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Machine learning-based comparison of factors influencing estimated glomerular filtration rate in Chinese women with or without nonalcoholic fatty liver

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World Journal of Clinical Cases 2024年第15期12卷 2506-2521页

作者： I-Chien Chen Lin-Ju chou Shih-Chen Huang ta-Wei Chu Shang-Sen Lee Department of Nursing Kaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Department of Obstetrics and Gynecology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Chief Executive Officer's Office MJ Health Research FoundationTaipei 114Taiwan Department of Urology Taichung Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTaichung 427Taiwan School of Medicine Tzu Chi UniversityHualian 970Taiwan Department of Urology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND The prevalence of non-alcoholic fatty liver(NAFLD)has increased *** with NAFLD are known to have higher chance for renal function *** past studies used traditional multiple linear regression(MLR)to identify risk factors for decreased estimated glomerular filtration rate(eGFR).However,medical research is increasingly relying on emerging machine learning(Mach-L)*** present study enrolled healthy women to identify factors affecting eGFR in subjects with and without NAFLD(NAFLD+,NAFLD-)and to rank their *** To uses three different Mach-L methods to identify key impact factors for eGFR in healthy women with and without *** A total of 65535 healthy female study participants were enrolled from the taiwan MJ cohort,accounting for 32 independent variables including demographic,biochemistry and lifestyle parameters(independent variables),while eGFR was used as the dependent *** from MLR,three Mach-L methods were applied,including stochastic gradient boosting,eXtreme gradient boosting and elastic *** of estimation were used to define method accuracy,where smaller degree of error indicated better model *** Income,albumin,eGFR,High density lipoprotein-Cholesterol,phosphorus,forced expiratory volume in one second(FEV1),and sleep time were all lower in the NAFLD+group,while other factors were all significantly higher except for smoking ***-L had lower estimation errors,thus outperforming *** Model 1,age,uric acid(UA),FEV1,plasma calcium level(Ca),plasma albumin level(Alb)and T-bilirubin were the most important factors in the NAFLD+group,as opposed to age,UA,FEV1,Alb,lactic dehydrogenase(LDH)and Ca for the *** the importance percentage was much higher than the 2nd important factor,we built Model 2 by removing *** The eGFR were lower in the NAFLD+group compared to the NAFLD-group,with age being was the most important impact factor in both groups of he

关键词： Non-alcoholic fatty liver Estimated glomerular filtration rate Machine learning Chinese women

Eco-Environmental Impact Assessment of Pre-Leisure Beach Nourishment on the Benthic Invertebrate Community at Anping Coast

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China Ocean Engineering 2011年第2期25卷 215-236页

作者： Chun-Han SHIH Yi-Yu KUO ta-Jen CHU Wen-Chieh chou Wei-Tse CHANG Ying-chou LEE Institute of Fisheries Science National Taiwan University Taipei 10617 China Department of Civil Engineering National Chiao Tung University Hsinchu 30010 China Department of Leisure and Recreation Management Chung Hua University Hsinchu 30012 China Department of Civil Engineering Chung Hua University Hsinchu 30012 China

In recent years, owing to global warming and the rising sea levels, beach nourishment and groin building have been increasingly employed to protect coastal land from shoreline erosion. These actions may degrade beach habitats and reduce biomass and invertebrate density at sites where they were employed. We conducted an eco-environmental evaluation at the Anping artificial beach-nourishment project area. At this site, sand piles within a semi-enclosed spur groin have been enforced by use of eco-engineering concepts since 2003. Four sampling sites were monitored during the study period from July 2002 to September 2008. The environmental impact assessment and biological investigations that we conducted are presented here. The results from this study indicate that both biotic （number of species, number of individual organisms, and Shannon-Wiener diversity） and abiotic parameters （suspended solids, biological oxygen demand, chemical oxygen demand, dissolved inorganic nitrogen, dissolved inorganic phosphorus, total phosphorus, total organic carbon, median diameter, and water content） showed significant differences before and after beach engineering construction. Biological conditions became worse in the beginning stages of the engineering but improved after the restoration work completion. This study reveals that the composition of benthic invertebrates changed over the study period, and two groups of organisms, Bivalvia and Gastropoda, seemed to be particularly suitable to this habitat after the semi-enclosed artificial structures completion.

关键词： beach nourishment benthic invertebrate eco-engineering ecological restoration spur groin

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Identifying Indicator Species in Habitats Created by Coastal Structures

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China Ocean Engineering 2010年第1期24卷 117-134页

作者： Yi-Yu KUO Chun-Han SHIH Ying-chou LEE Wei-Tse CHANG ta-Jen CHU Department of Civil Engineering National Chiao Tung University Hsinchu 30010 China Institute of Fisheries Science National Taiwan University Taipei 10617 China Department of Leisure and Recreation Management Chung Hua Univershy Hsinchu 30012 China

In this paper, three approachs were developed to find indicator species from the habitat created by coastal structures. These approachs consist of a model of species co-occurrence probability, a model of k-environmental factor probability and a composite model. Simultaneously, a case study was conducted in Hsinchu Fishing Port of north-western taiwan. Based on the aforementioned models, three primary producer species, Ahnfeltiopsis flabelliformis, Chondrus ocellatus and Sarcodia montagneana, were chosen as the indicator species which had the highest co-occurrence probabilities and showed greater tolerance to more critical environment. It is imperative to understand how the three species under particular co-occurring conditions and environmental factors influence the composition of sessile assemblages in coastal water. The results indicate that for the purpose of increasing biodiversity, these models are feasible to find indicator species of artificial structures, and to help make it possible to design coastal structures based on biological considerations. This study provides an innovative approach for further advanced application in the artificial habitat of coast management.

关键词： coastal structures indicator species sessile organisms ecological restoration

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Risk factors predict microscopic extranodal tumor deposits in advanced stage Ⅲ colon cancer patients

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World Journal of Gastroenterology 2023年第11期29卷 1735-1744页

作者： Yi-Han Jhuang Yu-Ching chou Yu-Chun Lin Je-Ming Hu ta-Wei Pu Chao-Yang Chen Division of Cardiovascular Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Tri-Service General Hospital Song-shan BranchNational Defense Medical CenterTaipei 114TaiwanChina

BACKGROUND Colorectal cancer is a frequent cause of cancer-related mortality in patients with lymph node or distant *** tumor deposits(TDs)are considered prognostically distinct from lymph node *** To investigate risk factors for extranodal TDs in stage III colon *** This was a retrospective cohort *** selected 155 individuals diagnosed with stage III colon cancer from the database of the Cancer Registry of the Tri-Service General *** patients were allocated into the groups with/without *** Cox regression analysis and Kaplan-Meier method were *** primary outcomes investigate the association between the covariates and extranodal TDs,and prognostic significance of the covariates regarding the *** There were 136 individuals in the non-N1c group and 19 individuals in the N1c *** with lymphovascular invasion(LVI)had a higher risk of *** survival rates of patients with and without LVI were 6.64 years and 8.61 years,respectively(P=0.027).The N1c patients without LVI had higher overall survival than those who with LVI(7.73 years vs 4.42 years,P=0.010).CONCLUSION Patients having stage III colon cancer with LVI have a higher probability of having TDs than those with stage III colon cancer without *** III colon cancer patients with TDs and LVI could have poor prognosis and outcome.

关键词： Colon cancer Tumor deposits Lymphovascular invasion Risk factor

Predictors of rebleeding after initial hemostasis with epinephrine injection in high-risk ulcers

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World Journal of Gastroenterology 2010年第43期16卷 5490-5495页

作者： Ming-Luen Hu King-Wah Chiu Yi-Chun Chiu Yeh-Pin chou Tsung-Hui Hu shue-Shian Chiou Seng-Kee Chuah Division of Hepatogastroenterology Department of Internal Medicine Chang Gung Memorial Hospital-Kaohsiung Medical Center Chang Gung University College of Medicine

AIM: To identify the predictors of rebleeding after initial hemostasis with epinephrine injection (EI) in patients with high-risk ulcers. METHODS: Recent studies have revealed that endoscopic thermocoagulation, or clips alone or combined with EI are superior to EI alone to arrest ulcer bleeding. However, the reality is that EI monotherapy is still common in clinical practice. From October 2006 to April 2008, high-risk ulcer patients in whom hemorrhage was stopped after EI monotherapy were studied using clinical, laboratory and endoscopic variables. The patients were divided into 2 groups: sustained hemostasis and rebleeding. RESULTS: A total of 175 patients (144, sustainedhemostasis; 31, rebleeding) were enrolled. Univariate analysis revealed that older age (≥ 60 years), advanced American Society of Anesthesiology (ASA) status (category Ⅲ , Ⅳ and Ⅴ ), shock, severe anemia (hemoglobin tasis, 15 (48.4%) suffered from delayed hemostasis causing major complications and 13 (41.9%) died of these complications. CONCLUSION: Endoscopic EI monotherapy in patients with high-risk ulcers should be avoided. Initial hemostasis with thermocoagulation, clips or additional hemostasis after EI is mandatory for such patients to ensure better hemostatic status and to prevent subsequent rebleeding, surgery, morbidity and mortality.

关键词： Epinephrine injection High-risk ulcers Initial hemostasis Predictors Rebleeding

Insect Flight from the Perspective of a Force Element Theory Using a Simplified Model

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Insect Flight from the Perspective of a Force Element Theory...

Upper gastrointestinal carcinoid tumors incidentally found by endoscopic examinations

2009年度海峡两岸工程力学研讨会

作者： Chien C.Chang Chin-chou Chu Cheng-ta Hsieh Institute of Applied Mechanics National Taiwan University Division of Mechanics Applied SciencesAcademia Sinica

Bird or insect flight has been of great interest to general audience,not only to *** works have been devoted to the study of aerodynamics of insect wings,for example,the hovering *** is generally considered that the lift supporting the insect comes from the unsteadiness of the ***,the term "unsteadiness" itself is loose and imprecise at *** may include several unsteady components:the motion of wing,vortex in the flow as well as the surface *** various contributions are now examined from the perspective of a force element theory to gain more insight into the mechanisms of generating lift.

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World Journal of Gastroenterology 2005年第44期11卷 7028-7032页

作者： Tsung-Hui Hu Chung-Mou Kuo King-Wah Chiu Chung-Huang Kuo Keng-Liang Wu Yeh-Pin chou Sheng-Nan Lu shue-Shian Chiou Chi-Sin Changchien Hock-Liew Eng Department of Hepato-Gastroenterology Chang Gung Memorial Hospital 123 Ta-Pei Road Niao-sung Hsiang Kaohsiung HsienTaiwan China Department of Pathology Chang Gung Memorial Hospital 123 Ta-Pei Road Niao-sung Hsiang Kaohsiung HsienTaiwan China

AIM: This study shares Asian clinical experiences of carcinoid tumors that originated in the upper gastrointestinal ***: From May 1987 to June 2002, we had found only 13 cases of histologically confirmed carcinoid tumors in the upper gastrointestinal tract by endoscopic examinations. There were eight males and five *** mean age was 53.16±20.51 years that ranged from 26 to 82 years. Each of their clinical presentations,locations, tumor morphology, and size and the treatment outcome were analyzed and ***: One patient had a polypoid lesion at the lower esophagus, nine were stomach lesions and three located at the duodenum. All patients with polypoid and submucosal tumor types were of small size (＜1.7 cm) and all patients survived after simple excision or *** of the five patients in tumor mass forms died and the tumors were more than 2.0 cm in ***: Carcinoid tumors rarely originated from the upper gastrointestinal tract and are usually found accidentally after endoscopic study. Bigger size (more than 2 cm) tumor masses may indicate a more severe disease and poor prognosis.

关键词： Upper gastrointestinal carcinoid tumors Tumor morphology Sizes Treatment courses Prognosis

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由江西泰河山钨矿石所萃取氧化钨之净化研究

化工学报 1950年第Z1期 48-53页

作者： ta-Yao chou and Che-Pin Chen

本报告将得自江西泰河山钨矿石之氧化钨(见化学工程第十六卷第118页)加以净化。研究之结果,所用之净化方法,分为单纯与复杂两类。结果显示:(1)复杂方法较单纯方法纯为优;(2)复杂方法中最有效者,能待纯度达99.9%以上之氧化钨;(3)此最有... 详细信息

本报告将得自江西泰河山钨矿石之氧化钨(见化学工程第十六卷第118页)加以净化。研究之结果,所用之净化方法,分为单纯与复杂两类。结果显示:(1)复杂方法较单纯方法纯为优;(2)复杂方法中最有效者,能待纯度达99.9%以上之氧化钨;(3)此最有效净化方法之重点步骤,系先使不纯净之氧化钨结晶为七仲(para)钨酸氨,次用苛性钠溶液使之分解为钨酸钠,复使之结晶为七仲钨酸氨,最后即得极纯之氧化钨。

关键词：氧化钨钨化合物钨酸钠钨矿石河山江西净化研究

面向自定义语音唤醒的关键词相关的单通道语音增强

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声学学报 2023年第2期48卷 415-424页

作者：刘作桢吴愁黎塔赵庆卫中国科学院声学研究所语言声学与内容理解重点实验室北京100190 中国科学院大学北京100049

提出一种面向自定义语音唤醒的单通道语音增强方法。该方法预先将关键词音素信息存入文本编码矩阵,并在常规语音增强模型基础上添加一个基于注意力机制的音素偏置模块。该模块利用语音增强模型中间特征从文本编码矩阵中获取当前帧的音... 详细信息

提出一种面向自定义语音唤醒的单通道语音增强方法。该方法预先将关键词音素信息存入文本编码矩阵,并在常规语音增强模型基础上添加一个基于注意力机制的音素偏置模块。该模块利用语音增强模型中间特征从文本编码矩阵中获取当前帧的音素信息,并将其融入语音增强模型的后续计算中,从而提升语音增强模型对关键词相关音素的增强效果。在不同噪声环境下的实验结果表明,该方法可以更有效地抑制关键词部分噪声。同时所提出方法对比常规语音增强方法与其他文本相关语音增强方法,在自定义语音唤醒性能上可以分别获得14.3%和7.6%的相对提升。

关键词：语音增强语音唤醒关键词相关深度学习

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