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Study of cytoskeleton from microscopic point of view:Our experience

BIOCELL 2022年第4期46卷 881-884页

作者： cinzia signorini GIULIA COLLODEL ELENA MORETTI Department of Molecular and Developmental Medicine of University of Siena SienaI-53100Italy

The manuscript deals with our studies and experiences in the assessment of cytoskeleton in different cellular models and *** immunofluorescent study of several cytoskeletal proteins was relevant in the evaluation of a therapy for osteoarthritis,in case of alkaptonuria and in testing the efficacy of docetaxel in neuroblastoma cancer cells leading to apoptosis.A relevant part of our experience focus on the study of cytoskeleton in seminiferous epithelium and spermatozoa,identifying alterations affecting blood-testis barrier after a silver nanoparticle treatment,chromosomal segregation in case of varicocele,sperm motility and diagnosing systematic sperm defects as“Primary ciliary dyskinesia”and“Dysplasia of the fibrous sheath”.The evaluation of cytoskeleton represents a specific and sensitive analysis in establishing the health status of different cells.

关键词： cytoskeleton Environment Immunocytochemistry Pathological condition

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Fatty Acids and Autism Spectrum Disorders: The Rett Syndrome Conundrum

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Food and Nutrition Sciences 2013年第9期4卷 71-75页

作者： Claudio De Felice cinzia signorini Silvia Leoncini Alessandra Pecorelli Thierry Durand Jean-Marie Galano Valérie Bultel-Poncé Alexandre Guy Camille Oger Gloria Zollo Giuseppe Valacchi Lucia Ciccoli Joussef Hayek Child Neuropsychiatry Unit University Hospital AOUS Policlinico “S. M. Alle Scotte” Siena Italy Department of Life Science and Biotechnologies University of Ferrara Ferrara Italy Department of Food and Nutrition Kyung Hee University Seoul South Korea. Department of Molecular and Developmental Medicine University of Siena Siena Italy Department of Molecular and Developmental Medicine University of Siena Siena Italy Child Neuropsychiatry Unit University Hospital AOUS Policlinico “S. M. Alle Scotte” Siena Italy Institut des Biomolécules Max Mousseron (IBMM) Montpellier France Neonatal Intensive Care Unit University Hospital AOUS Policlinico “S. M. Alle Scotte” Siena Italy

Autism spectrum disorders (ASDs) are epidemically explosive clinical entities, but their pathogenesis is still unclear and a definitive cure does not yet exist. Rett syndrome (RTT) is a rare genetically determined cause of autism linked to mutations in the X-linked MeCP2 gene or, more rarely, in CDKL5 or FOXG1. A wide phenotypical heterogeneity is a known feature of the disease. Although several studies have focused on the molecular genetics and possible protein changes at different levels, to date very little attention has been paid to fatty acids in this disease, which could be considered as a natural paradigm for the ASDs. To this regard, a quite enigmatic feature of the disease is the evidence in the affected patients of an extensive peroxidation of polyunsaturated fatty acids (arachidonic acid, AA, docosaexahenoic acid, DHA, adrenic acid, AdA and, to a lesser extent, eicosapentaenoic acid, EPA), in contrast with amelioration of the redox changes and phenotypical severity following the supplementation of some of those same fatty acids (DHA + EPA). Therefore, fatty acids may represent a kind of Janus Bifrons in the particular context of RTT. Here, we propose a rational explanation for this apparent “fatty acid paradox” in RTT. A better understanding of this paradox could also be of help to get a better insight into the complex mechanism of action for polyunsaturated fatty acids in health and disease.

关键词： Fatty Acids Arachidonic Acid Docosahexaenoic Acid Adrenic Acid Eicosapentaenoic Acid Rett Syndrome Autism Spectrum Disorders

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