERDAS)Research Consortium as they joined efforts in response to filling this gap in knowledge and evidence by supporting the development of a series of scoping reviews that highlight priority research gaps and policy implications to address vector-borne and other infectious diseases at the urban ***:The set of scoping reviews proposed in this special issue presents a critical analysis of the state-of-the-art of research on urban health interventions for the prevention and control of vector-borne and other infectious diseases of *** authors of the 6 reviews highlighted severe gaps in knowledge and identified organizational and theoretical lim

关键词： Vector-borne diseases Urban health interventions Climate change Effectiveness Research priority setting Surveillance Vector control

Role of terpenes from aphid-infested potato on searching and oviposition behavior of Episyrphus balteatus

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Insect Science 2007年第1期14卷 57-63页

作者： NICOLAS HARMEL RAKI ALMOHAMAD MARIE-LAURE FAUCONNIER PATRICK DU JARDIN FRANCOIS VERHEGGEN MICHEL MARLIER ERIC HAUBRUGE frederic FRANCIS Department of Functional and Evolutionary Entomology Department of Plant Biology Department of General and Organic Chemistry Gembloux Agricultural University Gembloux Belgium

To cope with pathogen and insect attacks, plants develop different mechanisms of defence, in both direct （physical and chemical） and indirect ways （attractive volatiles to entomophagous beneficials）. Plants are then able to express traits that facilitate ＂top-down＂ control of pests by attracting herbivore predators. Here we investigate the indirect defence mechanism of potato plants by analyzing the volatile patterns of both healthy and aphid- infested plants. Important changes in the emitted terpene pattern by the Myzus persicae infested host plant were observed. Using Solid Phase MicroExtraction （SPME） and GC-MS, the （E）-fl-farnesene （EBF） appeared to be emitted by aphid-infested potato and not by healthy plants. To assess the infochemical role of these volatile releases after aphid damage on the aphidophagous predators Episyrphus balteams, the hoverfly foraging behavior was assessed using the Observer 5.0 software （Noldus, Wageningen, The Netherlands）. Aphidfree potato plants were also used as a control volatile source in the predator behavioral study. While aphid-infested plants induced efficient searching and acceptation behaviors leading to egg-laying, no kairomonal effect of healthy potato plants was observed, leading to longer immobility durations and shorter searching periods in the net cage. High oviposition rate of E. balteatus was observed when aphid-infested potato was used （mean of 48.9 eggs per laying and per female）. On the other hand, no egg was produced by the hoverfly on healthy aphid-free plants. The E. balteatus foraging and reproductive behaviors according to the volatile emission from aphid-infested plants are discussed in relation to the potential use of active infochemical molecules in integrated aphid pest management.

关键词： aphid infested behavior Episyrphus balteatus potato terpenes