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Intracellular alpha-fetoprotein mitigates hepatocyte apoptosis and necroptosis by inhibiting endoplasmic reticulum stress

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World Journal of Gastroenterology 2022年第26期28卷 3201-3217页

作者： Yun-Fen Chen Si-Ying Liu Qi-jiao cheng Yu-jiao Wang Shuang Chen Yi-Yang Zhou Xia Liu Zhi-Gang Jiang Wei-Wei Zhong Yi-Huai He Department of Infectious Diseases The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of General Medicine The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina School of Public Health Zunyi Medical UniversityZunyi 563099Guizhou ProvinceChina Department of Endoscopy Jingmen No.1 People’s HospitalJingmen 448000Hubei ProvinceChina

BACKGROUND Endoplasmic reticulum(ER)stress contributes to the pathogenesis of chronic liver diseases,but how hepatocytes respond to ER stress has not been ***(AFP)is secreted by hepatoma cells and elevated levels of serum AFP are associated with development of liver *** To investigate whether and how AFP could regulate ER stress and hepatocyte *** The distribution of AFP and the degrees of ER stress in liver tissues and liver injury were characterized by histology,immunohistochemistry,and Western blot in biopsied human liver specimens,two mouse models of liver injury and a cellular *** levels of AFP in sera and the supernatants of cultured cells were quantified by *** High levels of intracellular AFP were detected in liver tissues,particularly in the necrotic areas,from patients with chronic liver diseases and mice after carbon tetrachloride(CCl4)administration or induction of ER stress,but not from the *** induced intracellular AFP was accompanied by elevated activating transcription factor-6(ATF6)expression and protein kinase R-like ER kinase(PERK)phosphorylation in mouse *** stress induced AFP expression in LO2 cells and decreased their ***6,but not PERK,silencing mitigated the ER-stress-induced AFP expression in LO2 ***,AFP silencing deteriorated the ER stress-mediated LO2 cell injury and CCl4 administration-induced liver damages by increasing levels of cleaved caspase-3,the C/enhancer binding protein homologous protein expression,mixed lineage kinase domain-like pseudokinase and PERK phosphorylation,but decreasing ATF6 *** ER stress upregulated intra-hepatocyte AFP expression by activating ATF6 during the process of liver injury and intracellular AFP attenuated hepatocyte apoptosis and necroptosis by alleviating ER stress.

关键词： Alpha-fetoprotein Endoplasmic reticulum stress Necroptosis Apoptosis Liver injury

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基于卡尔曼滤波的自适应极化参数估计方法

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数据采集与处理 2008年第4期23卷 467-470页

作者：焦程鹏中国科学院电子学研究所北京100080

干扰的极化状态估计是极化滤波器设计中首要解决的问题。本文提出了一种基于卡尔曼滤波技术的自适应极化参数估计方法,由双极化回波模型进一步建立卡尔曼递推方程,递推方程的计算结果用于极化滤波器的设计。仿真试验中,将本文提出的自... 详细信息

干扰的极化状态估计是极化滤波器设计中首要解决的问题。本文提出了一种基于卡尔曼滤波技术的自适应极化参数估计方法,由双极化回波模型进一步建立卡尔曼递推方程,递推方程的计算结果用于极化滤波器的设计。仿真试验中,将本文提出的自适应极化参数估计性能与变步长LM S算法的极化参数估计性能相比较。仿真结果表明,本文提出的算法具有很好的鲁棒性,同时其学习、跟踪性能优于变步长LM S算法。

关键词：极化自适应卡尔曼滤波

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Rosuvastatin escape in a Chinese elderly with hyperlipidemia

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Chinese Medical Journal 2013年第18期126卷 3578-3579页

作者： CHEN Xu-jiao cheng Lei CHU jiao-jiao CHEN Jia TANG Xiao-fang ZHANG Xue-feng Department of Geriatrics Zhejiang Hospital Hangzhou Zhejiang 310013 China

Statin is being used widely in patients who have ＇hyperlipidemia, coronary arterial disease （CAD）or other atherosclerosis diseases. Analysis shows that lowering plasma low density lipoprotein cholesterol C （LDL-C） level depends on the dose and various statins treated. LDL-C will achieve the maximal effects after 7-10 days administration.1＇2 Rosuvastatin is a hydrophilic statin, does not metabolize depending on cytochrome P 450 3A4, meaning less drug-drug interactions in cases of multipharmacy. 3 It shows to be the most potent of the available statins, with the greatest effect of lowering LDL-C in the Mercury I and II trials and the STELLAR trial,a＇5 decreasing LDL-C levels at approximately 50% of dose of atorvastatin.5 The recommended starting dose of rosuvastatin is 5-10 mg, according the individual patient＇s baseline LDL-C. Most patients get effective treatment after rosuvastatin therapy. However, few patients fail to get to the target range of LDL-C. One of possible mechanisms is statin escape.

关键词： rosuvastain escape elderly hyperlipidemia genetic polymorphism

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Aero-Hydro-Elastic-Servo Modeling and Dynamic Response Analysis of A Monopile Offshore Wind Turbine Under Different Operating Scenarios

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China Ocean Engineering 2024年第3期38卷 379-393页

作者： XIE Shuang-yi GAO Jian LI Yong-ran JIANG Shu-xin ZHANG cheng-lin HE jiao College of Mechanical Engineering Chongqing University of TechnologyChongqing 400044China Beijing Institute of Precision Mechatronics and Controls Beijing 100076China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China Fishery Machinery and Instrument Research Institute Chinese Academy of Fishery SciencesShanghai 200092China School of Mechanical and Power Engineering Chongqing University of Science&TechnologyChongqing 401331China

This paper constructs a coupled aero-hydro-elastic-servo simulation framework for a monopile offshore wind turbine(OWT).In this framework,a detailed multi-body dynamics model of the monopile OWT including the gearbox,blades,tower and other components(nacelle,hub,bedplate,etc.)has been explicitly *** effects of pile−soil interaction,controller and operational conditions on the turbine dynamic responses are studied systematically in time domain and frequency *** results show that(1)a comprehensive drivetrain model has the capability to provide a more precise representation of the complex dynamic characteristics exhibited by drivetrain components,which can be used as the basis for further study on the dynamic characteristics of the drivetrain.(2)The pile−soil interaction can influence the wind turbine dynamic responses,particularly under the parked condition.(3)The effect of the pile−soil interaction on tower responses is more significant than that on blade responses.(4)The use of the controller can substantially affect the rotor characteristics,which in turn influences the turbine dynamic responses.(5)The tower and blade displacements under the operational condition are much larger than those under the parked *** model and methodology presented in this study demonstrate potential for examining complex dynamic behaviors of the monopile *** ensure accuracy and precision,it is imperative to construct a detailed model of the wind turbine system,while also taking into account simulation efficiency.

关键词： offshore wind turbine(OWT) pile−soil interaction dynamic response parked condition operating condition

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p-wave resonances in the exponential cosine screened Coulomb potential

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Communications in Theoretical Physics 2024年第7期76卷 105-113页

作者： Yuan-cheng Wang Li Guang jiao Aihua Liu Yew Kam Ho Stephan Fritzsche College of Physical Science and Technology Shenyang Normal UniversityShenyang 110034China College of Physics Jilin UniversityChangchun 130012China Helmholtz-Institut Jena D-07743 JenaGermany GSI Helmholtzzentrum fur Schwerionenforschung GmbH D-64291 DarmstadtGermany Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China Institute of Atomic and Molecular Sciences Academia SinicaTaipei 10617TaiwanChina

We perform benchmark calculations of the p-wave resonances in the exponentially cosine screened Coulomb potential using the uniform complex-scaling generalized pseudo-spectral *** present results show significant improvement in calculation accuracy compared to previous predictions and correct the misidentification of resonance electron configuration in previous *** is found that the resonance states approximately follow an n^(2)-scaling law which is similar to the bound *** birth of a new resonance would distort the trajectory of an adjacent higher-lying resonance.

关键词： complex-scaling method shape resonance generalized pseudospectral method exponential cosine screened Coulomb potential

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Rational design of vitamin C/defective carbon van der Waals heterostructure for enhanced activity,durability and storage stability toward oxygen reduction reaction

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Journal of Energy Chemistry 2024年第1期88卷 103-111,I0003页

作者： Ruiqi cheng Kaiqi Li Huanxin Li Tianshuo Zhao Yibo Wang Qingyue Xue jiao Zhang Chaopeng Fu Shanghai Key Laboratory of Advanced High-temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Christopher Ingold Laboratory Department of ChemistryUniversity College LondonLondon WC1H 0AJUK Department of Chemistry Physical&Theoretical Chemistry LaboratoryUniversity of OxfordSouth Parks RoadOxford OX13QZUK

Metal-free defective carbon materials with abundant active sites have been widely studied as low-cost and efficient oxygen reduction reaction(ORR)electrocatalysts in metal-air ***,the active sites in defective carbon are easily subjected to serious oxidation or hydroxylation during ORR or storage,leading to rapid degradation of ***,we design a van der Waals heterostructure comprised of vitamin C(VC)and defective carbon(DC)to not only boost the activity but also enhance the durability and storage stability of the DC-VC *** formation of VC van der Waals between DC and VC is demonstrated to be an effective strategy to protect the defect active sites from oxidation and hydroxylation degradation,thus significantly enhancing the electrochemical durability and storage anti-aging ***,the DC-VC van der Waals can reduce the reaction energy barrier to facilitate the *** findings are also confirmed by operando Fourier transform infrared spectroscopy and density functional theory *** is necessary to mention that the preparation of this DC-VC electrocatalyst can be scaled up,and the ORR performance of the largely produced electrocatalyst is demonstrated to be very ***,the DC-VC-based aluminum-air batteries display very competitive power density with good performance maintenance.

关键词： Van der Waals heterostructure Oxygen reduction reaction Stability Scalable production Aluminum-air battery

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Fundamental Understanding on Selenium Electrochemistry:From Electrolytic Cell to Advanced Energy Storage

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Energy & Environmental Materials 2024年第3期7卷 236-256页

作者： Jiguo Tu cheng Chang Jingxiu Wang Haiping Lei R.Vasant Kumar Mingyong Wang Shuqiang jiao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK

Selenium(Se),as an important quasi-metal element,has attracted much attention in the fields of thin-film solar cells,electrocatalysts and energy storage applications,due to its unique physical and chemical ***,the electrochemical behavior of Se in different systems from electrolytic cell to battery are complex and not fully *** this article,we focus on the electrochemical processes of Se in aqueous solutions,molten salts and ionic liquid electrolytes,as well as the application of Se-containing materials in energy ***,the electrochemical behaviors of Se-containing species in different systems are comprehensively summarized to understand the complexity of the kinetic processes and guide the Se ***,the relationship between the deposition conditions and resulting structure and morphology of electrodeposited Se is discussed,so as to regulate the morphology and composition of the ***,the advanced energy storage applications of Se in thin-film solar cells and secondary batteries are reviewed,and the electrochemical reaction processes of Se are systematically comprehended in monovalent and multivalent metal-ion *** on understanding the fundamental electrochemistry mechanism,the future development directions of Se-containing materials are considered in view of the in-depth review of reaction kinetics and energy storage applications.

关键词： electrochemical behaviors electrodeposition electrolytes energy storage selenium

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Evidence-Based Dampness-Heat ZHENG(Syndrome) in Cancer: Current Progress toward Establishing Relevant Animal Model with Pancreatic Tumor

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Chinese Journal of Integrative Medicine 2024年第1期30卷 85-95页

作者： jiao Ju-ying cheng Chien-shan CAO Zhang-qi CHEN Lian-yu CHEN Zhen Department of Integrative Oncology Fudan University Shanghai Cancer CenterShanghai(200032)China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai(200032)China

Cancer is one of the deadliest diseases affecting the health of human beings. With limited therapeutic options available, complementary and alternative medicine has been widely adopted in cancer management and is increasingly becoming accepted by both patients and healthcare workers alike. Chinese medicine characterized by its unique diagnostic and treatment system is the most widely applied complementary and alternative medicine. It emphasizes symptoms and ZHENG(syndrome)-based treatment combined with contemporary disease diagnosis and further stratifies patients into individualized medicine subgroups. As a representative cancer with the highest degree of malignancy, pancreatic cancer is traditionally classified into the "amassment and accumulation". Emerging perspectives define the core pathogenesis of pancreatic cancer as "dampness-heat" and the respective treatment "clearing heat and resolving dampness" has been demonstrated to prolong survival in pancreatic cancer patients, as has been observed in many other cancers. This clinical advantage encourages an exploration of the essence of dampness-heat ZHENG(DHZ) in cancer and investigation into underlying mechanisms of action of herbal formulations against dampness-heat. However, at present, there is a lack of understanding of the molecular characteristics of DHZ in cancer and no standardized and widely accepted animal model to study this core syndrome in vivo. The shortage of animal models limits the ability to uncover the antitumor mechanisms of herbal medicines and to assess the safety profile of the natural products derived from them. This review summarizes the current research on DHZ in cancer in terms of the clinical aspects, molecular landscape, and animal models. This study aims to provide comprehensive insight that can be used for the establishment of a future standardized ZHENG-based cancer animal model.

关键词： cancer Chinese medicine syndrome ZHENG dampness-heat syndrome animal model pancreatic tumor evaluation methods

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Late-stage modification of bioactive compounds:Improving druggability through efficient molecular editing

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1030-1076页

作者： Tongyu Huo Xinyi Zhao Zengrui cheng Jialiang Wei Minghui Zhu Xiaodong Dou Ning jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Changping Laboratory Beijing 102206China Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal UniversityShanghai 200062China

Synthetic chemistry plays an indispensable role in drug discovery,contributing to hit compounds identification,lead compounds optimization,candidate drugs preparation,and so *** Nobel Prize laureate James Black emphasized,“the most fruitful basis for the discovery of a new drug is to start with an old drug”***-stage modification or functionalization of drugs,natural products and bioactive compounds have garnered significant interest due to its ability to introduce diverse elements into bioactive compounds *** modifications alter the chemical space and physiochemical properties of these compounds,ultimately influencing their potency and *** enrich a toolbox of chemical modification methods for drug discovery,this review focuses on the incorporation of halogen,oxygen,and nitrogen—the ubiquitous elements in pharmacophore components of the marketed drugs—through late-stage modification in recent two decades,and discusses the state and challenges faced in these *** also emphasize that increasing cooperation between chemists and pharmacists may be conducive to the rapid discovery of new activities of the functionalized ***,we hope this review would serve as a valuable resource,facilitating the application of late-stage modification in the construction of novel molecules and inspiring innovative concepts for designing and building new drugs.

关键词： Late-stage modification Drug space Halogenation Oxygenation Nitrogenation Synthetic chemistry

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In-situ transformed Mott-Schottky heterointerface in silver/manganese oxide nanorods boosting oxygen reduction,oxygen evolution,and hydrogen evolution reactions

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Nano Research 2024年第5期17卷 3622-3632页

作者： Ruiqi cheng Kaiqi Li Huanxin Li Fengzhan Sun Xiaoqian He Tianshuo Zhao jiao Zhang Chaopeng Fu Shanghai Key Laboratory of Advanced High-temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Christopher Ingold Laboratory Department of ChemistryUniversity College LondonLondon WC1H 0AJUK Department of Chemistry Physical&Theoretical Chemistry LaboratoryUniversity of OxfordSouth Parks RoadOxford OX13QZUK Center of Hydrogen Science School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The development of non-platinum group metal(non-PGM)and efficient multifunctional electrocatalysts for oxygen reduction reaction(ORR),oxygen evolution reaction(OER),and hydrogen evolution reaction(HER)with high activity and stability remains a great ***,by in-situ transforming silver manganese composite oxide heterointerface into boosted Mott-Schottky heterointerface through a facile carbon reduction strategy,a nanorod-like silver/manganese oxide with superior multifunctional catalytic activities for ORR,OER and HER and stability was *** nanorod-like silver/manganese oxide with Mott-Schottky heterointerface(designated as Ag/Mn_(3)O_(4))exhibits an ORR half-wave potential of 0.831 V(***)in 0.1 M KOH,an OER overpotential of 338 mV and a HER overpotential of 177 mV at the current density of 10 mA·cm^(-2)in 1 M KOH,contributing to its noble-metal benchmarks comparable performance in aqueous aluminum-air(Al-air)battery and laboratorial overall water splitting electrolytic ***,in-situ electrochemical Raman and synchrotron radiation spectroscopic measurements were conducted to further illustrate the catalytic mechanism of Ag/Mn_(3)O_(4)Mott-Schottky heterointerface towards various electrocatalytic *** the heterointerface,the Ag phase serves as the electron donor and the active phase for ORR and HER,while the Mn_(3)O_(4)phase serves as the electron acceptor and the active phase for OER,*** work deepens the understanding of the Mott-Schottky effect on electrocatalysis and fills in the gap in fundamental physical principles that are behind measured electrocatalytic activity,which offers substantial implications for the rational design of cost-effective multifunctional electrocatalysts with Mott-Schottky effect.

关键词： heterointerface electron donor-acceptor pair electrocatalyst Al-air battery water splitting

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