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Minimally invasive surgery for glycogen storage disease combined with inflammatory bowel disease:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4342-4347页

作者： Jian Wan Zi-Chao Zhang Mu-Qing Yang Xiao-Min Sun Lu Yin chun-qiu chen Center for Difficult and Complicated Abdominal Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Department of Gastroenterology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China

BACKGROUND Inflammatory bowel disease(IBD)is rare in patients with glycogen storage disease(GSD).In GSD patients,a decrease in the number of neutrophils leads to prolonged intestinal infection,leading to the formation of chronic inflammation and eventually the development of *** invasive surgery for patients with IBD has been proven to reduce inflammatory responses and postoperative risks and ultimately promote rapid *** we discuss minimally invasive surgery and the perioperative management in a patient with GSD and *** SUMMARY A 23-year-old male had GSD Ib associated with IBD-like disease for 10 *** standard treatments,such as mesalazine,prednisone and adalimumab,the patient eventually developed colonic stenosis with incomplete *** adequate assessment,the patient was treated with minimally invasive surgery and discharged in stable *** Minimally invasive surgery for patients with IBD and GSD is safe,feasible and effective.

关键词： Minimally invasive surgery Glycogen storage disease Inflammatory bowel disease Perioperative Rapid recovery Case report

p38 MAPK inhibition alleviates experimental acute pancreatitis in mice

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Hepatobiliary & Pancreatic Diseases International 2015年第1期14卷 101-106页

作者： Ming-Hua Cao Jing Xu Hai-Dong Cai Zhong-Wei Lv Ya-Jing Feng Kun Li chun-qiu chen Yong-Yu Li Department of Pathophysiology Institute of Digestive Disease Tongji University School of Medicine The Seventh People's Hospital of Shanghai The Tenth People's Hospital of Shanghai Tongji University School of Medicine

BACKGROUND： The mitogen-activated protein kinases （MAPKs） signaling pathway is involved in inflammatory process. However,the mechanism is not clear. The present study was to investigate the role of p38 MAPK in acute pancreatitis in ***： Mice were divided into 4 groups： saline control; acute pancreatitis induced with repeated injections of cerulein; control plus p38 MAPK inhibitor SB203580; and acute pancreatitis plus SB203580. The pancreatic histology, pancreatic enzymes, cytokines, myeloperoxidase activity, p38 MAPK and heat shock protein （HSP） 60 and 70 were ***： Repeated injections of cerulein resulted in acute pancreatitis in mice, accompanying with the activation of p38 MAPK and overexpression of HSP60 and HSP70 in the pancreatic tissues. Treatment with SB203580 significantly inhibited the activation of p38 MAPK, and furthermore, inhibited the expression of HSP60 and HSP70 in the pancreas, the inflammatory cytokines in the serum, and myeloperoxidase activity in the ***： The p38 MAPK signaling pathway is involved in the regulation of inflammatory response and the expression of HSP60 and HSP70 in acute pancreatitis.

关键词： acute pancreatitis p38 MAPK heat shock protein

Prognosis of patients with gastric cancer and solitary lymph node metastasis

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World Journal of Gastroenterology 2013年第46期19卷 8611-8618页

作者： chun-qiu chen Xiao-Jiang Wu Zhen Yu Zhao-De Bu Ke-Qiang Zuo Zi-Yu Li Jia-Fu Ji Department of General Surgery Tenth People’s Hospital of Shanghai Tongji University School of Medicine Department of Surgery Beijing Cancer Hospital Peking University School of Oncology

AIM:To investigate the relationship of solitary lymph node metastasis(SLNM)and age with patient survival in gastric cancer(GC).METHODS:The medical records databases of China’s Beijing Cancer Hospital at the Peking University School of Oncology and Shanghai Tenth People’s Hospital affiliated to Tongji University were searched retrospectively to identify patients with histologically proven GC and SLNM who underwent surgical resection between October 2003 and December *** with distant metastasis or gastric stump carcinoma following resection for benign disease were excluded from the *** total,936 patients with GC+SLNM were selected for analysis and the recorded parameters of clinicopathological disease and follow-up(range:13-2925 d)were *** Kaplan-Meier method was used to stratify patients by age(≤50 years-old,n=198;50-64 years-old,n=321;≥65 years-old,n=446)and by metastatic lymph node ratio[MLR<0.04(1/25),n=180;0.04-0.06(1/25-1/15),n=687;≥0.06(1/15),n=98]for 5-year survival *** significance of intergroup differences between the survival curves was assessed by a log-rank test. RESULTS:The 5-year survival rate of the entire GC+SLNM patient population was 49.9%.Stratification analysis showed significant differences in survival time(post-operative days)according to age:≤50 yearsold:950.7±79.0 vs 50-64 years-old:1697.8±65.9 vs≥65 years-old:1996.2±57.6,all P<*** addition,younger age(≤50 years-old)correlated significantly with mean survival time(r=0.367,P<0.001).Stratification analysis also indicated an inverse relationship between increasing MLR and shorter survival time:<0.04:52.8%and 0.04-0.06:51.1%vs≥0.06:40.5%,P<*** patients with the shortest survival times and rates were younger and had a high MLR(≥0.06):≤50 years-old:496.4±133.0 and 0.0%vs 50-65 years-old:1180.9±201.8 and 21.4%vs≥65 years-old:1538.4±72.4 and 37.3%,all P<*** same significant trend in shorter survival times and rates for younger patients was seen with t

关键词： Gastric cancer Solitary lymph node metas-tasis Age Metastatic lymph node ratio Survival

Distribution,function and physiological role of melatonin in the lower gut

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World Journal of Gastroenterology 2011年第34期17卷 3888-3898页

作者： chun-qiu chen Jakub Fichna Mohammad Bashashati Yong-Yu Li Martin Storr Department of Gastrointestinal Surgery Shanghai Tenth People＇s Hospital Tongji University School of Medicine 200072 Shanghai China Division of Gastroenterology Department of Medicine University of Calgary 3330 Hospital Dr NW T2N 0N1 Calgary Alberta Canada Department of Pathophysiology Tongji University School of Medicine 200092 Shanghai China

Melatonin is a hormone with endocrine, paracrine andautocrine actions. It is involved in the regulation of multiple functions, including the control of the gastroin-testinal (GI) system under physiological and pathophys-iological conditions. Since the gut contains at least 400times more melatonin than the pineal gland, a reviewof the functional importance of melatonin in the gutseems useful, especially in the context of recent clinicaltrials. Melatonin exerts its physiological effects throughspecific membrane receptors, named melatonin-1 re-ceptor (MT1), MT2 and MT3. These receptors can befound in the gut and their involvement in the regulationof GI motility, inflammation and pain has been reportedin numerous basic and clinical studies. Stable levels ofmelatonin in the lower gut that are unchanged follow-ing a pinealectomy suggest local synthesis and, further more, implicate physiological importance of endogenous melatonin in the GI tract. Presently, only a small number of human studies report possible beneficial and also possible harmful effects of melatonin in case reports and clinical trials. These human studies include patients with lower GI diseases, especially patients with irritable bowel syndrome, inflammatory bowel disease and colorectal cancer. In this review, we summarize the presently available information on melatonin effects in the lower gut and discuss available in vitro and in vivo data. We furthermore aim to evaluate whether melatonin may be useful in future treatment of symptoms or diseases involving the lower gut.

关键词： Melatonin Ileum Colon Receptor Motility Inflammatory bowel disease Clinical trial

Laparoscopy for Crohn's disease:A comprehensive exploration of minimally invasive surgical techniques

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World Journal of Gastrointestinal Surgery 2021年第10期13卷 1190-1201页

作者： Jian Wan Chang Liu Xiao-Qi Yuan Mu-Qing Yang Xiao-Cai Wu Ren-Yuan Gao Lu Yin chun-qiu chen Center for Difficult and Complicated Abdominal Surgery Shanghai Tenth People's HospitalTongji University School of MedicineShanghai 200072China Department of Medical Ultrasound Shanghai Tenth People’s HospitalUltrasound Research and Education InstituteTongji University School of MedicineShanghai 200072China

BACKGROUND Along with the unceasing progress of medicine,Crohn's disease(CD),especially complex CD,is no longer a taboo for minimally invasive ***,considering its special disease characteristics,more clinical trials are needed to confirm the safety and feasibility of laparoscopic surgery for *** To investigate the safety and feasibility of laparoscopic enterectomy for CD,assess the advantages of laparoscopy over laparotomy in patients with CD,and discuss comprehensive minimally invasive surgical techniques in complex *** This study prospectively collected clinical data from patients with CD who underwent enterectomy from January 2017 to January *** was registered in the Chinese clinical trial database with the registration number *** were divided into a laparoscopy group and a traditional laparotomy group according to the surgical *** baseline characteristics,operation time,intraoperative blood loss,temporary stoma,levels of abdominal adhesion,pathological characteristics,days to flatus and soft diet,postoperative complications,hospitalization time,readmission rate within 30 d,and hospitalization cost were compared between the two *** A total of 120 eligible patients were enrolled into the pre-standardized groups,including 100 in the laparoscopy group and 20 in the laparotomy *** with the laparotomy group,the postoperative hospitalization time in the laparoscopy group was shorter(9.1±3.9 d vs 11.0±1.6 d,P<0.05),the days to flatus were fewer(2.8±0.8 d vs 3.5±0.7 d,P<0.05),the days to soft diet were fewer(4.2±2.4 d vs 6.2±2.0 d,P<0.05)and the intraoperative blood loss was less(103.3±80.42 mL vs 169.5±100.42 mL,P<0.05).There were no statistically significant differences between the two groups in preoperative clinical data,operation time(149.0±43.8 min vs 159.2±40.0 min),stoma rate,levels of abdominal adhesion,total cost of hospitalization,incidence of postoperative complications[8.0%(8/100)

关键词： Crohn’s disease Minimally invasive surgery Rapid recovery Inflammatory bowel disease Ultrasound

Laparoscopic vs open surgery in ileostomy reversal in Crohn’s disease:A retrospective study

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World Journal of Gastrointestinal Surgery 2021年第11期13卷 1414-1422页

作者： Jian Wan Xiao-Qi Yuan Tian-Qi Wu Mu-Qing Yang Xiao-Cai Wu Ren-Yuan Gao Lu Yin chun-qiu chen Center for Difficult and Complicated Abdominal Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200092China

BACKGROUND Although minimally invasive surgery is becoming more commonly applied for ileostomy reversal(IR),there have been relatively few studies of IR for patients with Crohn's disease(CD).It is therefore important to evaluate the potential benefits and risks of laparoscopy for patients with *** To compare the safety,feasibility,and short-term and long-term outcomes of laparoscopic IR(LIR)vs open IR(OIR)for the treatment of *** The baseline characteristics,operative data,and short-term(30-d)and long-term outcomes of patients with CD who underwent LIR and OIR at our institution between January 2017 and January 2020 were retrieved from an electronic database and retrospectively *** Of the 60 patients enrolled in this study,LIR was performed for 48 and OIR for *** were no statistically significant differences in baseline characteristics,operation time,intraoperative blood loss,days to flatus and soft diet,postoperative complications,hospitalization time,readmission rate within 30 d,length of hospitalization,hospitalization costs,or reoperation rate after IR between the two ***,patients in the LIR group more frequently required lysis of adhesions as compared to those in the OIR group(87.5%vs 41.7%,respectively,P<0.05).Notably,following exclusion of patients who underwent enterectomy plus IR,OIR was more advantageous in terms of postoperative recovery of gastrointestinal function and hospitalization *** The safety and feasibility of LIR for the treatment of CD are comparable to those of OIR with no increase in intraoperative or postoperative complications.

关键词： Crohn’s disease Laparoscopy Ileostomy reversal Intestinal adhesion Enterolysis Faster recovery

Predicting short-term major postoperative complications in intestinal resection for Crohn’s disease:A machine learning-based study

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 717-730页

作者： Fang-Tao Wang Yin Lin Xiao-Qi Yuan Ren-Yuan Gao Xiao-Cai Wu Wei-Wei Xu Tian-Qi Wu Kai Xia Yi-Ran Jiao Lu Yin chun-qiu chen Diagnostic and Treatment Center for Refractory Diseases of Abdomen Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China

BACKGROUND Due to the complexity and numerous comorbidities associated with Crohn’s disease(CD),the incidence of postoperative complications is high,significantly impacting the recovery and prognosis of ***,additional stu-dies are required to precisely predict short-term major complications following intestinal resection(IR),aiding surgical decision-making and optimizing patient *** To construct novel models based on machine learning(ML)to predict short-term major postoperative complications in patients with CD following *** A retrospective analysis was performed on clinical data derived from a patient cohort that underwent IR for CD from January 2017 to December *** study participants were randomly allocated to either a training cohort or a validation *** logistic regression and random forest(RF)were applied to construct models in the training cohort,with model discrimination evaluated using the area under the curves(AUC).The validation cohort assessed the performance of the constructed *** Out of the 259 patients encompassed in the study,5.0%encountered major postoperative complications(Clavien-Dindo≥III)within 30 d following IR for *** AUC for the logistic model was 0.916,significantly lower than the AUC of 0.965 for the RF *** logistic model incorporated a preoperative CD activity index(CDAI)of≥220,a diminished preoperative serum albumin level,conversion to laparotomy surgery,and an extended operation time.A nomogram for the logistic model was *** for the surgical approach,the other three variables ranked among the top four important variables in the novel ML *** Both the nomogram and RF exhibited good performance in predicting short-term major postoperative complic-ations in patients with CD,with the RF model showing more superiority.A preoperative CDAI of≥220,a di-minished preoperative serum albumin level,and an extended operation time might be the most crucial ***

关键词： Crohn’s disease Postoperative complications Nomogram Random forest Intestinal resection

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing qiu Mengting Yang Danfeng Gong Haiying Liang Tingting chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi Qi Xueying chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling