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Changes of protein expression during tumorosphere formation of small cell lung cancer circulating tumor cells

Oncology Research 2023年第1期31卷 13-22页

作者： SANDRA STICKLER BARBARA RATH MAXIMILIAN HOCHMAIR clemens lang LUKAS WEIGL GERHARD HAMILTON Institute of Pharmacology Medical University of ViennaViennaAustria Karl Landsteiner Institute of Lung Research and Pulmonary Oncology Klinik FloridsdorfViennaAustria Department of Trauma Surgery Sozialmedizinisches Zentrum OstDonauspitalViennaAustria Division of Special Anesthesia and Pain Medicine Medical University of ViennaViennaAustria

Small cell lung cancer(SCLC)is frequently disseminated and has a dismal prognosis with survival times of approximately two *** cancer responds well to initial chemotherapy but recurs within a short time as a globally chemoresistant *** tumor cells(CTCs)are held responsible for metastasis,the extremely high numbers of these cells in advanced SCLC allowed us to establish several permanent CTC cell *** CTCs are distinguished by the spontaneous formation of large spheroids,termed tumorospheres,in regular tissue *** contain quiescent and hypoxic cells in their interior and are associated with high chemoresistance compared to single cell *** CTC lines were compared for their expression of 84 proteins associated with cancer either as single cells or in the form of tumorospheres in Western blot *** the exception of the UHGc5 line,all other CTC lines express EpCAM and lack a complete EpCAM-negative,vimentin-positive epithelial-mesenchymal transition(EMT)*** formation of tumorospheres the expression of EpCAM,that mediates cell-cell adhesion is markedly *** such as E-Cadherin,p27 KIP1,Progranulin,BXclx,Galectin-3,and Survivin showed variable changes for the distinct CTC cell *** conclusion,EpCAM presents the most critical marker for individual SCLC CTCs and the assembly of highly chemoresistant tumorospheres.

关键词： SCLC Spheroid Chemoresistance EpCAM Topotecan Epirubicin

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ADAPTIVITY IN SPACE AND TIME FOR MAGNETOQUASISTATICS

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Journal of Computational Mathematics 2009年第5期27卷 642-656页

作者： Markus clemens Jens lang Delia Teleaga Georg Wimmer Helmut-Schmidt-Universitat Hamburg Holstenhofweg 8522043 HamburgGermany Technische Universitat Darmstadt Schlossgartenstraβe 764289 DarmstadtGermany

This paper addresses fully space-time adaptive magnetic field computations. We describe an adaptive Whitney finite element method for solving the magnetoquasistatic formulation of Maxwell＇s equations on unstructured 3D tetrahedral grids. Spatial mesh re- finement and coarsening are based on hierarchical error estimators especially designed for combining tetrahedral H（curl）-conforming edge elements in space with linearly implicit Rosenbrock methods in time. An embedding technique is applied to get efficiency in time through variable time steps. Finally, we present numerical results for the magnetic recording write head benchmark problem proposed by the Storage Research Consortium in Japan.

关键词： Magnetoquasistatics Space-time adaptivity Edge elements Rosenbrock meth-ods Hierarchical error estimator SRC benchmark problem.

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