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Anchoring mechanical characteristics of Ductile-Expansion bolt

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International Journal of Mining Science and Technology 2024年第8期34卷 1115-1134页

作者： Yu chen Wang Liu linchong Huang Hang lin Yixian Wang Yanlin Zhao Cungang lin State Key Laboratory for Tunnel Engineering Guangzhou 510275China Guangdong Research Center for Underground Space Exploitation Technology Guangdong Key Laboratory of Marine Civil EngineeringSchool of Civil EngineeringSun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China School of Resources and Safety Engineering Central South UniversityChangsha 410083China School of Civil Engineering Hefei University of TechnologyHefei 230009China School of Energy and Safety Engineering Hunan University of Science and TechnologyXiangtan 411201China

The application of ductile rock bolts has been a crucial method for solving the problems of large deformations,energy absorption and stability control issues in deep rock *** study the anchoring mechanism of the key expansive structure,this paper proposes a novel type of bolt—the Ductile-Expansion bolt,and conducts research on anchoring mechanics,energy absorption characteristics,and failure modes of the *** addition,this paper defines the concept of load-volume ratio of metal rock bolts and proves the Ductile-Expansion bolt is capable of better improving the unit volume bearing capacity of the bolt ***,laboratory and field tests verify the Ductile-Expansion bolt had better anchoring effect than the traditional rebar bolt,with the expansion structure favorably enhancing the ductility and energy absorption performance of the ***,this paper microscopically analyzes the crack propagation and distribution morphology of the bolts by establishing a 3D coupled numerical model based on *** results illustrate the interface at the variable diameter of the Ductile-Expansion bolt serves as the transition zone between high and low stress *** expansion structure can impose radial compression on the medium around the bolt,which can improve the bolt anchorage performance.

关键词： Ductile-Expansion bolt Pull-out test Peak load Anchoring mechanical characteristics

A vision system based on CNN-LSTM for robotic citrus sorting Author links open overlay panel

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Information Processing in Agriculture 2024年第1期11卷 14-25页

作者： Yonghua Yu Xiaosong An Jiahao lin Shanjun Li Yaohui chen College of Engineering Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Agricultural Equipment in Mid-Lower Yangtze River Ministry of Agriculture and Rural AffairsWuhan 430070China National R&D Center for Citrus Preservation Wuhan 430070China Citrus Mechanization Research Base Ministry of Agriculture and Rural AffairsWuhan 430070China

Compared with manual sorting of citrus fruit,vision-based sorting solutions can help achieve higher accuracy and *** this study,we present a vision system based on CNN-LSTM,which can cooperate with robotic grippers for real-time sorting and is readily applicable to various citrus processing plants.A CNN-based detector was adopted to detect the defective oranges in view and temporarily classify them into corresponding types,and an LSTM-based predictor was used to predict the position of the oranges in a future frame based on image sequential *** fusion of CNN and LSTM networks enabled the system to track defective ones during rotation and identify their true types,and their future path was also predicted which is vital for predictive control of visually guided robotic *** detection accuracy of 94.1%was obtained based on experimental results,and the error for path prediction was within 4.33 pixels 40 frames *** average time to process a frame was between 28 and 62 frames per second,which also satisfied real-time *** results proved the potential of the proposed system for automated citrus sorting with good precision and efficiency,and it can be readily extended to other fruit crops featuring high versatility.

关键词： Deep learning Long short-term memory Vision system Online citrus sorting Path prediction

Realgar-indigo naturalis formula for the treatment of patients with relapsed and arsenic trioxide-resistant acute promyelocytic leukemia:A case series

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Journal of Integrative Medicine 2024年第5期22卷 614-620页

作者： Yong-guang Fang Shi-lin Huang Nan-nan chen Department of Hematology PLA 967th HospitalDalian 116021Liaoning ProvinceChina

Introduction There is currently no standard treatment for relapsed and arsenic trioxide(ATO)-resistant acute promyelocytic leukemia(APL).Here,we report a case series of realgar-indigo naturalis formula(RIF)for the successful treatment of patients with relapsed and ATO-resistant *** presentation Two patients in the first relapse and one in the second relapse failed to achieve hematologic complete remission(HCR)when reinduced by ATO;the other five patients progressed to relapse during ATO-based regimens for post-remission *** eight patients received RIF in three doses per day totaling 130 mg/kg(≤30 pills)as induction therapy and achieved HCR at a median time of 46.5 *** received 5 years of post-remission therapy,which consisted of combined chemotherapy followed by *** this period,the patients did not experience renal dysfunction or QT interval *** the last follow-up,three patients survived without relapse,two patients survived with a second or third relapse and third or fourth remission,and the other three patients relapsed for a third or fourth time and *** 5-year overall survival and event-free survival rates were 75.0%(95%confidence interval[CI]:31.5–93.1)and 37.5%(95%CI:5.6–71.7),*** RIF for induction therapy and RIF combined with chemotherapy for post-remission therapy may represent an effective and safe protocol for the treatment of patients with relapsed and ATO-resistant APL.

关键词： Acute promyelocytic leukemia Realgar-indigo naturalis formula Arsenic Trioxide Resistant Case report

CRISPR/Cas9-mediated NlinR2 mutants:Analyses of residual mRNA and truncated proteins

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Journal of Integrative Agriculture 2024年第6期23卷 2006-2017页

作者： Jun Lü Jingxiang chen Yutao Hu lin chen Shihui Li Yibing Zhang Wenqing Zhang State Key Laboratory of Biocontrol/School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China Development of Food Science and Engineering Moutai InstituteRenhuai 564507China

CRISPR/Cas9 technology is a powerful genome manipulation tool in ***,little is known about whether mRNA and protein of a target gene are completely cleared in homozygous *** study generated homozygous mutants of the insulin receptor gene 2(NlinR2)in the brown planthopper(Nilaparvata lugens)using CRISPR/Cas9 genome *** frameshift mutants,E5_D17 and E6_I7,differentiated towards long wings,but there were differences in wing morphology,with E5_D17 showing wing *** investigations revealed the presence of residual expression of NlinR2 mRNA in both mutants,as well as the occurrence of spliceosomes featuring exon skipping splicing in E5_***,the E5_D17 exhibited the detection of N-terminally truncated NlinR2 *** interference experiments indicated that the knockdown of NlinR2 expression in the E5_D17 mutant line increased the proportion of wing deformities from 11.1 to 65.6%,suggesting that the residual NlinR2 mRNA of the E5_D17 mutant might have retained some genetic *** results imply that systematic characterization of residual protein expression or function in CRISPR/Cas9-generated mutant lines is necessary for phenotypic interpretation.

关键词： CRISPR/Cas9 Nilaparvata lugens residual mRNA skipping exon truncated protein

Stochastic Gradient Compression for Federated Learning over Wireless Network

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China Communications 2024年第4期21卷 230-247页

作者： lin Xiaohan Liu Yuan chen Fangjiong Huang Yang Ge Xiaohu School of Electronic and Information Engineering South China University of TechnologyGuangzhou 510641China Key Laboratory of Dynamic Cognitive System of Electromagnetic Spectrum Space Ministry of Industry and Information TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016China School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhan 430074China

As a mature distributed machine learning paradigm,federated learning enables wireless edge devices to collaboratively train a shared AI-model by stochastic gradient descent(SGD).However,devices need to upload high-dimensional stochastic gradients to edge server in training,which cause severe communication *** address this problem,we compress the communication by sparsifying and quantizing the stochastic gradients of edge *** first derive a closed form of the communication compression in terms of sparsification and quantization ***,the convergence rate of this communicationcompressed system is analyzed and several insights are ***,we formulate and deal with the quantization resource allocation problem for the goal of minimizing the convergence upper bound,under the constraint of multiple-access channel *** show that the proposed scheme outperforms the benchmarks.

关键词： federated learning gradient compression quantization resource allocation stochastic gradient descent(SGD)

Combined effects of massive reclamation and dredging on the variations in hydrodynamic and sediment transport in lingdingyang Estuary,China

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Frontiers of Earth Science 2024年第1期18卷 127-147页

作者： Kanglin chen Yitong lin Jing LIU Zixiao HE Liangwen JIA School of Geography and Remote Sensing Guangzhou UniversityGuangzhou 510006China School of Marine Science Sun Yat-Sen UniversityGuangzhou 510275China School of Marine Engineering and Technology Sun Yat-Sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519080China Guangdong Province Engineering Research Center of Coasts Islands and ReefsGuangzhou 510275China

Anthropogenic disturbances associated with the rapid development of coastal cities have drastically influenced the hydrodynamics and sediment transport processes in many large estuaries *** Estuary(LE),located in the central and southern part of the Pearl River Delta,southern China with a long history of high-intensity anthropogenic disturbances,was studied to explore the contribution rate and mechanism underlying the alteration in hydrodynamics and sediment transport under each phase of human activity.A state-of-the-art modeling tool(TELEMAC-2D),was used to study the variations in the hydrodynamics and sediment transport,accounting for reclamation-induced shoreline and dredging-induced topography *** results indicated that:i)under the influence of successive land reclamation,the general distribution of the Confluence Hydrodynamic Zone(CHZ)in LE varied from scattered to concentrated,and these zones moved 3–5 km ***)Large-scale channel dredging weakened the residual flow in LE,decreasing the residual flow in the Inner-lingding Estuary(ILE)by 62.45%.This was initiated by the enhancement of tidal dynamics through changes in the bottom friction caused by dredging in the *** contrast,massive reclamation decreased the residual flow in the ILE by 17.55%and increased that in the Outer-lingding Estuary(OLE).iii)Despite disturbances related to land reclamation and dredging,the estuarine jet flow in LE remained a turbulent jet system,and the estuarine jet flow became more *** addition,the position of the estuarine jet source moved 6–13 km ***)Both reclamation and dredging decreased the SSC in the ILE and increased the SSC in the *** weakened the SSC in the ILE by 62.19%,whereas dredging enhanced the SSC in the OLE by 49%.Spatially,reclamation resulted in an increase in the SSC near the outlets and a decrease in the SSC in the northern portion of the Western *** mainly increased the SSC in the north

关键词： reclamation and dredging estuarine jet flow dynamics and sediment transport mechanism lingdingyang Estuary

Equilibrium Reinsurance Strategy and Mean Residual Life Function

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 758-777页

作者： Dan-ping LI Lv chen lin-yi QIAN Wei WANG School of Statistics Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOEEast China Normal UniversityShanghai 200062China Academy of Statistics and Interdisciplinary Sciences Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOEEast China Normal UniversityShanghai 200062China School of Mathematics and Statistics Ningbo UniversityNingbo 315211China

In this paper,we analyze the relationship between the equilibrium reinsurance strategy and the tail of the distribution of the *** Mean Residual Life(MRL)has a close relationship with the tail of the distribution,we consider two classes of risk distributions,Decreasing Mean Residual Life(DMRL)and Increasing Mean Residual Life(IMRL)distributions,which can be used to classify light-tailed and heavy-tailed distributions,*** assume that the underlying risk process is modelled by the classical CramérLundberg model *** the mean-variance criterion,by solving the extended Hamilton-Jacobi-Bellman equation,we derive the equilibrium reinsurance strategy for the insurer and the reinsurer under DMRL and IMRL,***,we analyze how to choose the reinsurance premium to make the insurer and the reinsurer agree with the same reinsurance *** find that under the case of DMRL,if the distribution and the risk aversions satisfy certain conditions,the insurer and the reinsurer can adopt a reinsurance premium to agree on a reinsurance strategy,and under the case of IMRL,the insurer and the reinsurer can only agree with each other that the insurer do not purchase the reinsurance.

关键词： mean residual life excess-of-loss reinsurance insurer reinsurer stochastic control

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Honeycomb-like MoCo alloy on 3D nitrogen-doped porous graphene for efficient hydrogen evolution reaction

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Rare Metals 2024年第3期43卷 1072-1082页

作者： lin-Ping Wang Kuang Li Hua-Long Ding Le Xu chen Huang Jiao-Jiao Zhou Cong-TaoWen Pei-lin Zhang Wei-Wei Wang Lu-Yang chen Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China State Key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai200050China State Key Laboratory of Chemical Engineering and School of Chemistry and Molecular Engineering East China University of Science and TechnologyShanghai200237China

An efficient electrocatalyst is indispensable to significantly reduce energy consumption and accelerate the conversion efficiency of water *** this work,the honeycomb-like porous MoCo alloy on nitrogen-doped three-dimensional(3D)porous graphene substrate(Mo_(0.3)Co_(0.7)@NPG)has been synthesized from the annealing of layered double hydroxide(MoCo-LDH@NPG).Especially,the Mo_(0.3)Co_(0.7)@NPG exhibits low hydrogen evolution overpotential of 75 mV(10 mA·cm^(-2))and a Tafel slope of 69.9 mV·dec^(-1),which can be attributed to highly conductive NPG substrate,the unique nanostructure and the synergistic effect of Mo and ***,the Mo_(0.3)Co_(0.7)@NPG can maintain the original morphology and high catalytic activity after 50-h stability *** work proposes a general strategy to synthesize a multi-element alloy on conductive substrates with high porosity for electrocatalytic reaction.

关键词： MoCo alloy Three-dimensional nitrogen-doped porous graphene Hydrogen evolution reaction(HER)

Human bone marrow mesenchymal stem cell-derived exosomes loaded with gemcitabine inhibit pancreatic cancer cell proliferation by enhancing apoptosis

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4006-4013页

作者： Zu-Gui Tang tie-Mei chen Yi Lu Zhe Wang Xi-cheng Wang Yi Kong Department of Oncology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina Faculty of Pharmaceutical Sciences Shenzhen University of Advanced TechnologyShenzhen 518000Guangdong ProvinceChina Guangdong Pharmaceutical University Guangzhou 510006Guangdong ProvinceChina

BACKGROUND Pancreatic cancer remains one of the most lethal malignancies,and has limited effective ***(GEM),a chemotherapeutic agent,is commonly used for clinical treatment of pancreatic cancer,but it has characteristics of low drug delivery efficiency and significant side *** study tested the hypothesis that human bone marrow mesenchymal stem cell(MSC)-derived exosomes loaded with GEM(Exo-GEM)would have a higher cytotoxicity against human pancreatic cancer cells by enhancing their *** To investigate the cytotoxicity of MSC-derived Exo-GEM against pancreatic cancer cells in *** Exosomes were isolated from MSCs and characterized by transmission electron microscopy and nanoparticle tracking ***-GEM through electroporation,sonication,or incubation,and the loading efficiency was *** cytotoxicity of Exo-GEM or GEM alone against human pancreatic cancer Panc-1 and MiaPaca-2 cells was assessed by MTT and flow cytometry *** The isolated exosomes had an average size of 76.7 *** encapsulation efficacy and loading efficiency of GEM by electroporation and sonication were similar and significantly better than *** cytotoxicity of Exo-GEM against pancreatic cancer cells was stronger than free GEM and treatment with 0.02μM Exo-GEM significantly reduced the viability of both Panc-1 and MiaPaca-2 ***,Exo-GEM enhanced the frequency of GEMinduced apoptosis in both cell *** Human bone marrow MSC-derived Exo-GEM have a potent cytotoxicity against human pancreatic cancer cells by enhancing their apoptosis,offering a promising drug delivery system for improving therapeutic outcomes.

关键词： Mesenchymal stem cells Exosomes Extracellular vesicles Gemcitabine Pancreatic cancer Drug delivery