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Free ubiquitin: a novel therapeutic target for neurodegenerative diseases

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Neural Regeneration Research 2021年第9期16卷 1781-1782页

作者： chul-Woo Park Kwon-Yul Ryu Department of Life Science University of SeoulSeoulRepublic of Korea

Neurodegenerative diseases are widespread and the increasing number of patients with these diseases can no longer be ignored. Dementia is a symptom of many neurodegenerative diseases, and Alzheimer's disease(AD), which is associated with memory and learning disabilities, accounts for approximately 60 to 80% of all dementia cases(Wyss-Coray, 2016).

关键词： diseases degenerative Alzheimer

Electrochemical and electronic properties of nitrogen doped fullerene and its derivatives for lithium-ion battery applications

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Journal of Energy Chemistry 2018年第2期27卷 528-534页

作者： Parveen Sood Ki chul Kim Seung Soon Jang School of Materials Science and Engineering Georgia Institute of Technology Atlanta CA 30332-0245. USA Department of Chemical Engineering Konkuk University Seoul 05029 Republic of Korea Institute for Electronics and Nonotechnology Georgia Institute of Technology Atlanta GA 30332-0245 USA Parker H. Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Atlanta GA 30332-0245 USA

We have studied the redox potentials and electronic properties of C60 and C59N using density functional theory method. It is found that doping C60 with one nitrogen atom results in a slight increase in redox potential. Next, we have also studied C59N functionalized with various redox-active oxygen containing functional groups and strongly electron withdrawing functional groups. It is found that the intrinsic electronic structure of the molecule is the major determinant of the redox potential. Our DFT calculations show that the electron affinity to redox potential of functionalized C59N is correlated with the LUMO of the systems very well. This is the first systematic study on the redox properties and electronic structures of N-doped C60 systems.

关键词： DFT Redox potential C60 Doping Li-ion battery

Friction Behavior of Magnetorheological Fluids with Different Material Types and Magnetic Field Strength

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Chinese Journal of Mechanical Engineering 2016年第1期29卷 84-90页

作者： ZHANG Peng LEE Kwang-Hee LEE chul-Hee Department of Mechanical Engineering Inha University

Magnetorheological （MR） fluid is a type of a smart material that can control its mechanical properties under a magnetic field. Iron particles in MR fluid form chain structures in the direction of an applied magnetic field, which is known as MR effect, resulting in variation of stiffness, shear modulus, damping and tribological characteristics of MR fluid. As MR effect depends on the density of particles in the fluid or the strength of a magnetic field, the experiments are conducted to evaluate the friction property under reciprocating motion by changing the types of MR fluid and the strength of a magnetic field. The material of aluminum, brass, and steel are chosen for specimen as they are the most common material in mechanical applications. The surfaces of specimen are also observed by optical microscope before and after experiments to compare the surfaces with test conditions. The comparing results show that the friction coefficient increases as the strength of a magnetic field increases in regardless of types of MR fluid or the material. Also the density of particle in MR fluid affects the friction characteristic. The results from this research can be used to improve the performance of mechanical applications using MR fluid.

关键词： Magnetorheological (MR) fluid friction characteristics smart material magnetic field

Optimal design considering structural efficiency of compressed natural gas fuel storage vessels for automobiles

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 199-204页

作者： Myung-Chang KANG Hyung Woo LEE chul KIM National Core Research Center for Hybrid Materials Solution Pusan National University Research Institute of Mechanical Technology Pusan National University

The shape and thickness of the dome were investigated with the aim of optimizing the type II CNG storage vessels by using a finite element analysis technique. The thickness of the liners and reinforcing materials was optimized based on the requirement of the cylinder and dome parts. In addition, the shape of the dome, which is most suitable for type lI CNG storage vessels, was proposed by a process of review and analysis of various existing shapes, and the minimum thickness was established in this sequence： metal liners, composite materials and dome parts. Therefore, the new proposed shape products give a mass reduction of 4.8 kg（5.1%）

关键词： CNG fuel storage vessel mechanical property dome part bursting structural analysis

1.45 GPa ultrastrong cryogenic strength with superior impact toughness in the in-situ nano oxide reinforced CrMnFeCoNi high-entropy alloy matrix nanocomposite manufactured by laser powder bed fusion

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Journal of Materials Science & Technology 2022年第2期97卷 10-19页

作者： Young-Kyun Kim Min-chul Kim Kee-Ahn Lee Department of Materials Science and Engineering Inha UniversityIncheon 22212Republic of Korea Korea Atomic Energy Research Institute(KAERI) Daejeon 34057Republic of Korea

CrMnFeCoNi high-entropy alloys(HEAs)exhibit an excellent combination of tensile strength and ductility at cryogenic *** study led to the introduction of a new method for the development of high-performance CrMnFeCoNi HEAs at cryogenic temperatures by jointly utilizing additive manufacturing(AM)and the addition of interstitial *** interstitial oxygen present in the powder feedstock was transformed into beneficial nano-sized oxides during AM *** HEA nanocomposite fabricated using laser powder bed fusion(L-PBF)not only contains heterogeneous grains and substructures but also a high number density of nano-sized *** tensile results revealed that the L-PBF HEA nanocomposite has superior yield strengths of 0.77 GPa and 1.15 GPa,and tensile strengths of 0.92 GPa and 1.45 GPa at 298 K and 77 K,*** addition,the Charpy impact energies of the samples tested at 298 K and 77 K were measured as 176.2 J and 103.7 J,*** results indicate that the L-PBF HEA nanocomposite successfully overcomes the well-known strength-toughness *** tensile deformation microstructure contained a relatively large number of deformation twins(DTs)at cryogenic temperature,a possible consequence of the decrease in the stacking fault energy with decreasing *** the other hand,cracks were found to propagate along the grain boundaries at room temperature,whereas a transgranular crack was observed at cryogenic temperature in the specimens fractured as a result of the Charpy impact.

关键词： Laser powder bed fusion High-entropy alloy matrix nanocomposite Nano-oxide:cryogenic Tensile Impact toughness

Suspected uncomplicated cecal diverticulitis diagnosed by imaging:Initial antibiotics vs laparoscopic treatment

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World Journal of Gastroenterology 2010年第38期16卷 4854-4857页

作者： Hyoung-chul Park Bong Hwa Lee Department of Surgery Hallym University College of Medicine

AIM:To compare the recurrence rate following initial antibiotic management to that following laparoscopic treatment for suspected uncomplicated cecal diverticulitis. METHODS: We examined the records of 132 patients who were diagnosed with uncomplicated cecal diverticulitis and a first attack during an 8-year period. The diagnosis of uncomplicated diverticulitis was made based on imaging findings, such as inflamed diverticulum or a phlegmon with cecal wall thickening. Concurrent appendiceal dilatation from 8 to 12 mm was observed in 36 patients (27%). One hundred and two patients were treated initially with antibiotics only, whereas 30 underwent laparoscopic treatment, including partial cecectomy (n=8) or appendectomy with diverticulectomy (n=9) or appendectomy alone (n =13). We compared clinical outcomes in both groups over a median follow-up period of 46 mo. RESULTS: All patients were successfully treated with initial therapy. Of the 102 patients who initially received only antibiotic treatment, 6 (6%) had a recurrence (3 in the cecum and 3 in the ascending colon or transverse colon) during the follow-up period. Five of these pa-tients were managed with repeated antibiotic treatmentand 1 underwent ileocolic resection for perforation. Of the 30 patients treated by the laparoscopic approach, 2 (7%) had a recurrence (ascending colon) which was treated with antibiotics. CONCLUSION: Initial antibiotic management for suspected uncomplicated cecal diverticulitis showed comparable effi cacy to laparoscopic treatment in the prevention of recurrence.

关键词： Antibiotics Cecal diverticulitis Laparoscopy Radiological imaging

EMMS drag model for simulating a gas-solid fluidized bed of geldart B particles: Effect of bed model parameters and polydisperity

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Particuology 2020年第4期18卷 142-154页

作者： Krishnadash SKshetrimayum Seongho Park Chonghun Han chul-Jin Lee School of Chemical Engineering and Materials Science Chung-Ang University06974 SeoulSouth Korea School of Chemical and Biological Engineering Seoul National UniversitySan 56-1Shillim-dongKwanak-guSeoul151-742South Korea

The energy minimization multi-scale(EMMS)is a heterogeneous drag model widely used to simulate gas-solid fluidized *** this work,we conducted computational fluid dynamics simulations of a gas-solid fluidized bed for Geldart B particles to compare the EMMS with the homogeneous Gidaspow drag *** results from both the homogeneous and heterogeneous drag models were compared with literature experimental data on pressure drop and bed *** was no noticeable difference in predicted bed characteristics in the slugging ***,in the turbulent regime,the EMMS model predicted slightly lower bed expansion than did the Gidaspow *** evaluated the effects of solid-solid and solid-wall interaction parameters by varying the restitution and specularity *** expansion increases by a factor of 1.05-1.08 when the restitution coefficient increases from 0.9 to *** models predict a higher solid volume fraction and higher solid downflow velocity near the wall for a low specularity coefficient of 0.01 or *** we considered solid phases of different sizes to model polydisperity,the simulation predicted vertical segregation of 300,350,and 400μm in the fluidized region due to ***,the drag models made similar predictions in bad characteristics from cold model simulation ofa polysilicon fluidized-bed reactor,although there was very little vertical segregation of solid particles for this case.

关键词： CFD simulation Energy minimization multi-scale drag Gas-solid fluidized bed Polydisperity Fluidized-bed reactor

Relaxation of rabbit cavernous smooth muscle to 17β-estradiol: a non-genomic, NO-independent mechanism

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Asian Journal of Andrology 2004年第2期6卷 127-131页

作者： Sae-chul Kim Kyung-Kun Seo Soon-chul Myung Moo Yeol Lee Department of Urology College of Medicine Chung-Ang University Seoul 140-757 KoreaDepartment of Urology College of Medicine Chung-Ang University Seoul 140-757 KoreaDepartment of Urology College of Medicine Chung-Ang University Seoul 140-757 KoreaDepartment of Physiology College of Medicine Chung-Ang University Seoul 140-757 Korea

Aim: To investigate whether estrogen was involved in relaxation of rabbit cavernous smooth muscle. Methods: Relaxation response of the rabbit cavernous smooth muscles to 17β-estradiol (0.3, 3, 30 and 300 nmol/L) were observed in vitro. The response of the muscle strips to estrogen after incubation with either actinomycin D (10μmol/L) or L-NAME (10μmol/L) were also evaluated. Inside-out mode of patch clamp in a single smooth muscle cell was applied to investigate the Maxi-K channel activities. Results: Estrogen caused a dose-dependent relaxation of the strips precontracted with norepinephrine. The maximal response was noted about 10 minutes after treatment. The estrogen-induced relaxation was prevented by neither actinomycin D nor L-NAME, suggesting that the response was not mediated by gene transcription or nitric oxide (NO). Application of 17β-estradiol increased the Maxi-K channel activities. Conclusion: 17β-estradiol may be involved in relaxation of rabbit cavernous smooth muscles via a non genomic and NO independent mechanism. 17β-estradiol stimulates Maxi-K channel of the rabbit cavernous myocyte.

关键词： 17β-estradiol cavernous smooth muscles Maxi-K channel relaxation

Multi-Generator Discriminator Network Using Texture-Edge Information

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Computers, Materials & Continua 2023年第5期75卷 3537-3551页

作者： Kyeongseok Jang Seongsoo Cho Kwang chul Son Department of Plasma Bio Display Kwangwoon University20Gwangun-roNowon-guSeoul01897Korea School of Software Soongsil University369Sangdo-roDongjak-guSeoul06978Korea Department of Information Contents Kwangwoon University20Gwangun-roNowon-guSeoul01897Korea

In the proposed paper,a parallel structure type Generative Adversarial Network(GAN)using edge and texture information is *** the existing GAN-based model,many learning iterations had to be given to obtaining an output that was somewhat close to the original data,and noise and distortion occurred in the output image even when learning was *** solve this problem,the proposed model consists of two generators and three discriminators to propose a network in the form of a parallel *** the network,each edge information and texture information were received as inputs,learning was performed,and each character was combined and outputted through the Combine *** this,edge information and distortion of the output image were improved even with fewer iterations than DCGAN,which is the existing GAN-based *** a result of learning on the network of the proposed model,a clear image with improved contour and distortion of objects in the image was output from about 50,000 iterations.

关键词： Deep learning convolution neural network generative adversarial network edge information texture information