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Clinical significance and risk factors of postembolization fever in patients with hepatocellular carcinoma

World Journal of Gastroenterology 2013年第2期19卷 284-289页

作者： chung Hwan Jun Ho Seok Ki hoon Ki Lee Kang Jin Park Seon Young Park Sung Bum Cho Chang Hwan Park Young Eun Joo Hyun Soo Kim Sung Kyu Choi Jong Sun Rew Division of Gastroenterology Department of Internal MedicineChonnam National University Medical SchoolGwangju 501-757South Korea

AIM:To investigate tumor response and survival in patients with postembolization fever(PEF) and to determine the risk factors for ***:Four hundred forty-three hepatocellular carcinoma(HCC) patients who underwent the first session of transcatheter arterial chemoembolization(TACE) between January 2005 and December 2009 were analyzed *** was defined as a body temperature greater than 38.0 ℃ that developed within 3 d of TACE without evidence of *** tumor progression-free interval was defined as the interval from the first TACE to the second TACE based on mRECIST *** staging was based on the American Joint Committee on Cancer tumor,node,metastases(TNM) classification of malignant *** patients were admitted before their 1 st TACE treatment,and blood samples were obtained from all patients before and after *** variables and host-related variables were compared between two groups:patients with PEF vs patients without ***,variables related to 20-mo mortality and tumor progression-free survival were ***:The study population comprised 370(85.4%) men and 73(14.6%) women with a mean age of 62.29 ± 10.35 years.A total of 1836 TACE sessions were conducted in 443 patients,and each patient received between 1 and 27(mean:4.14 ± 3.57) TACE *** mean follow-up duration was 22.23 ± 19.6 mo(range:0-81 mo).PEF developed in 117 patients(26.41%) at the time of the first TACE *** was not associated with 20-mo survival(P = 0.524) or computed tomography(CT) response(P = 0.413) in a univariate analysis.A univariate analysis further indicated that diffuse-type HCC(P = 0.021),large tumor size(≥ 5 cm)(P = 0.046),lipiodol dose(≥ 7 mL,P = 0.001),poor blood glucose control(P = 0.034),alanine aminotransferase(ALT) value after TACE(P = 0.004) and C-reactive protein(CRP) value after TACE(P = 0.036) served as possible risk factors correlated with *** ALT value after TACE(P = 0.02

关键词： Chemoembolization Therapeutic Fever Carcinoma Hepatocellular Prognosis Progression-free survival

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Dual Channel SIS Receiver of Trao Telescope

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天文研究与技术 1999年第S1期 82-85页

作者： Jong Ae Park 1,2 , Seog Tae Han 1, Tai Seong Kim 1, Kwang Dong Kim 1, Hyo Ryoung Kim 1, Hyun Soo chung 1, Jae hoon Jung 1, Chang hoon Lee 1, Se Hyung Cho 1, Jongmann Yang 2 1. Taeduk Radio Astronomy Observatory (TRAO), Hwaam dong,

We have developed the dual channel receiver with 100GHz and 150GHz band, which is used to make the simultaneous observation with two bands. The SIS mixers are used in both bands. The constructed dewar for receiver has the performance with the vacuum of 10 -8 Torr and the temperature of 4 2K. The receiver noise temperature is 50K (DSB) for 100GHz band and 80K (DSB) for 150GHz band ,respectively. In order to achieve the simultaneous observations, the quasioptical system is precisely designed, and also evaluated by the measurement in the laboratory. We have observed the various sources using this receiver since October 1998. The relative pointing offset between two bands is 3″.

关键词： SIS Dual Channel SIS Receiver of Trao Telescope

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Development of an analytical method for multi-residue quantification of 18 anthelmintics in various animal-based food products using liquid chromatography-tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2021年第1期11卷 68-76页

作者： Kyung-Hee Yoo Da-Hee Park A.M.Abd El-Aty Seong-Kwan Kim Hae-Ni Jung Da-Hye Jeong Hee-Jung Cho Ahmet Hacimuftuoglu Jae-Han Shim Ji hoon Jeong Ho-Chul Shin Department of Veterinary Pharmacology and Toxicology College of Veterinary MedicineKonkuk UniversitySeoul143-701Republic of Korea State Key Laboratory of Biobased Material and Green Papermaking College of Food Science and EngineeringQilu University of TechnologyShandong Academy of ScienceJinan250353China Department of Pharmacology Faculty of Veterinary MedicineCairo University12211GizaEgypt Department of Medical Pharmacology Medical FacultyAtaturk UniversityErzurum25240Turkey Department of Veterinary Physiology College of Veterinary MedicineKonkuk UniversitySeoul143-701Republic of Korea Natural Products Chemistry Laboratory College of Agriculture and Life SciencesChonnam National UniversityGwangju500-757Republic of Korea Department of Pharmacology College of MedicineChung-Ang UniversitySeoul156-756Republic of Korea

In this study,we developed a simple screening procedure for the determination of 18 anthelmintics(including benzimidazoles,macrocyclic lactones,salicylanilides,substituted phenols,tetrahydropyrimidines,and imidazothiazoles)in five animal-derived food matrices(chicken muscle,pork,beef,milk,and egg)using liquid chromatography-tandem mass *** were extracted using acetonitrile/1% acetic acid(milk and egg)and acetonitrile/1% acetic acid with 0.5 mL of distilled water(chicken muscle,pork,and beef),and purified using saturated n-hexane/acetonitrile.A reversed-phase analytical column and a mobile phase consisting of(A)10 mM ammonium formate in distilled water and(B)methanol were used to achieve optimal chromatographic ***-matched standard calibration curves(R^(2)≥0.9752)were obtained for concentration equivalent to ×1/2,×1,×2,×3,×4,and×5 fold the maximum residue limit(MRL)stipulated by the Korean Ministry of Food and Drug *** of 61.2e118.4%,with relative standard deviations(RSDs)of ≤19.9%(intraday and interday),were obtained for each sample at three spiking concentrations(×1/2,×1,and ×2 the MRL values).Limits of detection,limits of quantification,and matrix effects were 0.02e5.5 mg/kg,0.06e10 mg/kg,and -98.8 to 13.9%(at 20 μg/kg),*** five samples of each food matrix(chicken muscle,pork,beef,milk,and egg)purchased from large retailers in Seoul that were tested,none of the target analytes were *** has therefore been shown that this protocol is adaptable,accurate,and precise for the quantification of anthelmintic residues in foods of animal origin.

关键词： Anthelmintics Tandem mass spectrometry Animal-based food products Residue analysis Method validation

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Large-scale and high-quality Ⅲ-nitride membranes through microcavity-assisted crack propagation by engineering tensile-stressed Ni layers

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Opto-Electronic Science 2022年第10期 45-55页

作者： Jung-Hong Min Kwangjae Lee Tae-hoon chung Jung-Wook Min Kuang-Hui Li Chun Hong Kang Hoe-Min Kwak Tae-Hyeon Kim Youyou Yuan Kyoung-Kook Kim Dong-Seon Lee Tien Khee Ng Boon S.Ooi Photonics Laboratory Computer Electrical and Mathematical Sciences and Engineering Division (CEMSE) King Abdullah University of Science and Technology (KAUST) Department of Electrical Engineering Stanford University Light Source Research Division Korea Photonics Technology Institute (KOPTI) School of Electrical Engineering and Computer Science Gwangju Institute of Science and Technology Department of Advanced Convergence Technology Research Institute of Advanced Convergence Technology Korea Polytechnic University King Abdullah University of Science and Technology (KAUST)

Epitaxially grown Ⅲ-nitride alloys are tightly bonded materials with mixed covalent-ionic bonds. This tight bonding presents tremendous challenges in developing Ⅲ-nitride membranes, even though semiconductor membranes can provide numerous advantages by removing thick, inflexible, and costly substrates. Herein, cavities with various sizes were introduced by overgrowing target layers, such as undoped GaN and green LEDs, on nanoporous templates prepared by electrochemical etching of n-type GaN. The large primary interfacial toughness was effectively reduced according to the design of the cavity density, and the overgrown target layers were then conveniently exfoliated by engineering tensile-stressed Ni layers. The resulting Ⅲ-nitride membranes maintained high crystal quality even after exfoliation due to the use of GaN-based nanoporous templates with the same lattice constant. The microcavity-assisted crack propagation process developed for the current Ⅲ-nitride membranes forms a universal process for developing various kinds of largescale and high-quality semiconductor membranes.

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Large-scale and high-quality III-nitride membranes through microcavity-assisted crack propagation by engineering tensile-stressed Ni layers

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Opto-Electronic Science 2022年第10期1卷 51-61,42-50页

作者： Jung-Hong Min Kwangjae Lee Tae-hoon chung Jung-Wook Min Kuang-Hui Li Chun Hong Kang Hoe-Min Kwak Tae-Hyeon Kim Youyou Yuan Kyoung-Kook Kim Dong-Seon Lee Tien Khee Ng Boon S.Ooi Photonics Laboratory ComputerElectrical and Mathematical Sciences and Engineering Division(CEMSE)King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Department of Electrical Engineering Stanford UniversityStanfordCA 94305USA Light Source Research Division Korea Photonics Technology Institute(KOPTI)Gwangju 61007Republic of Korea School of Electrical Engineering and Computer Science Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Advanced Convergence Technology Research Institute of Advanced Convergence TechnologyKorea Polytechnic University237 Sangidaehak-roSiheung-si 15073Republic of Korea King Abdullah University of Science and Technology(KAUST) Thuwal 23955-6900Saudi Arabia

Epitaxially grown III-nitride alloys are tightly bonded materials with mixed covalent-ionic *** tight bonding presents tremendous challenges in developing III-nitride membranes,even though semiconductor membranes can provide numerous advantages by removing thick,inflexible,and costly ***,cavities with various sizes were introduced by overgrowing target layers,such as undoped GaN and green LEDs,on nanoporous templates prepared by electrochemical etching of n-type *** large primary interfacial toughness was effectively reduced according to the design of the cavity density,and the overgrown target layers were then conveniently exfoliated by engineering tensile-stressed Ni *** resulting III-nitride membranes maintained high crystal quality even after exfoliation due to the use of GaN-based nanoporous templates with the same lattice *** microcavity-assisted crack propagation process developed for the current III-nitride membranes forms a universal process for developing various kinds of large-scale and high-quality semiconductor membranes.

关键词： III-nitride alloys membranes nanoporous Ni stressor light-emitting diodes ultraviolet photodetectors

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Risk factors for tuberculosis after gastrectomy in gastric cancer

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World Journal of Gastroenterology 2016年第8期22卷 2585-2591页

作者： Won Jai Jung Young Mok Park Joo Han Song Kyung Soo chung Song Yee Kim Eun Young Kim Ji Ye Jung Moo Suk Park Young Sam Kim Se Kyu Kim Joon Chang Sung hoon Noh Ji Yeong An Young Ae Kang Division of Respiratory and Critical Care Medicine Department of Internal Medicine Korea University College of Medicine Division of Pulmonology Department of Internal Medicine Severance Hospital Institute of Chest Diseases Yonsei University College of Medicine Department of Surgery Yonsei University College of Medicine

AIM: To examine incidence of tuberculosis(TB) in gastrectomy patients and investigate the risk factors for developing TB after gastrectomy in patients with gastric ***: A retrospective cohort study of gastrectomy patients with gastric cancer was performed at a university-affiliated hospital in Seoul, South Korea between January 2007 and December 2009. We reviewed patient medical records and collected data associated with the risk of TB, surgery, and gastric cancer. Standardized incidence ratios(SIRs) of TB were calculated to compare the incidence of TB in gastrectomy patients with that in the general Korean population, and risk factors for TB after gastrectomies were ***: Among the 1776 gastrectomy patients, 0.9%(16/1776) developed post-gastrectomy TB, with an incidence of 223.7 cases per 100000 patients per year. The overall incidence of TB in gastrectomy patients, adjusted by sex and age, was significantly higher thanthat in the general population(SIR = 2.22, 95%CI: 1.27-3.60). Previous TB infection [odds ratio(OR) = 7.1, P < 0.001], lower body mass index(BMI)(kg/m2; OR = 1.21, P = 0.043) and gastrectomy extent(total gastrectomy vs subtotal gastrectomy)(OR = 3.48, P = 0.017) were significant risk factors for TB after gastrectomy in a multivariate ***: TB incidence after gastrectomy is higher than that in the general population. Previous TB infection, lower BMI, and total gastrectomy are risk factors for TB after gastrectomy in patients with gastric cancer.

关键词： Tuberculosis Gastrectomy Body mass index Risk factor Gastric cancer

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花青素通过LPS处理的成年小鼠中的JNK/Akt/GSK3β信号改善海马依赖性记忆功能并预防神经变性

花青素通过LPS处理的成年小鼠中的JNK/Akt/GSK3β信号改善海马依...

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作者： Muhammad Sohail Khan Tahir Ali Min Woo Kim Myeung hoon Jo Jong Il chung Myeong Ok Kim 张晗

小胶质细胞在大脑中发挥着关键作用,可保护神经细胞免受毒素侵害。然而,小胶质细胞的过度活化会导致有害作用。据报道,脂多糖(Lipopolysaccharide,LPS)可通过激活小胶质细胞以及直接引发神经炎症来影响神经元细胞。在本研究中,我们在动... 详细信息

小胶质细胞在大脑中发挥着关键作用,可保护神经细胞免受毒素侵害。然而,小胶质细胞的过度活化会导致有害作用。据报道,脂多糖(Lipopolysaccharide,LPS)可通过激活小胶质细胞以及直接引发神经炎症来影响神经元细胞。在本研究中,我们在动物模型和细胞培养中评估了花青素的抗炎及抗氧化作用抵抗LPS诱导的神经毒性的功效。腹膜内注射LPS(250μg/kg/天,持续1周)诱导ROS产生并促进神经炎症和神经变性,最终导致记忆障碍。然而,以花青素(24mg/kg/天)对实验动物治疗2周(LPS共同处理前1周和LPS共同处理的1周)可阻止ROS产生、抑制神经炎症和神经变性并且改善LPS处理小鼠的记忆功能。组织学和免疫印迹分析均表明花青素逆转了JNK的活化,其通过降低炎症标志物(p-NF-kB,TNF-α和IL-1β)的水平来阻止神经炎症,并通过降低Bax,细胞色素c,裂解的细胞凋亡蛋白酶3和裂解的PARP-1的表达,同时提高存活蛋白p-Akt,p-GSK3β和抗凋亡Bcl-2蛋白的水平,从而减少神经细胞凋亡/死亡。花青素治疗提高了记忆相关的突触前和突触后的蛋白水平,并改善了LPS处理的小鼠的海马依赖性记忆。总体而言,该研究结果表明,天然来源的抗氧化剂如花青素的使用改善了LPS处理的动物模型中的部分病理改变,并且我们相信花青素将会成为一种安全的治疗剂,用于减缓大脑中炎症诱导的神经变性,并且可治疗相关的神经性疾病,如阿尔茨海默病和帕金森病。

关键词：花青素脂多糖(LPS) 氧化应激神经炎症神经退行性变记忆障碍

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Differential diagnosis of left-sided abdominal pain:Primary epiploic appendagitis vs colonic diverticulitis

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World Journal of Gastroenterology 2013年第40期19卷 6842-6848页

作者： Jeong Ah Hwang Sun Moon Kim Hyun Jung Song Yu Mi Lee Kyung Min Moon Chang Gi Moon hoon Sup Koo Kyung Ho Song Yong Seok Kim Tae Hee Lee Kyu Chan Huh Young Woo Choi Young Woo Kang Woo Suk chung Division of Gastroenterology and Hepatology Department of Internal MedicineKonyang University College of MedicineDaejeon 302-718South Korea Department of Diagnostic Radiology Konyang University College of MedicineDaejeon 302-718South Korea

AIM:To investigate the clinical characteristics of left primary epiploic appendagitis and to compare them with those of left colonic ***:We retrospectively reviewed the clinical records and radiologic images of the patients who presented with left-sided acute abdominal pain and had computer tomography(CT) performed at the time of presentation showing radiological signs of left primary epiploic appendagitis(PEA) or left acute colonic diverticulitis(ACD) between January 2001 and December 2011. A total of 53 consecutive patients were enrolled and evaluated. We also compared the clinical characteristics,laboratory findings,treatments,and clinical results of left PEA with those of left ***:Twenty-eight patients and twenty-five patients were diagnosed with symptomatic left PEA and ACD,respectively. The patients with left PEA had focal abdominal tenderness on the left lower quadrant(82.1%). On CT examination,most(89.3%) of the patients with left PEA were found to have an oval fatty mass with a hyperattenuated ring sign. In cases of left ACD,the patients presented with a more diffuse abdominal tenderness throughout the left side(52.0%vs 14.3%; P = 0.003). The patients with left ACD had fever and rebound tenderness more often than those with left PEA(40.0% vs 7.1%,P = 0.004; 52.0% vs14.3%,P = 0.003,respectively). Laboratory abnormalities such as leukocytosis were also more frequently observed in left ACD(52.0% vs 15.4%,P = 0.006).CONCLUSION:If patients have left-sided localized abdominal pain without associated symptoms or laboratory abnormalities,clinicians should suspect the diagnosis of PEA and consider a CT scan.

关键词： Acute abdomen Differential diagnosis Appendix epiploica Colonic diverticulitis Multidetector computed tomography

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Peer-assisted learning to train high-school students to perform basic life-support

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World Journal of Emergency Medicine 2015年第3期6卷 186-190页

作者： Hyung Soo Choi Dong hoon Lee Chan Woong Kim Sung Eun Kim Je Hyeok Oh Emergnecy Medicine Department Chung-Ang University Hospital 102 Heukseok-ro Dongjak-gu

BACKGROUND: The inclusion of cardiopulmonary resuscitation(CPR) in formal education has been a useful approach to providing basic life support(BLS) services. However, because not all students have been able to learn directly from certified instructors, we studied the educational efficacy of the use of peer-assisted learning(PAL) to train high-school students to perform BLS ***: This study consisted of 187 high-school students: 68 participants served as a control group and received a 1-hour BLS training from a school nurse, and 119 were included in a PAL group and received a 1-hour CPR training from a PAL leader. Participants' BLS training was preceded by the completion of questionnaires regarding their background. Three months after the training, the participants were asked to respond to questionnaires about their willingness to perform CPR on bystander CPR and their retention of knowledge of ***: We found no statistically significant difference between the control and PAL groups in their willingness to perform CPR on bystanders(control: 55.2%, PAL: 64.7%, P=0.202). The PAL group was not significantly different from the control group(control: 60.78±39.77, PAL: 61.76±17.80, P=0.848) in retention of knowledge about BLS ***: In educating high school students about BLS, there was no significant difference between PAL and traditional education in increasing the willingness to provide CPR to bystanders or the ability to retain knowledge about BLS.

关键词： Peer-assisted learning Basic life support Education

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Weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2015年第14期21卷 4268-4274页

作者： Min-Young Lee Ki Sun Jung Hae Su Kim Ji Yun Lee Sung Hee Lim Moonjin Kim Hyun Ae Jung Sung Min Kim Jong Mu Sun myung-Ju Ahn Jeeyun Lee Se hoon Park Seong Yoon Yi In Gyu Hwang Sang-Cheol Lee Hee Kyung Ahn Do Hyoung Lim Soon Il Lee Keon Woo Park Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine Division of Hematology-Oncology Department of Internal MedicineInje University Ilsan-Paik Hospital Division of Hematology-Oncology Department of Internal MedicineChung-Ang University Hospital Division of Hematology-Oncology Department of Internal MedicineSoonchunhyang University Hospital Division of Hematology-Oncology Department of Internal MedicineGachon University Gil Hospital Division of Hematology-Oncology Department of Internal MedicineDankook University College of Medicine

AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate(FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma(SCC).METHODS: A multi-center, open-label, prospective phase Ⅱ study was ***-three esophageal SCC patients with documented progression after fluoropyrimidine/platinum-based first-line chemotherapy were enrolled and treated with docetaxel 35 mg/m2 and gemcitabine 1000 mg/m2 iv at a FDR(10 mg/m2 per minute) on days 1 and *** was repeatedevery twenty-one days until disease progression, unacceptable toxicity, or consent *** primary endpoint was response rate(RR), and secondary endpoints were safety, progression-free survival(PFS) and overall survival(OS).RESULTS: Combination of weekly docetaxel and FDR gemcitabine was well tolerated: the most common treatment-related adverse events were anemia(97%), fatigue(64%) and neutropenia(55%).One patient with multiple lung and lymph node metastases died of respiratory failure after receiving four cycles of chemotherapy, and the possibility of drug-induced pneumonitis could not be completely *** control(objective response plus stable disease) in the ITT population was achieved in 88% of patients, and the overall RR was 30%(95%CI: 15%-46%).The median PFS and OS were 4.0(95%CI: 3.4-4.6) and 8.8 mo(95%CI: 7.8-9.8 mo), ***: A combination of weekly docetaxel and FDR gemcitabine showed promising antitumor activity and tolerability in previously treated, metastatic esophageal SCC.

关键词： Clinical trial Phase Ⅱ Chemotherapy Carcinoma,Esop

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